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Molar and Trophoblastic Disease

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Management and Therapy of Early Pregnancy Complications

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Abstract

Gestational trophoblastic disease (GTD) has been known for over 2400 years and, in the last century, Dr. Ober was one of the first to compose a review of GTD history [1]. Hippocrates (460–370 AD) first described the hydatidiform mole as the “dropsy of the uterus.” In 600 AD, Aetius of Armida (502–575 AD) described a uterus “filled with bladder-like objects,” probably referring to a molar tissue. Velpeau and Boivin recognized hydatids as cystic dilations of chorionic villi in 1827. Marchand, in 1895, proved these tumors to be the sequelae of pregnancy, abortion, or hydatidiform mole and described the proliferation of the syncytium and cytotrophoblast [2]. Finally, Fels, Ernhart, Reossler, and Zondek proved the presence of high levels of gonadotropic hormone in the urine of patients with GTD [3].

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References

  1. Ober WB, Fass RO (1961) The early history of choriocarcinoma. J Hist Med Allied Sci 16:49–73

    Article  CAS  PubMed  Google Scholar 

  2. Milenkovic V, Lazovic B (2011) Gestational trophoblastic disease-literature review. Med Pregl 64(3–4):188–193

    Article  PubMed  Google Scholar 

  3. Seckl MJ, Sebire NJ, Berkowitz RS (2010) Gestational trophoblastic disease. Lancet 376(9742):717–729

    Article  PubMed  Google Scholar 

  4. Berkowitz RS, Goldstein DP (2013) Current advances in the management of gestational trophoblastic disease. Gynecol Oncol 128(1):3–5

    Article  PubMed  Google Scholar 

  5. Mueller UW, Hawes CS, Wright AE, Petropoulos A, DeBoni E, Firgaira FA et al (1990) Isolation of fetal trophoblast cells from peripheral blood of pregnant women. Lancet 336(8709):197–200

    Article  CAS  PubMed  Google Scholar 

  6. Benirschke K (2012) Trophoblastic neoplasm. In: Benirschke K, Burton GJ, Baergen RN (eds) Pathology of the human placenta, 6th edn. New York, Springer, pp 723–746

    Chapter  Google Scholar 

  7. Tse KY, Chan KL, Tam KF, Ngan YS (2012) An update on gestational trophoblastic disease. 2011. Obstet Gynecol Reprod Med 22(1):7–15

    Article  Google Scholar 

  8. Lurain JR (2010) Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol 203(6):531–539

    Article  PubMed  Google Scholar 

  9. Aziz MF, Kampono N, Moegni EM, Sjamsuddin S, Barnas B, Samil RS (1984) Epidemiology of gestational trophoblastic neoplasm at the Dr. Cipto Mandunkusumo Hospital, Jakarta, Indonesia. Adv Exp Med Biol 176:165–175

    Article  CAS  PubMed  Google Scholar 

  10. Prabha B, Molykutty J, Krishnan NM (1995) Gestational trophoblastic diseases as a clinical entity – a review. J Exp Clin Canc Res 14:239–246

    Google Scholar 

  11. Gul T, Yilmazturk A, Erden AC (1997) A review of trophoblastic diseases at the medical school of Dicle University. Eur J Obstet Gynecol Reprod Biol 74(1):37–40

    Article  CAS  PubMed  Google Scholar 

  12. Martin PM (1978) High frequency of hydatidiform mole in native Alaskans. Int J Gynaecol Obstet 15(5):395–396

    CAS  PubMed  Google Scholar 

  13. MacGregor C, Ontiveros E, Vargas E, Valenzuela S (1969) Hydatidiform mole. Obstet Gynecol 33(3):343–351

    CAS  PubMed  Google Scholar 

  14. Berkowitz RS, Cramer DW, Bernstein MR, Cassells S, Driscoli SG, Goldstein DP (1985) Risk factors for complete molar pregnancy from a case–control study. Am J Obstet Gynecol 152(8):1016–1020

    Article  CAS  PubMed  Google Scholar 

  15. Parazzini F, La Vecchia C, Mangili G, Caminiti C, Negri E, Cecchetti G et al (1988) Dietary factors and risk of trophoblastic disease. Am J Obstet Gynecol 158(1):93–99

    Article  CAS  PubMed  Google Scholar 

  16. Vargas R, Barroilhet LM, Esselen K, Diver E, Bernstein M, Goldstein DP et al (2014) Subsequent pregnancy outcomes after complete and partial molar pregnancy, recurrent molar pregnancy, and gestational trophoblastic neoplasia: an update from the New England Trophoblastic Disease Center. J Reprod Med 59:188–194

    PubMed  Google Scholar 

  17. Eagles N, Sebire NJ, Short D, Savage PM, Seckl MJ, Fisher RA (2015) Risk of recurrent molar pregnancies following complete and partial hydatidiform moles. Hum Reprod 30(9):2055–2063

    Article  CAS  PubMed  Google Scholar 

  18. Fisher RA, Hodges MD, Newlands ES (2004) Familial recurrent hydatidiform mole: a review. J Reprod Med 49(8):595–601

    PubMed  Google Scholar 

  19. Murdoch S, Djuric U, Mazhar B, Seoud M, Khan R, Kuick R et al (2006) Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat Genet 38(3):300–302

    Article  CAS  PubMed  Google Scholar 

  20. Parry DA, Logan CV, Hayward BE, Shires M, Landolsi H, Diggle C et al (2011) Mutations causing familial biparental hydatidiform mole implicate c6orf221 as a possible regulator of genomic imprinting in the human oocyte. Am J Hum Genet 89(3):451–458

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Savage PM, Sita-Lumsden A, Dickson S, Iyer R, Everard J, Coleman R et al (2013) The relationship of maternal age to molar pregnancy incidence, risks for chemotherapy and subsequent pregnancy outcome. J Obstet Gynaecol 33(4):406–411

    Article  CAS  PubMed  Google Scholar 

  22. Hando T, Ohno M, Kurose T (1998) Recent aspects of gestational trophoblastic disease in Japan. Int J Gynaecol Obstet 60(Suppl 1):S71–S76

    Article  PubMed  Google Scholar 

  23. La Vecchia C, Franceschi S, Parazzini F, Fasoli M, Decarli A, Gallus G et al (1985) Risk factors for gestational trophoblastic disease in Italy. Am J Epidemiol 121(3):457–464

    PubMed  Google Scholar 

  24. Brinton LA, Wu BZ, Wang W, Ershow AG, Song HZ, Li JY et al (1989) Gestational trophoblastic disease: a case–control study from the People’s Republic of China. Am J Obstet Gynecol 161(1):121–127

    Article  CAS  PubMed  Google Scholar 

  25. Atrash HK, Hogue CJ, Grimes DA (1986) Epidemiology of hydatidiform mole during early gestation. Am J Obstet Gynecol 154(4):906–909

    Article  CAS  PubMed  Google Scholar 

  26. Kurman RJ, Carcangiu ML, Herrington CS, Young RH (2014) WHO classification of tumors of female reproductive organs. International Agency for Research on Cancer, Lyon, pp 155–167

    Google Scholar 

  27. La Vecchia C, Parazzini F, Decarli A, Franceschi S, Fasoli M, Favali G et al (1984) Age of parents and risk of gestational trophoblastic disease. J Natl Cancer Inst 73(3):639–642

    PubMed  Google Scholar 

  28. Nguyen NM, Slim R (2014) Genetics and epigenetics of recurrent hydatidiform moles: basic science and genetic counselling. Curr Obstet Gynecol Rep 3:55–64

    Article  PubMed  PubMed Central  Google Scholar 

  29. Kim KR (2014) Gestational trophoblastic disease. In: Mutter GL, Prat J (eds) Pathology of the female reproductive tract, 3rd edn. Churchill Livingston Elsevier, Edinburgh, UK. pp 784–811

    Google Scholar 

  30. Fukunaga M, Katabuchi H, Nagasaka T, Mikami Y, Minamiguchi S, Lage JM (2005) Interobserver and intraobserver variability in the diagnosis of hydatidiform mole. Am J Surg Pathol 29(7):924–927

    Article  Google Scholar 

  31. Sun YS, Alexander M, Donald PG, Marilyn RB, Neil SH, Antonio FM et al (2015) Changing presentation of complete hydatidiform mole at the New England Trophoblastic Disease Center over the past three decades: does early diagnosis alter risk for gestational trophoblastic neoplasia? Gynecol Oncol 138(1):46–49

    Article  PubMed  Google Scholar 

  32. Kerkmeijer LG, Massuger LF, Ten Kate-Booij MJ, Sweep FC, Thomas CM (2009) Earlier diagnosis and serum human chorionic gonadotropin regression in complete hydatidiform mole. Obstet Gynecol 113(2 Pt 1):326–331

    Article  CAS  PubMed  Google Scholar 

  33. Mangili G, Garavaglia E, Cavoretto P, Gentile C, Scarfone G, Rabaiotti E (2008) Clinical presentation of hydatidiform mole in northern Italy: has it changed in the last 20 years. Am J Obstet Gynecol 198(3):302.e1–4

    Article  PubMed  Google Scholar 

  34. Soto-Wright V, Bernstein M, Goldstein DP, Berkowitz R (1995) The changing clinical presentation of complete molar pregnancy. Obstet Gynecol 86(5):775–779

    Article  CAS  PubMed  Google Scholar 

  35. Milenković V, Lazović B, Mirković L, Grujicić D, Sparić R (2013) Brain metastases of choriocarcinoma-a report on two cases. Vojnosanit Pregl 70(10):968–971

    Article  PubMed  Google Scholar 

  36. Baergen RN, Rutgers JL, Young RH, Osann K, Scully RE (2006) Placental site trophoblastic tumor: a study of 55 cases and review of the literature emphasizing factors of prognostic significance. Gynecol Oncol 100(3):511–520

    Article  PubMed  Google Scholar 

  37. Allison KH, Love JE, Garcia RL (2006) Epithelioid trophoblastic tumor: review of a rare neoplasm of the chorionic-type intermediate trophoblast. Arch Pathol Lab Med 130(12):1875–1877

    PubMed  Google Scholar 

  38. Cole LA (1998) hCG, its free subunits and its metabolites: roles in pregnancy and trophoblastic disease. J Reprod Med 43(1):3–10

    CAS  PubMed  Google Scholar 

  39. Elliott MM, Kardana A, Lustbader JW, Cole LA (1997) Carbohydrate and peptide structure of the α- and β-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine 7(1):15–32

    Article  CAS  PubMed  Google Scholar 

  40. Genest DR, Laborde O, Berkowitz RS, Goldstein DP, Bernstein MR, Lage J (1991) A clinicopathologic study of 153 cases of complete hydatidiform mole (1980–1990): histologic grade lacks prognostic significance. Obstet Gynecol 78(3 Pt 1):402–409

    CAS  PubMed  Google Scholar 

  41. Cole LA, Shahabi S, Butler SA, Mitchell H, Newlands ES, Behrman HR et al (2001) Utility of commonly used commercial hCG immunoassays in the diagnosis and management of trophoblastic diseases. Clin Chem 47(2):308–315

    CAS  PubMed  Google Scholar 

  42. Khanlian SA, Smith HO, Cole LA (2003) Persistent low levels of hCG: a premalignant gestational trophoblastic disease. Am J Obstet Gynecol 188(5):1254–1259

    Article  CAS  PubMed  Google Scholar 

  43. Cole LA, Khanlian SA (2004) Inappropriate management of women with persistent low hCG results. J Reprod Med 49(6):423–432

    PubMed  Google Scholar 

  44. De Backer B, Goffin F, Nisolle M, Minon JM (2013) Persistent low hCG levels beyond pregnancy: report of two cases and review of the literature. Ann Biol Clin (Paris) 71(4):496–502

    Google Scholar 

  45. Kohorn EI (2002) Persistent low-level “real” human chorionic gonadotropin: a clinical challenge and a therapeutic dilemma. Gynecol Oncol 85(2):315–320

    Article  PubMed  Google Scholar 

  46. Cole LA, Sutton JM (2003) hCG tests in the management of gestational trophoblastic diseases. Clin Obstet Gynecol 46(3):523–540

    Article  PubMed  Google Scholar 

  47. Hancock B (2006) hCG measurement in gestational trophoblastic neoplasia: a critical appraisal. J Reprod Med 51(11):859–860

    PubMed  Google Scholar 

  48. Schmitt C, Doret M, Massardier J, Hajri T, Schott AM, Raudrant D et al (2013) Risk of gestational trophoblastic neoplasia after hCG normalisation according to hydatidiform mole type. Gynecol Oncol 130(1):86–89

    Article  CAS  PubMed  Google Scholar 

  49. Benson CB, Genest DR, Bernstein MR, Soto-Wright V, Goldstein DP, Berkowitz RS (2000) Sonographic appearance of first trimester complete hydatidiform moles. Ultrasound Obstet Gynecol 16(2):188–191

    Article  CAS  PubMed  Google Scholar 

  50. Wang W, Tian X, Zhang T, Wang Y, Han Z, An R (2015) An characteristics of three-dimensional power doppler in gestational trophoblastic disease. Dis Markers 2015:917687

    PubMed  PubMed Central  Google Scholar 

  51. Naumoff P, Szulman AE, Weinstein B, Mazer J, Surti U (1981) Ultrasonography of partial hydatidiform mole. Radiology 140(2):467–470

    Article  CAS  PubMed  Google Scholar 

  52. Berkowitz RS, Goldstein DP (2009) Clinical practice. Molar pregnancy. N Engl J Med 360(16):1639–1645

    Article  CAS  PubMed  Google Scholar 

  53. Hancock BW, Tidy JA (2002) Current management of molar pregnancy. J Reprod Med 47(5):347–354

    PubMed  Google Scholar 

  54. Tidy JA, Gillespie AM, Bright N, Radstone CR, Coleman RE, Hancock BW (2000) Gestational trophoblastic disease: a study of mode of evacuation and subsequent need for treatment with chemotherapy. Gynecol Oncol 78(3 Pt 1):309–312

    Article  CAS  PubMed  Google Scholar 

  55. Elias KM, Goldstein DP, Berkowitz RS (2010) Complete hydatidiform mole in women older than age 50. J Reprod Med 55(5–6):208–212

    PubMed  Google Scholar 

  56. May T, Goldstein DP, Berkowitz RS (2011) Current chemotherapeutic management of patients with gestational trophoblastic neoplasia. Chemother Res Pract 2011:806256

    PubMed  PubMed Central  Google Scholar 

  57. Lurain JR (2011) Gestational trophoblastic disease II: classification and management of gestational trophoblastic neoplasia. Am J Obstet Gynecol 204(1):11–18

    Article  PubMed  Google Scholar 

  58. Lazovic B, Milenkovic V, Mirkovic L (2011) Morbidity and mortality of patients suffering from gestational trophoblastic diseases at the clinic of gynecology and obstetrics, clinical center of serbia in the period from 2000 to 2007. Med Pregl 64(11–12):579–582

    Article  PubMed  Google Scholar 

  59. Milenkovic V, Jeremic K, Lazovic B, Stefanovic A, Mirkovic L, Kadija S (2012) Fertility sparing therapy for metastatic gestational trophoblastic disease in young patients. Int J Gynaecol Obstet 116(2):170–171

    PubMed  Google Scholar 

  60. Agarwal R, Harding V, Short D, Fisher RA, Sebire NJ, Harvey R et al (2012) Uterine artery pulsatility index: a predictor of methotrexate resistance in gestational trophoblastic neoplasia. Br J Canc 106(6):1089–1094

    Article  CAS  Google Scholar 

  61. Lazovic B, Milenkovic V, Dordevic S (2012) Treatment of gestational trophoblastic disease-a 10 year experience. Med Pregl 65(5–6):579–582

    Google Scholar 

  62. Mapelli P, Mangili G, Picchio M, Gentile C, Rabaiotti E, Giorione V et al (2013) Role of 18 F-FDG PET in the management of gestational trophoblastic neoplasia. Eur J Nucl Mol Imag 40(4):505–513

    Article  CAS  Google Scholar 

  63. Froeling FE, Seckl MJ (2014) Gestational trophoblastic tumors: an update for 2014. Curr Oncol Rep 16(11):408

    Article  PubMed  Google Scholar 

  64. Ngan HY, Odicino F, Maisonneuve P, Creasman WT, Beller U, Quinn MA et al (2006) Gestational trophoblastic neoplasia. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer. Int J Gynecol Obstet 95(Suppl 1):S193–S203

    Article  Google Scholar 

  65. Schmid P, Nagai Y, Agarwal R, Hanckok B, Savage PM, Sebire NJ et al (2009) Prognostic markers and long-term outcome of placental site trophoblastic tumors: a retrospective observational study. Lancet 374(9683):48–55

    Article  CAS  PubMed  Google Scholar 

  66. Bolze PA, Riedl C, Massardier J, Lotz JP, You B, Schott AM et al (2015) Mortality of gestational trophoblastic neoplasia with a FIGO score of 13 and higher. Am J Obstet Gynecol. doi:10.1016/j.ajog.2015.09.083. [Epub ahead of print]

    PubMed  Google Scholar 

  67. Seckl MJ, Sebire NJ, Fisher RA, Golfier F, Massuger L, Sessa C (2013) Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow up. Ann Oncol 24(Suppl 6):vi39–vi50

    Google Scholar 

  68. Tse KY, Ngan YS (2012) Gestational trophoblastic disease. Best Pract Res Clin Obstet Gynaecol 26(3):357–370

    Article  CAS  PubMed  Google Scholar 

  69. Elias KM, Shoni M, Bernstein M, Goldstein DP, Berkowitz RS (2012) Complete hydatidiform mole in women aged 40 to 49 years. J Reprod Med 57(5–6):254–258

    PubMed  Google Scholar 

  70. Fu J, Fang F, Xie L, Chen H, He F, Wu T et al (2012) Prophylactic chemotherapy for hydatiform mole to prevent gestational trophoblastic neoplasia. Cochrane Database Syst Rev (10):CD007289

    Google Scholar 

  71. Ngu SF, Chan KL (2014) Management of chemoresistant and quiescent gestational trophoblastic disease. Curr Obstet Gynecol Rep 3(1):84–90

    Article  PubMed  PubMed Central  Google Scholar 

  72. Xiao C, Yang Y, Zhao J, Ren T, Feng F, Wan X et al (2015) Management and prognosis of patients with brain metastases from gestational trophoblastic neoplasia: a 24-year experience in Peking union medical college hospital. BMC Cancer 15:318

    Article  PubMed  PubMed Central  Google Scholar 

  73. Piura E, Piura B (2014) Brain metastases from gestational trophoblastic neoplasia: review of pertinent literature. Eur J Gynaecol Oncol 35(4):359–367

    CAS  PubMed  Google Scholar 

  74. Zhao J, Xiang Y, Wan XR, Feng FZ, Cui XC, Yang XY (2009) Molecular genetic analyses of choriocarcinoma. Placenta 30(9):816–820

    Article  CAS  PubMed  Google Scholar 

  75. Alazzam M, Tidy J, Hancock BW, Osborne R, Lawrie TA (2012) First line chemotherapy in low-risk gestational trophoblastic neoplasia. Cochrane Database Syst Rev (7):CD007102

    Google Scholar 

  76. Deng L, Zhang J, Wu T, Lawrie TA (2013) Combination chemotherapy for primary treatment of high-risk gestational trophoblastic tumor. Cochrane Database Syst Rev (1):CD005196

    Google Scholar 

  77. Moutte A, Doret M, Hajri T, Peyron N, Chateau F, Massardier P et al (2013) Placental site and epithelioid trophoblastic tumors: diagnostic pitfalls. Gynecol Oncol 128(3):568–572

    Article  PubMed  Google Scholar 

  78. Leiserowitz GS, Webb MJ (1996) Treatment of placental site trophoblastic tumor with hysterectomy and uterine reconstruction. Obstet Gynecol 88(4 Pt 2):696–699

    Article  CAS  PubMed  Google Scholar 

  79. Pfeffer PE, Sebire N, Lindsay I, McIndoe A, Lim A, Seckl MJ (2007) Fertility-sparing hysterectomy for placental-site trophoblastic tumor. Lancet Oncol 8(8):744–746

    Article  PubMed  Google Scholar 

  80. Wee L, Jauniaux E (2005) Prenatal diagnosis and management of twin pregnancies complicated by a co-existing molar pregnancy. Prenat Diagn 25(9):772–776

    Article  PubMed  Google Scholar 

  81. Davis MR, Howitt BE, Quade BJ, Crum CP, Horowitz NS, Goldstein DP et al (2015) Epithelioid trophoblastic tumor: a single institution case series at the New England Trophoblastic Disease Center. Gynecol Oncol 137(3):456–461

    Article  CAS  PubMed  Google Scholar 

  82. Scott EM, Smith AL, Desouki MM, Olawaiye AB (2012) Epithelioid trophoblastic tumor: a case report and review of literature. Case Rep Obstet Gynecol 2012:862472

    PubMed  PubMed Central  Google Scholar 

  83. Alazzam M, Tidy J, Osborne R, Coleman R, Hanckok BW, Lawrie TA (2012) Chemotherapy for resistant and recurrent gestational trophoblastic neoplasia. Cochrane Database Syst Rev (12):CD008891

    Google Scholar 

  84. Leenharattanarak P, Lertkhachonsuk R (2014) Quality of life in gestational trophoblastic neoplasia patients after treatment in Thailand. Asian Pac J Cancer Prev 15(24):10871–10874

    Article  PubMed  Google Scholar 

  85. Di Mattei VE, Carnelli I, Bernardi M, Pagani Bagliacca E, Zucchi P, Lavezzari L et al (2015) An investigative study into psychological and fertility sequelae of gestational trophoblastic disease: the impact on patients’ perceived fertility, anxiety and depression. PLoS One 10(6):e0128354

    Article  PubMed  PubMed Central  Google Scholar 

  86. Neubauer NL, Strohl AE, Schink JC, Lurain JR (2015) Fatal gestational trophoblastic neoplasia: an analysis of treatment failures at the Brewer Trophoblastic Disease Center from 1979–2012 compared to 1962–1978. Gynecol Oncol 138(2):339–342

    Article  PubMed  Google Scholar 

  87. Lybol C, Centen DW, Thomas CM, ten Kate-Booij MJ, Verheijen RH, Sweep FC et al (2012) Fatal cases of gestational trophoblastic neoplasia over four decades in the Netherlands: a retrospective cohort study. BJOG 119(12):1465–1472

    Article  CAS  PubMed  Google Scholar 

  88. Fisher RA, Savage PM, MacDermott C, Hook J, Sebire NJ, Lindsay I et al (2007) The impact of the molecular genetic diagnosis on the management of women with hCG-producing malignancies. Gynecol Oncol 107(3):413–419

    Article  CAS  PubMed  Google Scholar 

  89. Malhotra N, Deka D, Takkar D, Kochar S, Goel S, Sharma MC (2001) Hydatidiform mole with coexisting live fetus in dichorionic twin gestation. Eur J Obstet Gynecol Reprod Biol 94(2):301–303

    Article  CAS  PubMed  Google Scholar 

  90. Piura B, Rabinovich A, Hershkovitz R, Maor E, Mazor M (2008) Twin pregnancy with a complete hydatidiform mole and surviving co-existent fetus. Arch Gynecol Obstet 278(4):377–382

    Article  PubMed  Google Scholar 

  91. Matsui H, Sekiya S, Hando T, Wake N, Tomoda Y (2000) Hydatidiform mole coexistent with a twin live fetus: a national collaborative study in Japan. Hum Reprod 15(3):608–611

    Article  CAS  PubMed  Google Scholar 

  92. Sebire NJ, Foskett M, Paradinas FJ, Fisher RA, Francis RJ, Short D et al (2002) Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin. Lancet 359(9324):2165–2166

    Article  PubMed  Google Scholar 

  93. Seckl MJ, Dhillon T, Dancey G, Foskett M, Paradinas FJ, Rees HC et al (2004) Increased gestational age at evacuation of a complete hydatidiform mole: does it correlate with increased risk of requiring chemotherapy? J Reprod Med 49(7):527–530

    PubMed  Google Scholar 

  94. Peng HH, Huang KG, Chueh HY, Adlan AS, Chang SD, Lee CL (2014) Term delivery of a complete hydatidiform mole with a coexisting living fetus followed by successful treatment of maternal metastatic gestational trophoblastic disease. Taiwan J Obstet Gynecol 53(3):397–400

    Article  PubMed  Google Scholar 

  95. Joneborg U, Eloranta S, Johansson ALV, Marisons L, Weibull CE, Lambe M (2014) Hydatidiform mole and subsequent pregnancy outcome: a population-based cohort study. Am J Obstet Gynecol 211(6):681.e1–7

    Article  PubMed  Google Scholar 

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Acknowledgment

The authors thank Dr. Svetlana Milenkovic and Dr. Jasmina Atanackovic, histopathologists at the Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia, for their assistance in selecting photos.

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Authors and Affiliations

  1. Section of Pathological Anatomy, Department of Emergency and Organ Transplantation (DETO), University of Bari, Bari, Italy

    Leonardo Resta MD

  2. Department of Obstetrics and Gynecology, Santa Maria Hospital, G.V.M. Care and Research, Bari, Italy

    Antonio Malvasi MD

  3. International Translational Medicine and Biomodelling Research Group, Department of Applied Mathematics, Moscow Institute of Physics and Technology (State University), Moscow Region, Russia

    Antonio Malvasi MD

  4. Head of Obstetric Intensive Care Unit, Medical Faculty, University of Belgrade, Doktora Subotića 8, Belgrade, 11000, Serbia

    Ljiljana Mirković MD

  5. Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Višegradska 26, Belgrade, 11000, Serbia

    Ljiljana Mirković MD & Radmila Sparić MD

  6. Medical Faculty, University of Belgrade, Doktora Subotića 8, Belgrade, 11000, Serbia

    Radmila Sparić MD

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  1. Leonardo Resta MD
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  2. Antonio Malvasi MD
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  3. Ljiljana Mirković MD
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  4. Radmila Sparić MD
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Correspondence to Radmila Sparić MD .

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Editors and Affiliations

  1. Department of Obstetric and Gynecology, Santa Maria Hospital, Bari, Italy

    Antonio Malvasi

  2. Department of Obstetrics and Gynaecology, Vito Fazzi Hospital, Lecce, Lecce, Italy

    Andrea Tinelli

  3. Department of Obstetrics and Gynaecology, University of Perugia, Perugia, Italy

    Gian Carlo Di Renzo

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Resta, L., Malvasi, A., Mirković, L., Sparić, R. (2016). Molar and Trophoblastic Disease. In: Malvasi, A., Tinelli, A., Di Renzo, G. (eds) Management and Therapy of Early Pregnancy Complications. Springer, Cham. https://doi.org/10.1007/978-3-319-31377-1_9

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