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Tumors and Tumor-Like Lesions of the Hepatobiliary Tract pp 937–957Cite as

Infantile Hepatic Hemangioma/Hemangioendothelioma

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Abstract

Infantile hepatic hemangioma (IHE; previously termed infantile hepatic hemangioendothelioma) is a vascular liver tumor presenting as solitary or multiple lesions and diagnosed almost exclusively in infants and children before 6 months of age. Apart from focal involvement of the liver, a diffuse phenotype is also recognized. IHE usually manifests as hepatomegaly, but part of patients show cardiovascular failure due to intratumoral shunting, coagulopathy, jaundice, respiratory distress, and a distinct form of consumptive hypothyroidism. IHE can be associated with angiomatous lesions in other organs, including chorangioma of the placenta. Macroscopically, IHE manifests as solitary or multiple, well-circumscribed, and spherical vascular tumors. Histology is characterized by a network of densely arranged and thin vascular channels with an endothelial lining. Calcifications and other regressive changes can develop. Part of patients show a histology with variable cellular atypias, previously termed type 2 lesions. There is an overlap between such lesions and a distinct form of infantile hepatic angiosarcoma.

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References

  • Abuhamad AZ, Lewis D, Inati MN, Johnson DR, Copel JA (1993) The use of color flow Doppler in the diagnosis of fetal hepatic hemangioma. J Ultrasound Med 12:223–226

    CAS  PubMed  Google Scholar 

  • Amonkar P, Desai S, Deb R, Kane S, Kurkure P, Deshpande RK, Chinoy R (1999) Infantile hemangioendothelioma of the liver. Med Pediatr Oncol 32:392–394

    Article  CAS  PubMed  Google Scholar 

  • Andries GH, Kaump DH (1944) Multiple malignant hemangiomas of the liver. Am J Clin Pathol 14(suppl):489

    Article  Google Scholar 

  • Araujo AR, Maciel I, Costa JC, Vieira A, Enes C, Santos Silva E (2008) Infantile hepatic hemangioendothelioma. A multifocal, bilobular and asymptomatic case with spontaneous regression (in Spanish). An Pediatr (Barc) 68:507–510

    Article  CAS  Google Scholar 

  • Arcardi J, Nezelof C (1963) L’hémangiomatose multinodulaire du foie du nourrisson. Commentaires anatomocliniques à propos de quatre observations. Arch Fr Pédiatr 20:933

    Google Scholar 

  • Awan S, Davenport M, Portmann B, Howard ER (1996) Angiosarcoma of liver in children. J Pediatr Surg 31:1729–1732

    Article  CAS  PubMed  Google Scholar 

  • Ayling RM, Davenport M, Hadzic N, Metcalfe R, Buchanan CR, Howard ER, Mieli-Vergani G (2001) Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor. J Pediatr 138:932–935

    Article  CAS  PubMed  Google Scholar 

  • Balazs AE, Athanassaki I, Gunn SK, Tatevian N, Huang SA, Haymond MW, Karaviti LP (2007) Rapid resolution of consumptive hypothyroidism in a child with hepatic hemangioendothelioma following liver transplantation. Ann Clin Lab Sci 37:280–284

    CAS  PubMed  Google Scholar 

  • Bar-Sever Z, Horev G, Lubin E, Kornreich L, Naor N, Ziv N, Shimoni A, Grunebaum M (1994) A rare coexistence of a multicentric hepatic hemangioendothelioma with a large brain hemangioma in a preterm infant. Pediatr Radiol 24:141–142

    Article  CAS  PubMed  Google Scholar 

  • Bay A, Oner AF, Etlik O, Koseoglu B, Kaya A (2005) Unusual presentation of infantile hemangioendothelioma. Pediatr Blood Cancer 44:267–269

    Article  PubMed  Google Scholar 

  • Becker JM, Heitler MS (1989) Hepatic hemangioendothelioma in infancy. Surg Gynecol Obstet 168:189–200

    CAS  PubMed  Google Scholar 

  • Behr GG, Fishman SJ, Caty MG, Kulungowski AM, Paltiel HJ, Alomari AI (2012) Hepatic mesenchymal hamartoma and infantile hemangioma: a rare association. J Pediatr Surg 47:448–452

    Article  PubMed  Google Scholar 

  • Bejarano PA, Serrano MF, Casillas J, Dehner LP, Kato T, Mitral N, Rodriguez MM, Tzakis A (2003) Concurrent infantile hemangioendothelioma and mesenchymal hamartoma in a developmentally arrested liver of an infant requiring hepatic transplantation. Pediatr Dev Pathol 6:552–557

    Article  PubMed  Google Scholar 

  • Bellini F, Beltrame A (1965) On a case of hepatic hemangioendothelioma in an infant (in Italian). Arch Ital Chir 91:594–602

    CAS  PubMed  Google Scholar 

  • Berdon WE, Baker DH (1969) Giant hepatic hemangioma with cardiac failure in the newborn infant. Value of high-dosage intravenous urography and umbilical angiography. Radiology 92:1523–1528

    Article  CAS  PubMed  Google Scholar 

  • Berenguer B, Mulliken JB, Enjolras O, Boon LM, Wassef M, Josset P, Burrows PE et al (2003) Rapidly involuting congenital hemangioma: clinical and histopathologic features. Pediatr Dev Pathol 6:495–510

    Article  PubMed  Google Scholar 

  • Berezin SW, Sharnoff JG, Stein JD (1948) Primary hemangioendothelioma of the liver in infancy. N Engl J Med 238:906

    Article  CAS  PubMed  Google Scholar 

  • Berman B, Lim HWP (1978) Concurrent cutaneous and hepatic hemangiomata in infancy: report of a case and a review of the literature. J Dermatol Surg Oncol 4:869–873

    Article  CAS  PubMed  Google Scholar 

  • Berman JK, Kirkhoff P, Levene N (1955) Hepatic lobectomy for hemangioma of the liver in a five-day-old infant. AMA Arch Surg 71:249–253

    Article  CAS  PubMed  Google Scholar 

  • Bessho K, Etani Y, Ichimori H, Miyoshi Y, Namba N, Yoneda A, Ooue T, Chihara T et al (2010) Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism. Eur J Pediatr 169:215–221

    Article  CAS  PubMed  Google Scholar 

  • Bhattacharyya NK, Chatterjee U, Sen S, Sarkar S (2007) Infantile hemangio-endothelioma of liver: report of two cases. Indian J Pathol Microbiol 50:340–342

    PubMed  Google Scholar 

  • Blauel I (1942) Ueber das Hämangioendotheliom der Leber bei Kindern. Monatsschr F Kinderheilkde 91:345

    Google Scholar 

  • Blumenfeld TA, Fleming ID, Johnson WW (1969) Juvenile hemangioendothelioma of the liver. Report of a case and review of the literature. Cancer 24:853–857

    Article  CAS  PubMed  Google Scholar 

  • Bohm N, Jacobi H (1976) Infantile hemangiomatosis of liver (in German). Med Welt 27:1887–1891

    CAS  PubMed  Google Scholar 

  • Bondy J (1911) Angiosarcoma of the liver in an infant. JAMA 56:873

    Article  Google Scholar 

  • Boon LM, Burrows PE, Paltiel HJ, Lund DP, Ezekowitz RA, Folkman J, Mulliken JB (1996) Hepatic vascular anomalies in infancy: a twenty-seven-year experience. J Pediatr 129:346–354

    Article  CAS  PubMed  Google Scholar 

  • Braun P, Ducharme JC, Riopelle JL, Davignon A (1975) Hemangiomatosis of the liver in infants. J Pediatr Surg 10:121–126

    Article  CAS  PubMed  Google Scholar 

  • Breysem L, Allewaet S, Claus F, De Beer A, Van Geet C, Rayyan M, Smet MH (2008) The use of duplex doppler ultrasound in a case of multifocal hepatic hemangioma. JBR-BTR 91:145–148

    CAS  PubMed  Google Scholar 

  • Burke DR, Verstandig A, Edwards O, Meranze SG, McLean GK, Stein EJ (1986) Infantile hemangioendothelioma: angiographic features and factors determining efficacy of hepatic artery embolization. Cardiovasc Intervent Radiol 9:154–157

    Article  CAS  PubMed  Google Scholar 

  • Burman D, Mansell PWA, Warin R (1967) Miliary hemangiomata in the newborn. Arch Dis Child 42:193

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Burrows PE (1991) Variations in the vascular supply to infantile hepatic hemangio-endothelioma. Radiology 181:631–632

    Article  CAS  PubMed  Google Scholar 

  • Burrows PE, Rosenberg HC, Chuang HS (1985) Diffuse hepatic hemangiomas: percutaneous transcatheter embolization with detachable silicone balloons. Radiology 156:85–88

    Article  CAS  PubMed  Google Scholar 

  • Caussade L, Neimann N, Tridon P (1954) Hémangioendothéliome du foie chez un nouveau-né mort par rupture du foie. Arch Fr Pédiatr 11:514

    CAS  PubMed  Google Scholar 

  • Cerar A, Dolenc-Strazar ZD, Bartenjev D (1996) Infantile hemangioendothelioma of the liver in a neonate. Immunohistochemical observations. Am J Surg Pathol 20:871–876

    Article  CAS  PubMed  Google Scholar 

  • Cetinkaya S, Peltek Kendirici HN, Yilmaz Agladioglu S, Bas VN, Ozdemir S, Bozkurt C et al (2010) Hypothyroidism due to hepatic hemangioendothelioma: a case report. J Clin Res Pediatr Endocrinol 2:126–130

    Article  PubMed  PubMed Central  Google Scholar 

  • Chabalko JJ, Fraumeni JF (1975) Blood-vessel neoplasms in children: epidemiological aspects. Med Pediatr Oncol 1:135–141

    Article  CAS  PubMed  Google Scholar 

  • Chan YF, Choi AC, Ma L, Leung MP (1986) Infantile hemangioendothelioma of the liver: ultrastructural study of a type II case. Pathology 18:463–468

    Article  CAS  PubMed  Google Scholar 

  • Chen CC, Kong MS, Yang CP, Hung IJ (2003) Hepatic hemangioendothelioma in children: analysis of thirteen cases. Acta Paediatr Taiwan 44:8–13

    PubMed  Google Scholar 

  • Cho YH, Taplin C, Mansour A, Howman-Giles R, Hardwick R, Lord D, Howard NJ (2008) Case report: consumptive hypothyroidism consequent to multiple infantile hepatic haemangiomas. Curr Opin Pediatr 20:213–215

    Article  PubMed  Google Scholar 

  • Chou SY, Chiang HK, Chow PK, Wu CF, Liang SJ, Hsu CS (2005) Fetal hepatic hemangioma diagnosed prenatally with ultrasonography. Acta Obstet Gynecol Scand 84:301–302

    Article  PubMed  Google Scholar 

  • Christiaens L, Demaille A, Clay A, Farriaux JP (1964) Multinodular hemangiomatosis of the liver in an infant (in French). Lille Med 35:484–487

    CAS  PubMed  Google Scholar 

  • Christison-Lagay, Burrwos PE, Alomari A, Dubois J, Kozakewich HP, Lane TS, Paltiel HJ et al (2007) Hepatic hemangiomas: subtype classification and development of a clinical practice algorithm and registry. J Pediatr Surg 42:62–67

    Article  PubMed  Google Scholar 

  • Chuileannain FN, Rowlands S, Sampson A (1999) Ultrasonographic appearances of fetal hepatic hemangioma. J Ultrasound Med 18:379–381

    CAS  PubMed  Google Scholar 

  • Chung T, Hoffer FA, Burrows PE, Paltiel HJ (1996) MR imaging of hepatic hemangiomas of infancy and changes seen with interferon alpha-2a treatment. Pediatr Radiol 26:341–348

    Article  CAS  PubMed  Google Scholar 

  • Cleland RS (1959) Benign and malignant tumors of the liver. Pediatr Clin North Am 6:427–447

    Article  Google Scholar 

  • Cohen RC, Myers NA (1986) Diagnosis and management of massive hepatic hemangiomas in childhood. J Pediatr Surg 21:6–9

    Article  CAS  PubMed  Google Scholar 

  • Cornelius AS, Womer RB, Jakacki R (1989) Multiple hemangioendotheliomas of the liver. Med Pediatr Oncol 17:501–504

    Article  CAS  PubMed  Google Scholar 

  • Crocker DW, Cleland RS (1957) Infantile hemangioendothelioma of the liver; report of three cases. Pediatrics 19:596–606

    CAS  PubMed  Google Scholar 

  • Cruveiller J, Lafourcade J, Vallée G, Bocquet L, Laurent M, Turpin R (1965) Congenital hepatic hemangiomatosis. Clinical and scintigraphic study of a case with a favorable outcome (in French). Sem Hop 41:3049–3063

    CAS  PubMed  Google Scholar 

  • Dachman AH, Lichtenstein JE, Friedman AC, Hartman D (1983) Infantile hemangioendothelioma of the liver: a radiologic-pathologic-clinical correlation. AJR Am J Roentgenol 140:1093–1096

    Article  Google Scholar 

  • Daller JA, Bueno J, Gutierrez J, Dvorchik I, Towbin RB, Dickman PS, Mazariegos G, Reyes J (1999) Hepatic hemangioendothelioma: clinical experience and management strategy. J Pediatr Surg 34:98–105

    Article  CAS  PubMed  Google Scholar 

  • Daudet M (1965) Reflections apropos of a case of hepatic hemolymphangioma of the infant. Operation recovery (in French). Pediatrie 20:445–451

    CAS  PubMed  Google Scholar 

  • Davenport M, Hansen L, Heaton ND, Howard ER (1995) Hemangioendothelioma of the liver in infants. J Pediatr Surg 30:44–48

    Article  CAS  PubMed  Google Scholar 

  • de Bièvre P, Dufour P, Lefèbvre C, Vinatier D, Bernardi C, Depret S, Monnier JC (1994) Prenatal diagnosis of hepatic hemangioendothelioma. Apropos of a case (in French). J Gynécol Obstet Biol Reprod (Paris) 23:435–439

    Google Scholar 

  • de Lorimier AA, Simpson EB, Baum RS, Carlsson E (1967) Hepatic-artery ligation for hepatic hemangiomatosis. N Engl J Med 277:33–337

    Article  Google Scholar 

  • De Paoli AG, Williams M, Parsons SJ, Long E, Brothers L, Dargaville PA (2007) Massive hepatic congenital haemangioma: clinical dilemmas. J Paediatr Child Health 43:321–314

    Article  Google Scholar 

  • Dehner LP (1978) Hepatic tumors in the pediatric age group: a distinctive clinicopathologic spectrum. Perspect Pediatr Pathol 4:217–268

    CAS  PubMed  Google Scholar 

  • Dehner LP (1987) Liver, gallbladder and extrahepatic biliary tract. In: Dehner LP (ed) Pediatric surgical pathology, 2nd edn. Williams and Wilkins, Baltimore, pp 483–523

    Google Scholar 

  • Dehner LP, Ishak KG (1971) Vascular tumors of the liver in infants and children. Arch Pathol 92:101–111

    CAS  PubMed  Google Scholar 

  • Dempers J, Wadee SA, Boyd T, Wright C, Odendaal HJ, Sens MA, Prenatal Alcohol and SIDS and Stillbirth (PASS) network (2011) Hepatic hemangioendothelioma presenting as sudden unexpected death in infancy: a case report. Pediatr Dev Pathol 14:71–74

    Article  PubMed  Google Scholar 

  • Desbaillets P (1963) Hémangioendothéliome du foie à symptomatologie avant tout cardiaque. Radiol Clin 32:301

    CAS  PubMed  Google Scholar 

  • Diaz P, Ferrada C, Gonzales G, Espinoza J, Lopez I (1970) Hepatic diffuse hemangiomatosis (in Spanish). Rev Chil Pediatr 41:130–136

    CAS  PubMed  Google Scholar 

  • Dickie B, Dasgupta R, Nair R, Alonso MH, Ryckman FC, Tiao GM, Adams DM, Azizkhan RG (2009) Spectrum of hepatic hemangiomas: management and outcome. J Pediatr Surg 44:125–133

    Article  PubMed  Google Scholar 

  • Diment J, Yurim O, Pappo O (2001) Infantile hemangioendothelioma of the liver in an adult. Arch Pathol Lab Med 125:931–932

    CAS  PubMed  Google Scholar 

  • Dodrick JR (1938) Multiple malignant hemangio-endotheliomas in an infant. Am J Dis Child 55:559

    Google Scholar 

  • Dong KR, Zheng S, Xiao X (2009) Conservative management of neonatal hepatic hemangioma: a report from one institute. Pediatr Surg Int 25:493–498

    Article  PubMed  Google Scholar 

  • Dong SZ, Zhu M, Zhong YM, Yin MZ (2010) Use of foetal MRI in diagnosing hepatic hemangioendotheliomas: a report of four cases. Eur J Radiol 75:301–305

    Article  PubMed  Google Scholar 

  • Douri T (2005) Multiple cutaneous hemangiomas accompanied by hepatic hemangiomas. Dermatol Online 11:21

    Google Scholar 

  • Dreyfus M, Baldauf JJ, Dadoun K, Becmeur F, Berrut F, Ritter J (1996) Prenatal diagnosis of hepatic hemangioma. Fetal Diagn Ther 11:57–60

    Article  CAS  PubMed  Google Scholar 

  • Drut RM, Drut R (2004) Extracutaneous infantile haemangioma is also Glut1 positive. J Clin Pathol 57:1197–1200

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Drut R, Drut RM (2005) Expression of p57KIP2 in infantile hemangioma. J Mol Hist 36:195–197

    Article  CAS  Google Scholar 

  • Falcone DM, Friedman S, Peker H (1965) Precordial murmurs in high cardiac output states: differentiation from murmurs of congenital heart disease in infancy. J Pediatr 66:729

    Article  CAS  PubMed  Google Scholar 

  • Feldman PS, Shneidman D, Kaplan C (1978) Ultrastructure of infantile hemangioendothelioma of the liver. Cancer 42:521–527

    Article  CAS  PubMed  Google Scholar 

  • Feng ST, Chan T, Ching AS, Sun CH, Guo HY, Fan M, Meng QF, Li ZP (2010) CT and MR imaging characteristics of infantile hepatic hemangioendothelioma. Eur J Radiol 76:e24–e29

    Article  PubMed  Google Scholar 

  • Foote J (1919) Hemangio-endothelioma of liver. JAMA 73:1042

    Article  Google Scholar 

  • Fox PF, Cella LE (1951) Hemangioendothelioma of the liver. Ann Surg 134:1042–1047

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Franchi-Abella S, Gorincour G, Avni F, Guibaud L, Chevret L, Pariente D, SFIPP-GRRIF (2012) Hepatic haemangioma – prenatal imaging findings, complications and perinatal outcome in a case series. Pediatr Radiol 42:298–307

    Article  PubMed  Google Scholar 

  • Ganguly R, Mukherjee A (2010) Infantile hemangioendothelioma: a case report and discussion. Pathol Res Pract 206:53–58

    Article  CAS  PubMed  Google Scholar 

  • Garcia-Rodriguez E, Calderon-Lopez G, Salinas-Martin V, Ferrari-Cortes A, Pavon-Delgado A et al (2010) Neonatal fulminant type 2 infantile hepatic hemangioendothelioma involving skin, viscera and soft tissue. Fetal Pediatr Pathol 29:338–343

    Article  PubMed  Google Scholar 

  • Gembruch U, Baschat AA, Gloeckner-Hoffmann K, Gortner L, Germer U (2002) Prenatal diagnosis and management of fetuses with liver hemangiomata. Ultrasound Obstet Gynecol 19:454–460

    Article  CAS  PubMed  Google Scholar 

  • Gonen R, Fong K, Chiasson DA (1989) Prenatal sonographic diagnosis of hepatic hemangioendothelioma with secondary nonimmune hydrops fetalis. Obstet Gynecol 73:485

    CAS  PubMed  Google Scholar 

  • Gonzales-Crussi F, Reyes-Mugica M (1991) Cellular hemangiomas (“hemangioendotheliomas”) in infants. Light microscopic, immunohistochemical, and ultrastructural observations. Am J Surg Pathol 15:769–778

    Article  Google Scholar 

  • Goodale RH (1930) Hemangio-endothelioma of the liver. Arch Pathol 9:528–533

    Google Scholar 

  • Govender L, Panday S, Moodley J (2006) Prenatal diagnosis of congenital hepatic haemangioma. J Obstet Gynaecol 26:69–70

    Article  CAS  PubMed  Google Scholar 

  • Grabhorn E, Richter A, Fischer L, Krebs-Schmitt D, Ganschow R (2009) Neonates with severe infantile hepatic hemangioendothelioma: limitations of liver transplantation. Pediatr Transplant 13:560–564

    Article  PubMed  Google Scholar 

  • Graivier L, Votteler TP, Dorman GW (1967) Hepatic hemangiomas in newborn infants. J Pediatr Surg 2:299–307

    Article  CAS  PubMed  Google Scholar 

  • Güven A, Aygun C, Ince H, Aydin M, Pinarli FG, Baysal K, Küçüködük S (2005) Severe hypothyroidism caused by hepatic hemangioendothelioma in an infant of a diabetic mother. Horm Res 63:86–89

    Article  PubMed  CAS  Google Scholar 

  • Haferland W (1961) Hämangiomatose im Pfortadergebiet als Kasabach-Merrittsches Syndrome. Z Kinderheilkde 85:125–140

    Article  CAS  Google Scholar 

  • Halefoglu AM (2007) Magnetic resonance imaging of infantile hemangioendothelioma. Turk J Pediatr 49:77–81

    PubMed  Google Scholar 

  • Han SJ, Tsai CC, Tsai HM, Chen YJ (1998) Infantile hemangioendothelioma with a highly elevated serum alpha-fetoprotein level. Hepatogastroenterology 45:459–461

    CAS  PubMed  Google Scholar 

  • Hanchard B, Persuad V, Kerr G, Baum P (1983) Primary infantile haemangioendothelioma of the liver. West Indian Med J 32:44–47

    CAS  PubMed  Google Scholar 

  • Hase T, Kodama M, Kishida A, Matsushita M, Kurumi Y, Mizukuro T, Okabe H, Uno M, Ohta S (1995) Successful management of infantile hepatic hilar hemangioendothelioma with obstructive jaundice and consumption coagulopathy. J Pediatr Surg 30:1485–1487

    Article  CAS  PubMed  Google Scholar 

  • Hendrick JG (1948) Hemangioma of the liver causing death in a newborn infant. J Pediatr 32:309–310

    Article  CAS  PubMed  Google Scholar 

  • Herman TE, Siegel MJ (2000) Special imaging casebook. Infantile hepatic hemangioendothelioma. J Perinatol 20:447–449

    Article  CAS  PubMed  Google Scholar 

  • Herman TE, Siegel MJ (2001) Solitary hepatic hemangioendothelioma with extensive cystic necrosis and markedly elevated alpha-fetoprotein. J Perinatol 21:568–570

    Article  CAS  PubMed  Google Scholar 

  • Hernandez F, Navarro M, Encinas JL, Lopez Gutierrez JC, Lopez Santamaria M, Leal N et al (2005) The role of GLUT1 immunostaining in the diagnosis and classification of liver vascular tumors in children. J Pediatr Surg 40:801–804

    Article  PubMed  Google Scholar 

  • Hertleb M, Sliwinski Z, Boldys H, Kloc T, Baron J (1994) Angiomatosis of the liver (in Polish). Wiad Lek 47:138–141

    CAS  PubMed  Google Scholar 

  • Ho J, Kendrick V, Dewey D, Pacaud D (2005) New insight into the pathophysiology of severe hypothyroidism in an infant with multiple hepatic hemangiomas. J Pediatr Endocrinol Metab 18:511–514

    Article  PubMed  Google Scholar 

  • Holcomb GW, O’Neill JA, Mahboubi JR, Bishop HC (1988) Experience with hepatic hemangioendothelioma in infancy and childhood. J Pediatr Surg 23:661–666

    Article  PubMed  Google Scholar 

  • Horii KA, Drolet BA, Baselga E, Frieden IJ, Metry DW, Morel KD, Newell BD, Nopper AJ et al (2010) Risk of hepatic hemangiomas in infants with large hemangiomas. Arch Dermatol 146:201–203

    Article  PubMed  Google Scholar 

  • Horii KA, Drolet BA, Frieden IJ, Baselga E, Chamlin SL, Haggstrom AN, Holland KE et al (2011) Prospective study of the frequency of hepatic hemangiomas in infants with multiple cutaneous infantile hemangiomas. Pediatr Dermatol 28:245–253

    Article  PubMed  Google Scholar 

  • Howard WA (1936) Multiple hemangio-endotheliomas of the liver. J Pediatr 8:588

    Article  Google Scholar 

  • Howard D, La Rosa FG, Huang S, Salvatore D, Mulcahey M, Sang-Lee J, Wachs M et al (2011) Consumptive hypothyroidism resulting from hepatic vascular tumors in an athyreotic adult. J Clin Endocrinol Metab 96:1966–1970

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hsiao KH, Lin LH, Chen DF, Huang SH (2007) Hepatic mesenchymal hamartoma combined with infantile hepatic hemangioendothelioma in an infant. J Formos Med Assoc 106(suppl):S1–S4

    Article  PubMed  Google Scholar 

  • Huang SA (2005) Physiology and pathophysiology of type 3 deiodinase in humans. Thyroid 15:875–881

    Article  CAS  PubMed  Google Scholar 

  • Huang SA, Tu HM, Harney JW et al (2000) Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med 343:185–189

    Article  CAS  PubMed  Google Scholar 

  • Huang SA, Fish SA, Dorfman DM, Salvatore D, Kozakewich HP, Mandel SJ, Larsen PR (2002) A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab 87:4457–4461

    Article  CAS  PubMed  Google Scholar 

  • Hurmuzache E, Barbuta R, Haimovici M, Bogdan A (1968) Congenital multiple hepatic hemangioma in an infant, with favorable evolution (in Romanian). Pediatr (Bucur) 17:41–44

    CAS  Google Scholar 

  • Imteyaz H, Karnsakul W, Levine MA, Burrwos PE, Benson J, Hsu S, Schwarz KB (2012) Unusual case of hypothyroidism in an infant with hepatic hemangioma. J Pediatr Gastroenterol Nutr 54:692–695

    Article  PubMed  Google Scholar 

  • Iyer CP, Stanley P, Mahour GH (1996) Hepatic hemangiomas in infants and children: a review of 30 cases. Am Surg 62:356–360

    CAS  PubMed  Google Scholar 

  • Jackson C, Greene HL, O’Neill J, Kirchner S (1977) Hepatic hemangioendothelioma. Angiographic appearance and apparent prednisone responsiveness. Am J Dis Child 131:74–77

    Article  CAS  PubMed  Google Scholar 

  • Jassam N, Visser TJ, Brisco T, Bathia D, McClean P, Barth JH (2011) Consumptive hypothyroidism: a case report and review of the literature. Ann Clin Biochem 48:186–189

    Article  CAS  PubMed  Google Scholar 

  • Jayanthi V, Shankar TR, Ravindarn C, Sudalaimuthu S, Chandrasekar TS (2000) Diffuse hepatic hemangiomatosis: case report. Trop Gastroenterol 21:188–189

    CAS  PubMed  Google Scholar 

  • Jothilakshmi K, Matthai J, Paul S, Singal AK (2006) Symptomatic hepatic hemangioendothelioma in a newborn. Indian Pediatr 43:908–910

    CAS  PubMed  Google Scholar 

  • Kalpatthi R, Germak J, Mizelle K, Yeager N (2006) Thyroid abnormalities in infantile hepatic hemangioendothelioma. Pediatr Blood Cancer 49:1021–1024

    Article  Google Scholar 

  • Kanai N, Saito K, Homma Y, Makino S (1998) Infantile hemangioendothelioma of the liver associated with anomalous dilated and tortuous vessels on the placental surface. Pediatr Surg Int 13:175–176

    Article  CAS  PubMed  Google Scholar 

  • Kaniklides C, Dimopoulos PA, Bajic D (2000) Infantile hemangioendothelioma. A case report. Acta Radiol 41:161–164

    Article  CAS  PubMed  Google Scholar 

  • Karbel’ GG, Lebedev DV, Iastrebov II (1990) Hemangioendothelioma of the liver as the cause of sudden death (in Russian). Sud Med Ekspert 33:57–58

    Google Scholar 

  • Kardorff R, Fuchs J, Peuster M, Rodeck B (2001) Infantile hemangioendothelioma of the liver – sonographic diagnosis and follow-up (in German). Ultraschall Med 22:258–264

    Article  CAS  PubMed  Google Scholar 

  • Kasabach HA, Merritt KK (1940) Capillary hemangioma with extensive purpura: report of case. Am J Dis Child 59:1063–1070

    Article  Google Scholar 

  • Kasahara M, Kiuchi T, Haga H, Uemoto S, Uryuhara K, Fujimoto Y, Ogura Y, Oike F et al (2003) Monosegmental living-donor liver transplantation for infantile hepatic hemangioendothelioma. J Pediatr Surg 38:1108–1111

    Article  PubMed  Google Scholar 

  • Kassarjian A, Dubois J, Burrows PE (2002) Angiographic classification of hepatic hemangiomas in infants. Radiology 222:693–698

    Article  PubMed  Google Scholar 

  • Kassarjian A, Zurakowski D, Dubois J (2004) Infantile hepatic hemangiomas: clinical and imaging findings and their correlation with therapy. AJR Am J Roentgenol 182:785–795

    Article  PubMed  Google Scholar 

  • Kauffman SL, Stout AP (1961) Malignant hemangioendothelioma in infants and children. Cancer 14:1186–1196

    Article  CAS  PubMed  Google Scholar 

  • Kim TJ, Lee YS, Song YS, Park CK, Shim SI, Kang CS, Lee KY (2010) Infantile hemangioendothelioma with elevated serum alpha fetoprotein: report of two cases with immunohistochemical analysis. Hum Pathol 41:763–767

    Article  CAS  PubMed  Google Scholar 

  • Kirchner SG, Heller RM, Kasselberg AG, Greene HL (1981) Infantile hepatic hemangioendothelioma with subsequent malignant degeneration. Pediatr Radiol 11:42–45

    Article  CAS  PubMed  Google Scholar 

  • Konrad D, Ellis G, Perlman K (2003) Spontaneous regression of severe acquired infantile hypothyroidism associated with multiple liver hemangiomas. Pediatrics 112:1424–1426

    Article  PubMed  Google Scholar 

  • Kothny K (1912) Über ein Hämangioendotheliom in zirrhotischer Leber. Frankfurt Z Pathol 10:20–40

    Google Scholar 

  • Kristidis P, de Silva M, Howman-Giles R, Gaskin KJ (1991) Infantile hepatic haemangioma: investigation and treatment. J Paediatr Child Health 27:57–61

    Article  CAS  PubMed  Google Scholar 

  • Kulungowski AM, Alomari AI, Chawla A, Christison-Lagay ER, Fishman SJ (2012) Lessons from a liver hemangioma registry: subtype classification. J Pediatr Surg 47:165–170

    Article  PubMed  Google Scholar 

  • Kumar R, Gupta R, dasan BJ, Khullar S, Marwah A (2000) Infantile hemangioendothelioma of the liver, spleen and anterior abdominal wall. Clin Nucl Med 25:938

    Article  CAS  PubMed  Google Scholar 

  • Kumar PV, Salimi A, Ahmadi J (2010) Infantile hepatic hemangioendothelioma: report of a case with fine needle aspiration findings. Acta Cytol 54(suppl):807–810

    PubMed  Google Scholar 

  • Kunstadter RH (1933) Hemangioendothelioma of the liver in infancy. Am J Dis Child 46:803

    Article  Google Scholar 

  • Kuroda T, Kumagai M, Nosaka S, Nakazawa A, Takimoto T, Hoshino K, Infantile Hepatic Hemangioma Study Group, Japan (2011) Critical infantile hepatic hemangioma: results of a nationwide survey by the Japanese Infantile Hepatic Hemangioma Study Group. J Pediatr Surg 46:2239–2243

    Article  PubMed  Google Scholar 

  • Laird WP, Friedman S, Koop CE, Schwartz GJ (1976) Hepatic hemangiomatosis. Successful management by hepatic artery ligation. Am J Dis Child 130:657–659

    Article  CAS  PubMed  Google Scholar 

  • Lawley LP, Cerimele F, Weiss SW, North P, Cogen C, Kozakewich HP, Mulliken JB et al (2005) Expression of Wilms tumor 1 gene distinguishes vascular malformations from proliferative endothelial lesions. Arch Dermatol 141:1297–1300

    Article  PubMed  Google Scholar 

  • Lee TC, Barshes NR, Agee EE, O’Mahoney CA, Karpen SJ, Carter BA, Bristow JD et al (2006) Resolution of medically resistant hypothyroidism after liver transplantation for hepatic hemangioendothelioma. J Pediatr Surg 41:1783–1785

    Article  PubMed  Google Scholar 

  • Leonidas JC, Strauss L, Beck AR (1973) Vascular tumors of the liver in newborns. Am J Dis Child 125:507–510

    Article  CAS  PubMed  Google Scholar 

  • Levick CB, Rubic J (1953) Hemangioendothelioma of the liver simulating congenital heart disease in an infant. Arch Dis Child 28:49–51

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Linderkamp O, Hopner F, Klose H, Riegel K, Hecker WC (1976) Solitary hepatic hemangioma in a newborn infant complicated by cardiac failure, consumption coagulopathy, microangiopathic hemolytic anemia, and obstructive jaundice. Case report and review of the literature. Eur J Pediatr 124:23–29

    Article  CAS  PubMed  Google Scholar 

  • Lopez Gutiérrez JC, Avila LF, Sosa G, Patron M (2007) Placental anomalies in children with infantile hemangioma. Pediatr Dermatol 24:353–355

    Article  PubMed  Google Scholar 

  • Lu CC, Ko SF, Liang CD, Kuo HW, Tiao MM (2002) Infantile hepatic hemangioendothelioma presenting as early heart failure: report of two cases. Chang Gung Med J 25:405–410

    PubMed  Google Scholar 

  • Lunetta P, Karikoski R, Penttila A, Sajantila A (2004) Sudden death associated with a multifocal type II hemangioendothelioma of the liver in a 3-month-old infant. Am J Forensic Med Pathol 25:56–59

    Article  CAS  PubMed  Google Scholar 

  • Malvy P, Leborgne J, Le Neel JC, Bouhour JB, Petitier H, Lefèvre M (1978) Diffuse multinodular haemangioma of the liver in the infant presenting as acute asystole and treated by ligation of the hepatic artery (in French). Chirurgie 104:506–511

    CAS  PubMed  Google Scholar 

  • Marsciani A, Pericoli R, Alaggio R, Brisigotti M, Vergine G (2010) Massive response of severe infantile hepatic hemangioma to propranolol. Pediatr Blood Cancer 54:176

    Article  PubMed  Google Scholar 

  • Marton T, Silhavy M, Csapo Z, Szende B, Papp Z (1997) Multifocal hemangioendothelioma of the fetus and placenta. Hum Pathol 28:866–869

    Article  CAS  PubMed  Google Scholar 

  • Mason KP, Koka BV, Eldredge EA, Fishman SJ, Burrows PE (2001) Perioperative considerations in a hypothyroid infant with hepatic haemangioma. Pediatr Anaesth 11:228–232

    Article  CAS  Google Scholar 

  • Matolo NM, Johnson DG (1973) Surgical treatment of hepatic hemangioma in the newborn. Arch Surg 106:725–727

    Article  CAS  PubMed  Google Scholar 

  • Mattioli L, Lee KR, Holder TM (1974) Hepatic artery ligation for cardiac failure due to hepatic hemangioma in the newborn. J Pediatr Surg 9:859–862

    Article  CAS  PubMed  Google Scholar 

  • Mavili E, Kahriman G, Tuna IS, Coskun A (2006) Atypical imaging findings of infantile hemangioendothelioma: a case report. Acta Radiol 47:1091–1093

    Article  CAS  PubMed  Google Scholar 

  • McGahon JJ, Crellin PR, Whittinghill JA, Swenson OA (1964) Solitary infantile hemangioendothelioma of the liver: report of one case. Rocky Mt Med J 61:38–39

    Google Scholar 

  • McHugh K, Burrows PE (1992) Infantile hepatic hemangioendotheliomas: significance of portal venous and systemic collateral arterial supply. J Vasc Interv Radiol 3:337–344

    Article  CAS  PubMed  Google Scholar 

  • McLean RH, Moller JH, Warwick WJ, Satran L, Lucas RV (1972) Multinodular hemangiomatosis of the liver in infancy. Pediatrics 49:563–573

    CAS  PubMed  Google Scholar 

  • Meirowitz NB, Guzman ER, Underberg-Davis SJ, Pellegrino JE, Vintzileos AM (2000) Hepatic hemangioendothelioma: prenatal sonographic findings and evolution of the lesion. J Clin Ultrasound 28:258–263

    Article  CAS  PubMed  Google Scholar 

  • Mendiratta V, Anand R, Chander R, Harjai B, Gupta T (2008) Multiple neonatal haemangiomatosis with liver haemangiomas and anaemia. Australas J Dermatol 49:42–43

    Article  PubMed  Google Scholar 

  • Mhanni AA, Chodirker BN, Evans JA, Menticouglou S, Wiseman N, MacDonald N, Chudley AE (2000) Fetal hepatic haemangioendothelioma: a new association with elevated maternal serum alpha-fetoprotein. Prenat Diagn 20:432–435

    Article  CAS  PubMed  Google Scholar 

  • Mo JQ, Dimashkieh HH, Bove KE (2004) GLUT1 endothelial reactivity distinguishes hepatic infantile hemangioma from congenital hepatic vascular malformation with associated capillary proliferation. Hum Pathol 35:200–209

    Article  CAS  PubMed  Google Scholar 

  • Moazam F, Rodgers BM, Talbert JL (1983) Hepatic artery ligation for hepatic hemangiomatosis of infancy. J Pediatr Surg 18:120–123

    Article  CAS  PubMed  Google Scholar 

  • Moon SB, Kwon HJ, Park KW, Yun WJ, Jung SE (2009) Clinical experience with infantile hepatic hemangioendothelioma. World J Surg 33:597–602

    Article  PubMed  Google Scholar 

  • Morimura Y, Fujimori K, Ishida T, Ito A, Nomura Y, Sato A (2003) Fetal hepatic hemangioma representing non-reassuring pattern in fetal heart rate monitoring. J Obstet Gynaecol Res 29:347–350

    Article  PubMed  Google Scholar 

  • Morris J, Abbott J, Burrwos P, Levine D (1999) Antenatal diagnosis of fetal hepatic hemangioma treated with maternal corticosteroids. Obstet Gynecol 94:813–815

    CAS  PubMed  Google Scholar 

  • Mortele KJ, Vanzieleghem B, Mortele B, Benoit Y, Ros PR (2002) Solitary hepatic infantile hemangioendothelioma: dynamic gadolinium-enhanced MR imaging findings. Eur Radiol 12:862–865

    Article  PubMed  Google Scholar 

  • Mortensson W, Pettersson H (1979) Infantile hepatic haemangioendothelioma. Angiographic considerations. Acta Radiol Diagn (Stockh) 20:161–169

    CAS  Google Scholar 

  • Mouat F, Evans HM, Cutfield WS, Hofman PL, Jefferies C (2008) Massive hepatic hemangioendothelioma and consumptive hypothyroidism. J Pediatr Endocrinol Metab 21:701–703

    Article  PubMed  Google Scholar 

  • Murphy AM, Brenner C, Ann Lynch S (2006) Agenesis of the corpus callosum with interhemispheric cyst, hepatic hemangioma and trisomy 21. Clin Dysmorphol 15:149–151

    Article  PubMed  Google Scholar 

  • Nazir and Pervez (2006) Pub Med PMID 16410090

    Google Scholar 

  • Ng WH, Ching AS, Chan KF, Fung WT (2003) Clinics and diagnostic imaging (89). Infantile hepatosplenic haemangioendotheliomas. Singapore Med J 44:491–495

    CAS  PubMed  Google Scholar 

  • Nöller HG, Freundt KJ (1958) A case of thrombopenia-hemangioma syndrome in a young infant, Kasabach-Merritt disease (in German). Arch Kinderheilkd 157:258–270

    PubMed  Google Scholar 

  • Noronha R, Gonzales-Crussi F (1984) Hepatic angiosarcoma in childhood: a case report and review of the literature. Am J Surg Pathol 8:863–871

    Article  CAS  PubMed  Google Scholar 

  • North PE, Waner M, Miteracki A, Mihm MC (2000) GLUT1: a newly discovered immunohistochemical marker for juvenile hemangiomas. Hum Pathol 31:11–22

    Article  CAS  PubMed  Google Scholar 

  • Orzechowski G (1928) Hämangioendothelioma der Leber. Virchows Arch 267:63

    Article  Google Scholar 

  • Othersen HB, Watanatittan S (1978) Giant hemangiomatosis of the liver in infancy. Am Surg 44:20–25

    PubMed  Google Scholar 

  • Packard GB, Palmer HD (1955) Primary neoplasms of the liver in infants and children. Ann Surg 142:214

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Park CH, Hwang HS, Hong J, Pak MS (1996) Giant infantile hemangioendothelioma of the liver. Scintigraphic diagnosis. Clin Nucl Med 21:293–295

    Article  CAS  PubMed  Google Scholar 

  • Parmar RC, Bavdekar SB, Borwankar SS, Muranjan MN, Shenoy A (2001) Infantile hemangioendothelioma. Indian J Pediatr 68:459–461

    Article  CAS  PubMed  Google Scholar 

  • Pavlenishvili IV, Nemsadze KP (1978) Disseminated hemangiomatosis of the liver in a newborn infant (in Russian). Vopr Okhr Materin Det 23:85–87

    CAS  PubMed  Google Scholar 

  • Pellerin D, Alagille D, Bertin P (1971) Retentional jaundice and hepatic angiomatosis in a newborn (in French). Arch Fr Pediatr 28:1093–1100

    CAS  PubMed  Google Scholar 

  • Peters C, Langham S, Mullis PE, Dattani MT (2010) Use of combined liothyronine and thyroxine therapy for consumptive hypothyroidism associated with hepatic haemangiomas in infancy. Horm Res Paediatr 74:149–152

    Article  CAS  PubMed  Google Scholar 

  • Pethe VV, Kalgutkar AD, Mondkar J, Oak SN, Deodhar KP, Deshmukh SS (1995) Hepatic hemangioendothelioma of infancy with congestive heart failure – report of a case. Indian J Cancer 32:186–188

    CAS  PubMed  Google Scholar 

  • Pollice L, Pagliarulo G (1975) Primary hepatic infantile hemangioendothelioma (in Italian). Tumori 61:565–574

    CAS  PubMed  Google Scholar 

  • Pott Bartsch EM, Peak BW, Yoshizawa J, Goldstein RB, Ferrell LD, Coakley FV et al (2003) Giant fetal hepatic hemangioma. Case report and literature review. Fetal Diagn Ther 18:59–64

    Article  PubMed  Google Scholar 

  • Prabhu SR, Purandare SM (1977) Infantile hemangioendothelioma of the liver with congestive cardiac failure. Indian J Cancer 14:370–373

    CAS  PubMed  Google Scholar 

  • Presedo A, Martinez-Ibanez V, Castellote A, Lucaya X, Sanchez de Toledo J, Marques A, Boix-Ochoa J (1996) Infantile hepatic hemangioendothelioma of the liver: report of 11 cases (in Spanish). Cir Pediatr 9:51–54

    CAS  PubMed  Google Scholar 

  • Prokurat A, Kluge P, Chrupek M et al (2002) Hemangioma of the liver in children: proliferating vascular tumor or congenital vascular malformation? Med Pediatr Oncol 39:524–529

    Article  PubMed  Google Scholar 

  • Rake MO, Liberman MM, Dawson JL, Evans R, Raftery EB, Laws J, Williams R (1970) Ligation of the hepatic artery in the treatment of heart failure due to hepatic haemangiomatosis. Gut 11:512–515

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Razon MJ, Kraling BM, Mulliken JB, Bischoff J (1998) Increased apoptosis coincides with onset of involution in infantile hemangioma. Microcirculation 5:189–195

    Article  CAS  PubMed  Google Scholar 

  • Riley MR, Garcia MG, Cox KL, Berquist WE, Kerner JA (2006) Hepatic infantile hemangioendothelioma with unusual manifestations. J Pediatr Gastroenterol Nutr 42:109–113

    Article  PubMed  Google Scholar 

  • Ritter S, Jorn H, Ahaus M, Rath W (2003) Prenatal diagnosis of hepatic hemangioendothelioma and peripartual management 8 in German). Z Geburtshilfe Neonatol 207:29–32

    Article  CAS  PubMed  Google Scholar 

  • Robben SG, Meradji M, Woltering MC, Egeler RM (1999) Infantile hepatic hemangioendothelioma. JBR-BTR 82:123

    CAS  PubMed  Google Scholar 

  • Robbins BH, Castle RF (1965) Hemangiomas, hepatic involvement, congestive failure. Letter to the editor. Pediatrics 35:868

    CAS  PubMed  Google Scholar 

  • Robinson D, Hambleton G (1977) Cutaneous and hepatic haemangiomata. Arch Dis Child 52:155–157

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rocchini AP, Rosenthal A, Issenberg HJ, Nadas AS (1976) Hepatic hemangioendothelioma: hemodynamic observations and treatment. Pediatrics 57:131–135

    CAS  PubMed  Google Scholar 

  • Roebuck D, Sebire N, Lehmann E, Barnacle A (2012) Rapidly involuting congenital haemangioma (RICH) of the liver. Pediatr Radiol 42:308–314

    Article  PubMed  Google Scholar 

  • Rotman M, John M, Stowe S, Inamdar S (1980) Radiation treatment of pediatric hepatic hemangiomatosis and coexisting cardiac failure. N Engl J Med 302:852

    Article  CAS  PubMed  Google Scholar 

  • Ruppe MD, Huang SA, Jan de Beur SM (2005) Consumptive hypothyroidism caused by paraneoplastic production of type 3 iodothyronine deiodinase. Thyroid 15:1369–1372

    Article  CAS  PubMed  Google Scholar 

  • Sakamoto S, Kasahara M, Shigeta T, Fukuda A, Kakiuchi T, Miyasaka M, Nosaka S et al (2011) Living donor liver transplantation for multiple intrahepatic portosystemic shunts after involution of infantile hepatic hemangiomas. J Pediatr Surg 46:1288–1291

    Article  PubMed  Google Scholar 

  • Samuel M, Spitz L (1995) Infantile hepatic hemangioendothelioma: the role of surgery. J Pediatr Surg 30:1425–1429

    Article  CAS  PubMed  Google Scholar 

  • Sari N, Yalcin B, Akyüz C, Haliloglu M, Büyükpamukçu M (2006) Infantile hepatic hemangioendothelioma with elevated serum alpha-fetoprotein. Pediatr Hematol Oncol 23:639–647

    Article  PubMed  Google Scholar 

  • Schiavon G, Dal Pozzo A, Alessandrini H (1982) Hepatic hemangioma in the neonate: description of a case treated surgically with favorable outcome (in Italian). Pediatr Med Chir 4:571–573

    CAS  PubMed  Google Scholar 

  • Schmitz R, Heinig J, Klockenbusch W, Kiesel L, Steinhard J (2009) Antenatal diagnosis of a giant fetal hemangioma and treatment with maternal corticosteroid. Ultraschall Med 30:223–226

    Article  CAS  PubMed  Google Scholar 

  • Schneegans E, Korn R, Haarscher A, Alt J (1964) Multinodular hemangiomatosis of the liver (in French). Pediatrie 19:799–805

    CAS  PubMed  Google Scholar 

  • Schumann HD (1941) Beitrag zur Kasuistik des primären Hämangioendotheliomas der Leber. Frankfurt Z Pathol 55:1

    Google Scholar 

  • Schwartz AR (1945) Multiple malignant hemangioendothelioma in infant: report of a case. Arch Pediatr 62:1

    Google Scholar 

  • Selby DM, Stocker JT, Ishak KG (1992) Angiosarcoma of the liver in childhood: a clinicopathologic and follow-up study of 10 cases. Pediatr Pathol 12:485–498

    Article  CAS  PubMed  Google Scholar 

  • Selby DM, Stocker JT, Waclawiw MA, Hitchcock CL, Ishak KG (1994) Infantile hemangioendothelioma of the liver. Hepatology 20:39–45

    CAS  PubMed  Google Scholar 

  • Selke AC, Cornell SH (1969) Infantile hepatic hemangioendothelioma. Am J Roentgenol Radium Ther Nucl Med 106:200–203

    Article  CAS  PubMed  Google Scholar 

  • Seok JY, Kim YB (2010) Infantile hemangioendothelioma with increased serum alpha-fetoprotein (in Korean). Korean J Hepatol 16:192–196

    Article  PubMed  Google Scholar 

  • Sepulveda WH, Donetch G, Giuliano A (1993) Prenatal sonographic diagnosis of hepatic hemangioma. Eur J Obstet Gynecol Reprod Biol 48:73–76

    Article  CAS  PubMed  Google Scholar 

  • Sevinir B, Özkan TB (2007) Infantile hepatic hemangioendothelioma: clinical presentation and treatment. Turk J Gastroenterol 18:182–187

    PubMed  Google Scholar 

  • Shah KD, Beck R, Jhaveri MK, Keohane M, Weinberg B, Gerber MA (1987) Infantile hemangioendothelioma of heterotopic intrathoracic liver associated with diaphragmatic hernia. Hum Pathol 18:754–765

    Article  CAS  PubMed  Google Scholar 

  • Shaik S, Sanislo S, O’Brien JM, Alcorn D (2001) Congenital circumscribed choroidal haemangioma associated with infantile hepatic haemangioendothelioma. Br J Ophthalmol 85:626

    Google Scholar 

  • Sharp L, Makin E, Davenport M (2008) Hepatic haemangioendothelioma: a vertical association with biliary atresia? Eur J Pediatr Surg 18:277–279

    Article  CAS  PubMed  Google Scholar 

  • Sheu BC, Shyu MK, Lin YF, Lee CN, Hsieh FJ, Chou YH, Yau KI, Huang SF (1994) Prenatal diagnosis and corticosteroid treatment of diffuse neonatal hemangiomatosis: case report. J Ultrasound Med 13:495–499

    CAS  PubMed  Google Scholar 

  • Shturman-Ellstein R, Greco MA, Myrie C, Goldman EK (1978) Hydrops fetalis, hydramnios and hepatic vascular malformation associated with cutaneous hemangioma and chorangioma. Acta Paediatr Scand 67:239–243

    Article  CAS  PubMed  Google Scholar 

  • Siderys H, Moore TC, Shumacker HB (1962) Left hepatic lobectomy for hemangioma of the liver in the newborn. Surgery 52:502–504

    CAS  PubMed  Google Scholar 

  • Sidwell RU, Daubeney PE, Porter W, Roberts NM (2004) Neonatal hemangiomatosis and atrial septal defect: a rare cause of right heart failure in infancy. Pediatr Dermatol 21:66–69

    Article  PubMed  Google Scholar 

  • Sigamani E, Iyer VK, Agarwala S (2010) Fine needle aspiration cytology of infantile haemangioendothelioma of the liver: a report of two cases. Cytopathology 21:398–402

    Article  CAS  PubMed  Google Scholar 

  • Singh S, Chowdhury V, Prakash A, Aggarwal A (2008) Infantile haemangio-endothelioma of liver: a case report. J Indian Med Assoc 106:120

    PubMed  Google Scholar 

  • Skopec LL, Lakatua DJ (1989) Non-immune fetal hydrops with hepatic hemangioendothelioma and Kasabach-Merritt syndrome: a case report. Pediatr Pathol 9:87–93

    Article  CAS  PubMed  Google Scholar 

  • Sloane CE, Baek SM, Beck AR (1977) Solitary neonatal hepatic hemangioendothelioma: case report and discussion. Mt Sinai J Med 44:234–240

    CAS  PubMed  Google Scholar 

  • Slovis TL, Berdon WE, Holler JO, Casarella WJ, Baker DH (1975) Hemangiomas of the liver in infants. AJR Am J Roentgenol 123:791–801

    Article  CAS  Google Scholar 

  • Smith GG, Lohr JA, Malcolm BS, Kelser RW (1978) Hepatic hemangioendothelioma and hyperbilirubinemia. South Med J 71:1439–1441

    Article  CAS  PubMed  Google Scholar 

  • Sommacal D (1957) A case of multiple hemangiomatosis in infants (in German). Helv Paediatr Acta 12:666–678

    CAS  PubMed  Google Scholar 

  • Stanley P, Gates GF, Eto RT, Miller SW (1977) Hepatic cavernous hemangiomas and hemangioendotheliomas in infancy. AJR Am J Roentgenol 129:317–321

    Article  CAS  PubMed  Google Scholar 

  • Stanley P, Geer GD, Miller JH, Gilsanz V, Landing BH, Boechat IM (1989) Infantile hepatic hemangiomas. Clinical features, radiologic investigations, and treatment of 20 patients. Cancer 64:936–949

    Article  CAS  PubMed  Google Scholar 

  • Stone HH, Nielson IC (1965) Hemangioma of the liver in the newborn. Report of a successful outcome following hepatic lobectomy. Arch Surg 90:319–322

    Article  CAS  PubMed  Google Scholar 

  • Stovis TL, Berdon WE, Holler JO et al (1975) Hemangiomas of the liver in infants. AJR Am J Roentgenol 123:791

    Article  Google Scholar 

  • Strate SM, Rutlddge JC, Weinberg AG (1984) Delayed development of angiosarcoma in multinodular infantile hepatic hemangioendothelioma. Arch Pathol Lab Med 108:943–944

    CAS  PubMed  Google Scholar 

  • Sweed A, Weinberg T (1950) Hemangioendothelioma of the liver in infancy. Am J Dis Child 80:436–441

    CAS  Google Scholar 

  • Tan ST, Itinteang T, Leadbitter P (2011) Low-dose propranolol for multiple hepatic and cutaneous hemangiomas with deranged liver function. Pediatrics 127:e772–e776

    Article  PubMed  Google Scholar 

  • Tawes RL, Nelson JA, Hyde GA (1971) Hepatic hemangioma: successful resection in a neonate. Surgery 70:782–785

    PubMed  Google Scholar 

  • Taylor AC, Moore E (1933) Multiple hemangiomas showing certain malignant characteristics in an infant. Am J Cancer 19:31

    Google Scholar 

  • Terbruegge MO, Rennie JM, Haugen SE (2005) Congenital absence of the pericardium associated with congenital diaphragmatic hernia and hepatic hemangioendothelioma: case report and review of the literature. Pediatr Surg Int 21:557–559

    Article  Google Scholar 

  • Touloukian RJ (1970) Hepatic hemangioendothelioma during infancy: pathology, diagnosis and treatment with prednisone. Pediatrics 45:1–6

    Google Scholar 

  • Turowski C, Feist H, Alzen G, Glüer S, Petersen C (2009) Conversion of a neonatal hepatic hemangioma to focal nodular hyperplasia. Pathol Int 59:251–254

    Article  PubMed  Google Scholar 

  • Urbach AH, Zitelli BJ, Blatt J et al (1987) Elevated alpha-fetoprotein in a neonate with a benign hemangioendothelioma of the liver. Pediatrics 80:596–597

    CAS  PubMed  Google Scholar 

  • Van Acker P, Derom F, De Gendt G, Berzsenyi G (1975) Haemangioma of the liver in newborn infant (in Dutch). Acta Chir Belg 74:545–550

    PubMed  Google Scholar 

  • Van der Meijs BB, Merks JH, de Haan TR, Tabbers MM, van Rijn RR (2009) Neonatal hepatic haemangioendothelioma: treatment options and dilemmas. Pediatr Radiol 39:277–281

    Article  PubMed  Google Scholar 

  • Veeder BS, Austin JH (1913) Multiple congenital hemangio-endotheliomas of the liver. Am J Med Sci 143:102–107

    Article  Google Scholar 

  • Verger P, Guillard JM, Cixous P, Laigle JL (1972) Case of multinodular hemangiomatosis of the liver with favorable outcome (in French). Arch Fr Pédiatr 29:1115–1116

    CAS  PubMed  Google Scholar 

  • Videback A (1946) Haemangio-endothelioma of the liver. Acta Paediatr 33:129–143

    Article  Google Scholar 

  • Vorse HB, Smith EI, Luckstead EF, Fraser JJ (1983) Hepatic hemangiomatosis of infancy. Am J Dis Child 137:672–673

    CAS  PubMed  Google Scholar 

  • Walsh R, Harrington J, Beneck D, Ozkaynak MF (2004) Congenital infantile hemangioendothelioma type II treated with orthotopic liver transplantation. J Pediatr Hematol Oncol 26:121–123

    Article  PubMed  Google Scholar 

  • Wang J, Pei G, Yan J, Zhang G (2009) Coexistence of a giant splenic hemangioma and multiple hepatic hemangiomas mimicking a left adrenal neuroblastoma accompanied with multifocal hepatic metastases: pyrite answer. J Pediatr Hematol Oncol 31:983–984

    Article  PubMed  Google Scholar 

  • Warmann S, Bertram H, Kardorff R, Sasse M, Hausdorf G, Fuchs J (2003) Interventional treatment of infantile hepatic hemangioendothelioma. J Pediatr Surg 38:1177–1181

    Article  CAS  PubMed  Google Scholar 

  • Weinberg AG, Finegold MJ (1983) Primary hepatic tumors of childhood. Hum Pathol 14:512–537

    Article  CAS  PubMed  Google Scholar 

  • Winters RW, Robinson SJ, Bates G (1954) Hemangioma of the liver with heart failure. A case report. Pediatrics 14:117

    CAS  PubMed  Google Scholar 

  • Woltering MC, Robben S, Egeler RM (1997) Hepatic hemangioendothelioma of infancy: treatment with interferon alpha. J Pediatr Gastroenterol Nutr 24:348–351

    Article  CAS  PubMed  Google Scholar 

  • Wood BP, Putnam TC, Chacko AK (1977) Infantile hepatic hemangioendotheliomas associated with hemihypertrophy. Pediatr Radiol 5:242–245

    Article  CAS  PubMed  Google Scholar 

  • Yasunaga C, Sueishi K, Ohgami H, Suita S, Kawanami T (1989) Heterogeneous expression of endothelial cell markers in infantile hemangioendothelioma. Immunohistochemical study of two solitary cases and one multiple one. Am J Clin Pathol 91:673–681, Curr. Opin. Pediatr. 14, 99-102

    Article  CAS  PubMed  Google Scholar 

  • Yeh I, Bruckner AL, Sanchez R, Jeng MR, Newell BD, Frieden IJ (2011) Diffuse infantile hepatic hemangiomas: a report of four cases successfully managed with medical therapy. Pediatr Dermatol 28:267–275

    Article  PubMed  Google Scholar 

  • Yu Y, Flint AF, Mulliken JB, Wu JK, Bischoff J (2004) Endothelial progenitor cells in infantile hemangioma. Blood 103:1373–1375

    Article  CAS  PubMed  Google Scholar 

  • Zavota L, Bini F, Carano N, Agnetti A, Squarcia U (1984) Hepatic hemangiomatosis with congestive cardiac failure and development into a cholestatic hepatopathy (in Italian). Pediatr Med Chir 6:621–624

    CAS  PubMed  Google Scholar 

  • Zenge JP, Fenton L, Lovell MA, Grover TR (2002) Case report: infantile hemangioendothelioma. Curr Opin Pediatr 14:99–102

    Article  PubMed  Google Scholar 

  • Zenzen W, Perez-Atayde AR, Elisofon SA, Kim HB, Alomari AI (2009) Hepatic failure in a rapidly involuting congenital hemangioma of the liver: failure of embolotherapy. Pediatr Radiol 39:1118–1123

    Article  PubMed  Google Scholar 

  • Zerbini et al. (1991) Pub Med PMID 2036623

    Google Scholar 

  • Zhang Z, Chen HJ, Yang WJ, Bu H, Wei B, Long XY, Fu J, Zhang R, Ni YB, Zhang HY (2010) Infantile hepatic hemangioendothelioma: a clinicopathologic study in a Chinese population. World J Gastroenterol 16:4549–4557

    Article  PubMed  PubMed Central  Google Scholar 

  • Zürcher B, Caflisch U, Hofer B, Schärli A, Laissue J (1982) Hemangio-endothelioma of the liver (case report). Z Kinderchir 35:26–31

    PubMed  Google Scholar 

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  1. University of Bern, Bern, Switzerland

    Arthur Zimmermann

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  1. Arthur Zimmermann
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Zimmermann, A. (2017). Infantile Hepatic Hemangioma/Hemangioendothelioma. In: Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. Springer, Cham. https://doi.org/10.1007/978-3-319-26956-6_52

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  • DOI: https://doi.org/10.1007/978-3-319-26956-6_52

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  • Publisher Name: Springer, Cham

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  • Online ISBN: 978-3-319-26956-6

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