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Epstein Barr Virus Volume 1 pp 45–69Cite as

Epstein–Barr Virus Strain Variation

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 390))

Abstract

What is wild-type Epstein–Barr virus and are there genetic differences in EBV strains that contribute to some of the EBV-associated diseases? Recent progress in DNA sequencing has resulted in many new Epstein–Barr virus (EBV) genome sequences becoming available. EBV isolates worldwide can be grouped into type 1 and type 2, a classification based on the EBNA2 gene sequence. Type 1 transforms human B cells into lymphoblastoid cell lines much more efficiently than type 2 EBV and molecular mechanisms that may account for this difference in cell transformation are now becoming understood. Study of geographic variation of EBV strains independent of the type 1/type 2 classification and systematic investigation of the relationship between viral strains, infection and disease are now becoming possible. So we should consider more directly whether viral sequence variation might play a role in the incidence of some EBV-associated diseases.

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  1. Section of Virology, Department of Medicine, Imperial College, St Mary’s Campus, Norfolk Place, London, W2 1PG, UK

    Paul J. Farrell

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  1. Paul J. Farrell
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Correspondence to Paul J. Farrell .

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  1. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

    Christian Münz

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Farrell, P.J. (2015). Epstein–Barr Virus Strain Variation. In: Münz, C. (eds) Epstein Barr Virus Volume 1. Current Topics in Microbiology and Immunology, vol 390. Springer, Cham. https://doi.org/10.1007/978-3-319-22822-8_4

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