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Pathophysiology of Atopic Dermatitis/Eczema

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Book cover Atopic Dermatitis

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Abstract

Atopic diseases are strongly genetically influenced. This is evident from twin studies where monozygous twins show a concordance of 80 % of atopic eczema while dizygous twins only show ca. 20 %. The risk to develop atopic eczema is 40 % for children with one atopic parent. When both parents are affected by the same manifestation of atopy (e.g., father and mother with atopic eczema), the risk is between 70 and 80 %. Similar high concordance rates can be found for extrinsic (IgE-associated) and intrinsic (non-IgE-associated) atopic dermatitis.

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  1. Department of Dermatology and Allergology Biederstein, Technische Universitaet Muenchen (TUM), Munich, Bavaria, Germany

    Johannes Ring

  2. Christine Kuehne Center for Allergy Research and Education (CK-CARE), Hochgebirgsklinik (High Altitude Hospital), Davos, Switzerland

    Johannes Ring

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Ring, J. (2016). Pathophysiology of Atopic Dermatitis/Eczema. In: Atopic Dermatitis. Springer, Cham. https://doi.org/10.1007/978-3-319-22243-1_3

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