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Vogt-Koyanagi-Harada Syndrome

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Uveitis

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Abstract

Vogt-Koyanagi-Harada (VKH) syndrome is a bilateral granulomatous panuveitis characterized by serous retinal detachments and a spectrum of extraocular findings. The disease is thought to arise from a T-cell driven autoimmune response to melanocytes. The fundus features may vary at the time of ophthalmic examination due to the multiple clinical stages of VKH, thus it is important to be aware of these different presentations. The initial treatment in the acute uveitic stage is corticosteroids with a slow taper over three to six months. Relapsing or recurrent stages may require systemic, steroid-sparing immunomodulatory therapy. The visually significant complications of the disease include cataract, glaucoma, choroidal neovascularization, and subretinal fibrosis.

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Authors and Affiliations

  1. Retina Service, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, 02114, USA

    John B. Miller

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  1. John B. Miller
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Correspondence to John B. Miller .

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Editors and Affiliations

  1. Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    George N. Papaliodis

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Miller, J.B. (2017). Vogt-Koyanagi-Harada Syndrome. In: Papaliodis, G. (eds) Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-09126-6_41

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  • DOI: https://doi.org/10.1007/978-3-319-09126-6_41

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09125-9

  • Online ISBN: 978-3-319-09126-6

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