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Relapsing Polychondritis

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Uveitis

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Abstract

Relapsing polychondritis (RP) is a rare multisystem, autoimmune disorder characterized by destructive inflammation of cartilaginous and connective tissues in many organs, especially the auricular pinna, cartilage of the nose, tracheobronchial tree, eyes, and heart. The clinical spectrum can vary widely from mild inflammation to life-threatening cardiopulmonary and renal manifestations. Ocular manifestations, including nongranulomatous anterior uveitis, are reported in as many as 60–70 % of cases. The diagnosis is mainly based on typical clinical findings, with laboratory investigations assisting in identifying frequently associated rheumatologic and hematologic autoimmune disorders. Increased awareness among ophthalmologists is crucial, as prompt diagnosis is required to avoid severe life-threatening complications. Treatment data, while limited, is rapidly expanding with the use of newer biologic agents and represent potential effective tools for patients with severe disease.

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Authors and Affiliations

  1. Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, 02114, USA

    Jose Daniel Diaz

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  1. Jose Daniel Diaz
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Correspondence to Jose Daniel Diaz .

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Editors and Affiliations

  1. Ocular Immunology and Uveitis Service, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA

    George N. Papaliodis

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Diaz, J.D. (2017). Relapsing Polychondritis. In: Papaliodis, G. (eds) Uveitis. Springer, Cham. https://doi.org/10.1007/978-3-319-09126-6_34

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  • DOI: https://doi.org/10.1007/978-3-319-09126-6_34

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-09125-9

  • Online ISBN: 978-3-319-09126-6

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