Abstract
Lymphoepithelial carcinoma affects children and adults and presents at a mean age of approximately 55 years. Women and men are involved with similar frequency. The majority of cases involve the parotid gland, presenting as single or multiple masses. Most cases of lymphoepithelial carcinoma behave as intermediate- to high-grade malignancies. Lymphoepithelial carcinoma may be well-circumscribed or infiltrative, comprised of multiple cell types (epithelial and lymphoid), and exhibit a variety of architectural patterns (nests, cords, and sheets) (Figs. 16.1, 16.2, 16.3, 16.4, 16.5, 16.6, 16.7, 16.8, 16.9, 16.10, 16.11, 16.12, 16.13, 16.14, 16.15, 16.16 and 16.17).
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsSuggested Reading
Albeck H, Nielsen NH, Hansen HE, Bentzen J, Ockelmann HH, Bretlau P, et al. Epidemiology of nasopharyngeal and salivary gland carcinoma in Greenland. Arctic Med Res. 1992;51:189–95.
Ambrosio MR, Masrogiulio MG, Barone A, Rocca BJ, Gallo C, Lazzi S, et al. Lymphoepithelial-like carcinoma of the parotid gland: a case report and a brief review of the western literature. Diagn Pathol. 2013;8:115.
Bialas M, Sinczak A, Choinska-Stefanska A, Zygulska A. EBV-positive lymphoepithelial carcinoma of salivary gland in a woman of a non-endemic area--a case report. Pol J Pathol. 2002;53(4):235–8.
Friborg J, Hamilton-Therkildsen M, Homoe P, Kristensen C, Hui A, Liu FF, et al. A spectrum of basaloid morphology in a subset of EBV-associated “lymphoepithelial carcinomas” of major salivary glands. Head Neck Pathol. 2012;6:445–50.
Hamilton-Dutoit SJ, Therkildsen M, Neilsen NH, Jensen H, Hansen JP, Pallesen G. Undifferentiated carcinoma of the salivary gland in Greenlandic Eskimos: demonstration of Epstein-Barr virus DNA by in situ nucleic acid hybridization. Hum Pathol. 1991;22:811–5.
Hsiung CY, Huang CC, Wang CJ, Huang EY, Huang HY. Lymphoepithelioma-like carcinoma of salivary glands: treatment results and failure patterns. Br J Radiol. 2006;79:52–5.
Jen KY, Cheng J, Li J, Wu L, Li Y, Yu S, et al. Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas. Int J Cancer. 2003;105(5):654–60.
Jen KY, Higuchi M, Cheng J, Li J, Wu LY, Li YF, et al. Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas. Virus Genes. 2005;30(2):223–35.
Kuo T, Hsueh C. Lymphoepithelioma-like salivary gland carcinoma in Taiwan: a clinicopathological study of nine cases demonstrating strong association with Epstein-Barr virus. Histopathology. 1997;31:75–82.
Leung SY, Chung LP, Yuen ST, Ho CM, Wong MP, Chan SY. Lymphoepithelial carcinoma of the salivary gland: in situ detection of Epstein-Barr virus. J Clin Pathol. 1995;48:1022–7.
Li F, Zhu G, Wang Y, Wang Y, Chent T, Ji Q. A clinical analysis of 37 cases with lymphoepithelial carcinoma of the major salivary gland treated by surgical resection and postoperative radiotherapy: a single institution study. Med Oncol. 2014;31:957.
Nagao T, Ishida Y, Sugano I, Tajima Y, Matsuzaki O, Hino T, et al. Epstein-Barr virus-associated undifferentiated carcinoma with lymphoid stroma of the salivary gland in Japanese patients: comparison with benign lymphoepithelial lesion. Cancer. 1996;78:695–703.
Saku T, Cheng J, Jen KY, Tokunaga M, Li J, Zhang W, et al. Epstein-Barr virus infected lymphoepithelial carcinomas of the salivary gland in the Russia-Asia area: a clinicopathologic study of 160 cases. Arkh Patol. 2003;65(2):35–9.
Sheen TS, Tsai CC, Ko JY, Chang YL, Hsu MM. Undifferentiated carcinoma of the major salivary glands. Cancer. 1997;80:357–63.
Tsai CC, Chen CL, Hsu HC. Expression of Epstein-Barr virus in carcinomas of major salivary glands: a strong association with lymphoepithelioma-like carcinoma. Hum Pathol. 1996;27:258–62.
Wang CP, Chang YL, Ko JY, Lou PJ, Yeh CF, Sheen TS. Lymphoepithelial carcinoma versus large cell undifferentiated carcinoma of the major salivary glands. Cancer. 2004;101(9):2020–7.
Wenig BM. Lymphoepithlial-like carcinomas of the head and neck. Semin Diagn Pathol. 2015;32:74–86.
Wu DL, Shemen L, Brady T, Saw D. Malignant lymphoepithelial lesion of the parotid gland: a case report and review of the literature. Ear Nose Throat J. 2001;80(11):803–6.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer International Publishing AG, part of Springer Nature
About this chapter
Cite this chapter
García, J.J. (2019). Lymphoepithelial Carcinoma. In: Atlas of Salivary Gland Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-09021-4_16
Download citation
DOI: https://doi.org/10.1007/978-3-319-09021-4_16
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-09020-7
Online ISBN: 978-3-319-09021-4
eBook Packages: MedicineMedicine (R0)