Abstract
Five to 13 % of patients who survive an acute event in the intensive care unit require prolonged mechanical ventilation, which is the major feature of chronic critical illness syndrome. The transition from positive pressure ventilation to spontaneous unsupported breathing undoubtedly imposes an increased load. The inability to sustain spontaneous breathing and thus achieve liberation from a ventilator is clearly associated with an imbalance between the increased load and the capacity of the inspiratory muscles. The pathophysiology is complex, and in-depth knowledge is required. This review provides a comprehensive and structured analysis of the physiologic determinants.
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Lagonidis, D., Chouris, I. (2016). Physiologic Determinants of Prolonged Mechanical Ventilation and Unweanable Patients. In: Esquinas, A. (eds) Noninvasive Mechanical Ventilation and Difficult Weaning in Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-04259-6_1
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DOI: https://doi.org/10.1007/978-3-319-04259-6_1
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