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Redox Control of Gene Expression by Eukaryotic Transcription Factors NF-κB, AP-1 and SRF/TCF

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Book cover Oxidative Stress, Cell Activation and Viral Infection

Part of the book series: Molecular and Cell Biology Updates ((MCBU))

Summary

In higher eukaryotic cells, three unrelated transciption factor systems have been identified as regulators of gene transcription in response to alterations of the intracellular level of reactive oxygen intermediates. One is NF-kB, an inducible protein complex that activates gene transcription specifically in response to peroxides. A second one is AP-1, a factor newly synthesized upon stimulation of cells by both H2O2 as well as antioxidants. A third one is SRF/TCF, a nuclear transcription factor responsible for transcriptional activation of the gene encoding the AP-1 subunit c-fos in response to both H2O2 and antioxidants. In this article, we will review the current knowledge about redox regulation of gene expression by NF-κB, AP-1 and SRF/TCF and discuss the different molecular mechanisms by which these factors induce gene expression.

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Author information

Author notes

  1. M. Meyer

    Present address: European Molecular Biology Laboratory, Meyerhofstr. 1, W-6900, Heidelberg 1, Germany

  2. R. Schreck

    Present address: Howard Hughes Medical Institute, Fred Hutchinson Center, 1124 Columbia Street, Seattle, Washington, 98104, USA

Authors and Affiliations

  1. Laboratory for Molecular Biology, Gene Center, Am Klopferspitz 18a, W-8033, Martinsried, Germany

    M. Meyer, R. Schreck, J. M. Müller & P. A. Baeuerle

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  1. M. Meyer
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  2. R. Schreck
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  3. J. M. Müller
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  4. P. A. Baeuerle
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Editor information

Editors and Affiliations

  1. INSERM U. 294, 16, rue Henri Huchard, F-75018, Paris, France

    C. Pasquier

  2. Dept. SIDA & Rétrovirus, Unité d’Oncologie Virale, 25-28, rue du Dr. Roux, F-75015, Paris, France

    R. Y. Olivier

  3. Institut Gustave Roussy, INSERM U. 140, 39, rue Camille Desmoulins, F-94805, Villejuif Cedex, France

    C. Auclair

  4. Dept. of Molecular and Cell Biology, 251 Life Science Addition, Membrane Bioenergetics Group, 94720, Berkeley, CA, USA

    Lester Packer

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© 1994 Birkhäuser Verlag Basel/Switzerland

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Meyer, M., Schreck, R., Müller, J.M., Baeuerle, P.A. (1994). Redox Control of Gene Expression by Eukaryotic Transcription Factors NF-κB, AP-1 and SRF/TCF. In: Pasquier, C., Olivier, R.Y., Auclair, C., Packer, L. (eds) Oxidative Stress, Cell Activation and Viral Infection. Molecular and Cell Biology Updates. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7424-3_20

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  • DOI: https://doi.org/10.1007/978-3-0348-7424-3_20

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-7426-7

  • Online ISBN: 978-3-0348-7424-3

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