Abstract
In this chapter, we discuss what are the major receptors overexpressed in tumor cells and how these receptors have been widely tested as a targeted therapy in the treatment of cancer. We discuss the main classes of immunotherapy, including monoclonal antibodies, tyrosine kinase inhibitors, cancer vaccines, and checkpoint inhibitors, among others. Despite the benefits with the insertion of these immunotherapeutic agents in the cancer clinic, these drugs are not exempt from side effects, to which we highlight the main adverse events presented by patients during their administration.
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References
Deshpande PP, Biswas S, Torchilin VP (2013) Current trends in the use of liposomes for tumor targeting. Nanomedicine (Lond) 8(9):1509–1528
Hoskins WJ (2005) Principles and practice of gynecologic oncology. Lippincott Williams & Wilkins, Philadelphia
Large DE, Soucy JR, Hebert J, Auguste DT (2018) Advances in receptor-mediated, tumor-targeted drug delivery. Adv Ther 2(1):1800091
Templeton NS (2008) Gene and cell therapy: therapeutic mechanisms and strategies. CRC Press, Boca Raton, USA
Narrandes S, Xu W (2018) Gene expression detection assay for cancer clinical use. J Cancer 9(13):2249–2265
Perez-Diez A, Morgun A, Shulzhenko N (2007) Microarrays for cancer diagnosis and classification. In: Microarray technology and cancer gene profiling. Springer, New York, pp 74–85
Harvey KJ, Lukovic D, Ucker DS (2000) Caspase-dependent Cdk activity is a requisite effector of apoptotic death events. J Cell Biol 148(1):59–72
Jung MS, Yun J, Chae HD, Kim JM, Kim SC, Choi TS et al (2001) p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor. Oncogene 20(41):5818–5825
Senthivinayagam S, Mishra P, Paramasivam SK, Yallapragada S, Chatterjee M, Wong L et al (2009) Caspase-mediated cleavage of beta-catenin precedes drug-induced apoptosis in resistant cancer cells. J Biol Chem 284(20):13577–13588
Wang ZB, Gao HY, Wei L, Zhang AQ, Zhang JY, Wang Y et al (2018) Expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, and Ki-67 in ductal carcinoma in situ (DCIS) and DCIS with microinvasion. Medicine (Baltimore) 97(44):e13055
Magalhaes LG, Ferreira LLG, Andricopulo AD (2018) Recent advances and perspectives in cancer drug design. An Acad Bras Cienc 90(1 Supp. 2):1233–1250
Seebacher NA, Stacy AE, Porter GM, Merlot AM (2019) Clinical development of targeted and immune based anti-cancer therapies. J Exp Clin Cancer Res 38:156
Koury J, Lucero M, Cato C, Chang L, Geiger J, Henry D et al (2018) Immunotherapies: exploiting the immune system for cancer treatment. J Immunol Res 2018:1–16
Pandya PH, Murray ME, Pollok KE, Renbarger JL (2016) The immune system in cancer pathogenesis: potential therapeutic approaches. J Immunol Res 2016:4273943
Farkona S, Diamandis EP, Blasutig IM (2016) Cancer immunotherapy: the beginning of the end of cancer? BMC Med 14:73
Karachi A (2018) Immunotherapy for treatment of cancer. Intechopen
Stanculeanu DL, Daniela Z, Lazescu A, Bunghez R, Anghel R (2016) Development of new immunotherapy treatments in different cancer types. J Med Life 9(3):240–248
Ventola CL (2017) Cancer immunotherapy, Part 3: challenges and future trends. Pharm Ther 42(8):514–521
Egloff H, Kidwell KM, Schott A (2018) Ado-trastuzumab emtansine-induced pulmonary toxicity: a single-institution retrospective review. Case Rep Oncol 11:527–533
Baldo BA (2020) Monoclonal antibodies approved for cancer therapy. In: Safety of Biologics Therapy, Springer, Cham, Switzerland
Scheeren FA, Geelen CMMV, Yasuda E, Spits H, Beaumont T (2011) Antigen-specific monoclonal antibodies isolated from B cells expressing constitutively active STAT5. PLoS One 6(4):e17189
Nogales-Gadea G, Saxena A, Hoffmann C, Hounjet J, Coenen D, Molenaar P et al (2015) Generation of recombinant human IgG monoclonal antibodies from immortalized sorted B cells. J Vis Exp 100:e52830
Papaioannou NE, Beniata OV, Vitsos P, Tsitsilonis O, Samara P (2016) Harnessing the immune system to improve cancer therapy. Ann Transl Med 4(14):261
Schroeder HW, Cavacini L (2010) Structure and function of immunoglobulins. J Allergy Clin Immunol 125(202):S41–S52
Vidal TJ, Figueiredo TA, Pepe VLE (2018) O mercado brasileiro de anticorpos monoclonais utilizados para o tratamento de câncer. Cad Saude Publica 34(12):e00010918
Uyar NY (2018) Structure, physiology, and functions of autoantibodies. Intechopen
Chames P, Regenmortel MV, Weiss E, Baty D (2009) Therapeutic antibodies: successes, limitations and hopes for the future. Br J Pharmacol 157(2):220–233
Reichert JM (2012) Marketed therapeutic antibodies compendium. mAbs 4(3):413–415
Santos ML, Quintilio W, Manieri TM, Tsuruta LR, Moro AM (2018) Advances and challenges in therapeutic monoclonal antibodies drug development. Braz J Pharm Sci 54:e01007
Lu RM, Hwang YC, Liu IJ, Lee CC, Tsai HZ, Li HJ et al (2020) Development of therapeutic antibodies for the treatment of diseases. J Biomed Sci 27:1
Harding FA, Stickler MM, Razo J, DuBridge RB (2010) The immunogenicity of humanized and fully human antibodies residual immunogenicity resides in the CDR regions. MAbs 2(3):256–265
Goldenberg DM, Chatal JF, Barbet J, Boerman O, Sharkey RM (2007) Cancer imaging and therapy with bispecific antibody pretargeting. Update Cancer Ther 2(1):19–31
Sharkey RM, Rossi EA, McBride WJ, Chang CH, Goldenberg DM (2010) Recombinant bispecific monoclonal antibodies prepared by the dock-and-lock strategy for pretargeted radioimmunotherapy. Semin Nucl Med 40(3):190–203
Boyd K, Dearden CE (2008) Alemtuzumab in the treatment of chronic lymphocytic lymphoma. Expert Rev Anticancer Ther 8(4):525–533
Gajria D, Chandarlapaty S (2011) HER2-amplified breast cancer: mechanisms of trastuzumab resistance and novel targeted therapies. Expert Rev Anticancer Ther 11(2):263–275
Richard S, Selle F, Lotz JP, Khalil A, Gligorov J, Soares DG (2016) Pertuzumab and trastuzumab: the rationale way to synergy. An Acad Bras Cienc 88(1 Suppl):565–577
Tai W, Mahato R, Cheng K (2010) The role of HER2 in cancer therapy and targeted drug delivery. J Control Release 146(3):264–275
Corraliza-Gorjón I, Somovilla-Crespo B, Santamaria S, Garcia-Sanz JÁ, Kremer L (2017) New strategies using antibody combinations to increase cancer treatment effectiveness. Front Immunol 8:1804
Dillman RO (2006) Radioimmunotherapy of B-cell lymphoma with radiolabelled anti-CD20 monoclonal antibodies. Clin Exp Med 6(1):1–12
Jacobs SA (2007) 90Yttrium ibritumomab tiuxetan in the treatment of non-Hodgkin’s lymphoma: current status and future prospects. Biol Target Ther 1(3):215–227
Lambert JM, Chari RVJ (2014) Ado-trastuzumab emtansine (T-DM1): an antibody-drug conjugate (ADC) for HER2-positive breast cancer. J Med Chem 57(16):6949–6964
Staudacher AH, Brown MP (2017) Antibody drug conjugates and bystander killing: is antigen-dependent internalisation required? Br J Cancer 117(12):1736–1742
Thomas A, Teicher BA, Hassan R (2016) Antibody-drug conjugates for cancer therapy. Lancet Oncol 17(6):e254–e262
Sedykh SE, Prinz VV, Buneva VN, Nevinsky GA (2018) Bispecific antibodies: design, therapy, perspectives. Drug Des Devel Ther 12:195–208
Wang Q, Chen Y, Park J, Liu X, Hu Y, Wang T et al (2019) Design and production of bispecific antibodies. Antibodies (Basel) 8(3):43
Hu Y, Turner MJ, Shields J, Gale MS, Hutto E, Roberts BL et al (2009) Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model. Immunology 128(2):260–270
Niu G, Chen X (2010) Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy. Curr Cancer Drug Targets 11(8):1000–1017
Wang Y, Fei D, Vanderlaan M, Song A (2004) Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro. Angiogenesis 7(4):335–345
Iqbal N, Iqbal N (2014) Human epidermal growth factor receptor 2 (HER2) in cancers: overexpression and therapeutic implications. Mol Biol Int 2014:852748
Mitri Z, Constantine T, O’Regan R (2012) The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy. Chemother Res Pract 2012:743193
Galizia G, Lieto E, De Vita F, Orditura M, Castellano P, Troiani T et al (2007) Cetuximab, a chimeric human mouse anti-epidermal growth factor receptor monoclonal antibody, in the treatment of human colorectal cancer. Oncogene 26:3654–3660
Russell JS, Colevas AD (2012) The use of epidermal growth factor receptor monoclonal antibodies in squamous cell carcinoma of the head and neck. Chemother Res Pract 2012:761518
Mohammed R, Milne A, Kayani K, Ojha U (2019) How the discovery of rituximab impacted the treatment of B-cell non-Hodgkin’s lymphomas. J Blood Med 10:71–84
Smith MR (2003) Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene 22:7359–7368
Cartenì G, Fiorentino R, Vecchione L, Chiurazzi B, Battista C (2007) Panitumumab a novel drug in cancer treatment. Ann Oncol 18(Suppl 6):vi16–vi21
Trivedi S, Srivastava RM, Concha-Benavente F, Ferrone S, Garcia-Bates TM, Li J et al (2016) Anti-EGRF targeted monoclonal antibody isotype influences anti-tumor cellular immunity in head and neck cancer patients. Clin Cancer Res 22(21):5229–5237
Cáceres MC, Guerrero-Martín J, Pérez-Civantos D, Palomo-López P, Delgado-Mingorance JI, Durán-Gómez N (2019) The importance of early identification of infusion-related reactions to monoclonal antibodies. Ther Clin Risk Manag 15:965–977
Guan M, Zhou YP, Sun JL, Chen SC (2015) Adverse events of monoclonal antibodies used for cancer therapy. BioMed Res Int 2015:428169
Coulson A, Levy A, Gossell-Williams M (2014) Monoclonal antibodies in cancer therapy: mechanisms, successes and limitations. West Indian Med J 63(6):650–654
Fakih M, Vincent M (2010) Adverse events associated with anti-EGFR therapies for the treatment of metastatic colorectal cancer. Curr Oncol 17(Suppl 1):S18–S30
Mohan N, Jiang J, Dokmanovic M, Wu WJ (2018) Trastuzumab-mediated cardiotoxicity: current understanding, challenges, and frontiers. Antibiot Ther 1(1):13–17
Pavlidis ET, Pavlidis TE (2013) Role of bevacizumab in colorectal cancer growth and its adverse effects: a review. World J Gastroenterol 19(31):5051–5060
Hu-Lieskovan S, Ribas A (2016) New combination strategies using programmed cell death 1/programmed cell death ligand 1 checkpoint inhibitors as a backbone. Cancer J 23(1):10–22
Linck RDM, Costa RLP, Garicochea B (2017) Cancer immunology and melanoma immunotherapy. An Bras Dermatol 92(6):830–835
Nowicki TS, Hu-Lieskovan S, Ribas A (2018) Mechanisms of resistance to PD-1 and PD-L1 blockade. Cancer J 24(1):47–53
Riley RS, June CH, Langer R, Mitchell MJ (2019) Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov 18(3):175–196
Seidel JA, Otsuka A, Kabashima K (2018) Anti-PD-1 and anti-CTLA-4 therapies in cancer: mechanisms of action, efficacy, and limitations. Front Oncol 8:86
Rotte A (2019) Combination of CTLA-4 and PD-1 blockers for treatment of cancer. J Exp Clin Cancer Res 38:255
Marchetti A, Lorito AD, Buttitta F (2017) Why anti-PD1/PDL1 therapy is so effective? Another piece in the puzzle. J Thorac Dis 9(12):4863–4866
Alsaab HO, Sau S, Alzhrani R, Tatiparti K, Bhise K, Kashaw SK et al (2017) PD-1 and PD-L1 checkpoint signaling inhibition for cancer immunotherapy: mechanism, combinations, and clinical outcome. Front Pharmacol 8:561
Kim JM, Chen DS (2016) Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure). Ann Oncol 27(8):1492–1504
Qin W, Hu L, Zhang X, Jiang S, Li J, Zhang Z et al (2019) The diverse function of Pd-1/PD-L pathway beyond cancer. Front Immunol 10:2298
Cummings AL, Garon EB (2017) The ascent of immune checkpoint inhibitors: is the understudy ready for a leading role? Cancer Biol Med 14(4):341–347
Davis AA, Patel VG (2019) The role of PD-L1 expression as a predictive biomarker: an analysis of all US Food and Drug Administration (FDA) approvals of immune checkpoint inhibitors. J Immunother Cancer 7(1):278
Wu X, Gu Z, Chen Y, Chen B, Chen W, Weng L et al (2019) Application of Pd-1 blockade in cancer immunotherapy. Comput Struct Biotechnol J 17:661–674
Brunner-Weinzierl MC, Rudd CE (2018) CTLA-4 and PD-1 control of T-cell motility and migration: implications for tumor immunotherapy. Front Immunol 9:2737
Gu D, Ao X, Yang Y, Chen Z, Xu X (2018) Soluble immune checkpoints in cancer: production, function and biological significance. J Immunother Cancer 6:132
Marhelava K, Pilch Z, Bajor M, Graczyk-Jarzynka A, Zagozdzon R (2019) Targeting negative and positive immune checkpoints with monoclonal antibodies in therapy of cancer. Cancers (Basel) 11(11):1756
Singh P, Souza P, Scott KF, Hall BM, Verma ND, Becker TM et al (2019) Biomarkers in immune checkpoint inhibition therapy for cancer patients: what is the role of lymphocyte subsets and PD1/PD-L1? Transl Med Commun 4(2)
Choi J, Lee SY (2020) Clinical characteristics and treatment of immune-related adverse events of immune checkpoint inhibitors. Immune Netw 20(1):e9
Spiers L, Coupe N, Payne M (2019) Toxicities associated with checkpoint inhibitors – an overview. Rheumatology (Oxford) 58(Suppl 7):vii7–vii16
Hodi FS, O’Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB et al (2010) Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 363(8):711–723
Postow M (2015) Managing immune checkpoint-blocking antibody side effects. Am Soc Clin Oncol Educ Book:76–83
Garon EB, Rizvi NA, Hui R, Leighl N, Balmanoukian AS, Eder JP et al (2015) Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 372(21):2018–2028
Robert C, Schachter J, Long GV, Arance A, Grob JJ, Mortier L et al (2015) Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 372(26):2521–2532
Schmid P, Adams S, Rugo HS, Schneeweiss A, Barrios CH, Iwata H et al (2018) Atezolizumab and Nab-paclitaxel in advanced triple-negative breast cancer. N Engl J Med 379:2108–2121
Migden MR, Rischin D, Schmults CD, Guminski A, Hauschild A, Lewis KD et al (2018) PD-1 blockade with cemiplimab in advanced cutaneous squamous-cell carcinoma. N Engl J Med 379:341–335
Burg SHVD (2018) Correlates of immune and clinical activity of novel cancer vaccines. Semin Immunol 39:119–136
Emens LA (2008) Cancer vaccines: on the threshold of success. Expert Opin Emerg Drugs 13(2):295–308
Hollingsworth RE, Jansen K (2019) Turning the corner on therapeutic cancer vaccines. NPJ Vaccines 4:7
Finn OJ (2014) Vaccines for cancer prevention: a practical and feasible approach to the cancer epidemic. Cancer Immunol Res 2(8):708–713
Tashiro H, Brenner MK (2017) Immunotherapy against cancer-related viruses. Cell Res 27(1):59–73
D’Souza G, Dempsey A (2011) The role of HPV in head and neck cancer and review of the HPV vaccine. Prev Med 53(Suppl 1):S5–S11
Gillison ML (2008) Human papillomavirus-related diseases: oropharynx cancers and potential implications for adolescent HPV vaccination. J Adolesc Health 43(4 Suppl):S52–S60
Mitchell AE, Colvin HM (2010) Hepatitis and liver cancer: a national strategy for prevention and control of hepatitis B and C. National Academies Press, Washington
Bhat M, Ghali P, Deschenes M, Wong P (2014) Prevention and management of chronic hepatitis B. Int J Prev Med 5(Suppl 3):S200–S207
Niu B, Hann HW (2017) Hepatitis B virus-related hepatocellular carcinoma: carcinogenesis, prevention, and treatment. Intechopen
Lowndes CM (2006) Vaccines for cervical cancer. Epidemiol Infect 134(1):1–12
Flora SD, Bonanni P (2011) The prevention of infection-associated cancers. Carcinogenesis 32(6):787–795
Guo C, Manjili MH, Subjeck JR, Sarkar D, Fisher PB, Wang XY (2013) Therapeutic cancer vaccines: past, present and future. Adv Cancer Res 119:421–475
Jiang S, Good D, Wei MQ (2019) Vaccinations for colorectal cancer: progress, strategies, and novel adjuvants. Int J Mol Sci 20(14):3403
Vermaelen K (2019) Vaccine strategies to improve anti-cancer cellular immune responses. Front Immunol 10:8
Anassi E, Ndefo UA (2011) Sipuleucel-T (Provenge) injection. Pharm Therap 36(4):197–202
American Cancer Society. Immunotherapy for prostate cancer. 2019. Available on: https://www.cancer.org/cancer/prostate-cancer/treating/vaccine-treatment.html. Accessed 1 Aug 2020
Cheever MA, Higano CS (2011) PROVENGE (Sipuleucel-T) in prostate cancer: the first FDA-approved therapeutic cancer vaccine. Clin Cancer Res 17(11):3520–3526
Drake CG (2011) Update on prostate cancer vaccines. Cancer J 17(5):294–299
Hammerstrom AE, Cauley DH, Atkinson BJ, Sharma P (2011) Cancer immunotherapy: sipuleucel-T and beyond. Pharmacotherapy 31(8):813–828
Willigen WWV, Bloemendal M, Gerritsen WR, Schreibelt G, Vries IJM, Bol KF (2018) Dendritic cell cancer therapy: vaccinating the right patient at the right time. Front Immunol 9:2265
Waldman AD, Fritz JM, Lenardo MJ (2020) A guide to cancer immunotherapy: from T cell basic science to clinical practice. Nat Rev Immunol 20:651–668
Zhang JM, An J (2007) Cytokines, inflammation and pain. Int Anesthesiol Clin 45(2):27–37
Lee S, Margolin K (2011) Cytokines in cancer immunotherapy. Cancers (Basel) 3(4):3856–3893
Choudhry H, Helmi N, Abdulaal WH, Zeyadi M, Zamzami MA, Wu W et al (2018) Prospects of IL-2 in cancer immunotherapy. Biomed Res Int 2018:9056173
Jiang T, Zhou C, Ren S (2016) Role of IL-2 in cancer immunotherapy. OncoImmunology 5(6):e1163462
Nicholas C, Lesinski GB (2011) Immunomodulatory cytokines as therapeutic agents for melanoma. Immunotherapy 3(5):673–690
Dorr RT (1993) Interferon-𝛂 in malignant and viral diseases. Drugs 45:177–211
Kirkwood JM (2002) Cancer immunotherapy: the interferon-𝛂 experience. Semin Oncol 29(3):18–26
Roth MS, Foon KA (1986) Alpha interferon in the treatment of hematologic malignancies. Am J Med 81:871–882
Franssen LE, Mutis T, Lokhorst HM, Donk NWCJV (2019) Immunotherapy in myeloma: how far have we come? Therap Adv Hematol 10:2040620718822660
Matsushita M, Kawaguchi M (2018) Immunomodulatory effects of drugs for effective cancer immunotherapy. J Oncol 2018:8653489
Butterfield LH, Kaufman HL, Marincola FM (2017) Cancer immunotherapy principles and practice. Springer Publishing Company, New York, USA
Fuge O, Vasdev N, Allchorne P, Green JS (2015) Immunotherapy for bladder cancer. Res Rep Urol 7:65–79
Sharma P, Old LJ, Allison JP (2007) Immunotherapeutic strategies for high-risk bladder cancer. Semin Oncol 34(2):165–172
Anaya JM, Shoenfeld Y, Rojas-Villarraga A, Levy RA, Cervera R (2013) Autoimmunity: from bench to bedside. El Rosario University Press, Bogota
Nishida N, Yano H, Nishida T, Kamura T, Kojiro M (2006) Angiogenesis in cancer. Vasc Health Risk Manag 2(3):213–219
Stone WL, Leavitt L, Varacallo M (2020) Physiology, growth factor. StatPearls Publishing, USA
Wee P, Wang Z (2017) Epidermal growth factor receptor cell proliferation signaling pathways. Cancers (Basel) 9(5):52
Ardito F, Giuliani M, Perrone D, Troiano G, Muzio LL (2017) The crucial role of protein phosphorylation in cell signaling and its use as targeted therapy (review). Int J Mol Med 40(2):271–280
Lee S, Kim SM, Lee RT (2013) Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance. Antioxid Redox Signal 18(10):1165–207
Yang L, Shi P, Zhao G, Xu J, Peng W, Zhang J et al (2020) Targeting cancer stem cell pathways for cancer therapy. Signal Transduct Target Ther 5:1–35
Force T, Kuida K, Namchuk M, Parang K, Kyriakis JM (2004) Inhibitors of protein kinase signaling pathways. Circulation 109:1196–1205
Siveen KS, Prabhu KS, Achkar IW, Kuttikrishnan S, Shyam S, Khan AQ et al (2018) Role of non receptor tyrosine kinases in hematological malignances and its targeting by natural products. Mol Cancer 17(1):31
Matos K, Manso PG, Marback E, Furlanetto R, Alberti GN, Nosé V (2008) Protein expression of VEGF, IGF-1 and FGF in retroocular connective tissues and clinical correlation in Graves’ ophthalmopathy. Arq Bras Oftalmol 71(4):486–492
Goel HL, Mercurio AM (2013) VEGF targets the tumour cell. Nat Rev Cancer 13(12):871–882
Fauvel B, Yasri A (2014) Antibodies directed against receptor tyrosine kinases. MAbs 6(4):838–851
Ferreira PMP, Pessoa C (2017) Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challenges. Braz J Pharm Sci 53(2) e16076
Raval SH, Singh RD, Joshi DV, Patel HB, Mody SK (2016) Recent developments in receptor tyrosine kinases targeted anticancer therapy. Vet World 9(1):80–90
Jackson KD, Durandis R, Vergne MJ (2018) Role of cytochrome P450 enzymes in the metabolic activation of tyrosine kinase inhibitors. Int J Mol Sci 19(8)
Jeong W, Doroshow JH, Kummar S (2013) US FDA approved oral kinase inhibitors for the treatment of malignancies. Curr Probl Cancer 37(3):110–144
Such E, Liquori A, Mora E, Marco-Ayala J, Avetisyan G, Regadera A et al (2019) RNA sequencing analysis for the identification of a PCM1/PDGFRB fusion gene responsive to imatinib. Acta Haematol 142:92–97
Dutta PR, Maity A (2007) Cellular responses to EGFR inhibitors and their relevance to cancer therapy. Cancer Lett 254(2):165–77
Leite CAVG, Costa JVG, Callado RB, Torres JNL, Lima Júnior RCP, Ribeiro RA (2012) Receptores tirosina-quinase: implicações terapêuticas no câncer. Revista Brasileira de Oncologia Clínica 8(29):130–142
Penne K, Bohlin C, Schneider S, Allen D (2005) Gefitinib (Iressa™, ZD1839) and tyrosine kinase inhibitors: the wave of the future in cancer therapy. Cancer Nurs 28(6):481–486
Frampton JE, Easthope SE (2005) Spotlight on gefitinib in non-small-cell lung cancer. Am J Pharmacogenomics 5(2):133–136
Frampton JE, Easthope SE (2004) Gefitinib: a review of its use in the management of advanced non-small-cell lung cancer. Drugs 64(21):2475–2492
Haringhuizen A, van Tinteren H, Vaessen HFR, Baas P, van Zandwijk N (2004) Gefitinib as a last treatment option for non-small-cell lung cancer: durable disease control in a subset of patients. Ann Oncol 15:786–792
Bethune G, Bethune D, Ridgway N, Xu Z (2010) Epidermal growth factor receptor (EGFR) in lung cancer: an overview and update. J Thorac Dis 2(1):48–51
Lopes GL, Vattimo EFQ, Junior GC (2015) Identifying activating mutations in the EGFR gene: prognostic and therapeutic implications in non-small cell lung cancer. Journal Brasileiro de Pneumologia 41(4):365–375
Vyse S, Huang PH (2019) Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer. Signal Transduct Target Ther 4:5
Cicènas S, Geater SL, Petrov P, Hotko Y, Hooper G, Xia F et al (2016) Maintenance erlotinib versus erlotinib at disease progression in patients with advanced non-small-cell lung cancer who have not progressed following platinum-based chemotherapy (IUNO study). Lung Cancer 102:30–37
Rajappa S, Doval DC, Biswas J, Patil S, Somani N, Srinivasan S et al (2017) Efficacy of erlotinib as first-line maintenance therapy in patients with locally advanced or metastatic nonsmall cell lung cancer who have not experienced disease progression or unacceptable toxicity during chemotherapy. South Asian J Cancer 6(1):1–5
Wang Y, Schmid-Bindert G, Zhou C (2012) Erlotinib in the treatment of advanced non-small cell lung cancer: an update for clinicians. Ther Adv Med Oncol 4(1):19–29
Broecker-Preuss M, Muller S, Britten M, Worm K, Schmid KW, Mann K et al (2015) Sorafenib inhibits intracellular signaling pathways and induces cell cycle arrest and cell death in thyroid carcinoma cells irrespective of histological origin or BRAF mutational status. BMC Cancer 15:184
Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M (2008) Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther 7(10):3129–3140
Keskin D, Sadri S, Eskazan AE (2016) Dasatinib for the treatment of chronic myeloid leukemia: patient selection and special considerations. Drug Des Devel Ther 10:3355–3361
Shah NP, Rousselot P, Schiffer C, Rea D, Cortes JE, Milone J et al (2016) Dasatinib in imatinib-resistant or-intolerant chronic-phase, chronic myeloid leukemia patients: 7-year follow-up of study CA180-034. Am J Hematol 91(9):869–874
Jabbour E, Cortes J, Kantarjian H (2009) Nilotinib for the treatment of chronic myeloid leukemia: an evidence-based review. Core Evid 4:207–213
Fink MY, Chipuk JE (2013) Survival of HER2-positive brast cancer cells. Genes Cancer 4(5–6):187–195
Raina D, Uchida Y, Kharbanda A, Rajabi H, Panchamoorthy G, Jin C et al (2014) Targeting the MUC1-C oncoprotein downregulates HER2 activation and abrogates trastuzumab resistance in breast cancer cells. Oncogene 33:3422–3431
Kaufman B, Stein S, Casey MA, Newstat BO (2007) Lapatinib in combination with capecitabine in the management of ErbB2-positive (HER2-positive) advanced breast cancer. Biol Target Ther 2(1):61–65
Opdam FL, Guchelaar HJ, Bejinen JH, Schellens JHM (2012) Lapatinib for advanced or metastatic breast cancer. Oncologist 17(4):536–542
Wang J, Xu B (2019) Targeted therapeutic options and future perspectives for HER2-positive breast cancer. Signal Transduct Target Ther 4:34
Aggarwal BB, Danda D, Gupta S, Gehlot P (2009) Models for prevention and treatment of cancer: problems vs promises. Biochem Pharmacol 78(9):1083–1094
Krajewska J, Handkiewicz-Junak D, Jarzab B (2015) Sorafenib for the treatment of thyroid cancer: an updated review. Expert Opin Pharmacother 16(4):573–583
Burotto M, Manasanch EE, Wilkerson J, Fojo T (2015) Gefitinib and erlotinib in metastatic non-small cell lung cancer: a meta-analysis of toxicity and efficacy of randomized clinical trials. Oncologist 20(4):400–410
Chatsiproios D (2010) Safety profile and clinical recommendations for the use of Lapatinib. Breast Care (Basel) 5(Suppl 1):16–21
Cetin B, Benekli M, Turker I, Koral L, Ulas A, Dane F et al (2014) Lapatinib plus capecitabine for HER2-positive advanced breast cancer: a multicentre study of Anatolian Society of Medical Oncology (ASMO). J Chemother 26(5):300–305
Inayat F, Saif MW (2016) New drug and possible new toxicity - squamous cell carcinoma following imatinib in patients with gastrointestinal stromal tumors. Anticancer Res 36(11):6201–6204
Chamoun K, Rabinovich E, Baer L, Fastenau P, Lima M (2020) A case of neurocognitive deficit strongly related to dasatinib therapy. Hematol Transfus Cell Ther 42(1):80–82
Conchon M, Freitas CMBM, Rego MAC, Junior JWRB (2011) Dasatinib – clinical trials and management of adverse events in imatinib resistant/intolerant chronic myeloid leukemia. Rev Bras Hematol Hemoter 33(2):131–139
Boons CCLM, Timmers L, Janssen JJWM, Westerweel PE, Blijlevens NMA, Smit WM et al (2020) Response and adherence to nilotinib in daily practice (RAND study): an in-depth observational study of chronic myeloid leukemia patients treated with nilotinib. Eur J Clin Pharmacol 76:1213–1226
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Cavalcanti, I.D.L., Soares, J.C.S. (2021). Targeted Therapies in Cancer Treatment. In: Advances in Cancer Treatment. Springer, Cham. https://doi.org/10.1007/978-3-030-68334-4_5
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DOI: https://doi.org/10.1007/978-3-030-68334-4_5
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