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Bleeding Associated with Coagulation Factor Inhibitors

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Management of Bleeding Patients

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Abstract

Acquired autoantibodies targeting coagulation factors are fortunately rare. However, unfamiliarity with them can lead to misinterpretation of clinical presentations and screening laboratory tests, erroneous or delayed diagnoses, and inappropriate management decisions which may result in severe morbidity or mortality. Using acquired neutralizing antibodies to factor VIII (acquired hemophilia A) as a model for clinical presentation, laboratory diagnosis, management of bleeding, and immunosuppression treatment, this chapter reviews our current knowledge of acquired inhibitors of the coagulation system.

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Abbreviations

aPTT:

Activated partial thromboplastin time

FEIBA:

Factor eight inhibitor bypass activity

INR:

International normalized ratio

LA:

Lupus anticoagulant

NPP:

Normal pooled plasma

PT:

Prothrombin time

rFVIIa:

Recombinant factor VIIa

TT:

Thrombin time

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Author information

Authors and Affiliations

  1. Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Charles Eby

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  1. Charles Eby
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Correspondence to Charles Eby .

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Editors and Affiliations

  1. Department of Pathology and Immunology, Division of Transfusion Medicine and Coagulation, Baylor College of Medicine, Texas Children’s Hospital, Houston, TX, USA

    Jun Teruya

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Eby, C. (2021). Bleeding Associated with Coagulation Factor Inhibitors. In: Teruya, J. (eds) Management of Bleeding Patients. Springer, Cham. https://doi.org/10.1007/978-3-030-56338-7_10

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  • DOI: https://doi.org/10.1007/978-3-030-56338-7_10

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-56337-0

  • Online ISBN: 978-3-030-56338-7

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