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Atlas of Diagnostic Pathology of the Cervix pp 209–228Cite as

Epithelial Malignant Tumors of the Cervix: Other Epithelial Tumors (Adenosquamous Carcinoma, Adenoid Basal Carcinoma, Carcinoma with Adenoid Cystic-like Features, Undifferentiated Carcinoma)

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Abstract

Although squamous cell carcinomas and endocervical adenocarcinomas comprise the overwhelming majority of malignant tumors arising in the uterine cervix, other important but less common malignant epithelial neoplasms may also occur, including adenosquamous carcinoma, adenoid basal carcinoma, “adenoid cystic carcinoma,” and undifferentiated carcinoma. These tumors often display distinctive morphology, but they may be difficult to classify and raise a broad differential diagnosis, especially in biopsy specimens and when classic morphology is not readily apparent. Like most epithelial tumors in the cervix, these tumors are predominantly (but not exclusively) associated with human papillomavirus infection.

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References

  1. Colgan TJ, Kim KR, Hirschowitz L, McCluggage G. Other epithelial tumours. In: Kurman R, Carcangiu M, Herrington C, Young R, editors. WHO classification of tumours of female reproductive organs, WHO/IARC classification of tumours, vol. 6. 4th ed. Lyon, France: IARC; 2014. p. 194–6.

    Google Scholar 

  2. Cherry CP, Glucksmann A. Incidence, histology, and response to radiation of mixed carcinomas (adenoacanthomas) of the uterine cervix. Cancer. 1956;9:971–9.

    Article  CAS  Google Scholar 

  3. Stolnicu S, Hoang L, Hanko-Bauer O, Barsan I, Terinte C, Pesci A, et al. Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinical outcomes in 59 cases. Mod Pathol. 2019;32:269–79.

    Article  CAS  Google Scholar 

  4. Yoshida T, Sano T, Oyama T, Kanuma T, Fukuda T. Prevalence, viral load, and physical status of HPV 16 and 18 in cervical adenosquamous carcinoma. Virchows Arch. 2009;455:253–9.

    Article  CAS  Google Scholar 

  5. Yamakawa Y, Forslund O, Teshima H, Hasumi K, Kitagawa T, Hansson BG. Human papillomavirus DNA in adenocarcinoma and adenosquamous carcinoma of the uterine cervix detected by polymerase chain reaction (PCR). Gynecol Oncol. 1994;53:190–5.

    Article  CAS  Google Scholar 

  6. Pirog EC, Kleter B, Olgac S, Bobkiewicz P, Lindeman J, Quint WGV, et al. Prevalence of human papillomavirus DNA in different histological subtypes of cervical adenocarcinoma. Am J Pathol. 2000;157:1055–62.

    Article  CAS  Google Scholar 

  7. Quddus MR, Manna P, Sung CJ, Kerley S, Steinhoff MM, Lawrence WD. Prevalence, distribution, and viral burden of all 15 high-risk human papillomavirus types in adenosquamous carcinoma of the uterine cervix: a multiplex real-time polymerase chain reaction-based study. Hum Pathol. 2014;45:303–9.

    Article  CAS  Google Scholar 

  8. Martens JE, Smedts F, van Muyden RC, Schoots C, Helmerhorst TJ, Hopman A, et al. Reserve cells in human uterine cervical epithelium are derived from Müllerian epithelium at midgestational age. Int J Gynecol Pathol. 2007;26:463–8.

    Article  Google Scholar 

  9. Ueda Y, Miyatake T, Okazawa M, Kimura T, Miyake T, Fujiwara K, et al. Clonality and HPV infection analysis of concurrent glandular and squamous lesions and adenosquamous carcinomas of the uterine cervix. Am J Clin Pathol. 2008;130:389–400.

    Article  CAS  Google Scholar 

  10. Katagiri A, Nakayama K, Rahman MT, Rahman M, Katagiri H, Ishikawa M, et al. Frequent loss of tumor suppressor ARID1A protein expression in adenocarcinomas/adenosquamous carcinomas of the uterine cervix. Int J Gynecol Cancer. 2012;22:208–12.

    Article  Google Scholar 

  11. Fujiwara H, Mitchell MF, Arseneau J, Hale RJ, Wright TC. Clear cell adenosquamous carcinoma of the cervix. An aggressive tumor associated with human papillomavirus-18. Cancer. 1995;76:1591–600.

    Article  CAS  Google Scholar 

  12. Lennerz JKM, Perry A, Mills JC, Huettner PC, Pfeifer JD. Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion. Am J Surg Pathol. 2009;33:835–43.

    Article  Google Scholar 

  13. Farley JH, Hickey KW, Carlson JW, Rose GS, Kost ER, Harrison TA. Adenosquamous histology predicts a poor outcome for patients with advanced-stage, but not early-stage, cervical carcinoma. Cancer. 2003;97:2196–202.

    Article  Google Scholar 

  14. Shingleton HM, Bell MC, Fremgen A, Chmiel JS, Russell AH, Jones WB, et al. Is there really a difference in survival of women with squamous cell carcinoma, adenocarcinoma, and adenosquamous cell carcinoma of the cervix? Cancer. 1995;76(10 Suppl):1948–55.

    Article  CAS  Google Scholar 

  15. Russell MJ, Fadare O. Adenoid basal lesions of the uterine cervix: evolving terminology and clinicopathological concepts. Diagn Pathol. 2006;1:18.

    Article  Google Scholar 

  16. DePond WD, Flauta VS, Lingamfelter DC, Schnee DM, Menendez KP. Adenoid basal carcinoma of the cervix in a 20-year-old female: a case report. Diagn Pathol. 2006;1:20.

    Article  Google Scholar 

  17. Brainard JA, Hart WR. Adenoid basal epitheliomas of the uterine cervix: a reevaluation of distinctive cervical basaloid lesions currently classified as adenoid basal carcinoma and adenoid basal hyperplasia. Am J Surg Pathol. 1998;22:965–75.

    Article  CAS  Google Scholar 

  18. Grayson W, Taylor LF, Cooper K. Adenoid cystic and adenoid basal carcinoma of the uterine cervix: comparative morphologic, mucin, and immunohistochemical profile of two rare neoplasms of putative “reserve cell” origin. Am J Surg Pathol. 1999;23:448–58.

    Article  CAS  Google Scholar 

  19. Senzaki H, Osaki T, Uemura Y, Kiyozuka Y, Ogura E, Okamura A, et al. Adenoid basal carcinoma of the uterine cervix: immunohistochemical study and literature review. Jpn J Clin Oncol. 1997;27:437–41.

    Article  CAS  Google Scholar 

  20. Jones MW, Kounelis S, Papadaki H, Bakker A, Swalsky PA, Finkelstein SD. The origin and molecular characterization of adenoid basal carcinoma of the uterine cervix. Int J Gynecol Pathol. 1997;16:301–6.

    Article  CAS  Google Scholar 

  21. Parwani AV, Smith Sehdev AE, Kurman RJ, Ronnett BM. Cervical adenoid basal tumors comprised of adenoid basal epithelioma associated with various types of invasive carcinoma: clinicopathologic features, human papillomavirus DNA detection, and P16 expression. Hum Pathol. 2005;36:82–90.

    Article  CAS  Google Scholar 

  22. Cviko A, Briem B, Granter SR, Pinto AP, Wang TY, Yang YC, et al. Adenoid basal carcinomas of the cervix: a unique morphological evolution with cell cycle correlates. Hum Pathol. 2000;31:740–4.

    Article  CAS  Google Scholar 

  23. Liang Y, Lü B, Zhou C. Cervical adenoid basal carcinoma: Clinicopathologic features of 9 cases with reference to CK17 and Ki-67 expression. J Low Genit Tract Dis. 2019;23:77–81.

    Article  Google Scholar 

  24. Powers CN, Stastny JF, Frable WJ. Adenoid basal carcinoma of the cervix: a potential pitfall in cervicovaginal cytology. Diagn Cytopathol. 1996;14:172–7.

    Article  CAS  Google Scholar 

  25. Kerdraon O, Cornélius A, Farine M-O, Boulanger L, Wacrenier A. Adenoid basal hyperplasia of the uterine cervix: a lesion of reserve cell type, distinct from adenoid basal carcinoma. Hum Pathol. 2012;43:2255–65.

    Article  CAS  Google Scholar 

  26. Ferry JA, Scully RE. “Adenoid cystic” carcinoma and adenoid basal carcinoma of the uterine cervix. A study of 28 cases. Am J Surg Pathol. 1988;12:134–44.

    Article  CAS  Google Scholar 

  27. Xing D, Schoolmeester JK, Ren Z, Isacson C, Ronnett BM. Lower female genital tract tumors with adenoid cystic differentiation: p16 expression and high-risk HPV detection. Am J Surg Pathol. 2016;40:529–36.

    Article  Google Scholar 

  28. Shi H, Shao Y, Liu Q, Wang S, Lu W, Lu B. A clinicopathological and molecular analysis of cervical carcinomas with basaloid features. Histopathology. 2020;76:283–95.

    Article  Google Scholar 

  29. Xing D, Bakhsh S, Melnyk N, Isacson C, Ho J, Huntsman DG, et al. Frequent NFIB-associated gene rearrangement in adenoid cystic carcinoma of the vulva. Int J Gynecol Pathol. 2017;36:289–93.

    Article  CAS  Google Scholar 

  30. Albores-Saavedra J, Manivel C, Mora A, Vuitch F, Milchgrub S, Gould E. The solid variant of adenoid cystic carcinoma of the cervix. Int J Gynecol Pathol. 1992;11:2–10.

    Article  CAS  Google Scholar 

  31. Chen T-D, Chuang H-C, Lee L. Adenoid basal carcinoma of the uterine cervix: clinicopathologic features of 12 cases with reference to CD117 expression. Int J Gynecol Pathol. 2012;31:25–32.

    Article  Google Scholar 

  32. Shi X, Wu S, Huo Z, Ling Q, Luo Y, Liang Z. Co-existing of adenoid cystic carcinoma and invasive squamous cell carcinoma of the uterine cervix: a report of 3 cases with immunohistochemical study and evaluation of human papillomavirus status. Diagn Pathol. 2015;10:145.

    Article  Google Scholar 

  33. Jeong J, Ha SY, Cho HY, Chung DH, An J. Comparison of cytologic characteristics between adenoid cystic carcinoma and adenoid basal carcinoma in the uterine cervix. J Pathol Transl Med. 2015;49:396–402.

    Article  Google Scholar 

  34. Grayson W, Cooper K. A reappraisal of “basaloid carcinoma” of the cervix, and the differential diagnosis of basaloid cervical neoplasms. Adv Anat Pathol. 2002;9:290–300.

    Article  Google Scholar 

  35. Muc RS, Grayson W, Grobbelaar JJ. Adult extrarenal Wilms tumor occurring in the uterus. Arch Pathol Lab Med. 2001;125:1081–3.

    CAS  PubMed  Google Scholar 

  36. Lei J, Andrae B, Ploner A, Lagheden C, Eklund C, Nordqvist Kleppe S, et al. Cervical screening and risk of adenosquamous and rare histological types of invasive cervical carcinoma: population based nested case-control study. BMJ. 2019;365:l1207.

    Article  Google Scholar 

  37. Mills SE, Austin MB, Randall ME. Lymphoepithelioma-like carcinoma of the uterine cervix. A distinctive, undifferentiated carcinoma with inflammatory stroma. Am J Surg Pathol. 1985;9:883–9.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

    Anjelica Hodgson

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  1. Anjelica Hodgson
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Correspondence to Anjelica Hodgson .

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Editors and Affiliations

  1. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Robert A. Soslow

  2. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Kay J. Park

  3. Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Targu Mures, Romania

    Simona Stolnicu

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Hodgson, A. (2021). Epithelial Malignant Tumors of the Cervix: Other Epithelial Tumors (Adenosquamous Carcinoma, Adenoid Basal Carcinoma, Carcinoma with Adenoid Cystic-like Features, Undifferentiated Carcinoma). In: Soslow, R.A., Park, K.J., Stolnicu, S. (eds) Atlas of Diagnostic Pathology of the Cervix. Springer, Cham. https://doi.org/10.1007/978-3-030-49954-9_9

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  • DOI: https://doi.org/10.1007/978-3-030-49954-9_9

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  • Online ISBN: 978-3-030-49954-9

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