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The Paradoxical Relationship Between Skeletal and Cardiovascular Mineralization

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Book cover Cardiovascular Calcification and Bone Mineralization

Part of the book series: Contemporary Cardiology ((CONCARD))

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Abstract

Calcific vasculopathy, in which bone mineral is deposited within the walls of arteries and valves in the cardiovascular system, affects almost all individuals over age 65. It is also rapidly accelerated with metabolic disturbances such as atherosclerosis, chronic kidney disease, and diabetes, consistent with the evidence that it is a regulated process. Epidemiological studies show an inverse relationship between mineralization of vascular and bone tissue, in an age-independent manner. The potential interdependency between the skeletal and vascular systems has important clinical implications, where treatment of either condition may affect the other. In this review, we discuss anatomical similarities between the vascular and skeletal systems, the clinical significance of calcific vasculopathy, some of the key regulators in both systems, and the effects of current treatment modalities for atherosclerosis and osteoporosis on calcification.

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Acknowledgments

This work was supported in part by funding from the National Institutes of Health (AG061586, HL137647).

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Authors and Affiliations

  1. Chicago Medical School, Rosalind Franklin University of Medicine and Science, Chicago, IL, USA

    Sidney Iriana

  2. Department of Medicine, University of California, Los Angeles, Los Angeles, CA, USA

    Yin Tintut & Linda L. Demer

  3. Department of Physiology, University of California, Los Angeles, Los Angeles, CA, USA

    Yin Tintut & Linda L. Demer

  4. Department of Orthopaedic Surgery, University of California, Los Angeles, Los Angeles, CA, USA

    Yin Tintut

  5. Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA

    Linda L. Demer

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  1. Sidney Iriana
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Correspondence to Linda L. Demer .

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  1. Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Elena Aikawa

  2. Department of Biomedical Engineering, Florida International University, Miami, FL, USA

    Joshua D. Hutcheson

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Iriana, S., Tintut, Y., Demer, L.L. (2020). The Paradoxical Relationship Between Skeletal and Cardiovascular Mineralization. In: Aikawa, E., Hutcheson, J. (eds) Cardiovascular Calcification and Bone Mineralization. Contemporary Cardiology. Humana, Cham. https://doi.org/10.1007/978-3-030-46725-8_15

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  • DOI: https://doi.org/10.1007/978-3-030-46725-8_15

  • Published:

  • Publisher Name: Humana, Cham

  • Print ISBN: 978-3-030-46724-1

  • Online ISBN: 978-3-030-46725-8

  • eBook Packages: MedicineMedicine (R0)

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