Abstract
Many ultrasound-based elastographic methods have been developed over the last decade with transient elastography (TE) being the first used for liver fibrosis assessment while later, point shear wave elastography (pSWE) and 2D-SWE were implemented in many ultrasound systems. Many studies used liver biopsy as “gold standard” for direct comparison between different elastographic methods. This chapter reviews the comparison studies between TE, pSWE, and 2D-SWE. In addition, comparative studies between ultrasound-based elastographic methods and magnetic resonance elastography (MRE) are discussed. Finally, advantages and limitations of the different elastographic methods are presented. In summary, many studies show similar feasibility and performance for the different ultrasound-based elastographic methods; however, different cutoff values should be used for the different systems. MRE seems to be superior to ultrasound-based techniques but is not yet readily available and expensive.
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References
Dietrich CF, Bamber J, Berzigotti A, Bota S, Cantisani V, Castera L, et al. EFSUMB Guidelines and recommendations on the clinical use of liver ultrasound elastography, update 2017 (long version). Ultraschall Med. 2017;38(4):e16–47.
Ferraioli G, Wong VW, Castera L, Berzigotti A, Sporea I, Dietrich CF, et al. Liver ultrasound elastography: an update to the world federation for ultrasound in medicine and biology guidelines and recommendations. Ultrasound Med Biol. 2018;44(12):2419–40.
Fujimoto K, Kato M, Kudo M, Yada N, Shiina T, Ueshima K, et al. Novel image analysis method using ultrasound elastography for noninvasive evaluation of hepatic fibrosis in patients with chronic hepatitis C. Oncology. 2013;84(Suppl 1):3–12.
Castéra L, Foucher J, Bernard P-H, Carvalho F, Allaix D, Merrouche W, et al. Pitfalls of liver stiffness measurement: A 5-year prospective study of 13,369 examinations. Hepatology. 2010;54:828–35.
Sirli R, Sporea I, Bota S, Jurchis A. Factors influencing reliability of liver stiffness measurements using transient elastography (M-probe)-monocentric experience. Eur J Radiol. 2013;82(8):e313–6.
Sporea I, Sirli R, Mare R, Popescu A, Ivascu SC. Feasibility of transient elastography with M and XL probes in real life. Med Ultrason. 2016;18(1):7–10.
Sporea I, Popescu A, Gheorghe L, Cijevschi Prelipcean C, Sparchez Z, Voiosu R. “Quo vadis” liver biopsy? A multi-centre Romanian study regarding the number of liver biopsies performed for chronic viral hepatitis. J Gastrointestin Liver Dis. 2012;21(3):326.
European Association for Study of Liver; Asociacion Latinoamericana para el Estudio del Higado. EASL-ALEH Clinical Practice Guidelines: Non-invasive tests for evaluation of liver disease severity and prognosis. J Hepatol. 2015;63(1):237–64. https://doi.org/10.1016/j.jhep.2015.04.006.
Lupsor M, Badea R, Stefanescu H, Sparchez Z, Branda H, Serban A, et al. Performance of a new elastographic method (ARFI technology) compared to unidimensional transient elastography in the noninvasive assessment of chronic hepatitis C. Preliminary results. J Gastrointestin Liver Dis. 2009;18(3):303–10.
Sporea I, Bota S, Peck-Radosavljevic M, Sirli R, Tanaka H, Iijima H, et al. Acoustic radiation force impulse elastography for fibrosis evaluation in patients with chronic hepatitis C: an international multicenter study. Eur J Radiol. 2012;81(12):4112–8.
Friedrich-Rust M, Lupsor M, de Knegt R, Dries V, Buggisch P, Gebel M, et al. Point shear wave elastography by acoustic radiation force impulse quantification in comparison to transient elastography for the noninvasive assessment of liver fibrosis in chronic hepatitis C: a prospective international multicenter study. Ultraschall Med. 2015;36(03):239–47.
Bota S, Herkner H, Sporea I, Salzl P, Sirli R, Neghina AM, et al. Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. Liver Int. 2013;33(8):1138–47.
Conti F, Serra C, Vukotic R, Felicani C, Mazzotta E, Gitto S, et al. Assessment of liver fibrosis with elastography point quantification vs other noninvasive methods. Clin Gastroenterol Hepatol. 2019;17(3):510–7 e3.
Cassinotto C, Lapuyade B, Mouries A, Hiriart JB, Vergniol J, Gaye D, et al. Non-invasive assessment of liver fibrosis with impulse elastography: comparison of supersonic shear imaging with ARFI and FibroScan(R). J Hepatol. 2014;61(3):550–7.
Cassinotto C, Boursier J, de Ledinghen V, Lebigot J, Lapuyade B, Cales P, et al. Liver stiffness in nonalcoholic fatty liver disease: a comparison of supersonic shear imaging, FibroScan, and ARFI with liver biopsy. Hepatology. 2016;63(6):1817–27.
Lee MS, Bae JM, Joo SK, Woo H, Lee DH, Jung YJ, et al. Prospective comparison among transient elastography, supersonic shear imaging, and ARFI imaging for predicting fibrosis in nonalcoholic fatty liver disease. PLoS One. 2017;12(11):e0188321.
Herrmann E, de Ledinghen V, Cassinotto C, Chu WC, Leung VY, Ferraioli G, et al. Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: an individual patient data-based meta-analysis. Hepatology. 2018;67(1):260–72.
Sporea I, Bota S, Jurchis A, Sirli R, Gradinaru-Tascau O, Popescu A, et al. Acoustic radiation force impulse and supersonic shear imaging versus transient elastography for liver fibrosis assessment. Ultrasound Med Biol. 2013;39(11):1933–41.
Mulazzani L, Salvatore V, Ravaioli F, Allegretti G, Matassoni F, Granata R, et al. Point shear wave ultrasound elastography with Esaote compared to real-time 2D shear wave elastography with supersonic imagine for the quantification of liver stiffness. J Ultrasound. 2017;20(3):213–25.
Gao Y, Zheng J, Liang P, Tong M, Wang J, Wu C, et al. Liver fibrosis with two-dimensional US shear-wave elastography in participants with chronic hepatitis B: a prospective multicenter study. Radiology. 2018;289(2):407–15.
Sporea I, Mare R, Lupusoru R, Popescu A, Danila M, Bende F, et al. Comparative study between four ultrasound shear waves elastographic methods for liver fibrosis assessment. Med Ultrason. 2018;20(3):265–71.
Sporea I. One or more elastographic methods for liver fibrosis assessment? Med Ultrason. 2015;17(2):137–8.
Huwart L, Sempoux C, Vicaut E, Salameh N, Annet L, Danse E, et al. Magnetic resonance elastography for the noninvasive staging of liver fibrosis. Gastroenterology. 2008;135(1):32–40.
Bohte AE, de Niet A, Jansen L, Bipat S, Nederveen AJ, Verheij J, et al. Non-invasive evaluation of liver fibrosis: a comparison of ultrasound-based transient elastography and MR elastography in patients with viral hepatitis B and C. Eur Radiol. 2014;24(3):638–48.
Ichikawa S, Motosugi U, Morisaka H, Sano K, Ichikawa T, Tatsumi A, et al. Comparison of the diagnostic accuracies of magnetic resonance elastography and transient elastography for hepatic fibrosis. Magn Reson Imaging. 2015;33(1):26–30.
Xiao H, Shi M, Xie Y, Chi X. Comparison of diagnostic accuracy of magnetic resonance elastography and Fibroscan for detecting liver fibrosis in chronic hepatitis B patients: a systematic review and meta-analysis. PLoS One. 2017;12(11):e0186660.
Xiao G, Zhu S, Xiao X, Yan L, Yang J, Wu G. Comparison of laboratory tests, ultrasound, or magnetic resonance elastography to detect fibrosis in patients with nonalcoholic fatty liver disease: a meta-analysis. Hepatology. 2017;66(5):1486–501.
Imajo K, Kessoku T, Honda Y, Tomeno W, Ogawa Y, Mawatari H, et al. Magnetic resonance imaging more accurately classifies steatosis and fibrosis in patients with nonalcoholic fatty liver disease than transient elastography. Gastroenterology. 2016;150(3):626–37.e7.
Park CC, Nguyen P, Hernandez C, Bettencourt R, Ramirez K, Fortney L, et al. Magnetic resonance elastography vs transient elastography in detection of fibrosis and noninvasive measurement of steatosis in patients with biopsy-proven nonalcoholic fatty liver disease. Gastroenterology. 2017;152(3):598–607 e2.
Cui J, Heba E, Hernandez C, Haufe W, Hooker J, Andre MP, et al. Magnetic resonance elastography is superior to acoustic radiation force impulse for the diagnosis of fibrosis in patients with biopsy-proven nonalcoholic fatty liver disease: a prospective study. Hepatology. 2016;63(2):453–61.
Kohlhaas A, Durango E, Millonig G, Bastard C, Sandrin L, Golriz M, et al. Transient elastography with the XL probe rapidly identifies patients with non-hepatic ascites. Hepat Med. 2012;4:11–8.
Sporea I, Sirli RL, Deleanu A, Popescu A, Focsa M, Danila M, et al. Acoustic radiation force impulse elastography as compared to transient elastography and liver biopsy in patients with chronic hepatopathies. Ultraschall Med. 2011;32(Suppl 1):S46–52.
Gradinaru-Tascau O, Sporea I, Bota S, Jurchis A, Popescu A, Popescu M, et al. Does experience play a role in the ability to perform liver stiffness measurements by means of supersonic shear imaging (SSI)? Med Ultrason. 2013;15(3):180–3.
Jun BG, Park WY, Park EJ, Jang JY, Jeong SW, Lee SH, et al. A prospective comparative assessment of the accuracy of the FibroScan in evaluating liver steatosis. PLoS One. 2017;12(8):e0182784.
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Sporea, I. (2020). Comparison of Various Elastographic Techniques for Liver Fibrosis Assessment. In: Mueller, S. (eds) Liver Elastography. Springer, Cham. https://doi.org/10.1007/978-3-030-40542-7_45
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DOI: https://doi.org/10.1007/978-3-030-40542-7_45
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