Abstract
Amyloidosis is the deposition of protein in the extracellular space of various tissues. It occurs as a manifestation of plasma cell dyscrasia or long-term dialysis. Amyloidosis complicates 5–15% of cases of multiple myeloma and may present as radiolytic bone lesions that may be solitary, amyloidomas. The most common sites are the skull and spine. The average age of patients is 57 years. Radiologically, amyloidoma of the bone is an expansile lytic lesion; stippled radiodensity may be present. Waxy eosinophilic Congo red-positive deposits are present in the marrow space, synovial membrane, and juxta-articular soft tissues. Plasma cells are monoclonal with kappa and lambda light-chain immunostains. Solitary amyloidoma of the bone almost always progresses to disseminated amyloidosis or multiple myeloma.
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Suggested Reading
Casey TT, Stone WJ, DiRaimondo CR, et al. Tumoral amyloidosis of bone of beta2-microglobulin origin in association with long-term hemodialysis: a new type of amyloid disease. Hum Pathol. 1986;17:731–8.
Gejyo F, Homma N, Suzuki Y, et al. Serum levels of b-2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis. N Engl J Med. 1986;314:585–6.
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McCarthy, E. (2020). Amyloidosis in Bone. In: Santini-Araujo, E., Kalil, R.K., Bertoni, F., Park, YK. (eds) Tumors and Tumor-Like Lesions of Bone. Springer, Cham. https://doi.org/10.1007/978-3-030-28315-5_73
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DOI: https://doi.org/10.1007/978-3-030-28315-5_73
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