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A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb

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A Case-Based Guide to Neuromuscular Pathology

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Abstract

We describe a case of primary neurolymphomatosis (PNL) with unusual presentation of a right lumbosacral polyradiculoneuropathy with no other lesions shown on the whole body fludeoxyglucose-positron emission tomography (FDG-PET) scan. A right superficial peroneal nerve lesion biopsy revealed infiltration of the nerve by malignant CD20+ lymphoma cells. The lymphoma cells expressed Bcl-2 but not CD10, suggesting an origin in peripheral blood not lymph nodes. The patient responded very well to the combined radiotherapy and chemotherapy with the R-MPV (rituximab, methotrexate, procarbazine, and vincristine) regimen. The patient showed marked clinical improvement and complete resolution of lymphoma lesions on the PET scan.

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Author information

Authors and Affiliations

  1. Departments of Neurology and Pathology, Boston University Medical Center, Boston, MA, USA

    Lan Zhou

  2. Departments of Neurology, Neuroscience, and Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Susan Morgello

  3. Department of Neurology, New York University, New York, NY, USA

    Rajeev Motiwala

  4. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA

    Susan C. Shin

Authors
  1. Lan Zhou
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  2. Susan Morgello
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  3. Rajeev Motiwala
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  4. Susan C. Shin
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Corresponding author

Correspondence to Lan Zhou .

Editor information

Editors and Affiliations

  1. Departments of Neurology and Pathology, Boston University Medical Center, Boston, MA, USA

    Lan Zhou

  2. Department of Pathology, Neuropathology Section, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Dennis K. Burns

  3. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Chunyu Cai

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Zhou, L., Morgello, S., Motiwala, R., Shin, S.C. (2020). A 64-Year-Old Woman with Progressive Pain, Numbness and Weakness in the Right Lower Limb. In: Zhou, L., Burns, D., Cai, C. (eds) A Case-Based Guide to Neuromuscular Pathology. Springer, Cham. https://doi.org/10.1007/978-3-030-25682-1_37

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  • DOI: https://doi.org/10.1007/978-3-030-25682-1_37

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-25681-4

  • Online ISBN: 978-3-030-25682-1

  • eBook Packages: MedicineMedicine (R0)

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