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Results (2): Estimates of Diagnostic Accuracy

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Abstract

This chapter examines the presentation of the results of diagnostic test accuracy studies in terms of specific measures of discrimination and comparison. To exemplify the utility of these measures, studies of some of the key investigations currently used in dementia diagnosis, namely cognitive screening instruments (both performance based and informant based) and biomarkers based on functional neuroimaging and cerebrospinal fluid neurochemistry, are used.

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References

  • Abdel-Aziz K, Larner AJ. Six-item Cognitive Impairment Test (6CIT): pragmatic diagnostic accuracy study for dementia and MCI. Int Psychogeriatr. 2015;27:991–7.

    Article  CAS  PubMed  Google Scholar 

  • American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. Text revision (DSM-IV-TR). Washington: American Psychiatric Association; 2000.

    Google Scholar 

  • Bartlett JW, Frost C, Mattsson N, et al. Determining cut-points for Alzheimer’s disease biomarkers: statistical issues, methods and challenges. Biomark Med. 2012;6:391–400.

    Article  CAS  PubMed  Google Scholar 

  • Bevan Jones WR, Cope TE, Passamonti L, et al. [18F]AV-1451 PET in behavioural variant frontotemporal dementia due to MAPT mutation. Ann Clin Transl Neurol. 2016;3:940–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bossuyt PM, Reitsma JB, Bruns DE, et al. The STARD statement for reporting studies of diagnostic accuracy: explanation and elaboration. Clin Chem. 2003;49:7–18.

    Article  CAS  PubMed  Google Scholar 

  • Bottino CM, Zevallos-Bustamente SE, Lopes MA, et al. Combined instruments for the screening of dementia in older people with low education. Arq Neuropsiquiatr. 2009;67(2A):185–90.

    Article  PubMed  Google Scholar 

  • Brønnick K. Cognitive profile in Parkinson’s disease dementia. In: Emre M, editor. Cognitive impairment and dementia in Parkinson’s disease. Oxford: Oxford University Press; 2010. p. 27–43.

    Google Scholar 

  • Burns A, Lawlor B, Craig S. Assessment scales in old age psychiatry. 2nd ed. London: Martin Dunitz; 2004.

    Book  Google Scholar 

  • Carnero Pardo C, editor. Test cognitivos breves. Madrid: Ediciones SEN; 2015.

    Google Scholar 

  • Chan QL, Shaik MA, Xu J, Xu X, Chen CL, Dong Y. The combined utility of a brief functional measure and performance-based screening test for case finding of cognitive impairment in primary healthcare. J Am Med Dir Assoc. 2016;17:372e9–11.

    Article  Google Scholar 

  • Clark CM, Schneider JA, Bedell BJ, et al. Use of florbetapir-PET for imaging beta-amyloid pathology. JAMA. 2011;305:275–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cohen J. A coefficient of agreement for nominal scales. Educ Psychol Meas. 1960;20:37–46.

    Article  Google Scholar 

  • Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Hillsdale, NJ: Lawrence Erlbaum; 1988.

    Google Scholar 

  • Corbett A, Burns A, Ballard C. Don’t use antipsychotics routinely to treat agitation and aggression in people with dementia. BMJ. 2014;349:g6420.

    Article  PubMed  CAS  Google Scholar 

  • Cordell CB, Borson S, Boustani M, et al. Medicare Detection of Cognitive Impairment Workgroup. Alzheimer’s Association recommendations for operationalizing the detection of cognitive impairment during the Medicare Annual Wellness Visit in a primary care setting. Alzheimers Dement. 2013;9:141–50.

    Article  PubMed  Google Scholar 

  • Cummings J, Scheltens P, McKeith I, et al. Effect size analyses of souvenaid in patients with Alzheimer’s disease. J Alzheimers Dis. 2017;55:1131–9.

    Article  CAS  PubMed  Google Scholar 

  • Damian AM, Jacobson SA, Hentz JG, et al. The Montreal Cognitive Assessment and the Mini-Mental State Examination as screening instruments for cognitive impairment: item analyses and threshold scores. Dement Geratr Cogn Disord. 2011;31:126–31.

    Article  Google Scholar 

  • Doran M, Vinjamuri S, Collins J, Parker D, Larner AJ. SPECT perfusion imaging in the differential diagnosis of dementia: a retrospective regional audit. Int J Clin Pract. 2005;59:496–500.

    Article  CAS  PubMed  Google Scholar 

  • Dubois B, Feldman HH, Jacova C, et al. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria. Lancet Neurol. 2007;6:734–46.

    Article  PubMed  Google Scholar 

  • Dubois B, Feldman HH, Jacova C et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol 2014;13:614–29 [Erratum Lancet Neurol. 2014;13:757].

    Google Scholar 

  • Elhadd K, Bharambe V, Larner AJ. Functional cognitive disorders: can sleep disturbance contribute to a positive diagnosis? J Sleep Disord Ther. 2018;7:291.

    Google Scholar 

  • Ferreira D, Perestelo-Perez L, Westman E, et al. Meta-review of CSF core biomarkers in Alzheimer’s disease: the state-of-the-art after new revised diagnostic criteria. Front Aging Neurosci. 2014;6:47.

    PubMed  PubMed Central  Google Scholar 

  • Fleiss JL. Measuring nominal scale agreement among many raters. Psychol Bull. 1971;76:378–82.

    Article  Google Scholar 

  • Fleiss JL, Chilton NW. The measurement of interexaminer agreement on periodontal disease. J Periodontal Res. 1983;18:601–6.

    Article  CAS  PubMed  Google Scholar 

  • Flicker L, Logiudice D, Carlin JB, Ames D. The predictive value of dementia screening instruments in clinical populations. Int J Geriatr Psychiatry. 1997;12:203–9.

    Article  CAS  PubMed  Google Scholar 

  • Folstein MF, Folstein SE, McHugh PR. “Mini-mental state.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–98.

    Article  CAS  PubMed  Google Scholar 

  • Fooks J, Mutch L, Yudkin P, Johnson A, Elbourne D. Comparing two methods of follow up in a multicentre randomised trial. Arch Dis Child. 1997;76:369–76.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Fuzikawa C, Lima-Costa MF, Uchoa E, Shulman K. Correlation and agreement between the Mini-mental State Examination and the Clock Drawing Test in older adults with low levels of schooling: the Bambui Health Aging Study (BHAS). Int Psychogeriatr. 2007;19:657–67.

    Article  PubMed  Google Scholar 

  • Galvin JE, Roe CM, Powlishta KK, et al. The AD8. A brief informant interview to detect dementia. Neurology. 2005;65:559–64.

    Article  CAS  PubMed  Google Scholar 

  • Galvin JE, Roe CM, Xiong C, Morris JE. Validity and reliability of the AD8 informant interview in dementia. Neurology. 2006;67:1942–8.

    Article  PubMed  Google Scholar 

  • Galvin JE, Fagan AM, Holtzman DM, Mintun MA, Morris JC. Relationship of dementia screening tests with biomarkers of Alzheimer’s disease. Brain. 2010;133:3290–300.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gaugler JE, Kane RL, Johnston JA, Sarsour K. Sensitivity and specificity of diagnostic accuracy in Alzheimer’s disease: a synthesis of existing evidence. Am J Alzheimers Dis Other Dement. 2013;28:337–47.

    Article  Google Scholar 

  • Gomar JJ, Bobes-Bascaran MT, Conejero-Goldberg C, Davies P, Goldberg TE. Utility of combinations of biomarkers, cognitive markers and risk factors to predict conversion from mild cognitive impairment to Alzheimer disease in patients in the Alzheimer’s disease neuroimaging initiative. Arch Gen Psychiatry. 2011;68:961–9.

    Article  PubMed  Google Scholar 

  • Grimes DA, Schulz KF. Refining clinical diagnosis with likelihood ratios. Lancet. 2005;365:1500–5.

    Article  PubMed  Google Scholar 

  • Haddow LJ, Floyd S, Copas A, Gilson RJ. A systematic review of the screening accuracy of the HIV Dementia Scale and International HIV Dementia Scale. PLoS One. 2013;8:e61826.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hancock P, Larner AJ. The diagnosis of dementia: diagnostic accuracy of an instrument measuring activities of daily living in a clinic-based population. Dement Geriatr Cogn Disord. 2007;23:133–9.

    Article  CAS  PubMed  Google Scholar 

  • Hancock P, Larner AJ. Cambridge Behavioural Inventory for the diagnosis of dementia. Prog Neurol Psychiatry. 2008;12(7):23–5.

    Article  Google Scholar 

  • Hancock P, Larner AJ. Diagnostic utility of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and its combination with the Addenbrooke’s Cognitive Examination-Revised (ACE-R) in a memory clinic-based population. Int Psychogeriatr. 2009a;21:526–30.

    Article  CAS  PubMed  Google Scholar 

  • Hancock P, Larner AJ. Clinical utility of Patient Health Questionnaire-9 (PHQ-9) in memory clinics. Int J Psychiatry Clin Pract. 2009b;13:188–91.

    Article  CAS  PubMed  Google Scholar 

  • Hancock P, Larner AJ. Diagnostic utility of the Pittsburgh Sleep Quality Index in memory clinics. Int J Geriatr Psychiatry. 2009c;24:1237–41.

    Article  CAS  PubMed  Google Scholar 

  • Hancock P, Larner AJ. Test Your Memory (TYM) test: diagnostic utility in a memory clinic population. Int J Geriatr Psychiatry. 2011;26:976–80.

    Article  CAS  PubMed  Google Scholar 

  • Hancock P, Larner AJ. Cornell Scale for Depression in Dementia: clinical utility in a memory clinic. Int J Psychiatry Clin Pract. 2015;19:71–4.

    Article  PubMed  Google Scholar 

  • Harrison JK, Fearon P, Noel-Storr AH, McShane R, Stott DJ, Quinn TJ. Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a secondary care setting. Cochrane Database Syst Rev. 2015;2015:CD010772.

    Google Scholar 

  • Hatfield CF, Dudas RB, Dening T. Diagnostic tools for dementia. Maturitas. 2009;63:181–5.

    Article  PubMed  Google Scholar 

  • Heilbronner RL, Sweet JJ, Attaix DK, Krull KR, Henry GK, Hart RP. Official position of the American Academy of Clinical Neuropsychology on serial neuropsychological assessment: the utility and challenges of repeat test administrations in clinical and forensic contexts. Clin Neuropsychol. 2010;24:1267–78.

    Article  PubMed  Google Scholar 

  • Hodkinson HM. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age Ageing. 1972;1:233–8.

    Article  CAS  PubMed  Google Scholar 

  • Hort J, Bartos A, Pirttila T, Scheltens P. Use of cerebrospinal fluid biomarkers in diagnosis of dementia across Europe. Eur J Neurol. 2010;17:90–6.

    Article  CAS  PubMed  Google Scholar 

  • Hsieh S, Schubert S, Hoon C, Mioshi E, Hodges JR. Validation of the Addenbrooke’s Cognitive Examination III in frontotemporal dementia and Alzheimer’s disease. Dement Geriatr Cogn Disord. 2013;36:242–50.

    Article  PubMed  Google Scholar 

  • Hsieh S, McGrory S, Leslie F, et al. The Mini-Addenbrooke’s Cognitive Examination: a new assessment tool for dementia. Dement Geriatr Cogn Disord. 2015;39:1–11.

    Article  PubMed  Google Scholar 

  • Hu X, Zhou Y, Long J, et al. Diagnostic accuracy of the International HIV Dementia Scale and HIV Dementia Scale: a meta-analysis. Exp Ther Med. 2012;4:665–8.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ismail Z, Rajii TK, Shulman KI. Brief cognitive screening instruments: an update. Int J Geriatr Psychiatry. 2010;25:111–20.

    Article  PubMed  Google Scholar 

  • Ismail Z, Mulsant BH, Herrmann N, Rapoport M, Nilsson M, Shulman KI. Canadian academy of geriatric psychiatry survey of brief cognitive screening instruments. Can Geriatr J. 2013;16:54–60.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jaeschke R, Guyatt G, Sackett DL. Users’ guide to the medical literature. III. How to use an article about a diagnostic test. B. What are the results and will they help me in caring for my patients? JAMA. 1994;271:703–7.

    Article  CAS  PubMed  Google Scholar 

  • Johnson KA, Sperling RA, Gidicsin CM, et al. Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer’s disease dementia, mild cognitive impairment, and normal aging. Alzheimers Dement. 2013;9(5 Suppl):S72–83.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jones CM, Athanasiou T. Summary receiver operating characteristic curve analysis techniques in the evaluation of diagnostic tests. Ann Thorac Surg. 2005;79:16–20.

    Article  PubMed  Google Scholar 

  • Jorm AF, Jacomb PA. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med. 1989;19:1015–22.

    Article  CAS  PubMed  Google Scholar 

  • Julayanont P, Nasreddine ZS. Montreal Cognitive Assessment (MoCA): concept and clinical review. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 139–95.

    Chapter  Google Scholar 

  • Kelly C, Newton-Howes G. Guide to assessment scales in dementia. London: Current Medicine Group; 2004.

    Google Scholar 

  • Kiddle SJ, Voyle N, Dobson RJB. A blood test for Alzheimer’s disease: progress, challenges, and recommendations. J Alzheimers Dis. 2018;64(s1):S289–97.

    Article  PubMed  PubMed Central  Google Scholar 

  • Knafelc R, Lo Giudice D, Harrigan S, et al. The combination of cognitive testing and an informant questionnaire in screening for dementia. Age Ageing. 2003;32:541–7.

    Article  PubMed  Google Scholar 

  • Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Landau SM, Harvey D, Madison CM, et al. Comparing predictors of conversion and decline in mild cognitive impairment. Neurology. 2010;75:230–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33:159–74.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. An audit of the Addenbrooke’s Cognitive Examination (ACE) in clinical practice. Int J Geriatr Psychiatry. 2005;20:593–4.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. An audit of the Addenbrooke’s Cognitive Examination (ACE) in clinical practice. 2. Longitudinal change. Int J Geriatr Psychiatry. 2006;21:698–9.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Addenbrooke’s Cognitive Examination (ACE) for the diagnosis and differential diagnosis of dementia. Clin Neurol Neurosurg. 2007a;109:491–4.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. DemTect: 1-year experience of a neuropsychological screening test for dementia. Age Ageing. 2007b;36:326–7.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Addenbrooke’s Cognitive Examination-Revised (ACE-R) in day-to-day clinical practice. Age Ageing. 2007c;36:685–6.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Can IQCODE differentiate Alzheimer’s disease and frontotemporal dementia? Age Ageing. 2010;39:392–4.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Mini-Mental Parkinson (MMP) as a dementia screening test: comparison with the Mini-Mental State Examination (MMSE). Curr Aging Sci. 2012a;5:136–9.

    Article  PubMed  Google Scholar 

  • Larner AJ. Screening utility of the Montreal Cognitive Assessment (MoCA): in place of - or as well as - the MMSE? Int Psychogeriatr. 2012b;24:391–6.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Addenbrooke’s Cognitive Examination-Revised (ACE-R): pragmatic study of cross-sectional use for assessment of cognitive complaints of unknown aetiology. Int J Geriatr Psychiatry. 2013a;28:547–8.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Comparing diagnostic accuracy of cognitive screening instruments: a weighted comparison approach. Dement Geriatr Cogn Disord Extra. 2013b;3:60–5.

    Article  CAS  Google Scholar 

  • Larner AJ. Can the Frontal Assessment Battery (FAB) help in the diagnosis of behavioural variant frontotemporal dementia? A pragmatic study. Int J Geriatr Psychiatry. 2013c;28:106–7.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Dementia in clinical practice: a neurological perspective. Pragmatic studies in the cognitive function clinic. 2nd ed. London: Springer; 2014a.

    Book  Google Scholar 

  • Larner AJ. Effect size (Cohen’s d) of cognitive screening instruments examined in pragmatic diagnostic accuracy studies. Dement Geriatr Cogn Disord Extra. 2014b;4:236–41.

    Article  Google Scholar 

  • Larner AJ. Mini-Addenbrooke’s Cognitive Examination: a pragmatic diagnostic accuracy study. Int J Geriatr Psychiatry. 2015a;30:547–8.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. AD8 informant questionnaire for cognitive impairment: pragmatic diagnostic test accuracy study. J Geriatr Psychiatry Neurol. 2015b;28:198–202.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Speed versus accuracy in cognitive assessment when using CSIs. Prog Neurol Psychiatry. 2015c;19(1):21–4.

    Article  Google Scholar 

  • Larner AJ. Performance-based cognitive screening instruments: an extended analysis of the time versus accuracy trade-off. Diagnostics (Basel). 2015d;5:504–12.

    Article  Google Scholar 

  • Larner AJ. Optimizing the cutoffs of cognitive screening instruments in pragmatic diagnostic accuracy studies: maximising accuracy or Youden index? Dement Geriatr Cogn Disord. 2015e;39:167–75.

    Article  PubMed  Google Scholar 

  • Larner AJ. The Q∗ index: a useful global measure of dementia screening test accuracy? Dement Geriatr Cogn Disord Extra. 2015f;5:265–70.

    Article  CAS  Google Scholar 

  • Larner AJ. Mini-Addenbrooke’s Cognitive Examination diagnostic accuracy for dementia: reproducibility study. Int J Geriatr Psychiatry. 2015g;30:1103–4.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Cognitive screening instruments for the diagnosis of mild cognitive impairment. Prog Neurol Psychiatry. 2016a;20(2):21–6.

    Article  Google Scholar 

  • Larner AJ. Correlation or limits of agreement? Applying the Bland-Altman approach to the comparison of cognitive screening instruments. Dement Geriatr Cogn Disord. 2016b;42:247–54.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. M-ACE vs. MoCA: a weighted comparison. Int J Geriatr Psychiatry. 2016c;31:1089–90.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017a.

    Google Scholar 

  • Larner AJ. Short Montreal Cognitive Assessment: validation and reproducibility. J Geriatr Psychiatry Neurol. 2017b;30:104–8.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Does combining an informant questionnaire with patient performance scales improve diagnostic test accuracy for cognitive impairment? Int J Geriatr Psychiatry. 2017c;32:466–7.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. MACE versus MoCA: equivalence or superiority? Pragmatic diagnostic test accuracy study. Int Psychogeriatr. 2017d;29:931–7.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ. Dementia in clinical practice: a neurological perspective. Pragmatic studies in the cognitive function clinic. 3rd ed. London: Springer; 2018a.

    Book  Google Scholar 

  • Larner AJ. Eponyms revisited. Prog Neurol Psychiatry. 2018b;22(4):22.

    Article  Google Scholar 

  • Larner AJ. Number needed to diagnose, predict, or misdiagnose: useful metrics for non-canonical signs of cognitive status? Dement Geriatr Cogn Disord Extra. 2018c;8:321–7.

    Article  CAS  Google Scholar 

  • Larner AJ. Cognitive screeners for MCI: is correction of skewed data necessary? Prog Neurol Psychiatry. 2018d;22(4):27–30.

    Article  Google Scholar 

  • Larner AJ. Free-Cog: pragmatic test accuracy study. Dement Geriatr Cogn Disord. 2019a; accepted.

    Google Scholar 

  • Larner AJ. MACE for diagnosis of dementia and MCI: examining cut-offs and predictive values. Diagnostics (Basel). 2019b;9:51.

    Article  Google Scholar 

  • Larner AJ. Evaluating cognitive screening instruments with the “likelihood to be diagnosed or misdiagnosed” measure. Int J Clin Pract. 2019c;73:e13265.

    Article  PubMed  Google Scholar 

  • Larner AJ, Hancock P. Activities of daily living in frontotemporal dementia and Alzheimer disease. Neurology. 2008;70:658.

    Article  PubMed  Google Scholar 

  • Larner AJ, Hancock P. Does combining cognitive and functional scales facilitate the diagnosis of dementia? Int J Geriatr Psychiatry. 2012;27:547–8.

    Article  CAS  PubMed  Google Scholar 

  • Larner AJ, Hancock P. ACE-R or MMSE? A weighted comparison. Int J Geriatr Psychiatry. 2014;29:767–8.

    Article  PubMed  Google Scholar 

  • Larner AJ, Mitchell AJ. A meta-analysis of the accuracy of the Addenbrooke’s Cognitive Examination (ACE) and the Addenbrooke’s Cognitive Examination-Revised (ACE-R) in the detection of dementia. Int Psychogeriatr. 2014;26:555–63.

    Article  PubMed  Google Scholar 

  • Law E, Connelly PJ, Randall E, et al. Does the Addenbrooke’s Cognitive Examination-revised add to the Mini-Mental State Examination in established Alzheimer disease? Results from a national dementia research register. Int J Geriatr Psychiatry. 2013;28:351–5.

    Article  PubMed  Google Scholar 

  • Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–86.

    Article  CAS  PubMed  Google Scholar 

  • Lehmann S, Dumurgier J, Schraen S, et al. A diagnostic scale for Alzheimer’s disease based on cerebrospinal fluid biomarker profiles. Alzheimers Res Ther. 2014;6(3):38.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lischka AR, Mendelsohn M, Overend T, Forbes D. A systematic review of screening tools for predicting the development of dementia. Can J Aging. 2012;31:295–311.

    Article  PubMed  Google Scholar 

  • Liyanagedera S, Bracewell RM, Larner AJ. Diagnosing dementia with Lewy bodies: new diagnostic criteria. J R Coll Physicians Edinb. 2018;48:44–5.

    Article  CAS  PubMed  Google Scholar 

  • Mackinnon A, Mulligan R. Combining cognitive testing and informant report to increase accuracy in screening for dementia. Am J Psychiatry. 1988;155:1529–35.

    Article  Google Scholar 

  • Mallett S, Halligan S, Thompson M, Collins GS, Altman DG. Interpreting diagnostic accuracy studies for patient care. BMJ. 2012;344:e3999.

    Article  Google Scholar 

  • Marshall RJ. The predictive value of simple rules for combining two diagnostic tests. Biometrics. 1989;45:1213–22.

    Article  Google Scholar 

  • Martinez G, Vernooij RW, Fuentes Padilla P, et al. 18F PET with florbetapir for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2017a;11:CD012216.

    PubMed  Google Scholar 

  • Martinez G, Vernooij RW, Fuentes Padilla P, et al. 18F PET with florbetaben for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2017b;11:CD012883.

    PubMed  Google Scholar 

  • Mathuranath PS, Nestor PJ, Berrios GE, Rakowicz W, Hodges JR. A brief cognitive test battery to differentiate Alzheimer’s disease and frontotemporal dementia. Neurology. 2000;55:1613–20.

    Article  CAS  PubMed  Google Scholar 

  • Mattsson N, Zetterberg H, Hansson O, et al. CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment. JAMA. 2009;302:385–93.

    Article  CAS  PubMed  Google Scholar 

  • Mattsson N, Insel PS, Landau S, et al. Diagnostic accuracy of CSF Ab42 and florbetapir PET for Alzheimer’s disease. Ann Clin Transl Neurol. 2014;1:534–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • McKeith IG, Dickson DW, Lowe J, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB consortium. Neurology. 2005;65:1863–72.. [Erratum Neurology. 2005;65:1992].

    Article  CAS  PubMed  Google Scholar 

  • McKeith I, O’Brien J, Walker Z, et al. Sensitivity and specificity of dopamine transporter imaging with123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study. Lancet Neurol. 2007;6:305–13.

    Article  PubMed  Google Scholar 

  • McKeith IG, Boeve BF, Dickson DW, et al. Diagnosis and management of dementia with Lewy bodies: fourth consensus report of the DLB consortium. Neurology. 2017;89:88–100.

    Article  PubMed  PubMed Central  Google Scholar 

  • Metz CE. Basic principles of ROC analysis. Semin Nucl Med. 1978;8:283–98.

    Article  CAS  PubMed  Google Scholar 

  • Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR. The Addenbrooke’s Cognitive Examination Revised: a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry. 2006;21:1078–85.

    Article  PubMed  Google Scholar 

  • Mirzaei G, Adeli A, Adeli H. Imaging and machine learning techniques for diagnosis of Alzheimer’s disease. Rev Neurosci. 2016;27:857–70.

    PubMed  Google Scholar 

  • Mitchell AJ. The Mini-Mental State Examination (MMSE): an update on its diagnostic validity for cognitive disorders. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. London: Springer; 2013. p. 15–46.

    Chapter  Google Scholar 

  • Mitchell AJ, McGlinchey JB, Young D, Chelminski I, Zimmerman M. Accuracy of specific symptoms in the diagnosis of major depressive disorder in psychiatric out-patients: data from the MIDAS project. Psychol Med. 2009;39:1107–16.

    Article  CAS  PubMed  Google Scholar 

  • Molinuevo JL, Blennow K, Dubois B, et al. The clinical use of cerebrospinal fluid biomarker testing for Alzheimer’s disease diagnosis: a consensus paper from the Alzheimer’s Biomarkers Standardization Initiative. Alzheimers Dement. 2014;10:808–17.

    Article  PubMed  Google Scholar 

  • Morley JE, Morris JC, Berg-Weger M, et al. Brain health: the importance of recognizing cognitive impairment: an IAGG consensus conference. J Am Med Dir Assoc. 2015;16:731–9.

    Article  PubMed  PubMed Central  Google Scholar 

  • Morris E, Chalkidou A, Hammers A, Peacock J, Summers J, Keevil S. Diagnostic accuracy of (18)F amyloid PET tracers for the diagnosis of Alzheimer’s disease: a systematic review and meta-analysis. Eur J Nucl Med Mol Imaging. 2016;43:374–85.

    Article  CAS  PubMed  Google Scholar 

  • Moyer VA, US Preventive Services Task Force. Screening for cognitive impairment in older adults: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 2014;160:791–7.

    Article  PubMed  Google Scholar 

  • Nasreddine ZS, Phillips NA, Bédirian V, Charbonneau S, Whitehead V, Collin I, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53:695–9.

    Article  PubMed  Google Scholar 

  • National Institute for Health and Care Excellence. Dementia. Assessment, management and support for people living with dementia and their carers. NICE guideline 97. Methods, evidence and recommendations. London: NICE; 2018. https://www.nice.org.uk/guidance/ng97.

    Google Scholar 

  • Noel-Storr AH, Flicker L, Ritchie CW, et al. Systematic review of the body of evidence for use of biomarkers in the diagnosis of dementia. Alzheimers Dement. 2013;9:e96–105.

    Article  PubMed  Google Scholar 

  • Noel-Storr AH, McCleery JM, Richard E, et al. Reporting standards for studies of diagnostic test accuracy in dementia: the STARDdem Initiative. Neurology. 2014;83:364–73.

    Article  PubMed  PubMed Central  Google Scholar 

  • O’Brien JT, Oertel WH, McKeith IG, et al. Is ioflupane I123 injection diagnostically effective in patients with movement disorders and dementia? Pooled analysis of four clinical trials. BMJ Open. 2014;4:e005122.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ozer S, Noonan K, Burke M, et al. The validity of the Memory Alteration Test and the Test Your Memory test for community-based identification of amnestic mild cognitive impairment. Alzheimers Dement. 2016;12:987–95.

    Article  PubMed  PubMed Central  Google Scholar 

  • Papathanasiou ND, Boutsiadis A, Dickson J, Bomanji JB. Diagnostic accuracy of 123I-FP-CIT (DaTSCAN) in dementia with Lewy bodies: a meta-analysis of published studies. Parkinsonism Relat Disord. 2012;18:225–9.

    Article  PubMed  Google Scholar 

  • Pena-Casanova J, Fombuena NG, Fulla JG. Test neuropsicologicos. Fundamentos para una neuropsicologia clinica basada en evidencias. Barcelona: Masson; 2004.

    Google Scholar 

  • Richard E, Schmand BA, Eikelenboom P, Van Gool WA. The Alzheimer’s Disease Neuroimaging Initiative. MRI and cerebrospinal fluid biomarkers for predicting progression to Alzheimer’s disease in patients with mild cognitive impairment: a diagnostic accuracy study. BMJ Open. 2013;3:e002541.

    Article  PubMed  PubMed Central  Google Scholar 

  • Ritchie C, Smailagic N, Noel-Storr AH, et al. Plasma and cerebrospinal fluid amyloid beta for the diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2014;2014(6):CD008782.

    PubMed Central  Google Scholar 

  • Scheltens P, Blennow K, Breteler MMB, et al. Alzheimer’s disease. Lancet. 2016;388:505–17.

    Article  CAS  PubMed  Google Scholar 

  • Sells R, Larner AJ. The Poppelreuter figure visual perceptual function test for dementia diagnosis. Prog Neurol Psychiatry. 2011;15(2):17–18,20-21.

    Article  Google Scholar 

  • Shulman KI, Herrmann N, Brodaty H, et al. IPA survey of brief cognitive screening instruments. Int Psychogeriatr. 2006;18:281–94.

    Article  PubMed  Google Scholar 

  • Smith M, Wells J, Borrie M. Treatment effect size of memantine therapy in Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord. 2006;20:133–7.

    Article  CAS  PubMed  Google Scholar 

  • Stratford JA, LoGiudice D, Flicker L, Cook R, Waltrowicz W, Ames D. A memory clinic at a geriatric hospital: a report on 577 patients assessed with the CAMDEX over 9 years. Aust NZ J Psychiatry. 2003;37:319–26.

    Article  Google Scholar 

  • Swets JA. Measuring the accuracy of diagnostic systems. Science. 1988;240:1285–93.

    Article  CAS  PubMed  Google Scholar 

  • Talbot PR, Lloyd JJ, Snowden JS, Neary D, Testa HJ. A clinical role for 99mTc-HMPAO SPECT in the investigation of dementia? J Neurol Neurosurg Psychiatry. 1998;64:306–13.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tate RL. A compendium of tests, scales, and questionnaires. The practitioner’s guide to measuring outcomes after acquired brain impairment. Hove: Psychology Press; 2010.

    Google Scholar 

  • The Ronald and Nancy Reagan Research Institute of the Alzheimer’s Association and the National Institute on Aging Working Group. Consensus report of the Working Group on: “Molecular and biochemical markers of Alzheimer’s disease”. Neurobiol Aging. 1998;19:109–16.

    Article  Google Scholar 

  • Walter SD. Properties of the summary receiver operating characteristic (SROC) curve for diagnostic test data. Stat Med. 2002;21:1237–56.

    Article  CAS  PubMed  Google Scholar 

  • Williamson JC, Larner AJ. MACE for diagnosis of dementia and MCI: 3-year pragmatic diagnostic test accuracy study. Dement Geriatr Cogn Disord. 2018;45:300–7.

    Article  PubMed  Google Scholar 

  • Williamson JC, Larner AJ. Likelihood to be diagnosed or misdiagnosed: application to meta-analytic data for cognitive screening instruments. Neurodegener Dis Manag. 2019;9:91–5.

    Article  PubMed  Google Scholar 

  • Williamson JC, Bonello M, Larner AJ. Genetic investigation in dementia: new interpretive challenges. Prog Neurol Psychiatry. 2018;22(4):6–8.

    Article  Google Scholar 

  • Wojtowicz A, Larner AJ. Diagnostic test accuracy of cognitive screeners in older people. Prog Neurol Psychiatry. 2017;21(1):17–21.

    Article  Google Scholar 

  • Wojtowicz A, Schott JM, Larner AJ. CSF biomarkers and the diagnosis of variant forms of Alzheimer’s disease. Prog Neurol Psychiatry. 2017;21(2):13–5.

    Article  Google Scholar 

  • Yeo JM, Waddell B, Khan Z, Pal S. A systematic review and meta-analysis of (18)F-labeled amyloid imaging in Alzheimer’s disease. Alzheimers Dement (Amst). 2015;1(1):5–13.

    Google Scholar 

  • Zetterberg H, Blennow K. From cerebrospinal fluid to blood: the third wave of fluid biomarkers for Alzheimer’s disease. J Alzheimers Dis. 2018;64(s1):S271–9.

    Article  PubMed  Google Scholar 

  • Zhang S, Smailagic N, Hyde C, et al. (11)C-PIB-PET for the early diagnosis of Alzheimer’s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev. 2014;2017(7):CD010386.

    Google Scholar 

  • Ziso B, Larner AJ. AD8: likelihood to diagnose or misdiagnose. Poster presentation, Association of British Neurologists annual meeting, Edinburgh, 21–23 May 2019.

    Google Scholar 

  • Zwan MD, Bouwman FH, Konijnenberg E, et al. Diagnostic impact of [18F] flutemetamol PET in early-onset dementia. Alzheimers Res Ther. 2017;9(1):2.

    Article  PubMed  PubMed Central  Google Scholar 

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Larner, A.J. (2019). Results (2): Estimates of Diagnostic Accuracy. In: Diagnostic Test Accuracy Studies in Dementia. Springer, Cham. https://doi.org/10.1007/978-3-030-17562-7_5

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