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Radiation Therapy: Conjunctival and Eyelid Tumors

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Clinical Ophthalmic Oncology

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Abstract

Radiation therapy is most often administered as an adjunctive treatment for lesions with high-risk features, such as nodal metastases, perineural invasion, and aggressive histologic subtype, or as salvage therapy for residual or recurrent disease after surgery. Definitive radiation therapy is a standard for management of conjunctival lymphoma and an option for cutaneous basal or squamous cell cancers when the disease is locally advanced and resection would be excessively morbid. Treatment may be delivered via external beam radiation therapy (EBRT), which includes traditional megavoltage photons, proton therapy, orthovoltage X-rays, and electron beam therapy, or via brachytherapy, using handheld applicators, surface plaques, or interstitial seeds. Single or multi-fraction regimens may be selected. Radiation-induced morbidity is influenced by total and daily dose of radiation therapy, as well as irradiated volume. Various techniques exist to reduce dose to nearby organs at risk. For the treatment of large or locally invasive tumors, expected cosmesis after radiation therapy may be poor.

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Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH, USA

    Christopher Fleming & Shlomo Koyfman

  2. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Arun D. Singh

Authors
  1. Christopher Fleming
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  2. Shlomo Koyfman
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  3. Arun D. Singh
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Corresponding author

Correspondence to Arun D. Singh .

Editor information

Editors and Affiliations

  1. Ocular Onocology Service and Ophthalmic Pathology Laboratory, Department of Ophthalmology, Hadassah - Hebrew University Medical Center, Jerusalem, Israel

    Jacob Pe'er

  2. Department of Ophthalmic Oncology, Cole Eye Institute, Cleveland Clinic, Cleveland, OH, USA

    Arun D. Singh

  3. Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

    Bertil E. Damato

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Fleming, C., Koyfman, S., Singh, A.D. (2019). Radiation Therapy: Conjunctival and Eyelid Tumors. In: Pe'er, J., Singh, A., Damato, B. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-06046-6_23

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  • DOI: https://doi.org/10.1007/978-3-030-06046-6_23

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-06045-9

  • Online ISBN: 978-3-030-06046-6

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