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Clinical Care and Rehabilitation in Head and Neck Cancer pp 45–68Cite as

Human Papillomavirus-Related Head and Neck Cancer

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Abstract

Due in part to the dramatic increase in virally mediated cancers, the demographic landscape of head and neck cancer (HNCa) is rapidly changing. While the incidence of HNCa has declined at various anatomic subsites, this downward trend is masked by unbridled growth in the number of oropharyngeal squamous cell cancers (OPSCCs). The climbing incidence of OPSCCs is fueled by a dramatic rise in human papillomavirus (HPV)-related cancers, which are now recognized as a distinct disease entity.

At present, treatment practices for HNCa are selected based on disease- and patient-related factors. However, the emergence of HPV-related disease has led to renewed focus on biology-driven treatment approaches. In order to provide information regarding disease progression and prognosis, and disease- and treatment-related effects on function and quality of life to patients treated for HNCa, clinicians must be cognizant of the critical differences associated with virally mediated disease.

This chapter will provide information regarding the role of human papillomavirus (HPV) in carcinogenesis, its impact on the clinical and morphological features of HNCa, and implications for patient functioning and quality of life.

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Notes

  1. 1.

    For a comprehensive review of the numerous and complex molecular drivers of carcinogenesis that differentiate HPV-positive versus HPV-negative disease, see Gillison (2004).

  2. 2.

    The main premise of treatment de-escalation is that a reduction in treatment intensity is likely to be accompanied by a reduction in morbidity associated with standard treatment protocols. For a comprehensive review of recent and ongoing de-escalation trials, see Masterson et al. (2014).

References

  • Adelstein, D., Gillison, M. L., Pfister, D. G., Spencer, S., Adkins, D., Brizel, D. M., et al. (2017). NCCN guidelines insights: Head and neck cancers, version 2.2017. Journal of the National Comprehensive Cancer Network: JNCCN, 15(6), 761–770.

    Google Scholar 

  • Agrawal, N., Frederick, M. J., Pickering, C. R., Bettegowda, C., Chang, K., Li, R. J., et al. (2011). Exome sequencing of head and neck squamous cell carcinomas reveals inactivating mutations in NOTCH1. Science, 333(6046), 1154–1157.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • American Cancer Society. (2016). Cancer facts & figures 2016. Atlanta, GA: American Cancer Society; 2016. Retrieved October 6, 2017 from https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/annual-cancer-facts-and-figures/2016/cancer-facts-and-figures-2016.pdf

    Google Scholar 

  • American Joint Committee on Cancer. (2017a). Retrieved September 25, 2017, from https://cancerstaging.org/references-tools/Pages/What-is-Cancer-Staging.aspx

  • American Joint Committee on Cancer. (2017b). Retrieved August 14, 2017, from https://cancerstaging.org/About/news/Pages/Implementation-of-AJCC-8th-Edition-Cancer-Staging-System.aspx

  • Ang, K. K., Harris, J., Wheeler, R., Weber, R., Rosenthal, D. I., Nguyen-Tan, P. F., et al. (2010). Human papillomavirus and survival of patients with oropharyngeal cancer. New England Journal of Medicine, 363, 24–35.

    Article  CAS  Google Scholar 

  • Arbyn, M., de Sanjose, S., Saraiya, M., Sideri, M., Palefsky, J., Lacey, C., et al. (2012). EUROGIN 2011 roadmap on prevention and treatment of HPV-related disease. International Journal of Cancer, 131(9), 1969–1982.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Argiris, A., Li, S., Ghebremichael, M., Egloff, A. M., Wang, L., Forastiere, A. A., et al. (2014). Prognostic significance of human papillomavirus in recurrent or metastatic head and neck cancer: An analysis of eastern cooperative oncology group trials. Annals of Oncology, 25, 1210–1216.

    Article  Google Scholar 

  • Barnoya, J., & Glantz, S. (2004). Association of the California tobacco control program with declines in lung cancer incidence. Cancer Causes & Control, 15(7), 689–695.

    Article  Google Scholar 

  • Baxi, S. S., Shuman, A. G., Corner, G. W., Shuk, E., Sherman, E. J., Elkin, E. B., et al. (2013). Sharing a diagnosis of HPV-related head and neck cancer: The emotions, the confusion and what patients want to know. Head & Neck, 35(11), 1534–1541.

    Article  Google Scholar 

  • Blanchard, P., Baujat, B., Holostenco, V., Bourredjem, A., Baey, C., Bourhis, J., et al. (2011). Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): A comprehensive analysis by tumour site. Radiotherapy & Oncology, 100(1), 33–40.

    Article  Google Scholar 

  • Bledsoe, T. J., Noble, A. R., Hunter, G. K., Rybicki, L. A., Hoschar, A., Chute, D. J., et al. (2013). Oropharyngeal squamous cell carcinoma with known human papillomavirus status treated with definitive chemoradiotherapy: Patterns of failure and toxicity outcomes. Radiation Oncology, 8, 174.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bonner, J. A., Harari, P. M., Giralt, J., Azarnia, N., Shin, D. M., Cohen, R. B., … Ang, K. K. (2006). Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. New England Journal of Medicine, 354(6), 567–578.

    Article  CAS  Google Scholar 

  • Bornbaum, C. C., Doyle, P. C., Skarakis-Doyle, E., & Theurer, J. A. (2013). A critical exploration of the International Classification of Functioning, Disability, and Health (ICF) framework from the perspective of oncology: Recommendations for revision. Journal of Multidisciplinary Healthcare, 6, 75–86.

    Article  PubMed  PubMed Central  Google Scholar 

  • Bornbaum, C. C., Fung, K., Franklin, J. H., Nichols, A., Yoo, J., & Doyle, P. (2012). A descriptive analysis of the relationship between quality of life and distress in individuals with head and neck cancer. Supportive Care in Cancer, 20(9), 2157–2165.

    Article  PubMed  Google Scholar 

  • Bourhis, J., Overgaard, J., Audry, H., Ang, K. K., Saunders, M., Bernier, J., et al. (2006). Hyperfractionated or accelerated radiotherapy in head and neck cancer: A meta-analysis. Lancet, 368(9538), 843–854.

    Article  PubMed  Google Scholar 

  • Brizel, D. M., Albers, M. E., Fisher, S. R., Scher, R. L., Richtsmeier, W. J., Hars, V., et al. (1998). Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. New England Journal of Medicine, 338(25), 1798–1804.

    Article  CAS  Google Scholar 

  • Brown, D. R., Schroeder, J. M., Bryan, J. T., et al. (1999). Detection of multiple human papillomavirus types in condylomata acuminate lesions from other healthy and immunosuppressed patients. Journal of Clinical Microbiology, 37, 3316–3322.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Canadian Cancer Society. (2016a). Retrieved on August 16, 2017 from http://www.cancer.ca/en/cancer-information/cancer-101/canadian-cancer-statistics-publication/canadian-cancer-statistics-infographics/?region=on.

  • Canadian Cancer Society. (2016b). Canadian cancer statistics 2016. Special topic: HPV-associated cancers. Retrieved August 16, 2017 from http://www.cancer.ca/~/media/cancer.ca/CW/cancer%20information/cancer%20101/Canadian%20cancer%20statistics/Canadian-Cancer-Statistics-2016-EN.pdf?la=en.

  • Centers for Disease Control and Prevention (CDC). (2011). Vital signs: Current cigarette smoking among adults aged ≥ 18 years – United States, 2005-2010. Morbidity and Mortality Weekly Report, 60, 1207–1211.

    Google Scholar 

  • Centers for Disease Control and Prevention, National Center for Health Statistics. (n.d.). About the National Health and Nutrition Examination Survey. Retrieved August 17, 2017, from http://www.cdc.gov/nchs/nhanes/about_nhanes.htm

  • Chaturvedi, A. K., Anderson, W. F., Lortet-Tieulent, J., Curado, M. P., Ferlay, J., Franceschi, S., et al. (2013). Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers. Journal of Clinical Oncology, 31, 4550–4559.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chaturvedi, A. K., D’Souza, G., Gillison, M. L., & Katki, H. A. (2016). Burden of HPV-positive oropharynx cancers among ever and never smokers in the U.S. population. Oral Oncology, 60, 61–67.

    Article  PubMed  Google Scholar 

  • Chaturvedi, A. K., Engels, E. A., Pfeiffer, R. M., Hernandez, B. Y., Xiao, W., Kim, E., et al. (2011). Human papillomavirus and rising oropharyngeal cancer incidence in the United States. Journal of Clinical Oncology, 29(32), 4294–4301.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chaturvedi, A. K., Graubard, B. I., Broutian, T., Pickard, R. K., Tong, Z. Y., Xiao, W., et al. (2015). NHANES 2009-2012 findings: Association of sexual behaviors with higher prevalence of oral oncogenic human papillomavirus infections in U.S. men. Cancer Research, 75(12), 2468–2377.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen, P., Yu, W., Huang, J., Xu, H., Li, G., Chen, X., et al. (2017). Matched-pair analysis of survival in patients with poorly differentiated versus well-differentiated glottis squamous cell carcinoma. Oncotarget, 8(9), 14770–14776.

    PubMed  PubMed Central  Google Scholar 

  • Chu, A., Genden, E., Posner, M., & Sikora, A. (2013). A patient-centred approach to counselling patients with head and neck cancer undergoing human papillomavirus testing: A clinician’s guide. Oncologist, 18(2), 180–189.

    Article  PubMed  PubMed Central  Google Scholar 

  • Chung, C. H., & Gillison, M. L. (2009). Human papillomavirus in head and neck cancer: Its role in pathogenesis and clinical implications. Clinical Cancer Research, 15(22), 6758–6762.

    Article  CAS  PubMed  Google Scholar 

  • D’Souza, G., & Dempsey, A. (2011). The role of HPV in head and neck cancer and review of the HPV vaccine. Preventive Medicine, 53(1 Suppl), S5–S11.

    Article  PubMed  PubMed Central  Google Scholar 

  • D’Souza, G., Kreimer, A. R., Viscidi, R., Pawlita, M., Fakhry, C., Koch, W. M., et al. (2007). Case-control study of human papillomavirus and oropharyngeal cancer. New England Journal of Medicine, 356(19), 1944–1956.

    Article  Google Scholar 

  • D’Souza, G., Wentz, A., Kluz, N., Zhang, Y., Sugar, E., Youngfellow, R. M., et al. (2016). Sex differences in risk factors and natural history of oral human papillomavirus infection. Journal of Infectious Diseases, 213(12), 1893–1896.

    Article  Google Scholar 

  • D’Souza, G., Zhang, Y., Merritt, S., Gold, D., Robbins, H. A., Buckman, V., et al. (2016). Patient experience and anxiety during and after treatment for an HPV-related oropharyngeal cancer. Oral Oncology, 60, 90–95.

    Article  PubMed  PubMed Central  Google Scholar 

  • Dahlstrom, K. R., Garden, A. S., William, W. N., Jr., Lim, M. Y., & Sturgis, E. M. (2016). Proposed staging system for patients with HPV-related oropharyngeal cancer based on nasopharyngeal cancer n categories. Journal of Clinical Oncology, 34(16), 1848–1854.

    Article  PubMed  PubMed Central  Google Scholar 

  • Davis, K. C., Farrelly, M. C., Duke, J., Kelly, L., & Willett, J. (2012). Antismoking media campaign and smoking cessation outcomes, New York state, 2003–2009. Preventing Chronic Diseases, 9, E40. https://doi.org/10.5888/pcd9.110102

    Article  Google Scholar 

  • Davis, K. S., Lim, C. M., Clump, D. A., Heron, D. E., Ohr, J. P., Kim, S., et al. (2016). Tumor volume as a predictor of survival in human papillomavirus-positive oropharyngeal cancer. Head & Neck, 38(Suppl1), 1613–1617.

    Article  Google Scholar 

  • De Boer, M. F., McCormick, L. K., Pruyn, J. F., Ryckman, R. M., & van den Borne, B. W. (1999). Physical and psychosocial correlates of head and neck cancer: A review of the literature. Otolaryngology – Head and Neck Surgery, 120, 427–436.

    Article  PubMed  Google Scholar 

  • de Martel, C., Plummer, M., Vignat, J., & Franceschi, S. (2017). Worldwide burden of cancer attributable to HPV by site, country and HPV type. International Journal of Cancer, 141, 664–670.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Dodd, R. H., Marlow, L. A. V., & Waller, J. (2016). Discussing a diagnosis of human papillomavirus oropharyngeal cancer with patients: An exploratory qualitative study of health professionals. Head & Neck, 38(3), 394–401.

    Article  Google Scholar 

  • Dowthwaite, S. A., Franklin, J. H., Palma, D. A., Fung, K., Yoo, J., & Nichols, A. C. (2012). The role of transoral robotic surgery in the management of oropharyngeal cancer: A review of the literature. ISRN Oncology, 2012, 945162. https://doi.org/10.5402/2012/945162

    Article  PubMed  PubMed Central  Google Scholar 

  • Edge, S. B., Byrd, D. R., Compton, C. C., Fritz, A. G., Greene, F. L., & Trotti, A. (Eds.). (2010). AJCC cancer staging manual (7th ed.). New York, NY: Springer-Verlag.

    Google Scholar 

  • Eisbruch, A., Lyden, T., Bradford, C. R., Dawson, L. A., Haxer, M. J., Miller, A. E., et al. (2002). Objective assessment of swallowing dysfunction and aspiration after radiation concurrent with chemotherapy for head-and-neck cancer. International Journal of Radiation Oncology, Biology, Physics, 53(1), 23–28.

    Article  PubMed  Google Scholar 

  • El-Naggar, A. K., & Westra, W. H. (2012). p16 overexpression as a surrogate marking for HPV-related oropharyngeal carcinoma: A guide for interpretative relevance and consistency. Head & Neck, 34, 458–461.

    Article  Google Scholar 

  • Fakhry, C., & D’Souza, G. (2013). Discussing the diagnosis of HPV-OSCC: Common questions and answers. Oral Oncology, 49(9), 863–871.

    Article  PubMed  PubMed Central  Google Scholar 

  • Fakhry, C., & Gillison, M. L. (2006). Clinical implications of human papillomavirus in head and neck cancers. Journal of Clinical Oncology, 24(17), 2606–2611.

    Article  PubMed  Google Scholar 

  • Fakhry, C., Rosenthal, B. T., Clark, D. P., & Gillison, M. L. (2011). Associations between oral HPV16 infection and cytopathology: Evaluation of an oropharyngeal “pap-test equivalent” in high-risk populations. Cancer Prevention Research, 4(9), 1378–1384.

    Article  PubMed  Google Scholar 

  • Fakhry, C., Westra, W. H., Li, S., Cmelak, A., Ridge, J. A., Pinto, H., et al. (2008). Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. Journal of the National Cancer Institute, 100, 261–269.

    Article  CAS  PubMed  Google Scholar 

  • Fakhry, C., Zhang, Q., Nruyen-Tan, P. F., Rosenthal, D., El-Naggar, A., Garden, A. S., et al. (2014). Human papillomavirus and overall survival after progression of oropharyngeal squamous cell carcinoma. Journal of Clinical Oncology, 32, 3365–3373.

    Article  PubMed  PubMed Central  Google Scholar 

  • Feller, L., Wood, N. H., Khammissa, R. A. G., & Lemmer, J. (2010). Human papillomavirus-mediated carcinogenesis and HPV-associated oral and oropharyngeal squamous cell carcinoma. Part 1: Human papillomavirus-mediated carcinogenesis. Head & Face Medicine, 6, 14–19.

    Article  CAS  Google Scholar 

  • Ferris, R. L., Jaffee, E. M., & Ferrone, S. (2010). Tumor antigen-targeted, monoclonal antibody-based immunotherapy: Clinical response, cellular immunity, and immunoescape. Journal of Clinical Oncology, 28, 4390–4399.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Finnigan, J. P., Jr., & Sikora, A. G. (2014). Counseling the patient with potentially HPV-related newly diagnosed head and neck cancer. Current Oncology Reports, 16(3), 375.

    Article  PubMed  PubMed Central  Google Scholar 

  • Franceschi, S., Munoz, N., Bosch, X. F., Snijders, P. J., & Walboomers, J. M. (1996). Human papillomavirus and cancers of the upper aerodigestive tract: A review of epidemiological and experimental evidence. Cancer Epidemiology, Biomarkers and Prevention, 5(7), 567–575.

    CAS  PubMed  Google Scholar 

  • Garcia-Piñeres, A. H., Hildesheim, A., Herrero, R., Trivett, M., Williams, M., Atmetlla, I., et al. (2006). Persistent human papillomavirus infection is associated with a generalized decreased in immune responsiveness in older women. Cancer Research, 66(22), 11070–11076.

    Article  PubMed  CAS  Google Scholar 

  • Gasparini, R., & Panatto, D. (2009). Cervical cancer: From Hippocrates through Rigoni-Stern to zur Hausen. Vaccine, 27(1 Suppl), A4–A5.

    Article  PubMed  Google Scholar 

  • Gillison, M. L. (2004). Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Seminars in Oncology, 31(6), 744–754.

    Article  PubMed  Google Scholar 

  • Gillison, M. L., Broutian, T., Pickard, R. K. L., Tong, Z.-Y., Xiao, W., Kahle, L., et al. (2012). Prevalence of oral HPV infection in the United States, 2009-2010. Journal of the American Medical Association, 307(7), 693–703.

    Article  CAS  PubMed  Google Scholar 

  • Gillison, M. L., Chaturvedi, A. K., & Lowy, D. R. (2008). HPV prophylactic vaccines and the potential prevention of noncervical cancers in both men and women. Cancer, 113(10 Suppl), 3036–3046.

    Article  PubMed  Google Scholar 

  • Gillison, M. L., D’Souza, G., Westra, W., Sugar, E., Xiao, W., Begum, S., et al. (2008). Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. Journal of the National Cancer Institute, 100, 407–420.

    Article  PubMed  Google Scholar 

  • Gillison, M. L., Koch, W. M., Capone, R. B., Spafford, M., Westra, W. H., Wu, L., et al. (2000). Evidence for a causal association between human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. Journal of the National Cancer Institute, 92(9), 709–720.

    Article  CAS  PubMed  Google Scholar 

  • Gillison, M. L., Zhang, Q., Jordan, R., Xiao, W., Westra, W., Trotti, A., et al. (2012). Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. Journal of Clinical Oncology, 30, 2101–2111.

    Article  CAS  Google Scholar 

  • Gissman, L., Diehl, V., Schultz-Coulon, H. J., & zur Hausen, H. (1982). Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma. Journal of Virology, 44(1), 393–400.

    Google Scholar 

  • Giuliano, A. R., Tortolero-Luna, G., Ferrer, E., Burchell, A. N., de Sanjose, S., & Kjaer, S. K. (2008). Epidemiology of human papillomavirus infection in men, cancers other than cervical and benign conditions. Vaccine, 26(Suppl 10), K17–K28.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gooi, Z., Chan, J. Y., & Fakhry, C. (2016). The epidemiology of the human papillomavirus related to oropharyngeal head and neck cancer. Laryngoscope, 126(4), 894–900.

    Article  PubMed  Google Scholar 

  • Habbous, S., Chu, K. P., Lau, H., Schorr, M., Belayneh, M., Ha, M. N., et al. (2017). Human papillomavirus in oropharyngeal cancer in Canada: Analysis of 5 comprehensive cancer centres using multiple imputation. Canadian Medical Association Journal, 189, E1030–E1040.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hafkamp, H., Manni, J., Haesevoets, A., Voogd, A. C., Schepers, M., Bot, F. J., et al. (2008). Marked differences in survival rate between smokers and nonsmokers with HPV16-assocaited tonsillar carcinomas. International Journal of Cancer, 122, 2656–2664.

    Article  CAS  PubMed  Google Scholar 

  • Hanasoge, S., Magliocca, K. R., Switchenko, J. M., Saba, N. F., Wadsworth, J. T., El-Deiry, M. W., et al. (2016). Clinical outcomes in elderly patients with human papillomavirus-positive squamous cell carcinoma of the oropharynx treated with definitive chemoradiation therapy. Head & Neck, 38(6), 846–851.

    Article  Google Scholar 

  • Hariri, S., Unger, E. R., Sternberg, M., Dunne, E. F., Swan, D., Patel, S., et al. (2011). Prevalence of genital human papillomavirus among females in the United States, the National Health and Nutrition Examination Survery, 2003–2006. Journal of Infectious Diseases, 204(4), 566–573.

    Article  Google Scholar 

  • Health Protection Agency. (2011). Trends in genital herpes and genital warts infections, United Kingdom: 2000 to 2009. Retrieved August 17, 2017, from http://webarchive.nationalarchives.gov.uk/20140714092919/, http://www.hpa.org.uk/hpr/archives/2011/hpr1711.pdf

  • Herrero, R., Quint, W., Hildesheim, A., Gonzalez, P., Struijk, L., Katki, H. A., et al. (2013). Reduced prevalence of oral human papillomavirus (HPV) 4 years after bivalent HPV vaccination in a randomized clinical trial in Costa Rica. PLoS One, 8(7), E68329. https://doi.org/10.1371/journal.pone.0068329

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hildesheim, A., & Herrero, R. (2007). Human papillomavirus vaccine should be given before sexual debut for maximum benefit. Journal of Infectious Diseases, 196(10), 1431–1432.

    Article  Google Scholar 

  • Hildesheim, A., Herrero, R., Wacholder, S., Rodriguez, A. C., Solomon, D., Bratti, M. C., et al. (2007). Effect of human papillomavirus 16/18 L1 virus like particle vaccine among young women with preexisting infection: A randomized trial. JAMA, 298(7), 743–753.

    Article  CAS  PubMed  Google Scholar 

  • Hoffman, M., Cooper, D., Carrara, H., Rosenberg, L., Kelly, J., Stander, I., et al. (2003). Limited Pap screening associated with reduced risk of cervical cancer in South Africa. International Journal of Epidemiology, 32(4), 573–577.

    Article  CAS  PubMed  Google Scholar 

  • Horne, Z. D., Glaser, S. M., Vargo, J. A., Ferris, R. L., Balasubramani, G. K., Clump, D. A., et al. (2016). Confirmation of proposed human papillomavirus risk-adapted staging according to AJCC/UICC TNM criteria for positive oropharyngeal carcinomas. Cancer, 122(13), 2021–2030.

    Article  PubMed  Google Scholar 

  • Huang, S. H., Patel, S., O’Sullivan, B., Shen, X., Weinreb, I., Perez-Ordonez, B., et al. (2015). Longer survival in patients with human papillomavirus-related head and neck cancer after positive postradiation planned neck dissection. Head & Neck, 37(7), 946–952.

    Article  Google Scholar 

  • Huang, S. H., Perez-Ordonez, B., Liu, F. F., Waldron, J., Ringash, J., Irish, J., et al. (2012). Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy. International Journal of Radiation Oncology, Biology, Physics, 82(1), 276–283.

    Article  PubMed  Google Scholar 

  • Hutcheson, K. A., Holsinger, F. C., Kupferman, M. E., & Lewin, J. S. (2015). Functional outcomes after TORS for oropharyngeal cancer: A systematic review. European Archives of Otorhinolaryngology, 272(2), 463–471.

    Article  PubMed  Google Scholar 

  • Jemal, A., Simard, E. P., Dorell, C., Noone, A. M., Markowitz, L. E., Kohler, B., et al. (2013). Annual report to the nation on the status of cancer, 1975–2009, featuring the burden and trends in human papillomavirus (HPV)-associated cancers and HPV vaccination coverage levels. Journal of the National Cancer Institute, 105(3), 175–201.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kaka, A. S., Kumar, B., Kumar, P., Wakely, P. E., Jr., Kirsch, C. M., Old, M. O., et al. (2013). Highly aggressive HPV-related oropharyngeal cancer: Clinical, radiologic, and pathologic characteristics. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 116(3), 327–335.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kamerow, D. (2016). HPV vaccine: Effective but underused in the US. British Medical Journal, 353, i2060. https://doi.org/10.1136/bmj.12060. (Published 14 April 2016).

    Article  PubMed  Google Scholar 

  • Khariwala, S. S., Moore, M. G., Malloy, K. M., Gosselin, B., & Smith, R. V. (2015). The “HPV Discussion”: Effective use of data to deliver recommendations to patients impacted by HPV. Otolaryngology - Head and Neck Surgery, 153(2), 518–525.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kharytaniuk, N., Molony, P., Boyle, S., O’Leary, G., Werner, R., Heffron, C., et al. (2016). Association of extracapsular spread with survival according to human papillomavirus status in oropharyngeal squamous cell carcinoma and carcinoma of the unknown primary site. JAMA Otolaryngology - Head and Neck Surgery, 142(7), 683–690.

    Article  PubMed  Google Scholar 

  • Khwaia, S. S., Baker, C., Haynes, W., Spencer, C. R., Gay, H., Thorstad, W., et al. (2016). High E6 gene expression predicts for distant metastasis and poor survival in patients with HPV-positive oropharyngeal squamous cell carcinoma. International Journal Radiation Oncology, Biology, Physics, 95(4), 1132–1141.

    Article  CAS  Google Scholar 

  • Kliewer, E. V., Demers, A. A., Elliott, L., Lotocki, R., Butler, J. R., & Brisson, M. (2009). Twenty-year trends in the incidence and prevalence of diagnoses anogenital warts in Canada. Sexually Transmitted Diseases, 36(6), 380–386.

    Article  PubMed  Google Scholar 

  • Kreimer, A. R., Bhatia, R. K., Messeguer, A. L., Gonzalez, P., Herrero, R., & Giuliano, A. R. (2010). Oral human papillomavirus in health individuals: A systematic review of the literature. Sexually Transmitted Diseases, 37, 386–391.

    PubMed  Google Scholar 

  • Kreimer, A. R., Clifford, G. M., Boyle, P., & Franceschi, S. (2005). Human papillomavirus types in head and neck squamous cell carcinomas worldwide: A systematic review. Cancer Epidemiology, Biomarkers & Prevention, 14(2), 467–475.

    Article  CAS  Google Scholar 

  • Kreimer, A. R., Johansson, M., Waterboer, T., Kaaks, R., Chang-Claude, J., Drogen, D., et al. (2013). Evaluation of human papillomavirus antibodies and risk of subsequent head and neck cancer. Journal of Clinical Oncology, 31(21), 2708–2715.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kreimer, A. R., Pierce Campbell, C. M., Lin, H. Y., Fulp, W., Papenfuss, M. R., Abrahamsen, M., et al. (2013). Incidence and clearance of oral human papillomavirus infection in men: The HIM cohort study. Lancet, 382, 877–887.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kubicek, G. J., Champ, C., Fogh, S., Wang, F., Reddy, E., Intenzo, C., et al. (2010). FDG-PET staging and important of lymph node SUV in head and neck cancer. Head and Neck Oncology, 2, 19.

    Article  PubMed  PubMed Central  Google Scholar 

  • Kugaya, A., Akechi, T., Okuyama, T., Nakano, T., Mikami, I., Okamura, H., et al. (2000). Prevalence, predictive factors, and screening for psychologic distress in patients with newly diagnosed head and neck cancer. Cancer, 88, 2817–2223.

    Article  CAS  PubMed  Google Scholar 

  • Kumar, B., Cordell, K., Lee, J., Worden, F. P., Prince, M. D., Tran, H. H., et al. (2008). EGFR, p16, HPV titer Bcl-xL, and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. Journal of Clinical Oncology, 26(19), 3128–3137.

    Article  PubMed  Google Scholar 

  • Lacchetti, C., Waldron, J., Perez-Ordonez, B., Kamel-Reid, S., Cripps, C., & Gilbert, R. (2013). Routine HPV testing in HNSCC (program in evidence-based care evidence-based series no. 5–9). Toronto, ON: Cancer Care Ontario.

    Google Scholar 

  • Lassen, P., Eriksen, J. G., Hamilton-Dutoit, S., Tramm, T., Alsner, J., & Overgaard, J. (2009). Effect of HPV-associated p16INK4A expression on response to radiotherapy and survival in squamous cell carcinoma of the head and neck. Journal of Clinical Oncology, 27, 1992–1998.

    Article  CAS  PubMed  Google Scholar 

  • Lee, L. A., Huang, C. G., Liao, C. T., Lee, L. Y., Hsueh, C., Chen, T. C., et al. (2012). Human papillomavirus-16 infection in advanced oral cavity cancer patients is related to an increased risk of distant metastases and poor survival. PLoS One, 7(7), e40767. https://doi.org/10.1371/journal.pone.0040767

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin, B. M., Wang, H., D’Souza, G., Zhang, Z., Fakhry, C., Joseph, A. W., et al. (2013). Long-term prognosis and risk factors among patients with HPV-associated oropharyngeal squamous cell carcinoma. Cancer, 119(9), 3462–3472.

    Article  PubMed  Google Scholar 

  • Lindel, K., Beer, K. T., Laissue, J., Greiner, R. H., & Aebersold, D. M. (2001). Human papillomavirus positive squamous cell carcinoma of the oropharynx a radiosensitive subgroup of head and neck carcinoma. Cancer, 92(4), 805–813.

    Article  CAS  PubMed  Google Scholar 

  • Loning, T., Ikenberg, H., Becker, J., Gissmann, L., Hoepfer, I., & zur Hausen, H. (1985). Analysis of oral papillomas, leukoplakias, and invasive carcinomas for human papillomavirus type related DNA. The Journal of Investigative Dermatology, 84(5), 417–420.

    Article  CAS  PubMed  Google Scholar 

  • Louvanto, K., Rautava, J., Willberg, J., Wideman, L., Syrjänen, K., Grénman, S., et al. (2013). Genotype-specific incidence and clearance of human papillomavirus in oral mucosa of women: A six-year follow-up study. PLoS One, 8, e53413. https://doi.org/10.1371/journal.pone.0053413

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lydiatt, W. M., Patel, S. G., O’Sullivan, B., Brandwein, M. S., Ridge, J. A., Migliacci, J. C., et al. (2017). Head and neck cancers – major changes in the American Joint Committee on Cancer eighth edition cancer staging manual. CA: A Cancer Journal for Clinicians, 67, 122–137.

    Google Scholar 

  • Machtay, M., Moughan, J., Trotti, A., Garden, A. S., Weber, R. S., Cooper, J. S., et al. (2008). Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: An RTOG analysis. Journal of Clinical Oncology, 26(21), 3582–3589.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Markowitz, L. E., Liu, G., Hariri, S., Steinau, M., Dunne, E. F., & Unger, E. R. (2016). Prevalence of HPV after introduction of the vaccination program in the United States. Pediatrics, 137, 1–9.

    Article  Google Scholar 

  • Masterson, L., Moualed, D., Masood, A., Dwivedi, R. C., Benson, R., Sterling, J. C., et al. (2014). De-escalation treatment protocols for human papillomavirus-associated oropharyngeal squamous cell carcinoma. The Cochrane Database of Systematic Reviews, 15(2). https://doi.org/10.1002/14651858.CD010271.pub2

  • Maxwell, J. H., Ferris, R. L., Gooding, W., Cunningham, D., Mehta, V., Kim, S., et al. (2013). Extracapsular spread in head and neck carcinoma: Impact of site and human papillomavirus status. Cancer, 119(18), 3302–3308.

    Article  PubMed  Google Scholar 

  • Maxwell, J. H., Kumar, B., Feng, F., Worden, F. P., Lee, J., Eisbruch, A., et al. (2012). Tobacco use in HPV-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence. Clinical Cancer Research, 16(4), 1226–1235.

    Article  CAS  Google Scholar 

  • Maxwell, J. H., Mehta, V., Wang, H., Cunningham, D., Duvvuri, U., Kim, S., et al. (2014). Quality of life in head and neck cancer patients: Impact of HPV and primary treatment modality. Laryngoscope, 124(7), 1592–1597.

    Article  PubMed  Google Scholar 

  • McIlwain, W. R., Sood, A. J., Nguyen, S. A., & Day, T. A. (2014). Initial symptoms in patients with HPV-positive and HPV-negative oropharyngeal cancer. JAMA Otolaryngology - Head and Neck Surgery, 140(5), 441–447.

    Article  PubMed  Google Scholar 

  • McQuillan, G., Kruszon-Moran, D., Markowitz, L. E., Unger, E. R., & Paulose-Ram, R. (2017). Prevalence of HPV in adults aged 18–69: United States, 2011–2014. NCHS Data Brief, 280, 1–8.

    Google Scholar 

  • Mehanna, H., Beech, T., & Nicholson, T. (2013). Prevalence of human papillomavirus in oropharyngeal and non-oropharyngeal head and neck cancer – a systematic review and meta-analysis of trends by time and region. Head & Neck, 35(5), 747–755.

    Article  Google Scholar 

  • Mehanna, H., Franklin, N., Compton, N., Robinson, M., Powell, N., Biswas-Baldwin, N., et al. (2016). Geographic variation in human papillomavirus-related oropharyngeal cancer: Data from 4 multinational randomized trials. Head & Neck, 38(Suppl1), E1863–E1869.

    Article  Google Scholar 

  • Milbury, K., Rosenthal, D. I., El-Naggar, A., & Badr, H. (2013). An exploratory study of the informational and psychosocial needs of patients with human papillomavirus-associated oropharyngeal cancer. Oral Oncology, 49(11), 1067–1071.

    Article  PubMed  PubMed Central  Google Scholar 

  • Mundi, N., Theurer, J., Warner, A., Yoo, J., Fung, K., MacNeil, D., … Nichols, A. C. (2018). The impact of seasonal operating room closures on wait times for oral cancer surgery. Current Oncology, 25(1), 67.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Naik, M., Ward, M. C., Bledsoe, T. J., Kumar, A. M. S., Rybicki, L. A., Saxton, J. P., et al. (2015). It is not just IMRT: Human papillomavirus related oropharynx squamous cell carcinoma is associated with better swallowing outcomes after definitive chemoradiotherapy. Oral Oncology, 51, 800–804.

    Article  CAS  PubMed  Google Scholar 

  • National Comprehensive Cancer Network. (n.d.). About the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines (R)). Retrieved August 17, 2017, from https://www.nccn.org/professionals/default.aspx.

  • Nichols, A. C., Palma, D. A., Dhaliwal, S. S., Tan, S., Theurer, J., Chow, W., et al. (2013). The epidemic of human papillomavirus and oropharyngeal cancer in a Canadian population. Current Oncology, 20(4), 212–219.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Niedobitek, G., Pitteroff, S., Herbst, H., Shepherd, P., Finn, T., Anagnostopoulos, I., et al. (1990). Detection of human papillomavirus type 16 DNA in carcinomas of the palatine tonsil. Journal of Clinical Pathology, 43(11), 918–921.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Nien, H. H., Sturgis, E. M., Kies, M. S., El-Naggar, A. K., Morrison, W. H., Beadle, B. M., et al. (2016). Comparison of systemic therapies used concurrently with radiation for the treatment of human papillomavirus-associated oropharyngeal cancer. Head & Neck, 38(Suppl1), E1554–E1561.

    Article  Google Scholar 

  • O’Rorke, M. A., Ellison, M. V., Murray, L. J., Moran, M., James, J., & Anderson, L. A. (2012). Human papillomavirus related head and neck cancer survival: A systematic review and meta-analysis. Oral Oncology, 48(12), 1191–1201.

    Article  PubMed  Google Scholar 

  • O’Sullivan, B., Huang, S. H., Siu, L. L., Waldron, J., Zhao, H., Perez-Ordonez, B., et al. (2013). Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis. Journal of Clinical Oncology, 31(5), 543–550.

    Article  PubMed  CAS  Google Scholar 

  • O’Sullivan, D., Huang, S. H., Su, J., Garden, A. S., Sturgis, E. M., Dahlstrom, K., et al. (2016). Development and validation of a staging system for HPV-related oropharyngeal cancer by the International Collaboration on Oropharyngeal cancer Network for Staging (ICON-S): A multicenter cohort study. Lancet Oncology, 17(4), 440–451.

    Article  PubMed  Google Scholar 

  • Palma, D. (2017). Taking charge of cancer: What you need to know to get the best treatment. Oakland, CA: New Harbinger Publications.

    Google Scholar 

  • Parsons, J. T., Mendenhall, W. M., Stringer, S. P., Amdur, R. J., Hinerman, R. W., Villaret, D. B., et al. (2002). Squamous cell carcinoma of the oropharynx: Surgery, radiation therapy, or both. Cancer, 94(11), 2967–2980.

    Article  PubMed  Google Scholar 

  • Paz, I. B., Cook, N., Odom-Maryon, T., Xie, Y., & Wilczynski, S. P. (1997). Human papillomavirus (HPV) in head and neck cancer: An association of HPV 16 with squamous cell carcinoma of Waldeyer’s tonsillar ring. Cancer, 79(3), 595–604.

    Article  CAS  PubMed  Google Scholar 

  • Pickard, R. K. L., Xiao, W., Broutian, T. R., He, X., & Gillison, M. L. (2012). The prevalence and incidence of oral human papillomavirus infection among young men and women, aged 18-30 years. Sexually Transmitted Diseases, 39, 559–566.

    Article  PubMed  Google Scholar 

  • Pignon, J. P., le Maître, A., Maillard, E., Bourhis, J., & MACH-NC Collaborative Group. (2009). Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients. Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology, 92(1), 4–14.

    Article  Google Scholar 

  • Posner, M. R., Lorch, J. H., Goloubeva, O., Tan, M., Schumaker, L. M., Sarlis, N. J., et al. (2011). Survival and human papillomavirus in oropharynx cancer in TAX 324: A subset analysis from an international phase III trial. Annals of Oncology, 22(5), 1071–1077.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Proceddu, S. V. (2016). A TNM classification for HPV+ oropharyngeal cancer. Lancet Oncology, 17(4), 403–404.

    Article  Google Scholar 

  • Ramer, I., Varier, I., Zhang, D., Demicco, E. G., Posner, M. R., Misiukiewicz, K., et al. (2016). Racial disparities in incidence of human papillomavirus-associated oropharyngeal cancer in an urban population. Cancer Epidemiology, 44, 91–95.

    Article  PubMed  Google Scholar 

  • Rautava, J., Willberg, J., Louvanto, K., Wideman, L., Syrjanen, K., Grenman, S., et al. (2012). Prevalence, genotype distribution and persistence of human papillomavirus in oral mucosa of women: A six-year follow-up study. PLoS One, 7(8), e42171. https://doi.org/10.1371/journal.pone.0042171

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rettig, E., Keiss, A. P., & Fakhry, C. (2015). The role of sexual behavior in head and neck cancer: Implications for prevention and therapy. Expert Review of Anticancer Therapy, 15(1), 35–49.

    Article  CAS  PubMed  Google Scholar 

  • Ringash, J. (2015). Survivorship and quality of life in head and neck cancer. Journal of Clinical Oncology, 33(29), 3322–3327.

    Article  PubMed  Google Scholar 

  • Ringash, J., Fisher, R., Peters, L., Trotti, A., O’Sullivan, B., Corry, J., et al. (2016). Effect of p16 status on the quality-of-life experience during chemoradiation for locally advanced oropharyngeal cancer: A substudy of randomized trial trans-tasman radiation oncology group (TROG) 02.02 (HeadSTART). International Journal of Radiation Oncology, Biology, Physics, 97(4), 678–686.

    Article  PubMed  CAS  Google Scholar 

  • Rodriguez, C. P., Adelstein, D. J., Rybicki, L. A., Savvides, P., Saxton, J. P., Koyfman, S. A., et al. (2015). Randomizes phase III study of 2 cisplatin-based chemoradiation regimens in locally advanced head and neck squamous cell carcinoma: Impact of changing disease epidemiology on contemporary trial design. Head & Neck, 37(11), 1583–1589.

    Article  Google Scholar 

  • Salazar, C. R., Smith, R. V., Garg, M. K., Haigentz, M., Jr., Schiff, B. A., Kawachi, N., et al. (2014). Human papillomavirus-associated head and neck squamous cell carcinoma survival: A comparison by tumor site and initial treatment. Head and Neck Pathology, 8(1), 77–87.

    Article  PubMed  Google Scholar 

  • Samuels, S. E., Tao, Y., Lyden, T., Haxer, M., Spector, M., Malloy, K. M., et al. (2016). Comparisons of dysphagia and quality of life (QOL) in comparable patients with HPV-positive oropharyngeal cancer receiving chemo-irradiation or cetuximab-irradiation. Oral Oncology, 54, 68–74.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sasieni, P., Castanon, A., & Cuzick, J. (2009). Effectiveness of cervical screening with age: Population based case-control study of prospectively recorded data. British Medical Journal, 339, b2968. https://doi.org/10.1136/bmj.b2968

    Article  PubMed  PubMed Central  Google Scholar 

  • Schache, A. G., Powell, N. G., Cuschieri, K. S., Robinson, M., Leary, S., Mehanna, H., et al. (2016). HPV-related oropharynx cancer in the United Kingdom: An evolution in the understanding of disease etiology. Cancer Research, 76(22), 6598–6606.

    Article  CAS  PubMed  Google Scholar 

  • Schlecht, N. F., Brandwein-Gensler, M., Nuovo, G. J., Li, M., Dunne, A., Kawachi, N., et al. (2011). A comparison of clinically utilized human papillomavirus detection methods in head and neck cancer. Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc, 24(10), 1295–1305.

    Article  CAS  Google Scholar 

  • Schwartz, S. M., Daling, J. R., Doody, D. R., Wipf, G. C., Carter, J. J., Madeleine, M. M., et al. (1998). Oral cancer risk in relation to sexual history and evidence of human papillomavirus infection. Journal of the National Cancer Institute, 90(21), 1626–1636.

    Article  CAS  PubMed  Google Scholar 

  • Seiwert, T. (2013). Accurate HPV testing: A requirement for precision medicine for head and neck cancer. Annals of Oncology, 24(11), 2711–2713.

    Article  CAS  PubMed  Google Scholar 

  • Sharma, A., Mendez, E., Yueh, B., Lohavanichbutr, P., Houck, J., Doody, D. R., et al. (2012). Human papillomavirus-positive oral cavity and oropharyngeal cancer patients do not have better quality-of-life trajectories. Otolaryngology - Head and Neck Surgery, 146(5), 739–745.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sinha, P., Lewis, J. S., Jr., Piccirillo, J. F., Kallogieri, D., & Haughey, B. H. (2012). Extracapsular spread and adjuvant therapy in human papillomavirus-related, p16-positive oropharyngeal carcinoma. Cancer, 118(14), 3519–3530.

    Article  CAS  PubMed  Google Scholar 

  • Sinha, P., Pipkorn, P., Thorstad, W. L., Gay, H. A., & Haughey, B. H. (2016). Does elimination of planned postoperative radiation to the primary bed in p16-positive, transorally-resected oropharyngeal carcinoma associate with poorer outcomes? Oral Oncology, 61, 127–134.

    Article  PubMed  Google Scholar 

  • Sinha, P., Thorstad, W. T., Nussenbaum, B., Haughey, B. H., Adkins, D. R., Kallogieri, D., et al. (2014). Distant metastasis in p16-positive oropharyngeal squamous cell carcinoma: A critical analysis of patterns and outcomes. Oral Oncology, 50(1), 45–51.

    Article  CAS  PubMed  Google Scholar 

  • Snijders, P. J., Cromme, F. V., van den Brule, A. J., Schrijnemakers, H. F., Snow, G. B., Meijer, C. J., et al. (1992). Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology. International Journal of Cancer, 51(6), 845–850.

    Article  CAS  PubMed  Google Scholar 

  • Spanos, W. C., Nowicki, P., Lee, D. W., Hoover, A., Hostager, B., Gupta, A., et al. (2009). Immune response during therapy with cisplatin or radiation for human papillomavirus-related head and neck cancer. Archives of Otolaryngology - Head and Neck Surgery, 135(11), 1137–1146.

    Article  PubMed  Google Scholar 

  • Spector, M. E., Gallagher, K. K., Light, E., Ibrahim, M., Chanowski, E. J., Moyer, J. S., et al. (2012). Matted nodes: Poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status. Head & Neck, 34(12), 1727–1733.

    Article  Google Scholar 

  • Stokley, S., Jeyarajah, J., Yankey, D., Cano, M., Gee, J., Roark, J., et al. (2014). Human papillomavirus vaccination coverage among adolescents, 2007–2013, and postlicensure vaccine safety monitoring, 2006–2014 – United States. Morbidity and Mortality Weekly Report, 63, 620–624.

    Google Scholar 

  • Stransky, N., Egloff, A. M., Tward, A. D., Kostic, A. D., Cibulskis, K., Sivachenko, A., et al. (2011). The mutation landscape of head and neck squamous cell carcinoma. Science, 333(6046), 1157–1160.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Syrjänen, K. J., Syrjänen, S. M., Lamberg, M. A., & Pyrhönen, S. (1983). Human papillomavirus (HPV) involvement in squamous cell lesions of the oral cavity. Proceedings of the Finnish Dental Society, 79(1), 1–8.

    Google Scholar 

  • Taberna, M., Resteghini, C., Swanson, B., Pickard, R. K. L., Jiang, B., Xiao, W., et al. (2016). Low etiologic fraction for human papillomavirus in larynx squamous cell carcinoma. Oral Oncology, 61, 55–61.

    Article  CAS  PubMed  Google Scholar 

  • Thavaraj, S., Stokes, A., Guerra, E., Bibel, J., Halligan, E., Long, A., et al. (2011). Evaluation of human papillomavirus testing for squamous cell carcinoma of the tonsil in clinical practice. Journal of Clinical Pathology, 64(4), 308–312.

    Article  PubMed  Google Scholar 

  • Trosman, S. J., Koyfman, S. A., Ward, M. C., Al-Khudari, S., Nwizu, T., Greskovich, J. F., et al. (2015). Effect of human papillomavirus on patterns of distant metastatic failure in oropharyngeal squamous cell carcinoma treated with chemoradiotherapy. JAMA Otolaryngology – Head and Neck Surgery, 141(5), 457–462.

    Article  PubMed  Google Scholar 

  • Truong Lam, M., O’Sullivan, B., Gullane, P., & Hui Huang, S. (2016). Challenges in establishing the diagnosis of human papillomavirus-related oropharyngeal carcinoma. Laryngoscope, 126, 2270–2275.

    Article  PubMed  Google Scholar 

  • Urban, D., Corry, J., & Rischin, D. (2014). What is the best treatment for patients with human papillomavirus-positive and –negative OPSCC? Cancer, 120(10), 1462–1470.

    Article  PubMed  Google Scholar 

  • van Harten, M. C., Hoebers, F. J. P., Kross, K. W., van Werkhoven, E. D., van den Brekel, M. W. M., & van Dijk, B. A. C. (2015). Determinants of treatment waiting times for head and neck cancer in the Netherlands and their relation to survival. Oral Oncology, 51(3), 272–278.

    Article  PubMed  Google Scholar 

  • Veterans Affairs Laryngeal Cancer Study Group. (1991). Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. New England Journal of Medicine, 324(24), 1685–1690.

    Article  Google Scholar 

  • Vicus, D., Sutradhar, R., Lu, Y., Elit, L., Kupets, R., Paszat, L., et al. (2014). The association between cervical cancer screening and mortality from cervical cancer: A population based case-control study. Gynecologic Oncology, 133, 167–171.

    Article  PubMed  Google Scholar 

  • Ward, G., Mehta, V., & Moore, M. (2016). Morbidity, mortality and cost from HPV-related oropharyngeal cancer: Impact of 2-, 4-, and 9-valent vaccines. Human Vaccines & Immunotherapies, 12(6), 1343–1347.

    Article  Google Scholar 

  • Worsham, M. J., Stephen, J. K., Chen, K. M., Mahan, M., Schweitzer, V., Havard, S., et al. (2013). Improved survival with HPV among African Americans with oropharyngeal cancer. Clinical Cancer Research, 19(9), 2486–2492.

    Article  PubMed  PubMed Central  Google Scholar 

  • Xiao, C., Zhang, Q., Nquyen-Tan, P. F., List, M., Weber, R. S., Ang, K. K., et al. (2017). Quality of life and performance status from a substudy conducted within a prospective phase 3 randomized trial of concurrent standard radiation versus accelerated radiation plus cisplatin for locally advanced head and neck carcinoma: NRG Oncology RTOG 0129. International Journal of Radiation Oncology, Biology, Physics, 97(4), 667–677.

    Article  CAS  PubMed  Google Scholar 

  • Zafereo, M. E., Xu, L., Dahlstrom, K. R., Viamonte, C. A., El-Naggar, A. K., Wei, Q., et al. (2016). Squamous cell carcinoma of the oral cavity often overexpresses p16 but is rarely driven by human papillomavirus. Oral Oncology, 56, 47–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • zur Hausen, H. (1976). Condylomata acuminata and human genital cancer. Cancer Research, 36(2 pt 2), 794.

    CAS  PubMed  Google Scholar 

  • zur Hausen, H. (1982). Human genital cancer: Synergism between two virus infections or synergism between a virus infection and initiating events. Lancet, 2(8312), 1370–1372.

    Article  CAS  PubMed  Google Scholar 

  • zur Hausen, H. (2009). Papillomavirus in the causation of human cancers – a brief historical account. Virology, 384(2), 260–265.

    Article  CAS  PubMed  Google Scholar 

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    Julie A. Theurer

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Theurer, J.A. (2019). Human Papillomavirus-Related Head and Neck Cancer. In: Doyle, P. (eds) Clinical Care and Rehabilitation in Head and Neck Cancer. Springer, Cham. https://doi.org/10.1007/978-3-030-04702-3_4

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