Abstract
Over the past decade, animal studies using rodent models and nonhuman primates have provided compelling evidence that exposure to general anesthesia in young animals is associated with long-term neurocognitive, learning, and behavior deficits. In the United States, an estimated two million children under the age of 5 years undergo surgical procedures and diagnostic imaging studies each year (Rabbitts, Anesth Analg 111: 1011–1015, 2010; Tzong, J Neurosurg Anesthesiol 24: 391–395, 2012). Therefore, the potential neurotoxic effects from exposure of commonly used anesthetic agents in infants and young children during surgical procedures and diagnostic studies remain a significant matter of serious concern to parents, caretakers, and providers. The US Government Food and Drug Administration (FDA) recently issued a change in labeling regarding the safe use of anesthetic and sedative agents.
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Lei, S., Sun, L.S. (2019). ENT Surgery and Anesthesia Neurotoxicity in Children. In: Preciado, D., Verghese, S. (eds) Anesthetic Management for the Pediatric Airway . Springer, Cham. https://doi.org/10.1007/978-3-030-04600-2_18
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DOI: https://doi.org/10.1007/978-3-030-04600-2_18
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