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The Role of Potassium Channels in the Regulation of Neurotransmitter Release

  • Chapter
Molecular Mechanisms of Neurotransmitter Release

Part of the book series: Contemporary Neuroscience ((NEUROBIOL))

Abstract

Neurotransmitter release is critically dependent on the duration of the presynaptic action potential. A variety of K+ channels play key roles in determining spike width. Moreover, K+ channels control how readily terminals can spike, and also suppress aberrant firing. Finally, K+ channels, through their control of the presynaptic resting potential, may impact presynaptic calcium levels and the spontaneous and evoked release of transmitter.

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Acknowledgments

We wish to thank Drs. Paul Brehm, Hai Huang, and Sid Kuo for comments on the manuscript. This work was supported by National Institutes of Health (NIH) grants NS28901 and DC04450.

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Authors and Affiliations

  1. Oregon Hearing Research Center / Vollum Institute, Portland, OR, 97239, USA

    Laurence O. Trussell

  2. Oregon Hearing Research Center/Vollum Institute, Oregon Health and Science University, Portland, OR, USA

    Michael T. Roberts

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Correspondence to Laurence O. Trussell .

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Editors and Affiliations

  1. Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, USA

    Zhao-Wen Wang Ph.D.

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Trussell, L.O., Roberts, M.T. (2008). The Role of Potassium Channels in the Regulation of Neurotransmitter Release. In: Wang, ZW. (eds) Molecular Mechanisms of Neurotransmitter Release. Contemporary Neuroscience. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59745-481-0_9

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