Abstract
Stroke remains a leading cause of death and disability worldwide, with ischemic stroke accounting for the vast majority of all stroke cases. Despite advances in the treatment of acute stroke with tissue-plasminogen activator and more recently with mechanical thrombectomy, limitations in the use and availability of these advanced treatment options have excluded most stroke patients from benefit. Moreover, the rapid diagnosis of acute stroke remains challenging due to “stroke mimics” (other entities with similar presentations) and the lack of a rapid, easily accessible means to rule in cerebral ischemia with imaging modalities such as magnetic resonance imaging or computed tomography perfusion in the acute or hyperacute setting. While biomarkers in other areas of medicine (e.g., troponin in myocardial injury) are well-established and commonly used in clinical practice, the identification and implementation of stroke-related biomarkers has proven to be challenging. This chapter provides a brief overview of several key diagnostic vascular biomarkers in ischemic stroke, highlighting the current development status of these biomarkers, limitations in their use, and their potential application in and implications for stroke care.
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Arteaga, D., Worrall, B.B. (2020). Vascular-Related Biomarkers of Ischemic Stroke. In: Peplow, P.V., Martinez, B., Dambinova, S.A. (eds) Stroke Biomarkers. Neuromethods, vol 147. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9682-7_2
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