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Database and Bioinformatic Analysis of BCL-2 Family Proteins and BH3-Only Proteins

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BCL-2 Family Proteins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1877))

Abstract

BCL-2 proteins correspond to a structurally, functionally, and phylogenetically heterogeneous group of regulators that play crucial roles in the life and death of animal cells. Some of these regulators also represent therapeutic targets in human diseases including cancer. In the omics era, there is great need for easy data retrieval and fast analysis of the molecular players involved in cell death. In this chapter, we present generic and specific computational resources (such as the reference database BCL2DB) as well as bioinformatics tools that can be used to investigate BCL-2 homologs and BH3-only proteins.

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Acknowledgment

This work was supported by CNRS and Montpellier University. We also acknowledge financial support from the Fondation ARC (AA) and Ligue Contre le Cancer ComitÕ du Gard (AA).

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Authors and Affiliations

  1. ISEM, Institut des Sciences de l’Evolution de Montpellier, Université de Montpellier, UMR 5554, CNRS, IRD, EPHE, Montpellier, France

    Abdel Aouacheria

  2. PRABI, Rhône Alpes Bioinformatics Center, UCBL, Lyon1, Université de Lyon, Lyon, France

    Vincent Navratil

  3. Centre de Recherche en Cancérologie de Lyon, UMR Inserm U1052, CNRS 5286, Université Claude Bernard Lyon 1, Centre Léon Bérard, Lyon, France

    Christophe Combet

Authors
  1. Abdel Aouacheria
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  2. Vincent Navratil
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  3. Christophe Combet
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Corresponding author

Correspondence to Abdel Aouacheria .

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Editors and Affiliations

  1. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA

    Evripidis Gavathiotis

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Aouacheria, A., Navratil, V., Combet, C. (2019). Database and Bioinformatic Analysis of BCL-2 Family Proteins and BH3-Only Proteins. In: Gavathiotis, E. (eds) BCL-2 Family Proteins. Methods in Molecular Biology, vol 1877. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8861-7_2

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  • DOI: https://doi.org/10.1007/978-1-4939-8861-7_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8860-0

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