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Overview of BCL-2 Family Proteins and Therapeutic Potentials

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BCL-2 Family Proteins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1877))

Abstract

BCL-2 family proteins interact in a network that regulates apoptosis. The BH3 amino acid sequence motif serves to bind together this conglomerate protein family, both literally and figuratively. BH3 motifs are present in antiapoptotic and proapoptotic BCL-2 homologs, and in a separate group of unrelated BH3-only proteins often appended to the BCL-2 family. BH3-containing helices mediate many of their physical interactions to determine cell death versus survival, leading to the development of BH3 mimetics as therapeutics. Here we provide an overview of BCL-2 family interactions, their relevance in health and disease, and the progress toward regulating their interactions therapeutically.

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Acknowledgments

Supported by the National Institutes of Health USA grants RO1 NS083373 (JMH), RO1 NS037402 (JMH), RO1 GM077875 (JMH), and F31 AI122613 (JDH).

Author information

Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA

    Jason D. Huska, Heather M. Lamb & J. Marie Hardwick

Authors
  1. Jason D. Huska
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  2. Heather M. Lamb
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  3. J. Marie Hardwick
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Corresponding author

Correspondence to J. Marie Hardwick .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY, USA

    Evripidis Gavathiotis

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© 2019 Springer Science+Business Media, LLC, part of Springer Nature

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Huska, J.D., Lamb, H.M., Hardwick, J.M. (2019). Overview of BCL-2 Family Proteins and Therapeutic Potentials. In: Gavathiotis, E. (eds) BCL-2 Family Proteins. Methods in Molecular Biology, vol 1877. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8861-7_1

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  • DOI: https://doi.org/10.1007/978-1-4939-8861-7_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8860-0

  • Online ISBN: 978-1-4939-8861-7

  • eBook Packages: Springer Protocols

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