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Interstitial Cystitis: The Painful Bladder Syndrome

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Abstract

Recognition of interstitial cystitis has grown dramatically over the past decade. The whole neuroinflammatory soft tissue component in the pelvis has lent tremendous credibility to the study and funding of this process. In fact, entire sections at both national and international urology and gynecology conferences have been dedicated to the entity in and of itself as well as addressing the heterogeneity that is inherent in the vast array of both diagnostic and therapeutic options available. Finally, to support the significant impingement that this disease process can put upon those men and women who suffer with it, the federal government as well as the center for Medicare and Medicaid (CMS) has now recognized this disease process with an Official Disability Code in the USA. Now, those patients who cannot hold down their job because of pelvic pressure, pelvic pain, or even wetting their pants have an option. For more details, a list of physicians who dedicate all or part their practice to the diagnosis and treatment of IC are listed on the Interstitial Cystitis Association (ICA) website.

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References

  1. Dancel R, Mounsey A, Handler L. Medications used in IC. Am Fam Physician. 2015;91(2):116–7.

    PubMed  Google Scholar 

  2. Hanno PM, Erickson D, Moldwin R, Faraday MM, American Urological Association. Diagnosis and management of interstitial cystitis, BPS, AUA guidelines amendment. J Urol. 2015;193(5):1545–53.

    Article  PubMed  Google Scholar 

  3. Barr S. Diagnosis and management of IC. Obstet Gynecol Clin North Am. 2014;41(3):397–407.

    Article  PubMed  Google Scholar 

  4. Rourke W, Khan SA, Ahmed K, Masood S, Dasgupta P, Khan MS. Painful bladder syndrome/interstitial cystitis: aetiology, evaluation and management. Arch Ital Urol Androl. 2014;86(2):126–31. doi:10.4081/aiua.2014.2.126.

    Article  PubMed  Google Scholar 

  5. Jhang JF, Jiang YH, Kuo HC. Potential therapeutic effect of intravesical botulinum toxin type A on bladder pain syndrome/interstitial cystitis. Int J Urol. 2014;21 Suppl 1:49–55.

    Article  CAS  PubMed  Google Scholar 

  6. Kuo HC. Potential urine and serum biomarkers for patients with bladder pain syndrome/interstitial cystitis. Int J Urol. 2014;21 Suppl 1:34–41.

    Article  PubMed  Google Scholar 

  7. Meijlink JM. Interstitial cystitis and the painful bladder: a brief history of nomenclature, definitions and criteria. Int J Urol. 2014;21 Suppl 1:4–12.

    Article  PubMed  Google Scholar 

  8. Laviana A, Jellison F, Kim JH. Sacral neuromodulation for refractory overactive bladder, interstitial cystitis, and painful bladder syndrome. Neurosurg Clin North Am. 2014;25(1):33–46.

    Article  Google Scholar 

  9. Offiah I, McMahon SB, O'Reilly BA. Interstitial cystitis/bladder pain syndrome: diagnosis and management. Int Urogynecol J. 2013;24(8):1243–56.

    Article  CAS  PubMed  Google Scholar 

  10. Neuhaus J, Schwalenberg T. Intravesical treatments of bladder pain syndrome/interstitial cystitis. Nat Rev Urol. 2012;9(12):707–20.

    Article  CAS  PubMed  Google Scholar 

  11. Elliott CS, Payne CK. Interstitial cystitis and the overlap with overactive bladder. Curr Urol Rep. 2012;13(5):319–26.

    Article  PubMed  Google Scholar 

  12. Quillin RB, Erickson DR. Management of interstitial cystitis/bladder pain syndrome: a urology perspective. Urol Clin North Am. 2012;39(3):389–96.

    Article  PubMed  Google Scholar 

  13. Quillin RB, Erickson DR. Practical use of the new American Urological Association interstitial cystitis guidelines. Curr Urol Rep. 2012;13(5):394–401.

    Article  PubMed  Google Scholar 

  14. Vesela R, Aronsson P, Andersson M, Wsol V, Tobin G. The potential of non-adrenergic, non-cholinergic targets in the treatment of interstitial cystitis/painful bladder syndrome. J Physiol Pharmacol. 2012;63(3):209–16.

    CAS  PubMed  Google Scholar 

  15. FitzGerald MP, Payne CK, Lukacz ES, Yang CC, Peters KM, Chai TC, Nickel JC, Hanno PM, Kreder KJ, Burks DA, Mayer R, Kotarinos R, Fortman C, Allen TM, Fraser L, Mason-Cover M, Furey C, Odabachian L, Sanfield A, Chu J, Huestis K, Tata GE, Dugan N, Sheth H, Bewyer K, Anaeme A, Newton K, Featherstone W, Halle-Podell R, Cen L, Landis JR, Propert KJ, Foster HE Jr, Kusek JW, Nyberg LM; Interstitial Cystitis Collaborative Research Network. Randomized multicenter clinical trial of myofascial physical therapy in women with interstitial cystitis/painful bladder syndrome and pelvic floor tenderness. J Urol. 2012;187(6):2113–8.

    Google Scholar 

  16. Vij M, Srikrishna S, Cardozo L. Interstitial cystitis: diagnosis and management. Eur J Obstet Gynecol Reprod Biol. 2012;161(1):1–7.

    Article  PubMed  Google Scholar 

  17. Friedlander JI, Shorter B, Moldwin RM. Diet and its role in interstitial cystitis/bladder pain syndrome (IC/BPS) and comorbid conditions. BJU Int. 2012;109(11):1584–91.

    Article  PubMed  Google Scholar 

  18. Whitmore KE, Theoharides TC. When to suspect interstitial cystitis. J Fam Pract. 2011;60(6):340–8.

    PubMed  Google Scholar 

  19. Hanno PM, Burks DA, Clemens JQ, Dmochowski RR, Erickson D, Fitzgerald MP, Forrest JB, Gordon B, Gray M, Mayer RD, Newman D, Nyberg Jr L, Payne CK, Wesselmann U, Faraday MM, Interstitial Cystitis Guidelines Panel of the American Urological Association Education and Research, Inc. AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome. J Urol. 2011;185(6):2162–70. Epub 2011 Apr 16.

    Article  PubMed  Google Scholar 

  20. Parsons CL. The role of a leaky epithelium and potassium in the generation of bladder symptoms in interstitial cystitis/overactive bladder, urethral syndrome, prostatitis and gynaecological chronic pelvic pain. BJU Int. 2011;107(3):370–5.

    Article  PubMed  Google Scholar 

  21. Foster Jr HE, Hanno PM, Nickel JC, Payne CK, Mayer RD, Burks DA, Yang CC, Chai TC, Kreder KJ, Peters KM, Lukacz ES, FitzGerald MP, Cen L, Landis JR, Propert KJ, Yang W, Kusek JW, Nyberg LM, Interstitial Cystitis Collaborative Research Network. Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. J Urol. 2010;183(5):1853–8.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Shao Y, Shen ZJ, Rui WB, Zhou WL. Intravesical instillation of hyaluronic acid prolonged the effect of bladder hydrodistention in patients with severe interstitial cystitis. Urology. 2010;75(3):547–50.

    Article  PubMed  Google Scholar 

  23. Chung MK, Jarnagin B. Early identification of interstitial cystitis may avoid unnecessary hysterectomy. JSLS. 2009;13(3):350–7.

    PubMed  PubMed Central  Google Scholar 

  24. Hanno PM, Chapple CR, Cardozo LD. Bladder pain syndrome/interstitial cystitis: a sense of urgency. World J Urol. 2009;27(6):717–21.

    Article  PubMed  Google Scholar 

  25. Forrest JB, Moldwin R. Diagnostic options for early identification and management of interstitial cystitis/painful bladder syndrome. Int J Clin Pract. 2008;62(12):1926–34.

    Article  CAS  PubMed  Google Scholar 

  26. Keay S. Cell signaling in interstitial cystitis/painful bladder syndrome. Cell Signal. 2008;20(12):2174–9.

    Article  CAS  PubMed  Google Scholar 

  27. Sairanen J, Hotakainen K, Tammela TL, Stenman UH, Ruutu M. Urinary epidermal growth factor and interleukin-6 levels in patients with painful bladder syndrome/interstitial cystitis treated with cyclosporine or pentosan polysulfate sodium. Urology. 2008;71(4):630–3.

    Article  PubMed  Google Scholar 

  28. Warren JW, Brown J, Tracy JK, Langenberg P, Wesselmann U, Greenberg P. Evidence-based criteria for pain of interstitial cystitis/painful bladder syndrome in women. Urology. 2008;71(3):444–8.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Dimitrakov J, Kroenke K, Steers WD, Berde C, Zurakowski D, Freeman MR, Jackson JL. Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med. 2007;167(18):1922–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. van de Merwe JP. Interstitial cystitis and systemic autoimmune diseases. Nat Clin Pract Urol. 2007;4(9):484–91.

    Article  PubMed  Google Scholar 

  31. Teichman JM, Moldwin R. The role of the bladder surface in interstitial cystitis/painful bladder syndrome. Can J Urol. 2007;14(4):3599–607.

    PubMed  Google Scholar 

  32. Evans RJ, Sant GR. Current diagnosis of interstitial cystitis: an evolving paradigm. Urology. 2007;69(4 Suppl):64–72.

    Article  PubMed  Google Scholar 

  33. Forrest JB, Nickel JC, Moldwin RM. Chronic prostatitis/chronic pelvic pain syndrome and male interstitial cystitis: enigmas and opportunities. Urology. 2007;69(4 Suppl):60–3.

    Article  PubMed  Google Scholar 

  34. Sant GR, Kempuraj D, Marchand JE, Theoharides TC. The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis. Urology. 2007;69(4 Suppl):34–40.

    Article  PubMed  Google Scholar 

  35. Nazif O, Teichman JM, Gebhart GF. Neural upregulation in interstitial cystitis. Urology. 2007;69(4 Suppl):24–33.

    Article  PubMed  Google Scholar 

  36. van Ophoven A, Hertle L. The dual serotonin and noradrenaline reuptake inhibitor duloxetine for the treatment of interstitial cystitis: results of an observational study. J Urol. 2007;177(2):552–5.

    Article  PubMed  Google Scholar 

  37. Bogart LM, Berry SH, Clemens JQ. Symptoms of interstitial cystitis, painful bladder syndrome and similar diseases in women: a systematic review. J Urol. 2007;177(2):450–6.

    Article  PubMed  Google Scholar 

  38. Berry SH, Bogart LM, Pham C, Liu K, Nyberg L, Stoto M, Suttorp M, Clemens JQ. Development, validation and testing of an epidemiological case definition of interstitial cystitis/painful bladder syndrome. J Urol. 2010;183(5):1848–52. Epub 2010 Mar 29.

    Article  PubMed  PubMed Central  Google Scholar 

  39. Theoharides TC, Sant GR. Immunomodulators for treatment of interstitial cystitis. Urology. 2005;65(4):633–8.

    Article  PubMed  Google Scholar 

  40. Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology. 2005;65(1):45–8.

    Article  PubMed  Google Scholar 

  41. Oyama IA, Rejba A, Lukban JC, Fletcher E, Kellogg-Spadt S, Holzberg AS, Whitmore KE. Modified Thiele massage as therapeutic intervention for female patients with interstitial cystitis and high-tone pelvic floor dysfunction. Urology. 2004;64(5):862–5.

    Article  PubMed  Google Scholar 

  42. Ratner V. Interstitial cystitis: a chronic inflammatory bladder condition. World J Urol. 2001;19(3):157–9.

    Article  CAS  PubMed  Google Scholar 

  43. Liebert M. Basic science research on the urinary bladder and interstitial cystitis: new genetic approaches. Urology. 2001;57(6 Suppl 1):7–8.

    Article  CAS  PubMed  Google Scholar 

  44. Van De Merwe JP, Arendsen HJ. Interstitial cystitis: a review of immunological aspects, etiology and pathogenesis, with a hypothesis. BJU Int. 2000;85(8):995–9.

    Article  Google Scholar 

  45. Hunner GL. A rare type of bladder ulcer in women: report of cases. J Boston Med Surg. 1915;172:660–5.

    Article  Google Scholar 

  46. Kim J, Freeman MR. Antiproliferative factor signaling and interstitial cystitis/painful bladder syndrome. Int Neurourol J. 2011;15(4):184–91.

    Article  PubMed  PubMed Central  Google Scholar 

  47. Kim J, Keay SK, Freeman MR. Heparin-binding epidermal growth factor-like growth factor functionally antagonizes interstitial cystitis antiproliferative factor via mitogen-activated protein kinase pathway activation. BJU Int. 2009;103(4):541–6.

    Article  CAS  PubMed  Google Scholar 

  48. Chai TC, Zhang CO, Shoenfelt JL, Johnson Jr HW, Warren JW, Keay S. Bladder stretch alters urinary heparin-binding epidermal growth factor and antiproliferative factor in patients with interstitial cystitis. J Urol. 2000;163(5):1440–4.

    Article  CAS  PubMed  Google Scholar 

  49. Chai TC, Zhang C, Warren JW, Keay S. Percutaneous sacral third nerve root neurostimulation improves symptoms and normalizes urinary HB-EGF levels and antiproliferative activity in patients with interstitial cystitis. Urology. 2000;55(5):643–6.

    Article  CAS  PubMed  Google Scholar 

  50. Keay S, Zhang CO, Hise MK, Hebel JR, Jacobs SC, Gordon DA, Whitmore KE, Bodison S, Warren JW. A diagnostic in vitro urine assay for interstitial cystitis. Urology. 1998;52(6):974–8.

    Article  CAS  PubMed  Google Scholar 

  51. Keay S, Warren JW, Zhang CO, Tu LM, Gordon DA, Whitmore KE. Antiproliferative activity is present in bladder but not renal pelvic urine from interstitial cystitis patients. J Urol. 1999;162(4):1487–9.

    Article  CAS  PubMed  Google Scholar 

  52. Keay S, Kleinberg M, Zhang CO, Hise MK, Warren JW. Bladder epithelial cells from patients with interstitial cystitis produce an inhibitor of heparin-binding epidermal growth factor-like growth factor production. J Urol. 2000;164(6):2112–8.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to David A. Gordon M.D., FACS .

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Gordon, D.A., Pendli, H. (2017). Interstitial Cystitis: The Painful Bladder Syndrome. In: Gordon, D., Katlic, M. (eds) Pelvic Floor Dysfunction and Pelvic Surgery in the Elderly. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-6554-0_15

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  • DOI: https://doi.org/10.1007/978-1-4939-6554-0_15

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