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Lessons from the Murine Models of West Nile Virus Infection

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Book cover West Nile Virus

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1435))

Abstract

West Nile virus (WNV), a mosquito-borne, single positive-stranded RNA virus, has been the leading cause of arboviral encephalitis in the U.S. and other parts of the world over the past decade. Up to 50 % of WNV convalescent patients were reported to have long-term neurological sequelae or chronic kidney diseases. However, there are neither antiviral drugs nor vaccines available for humans. The underlying mechanism of the long-term sequelae is not clearly understood either. Animal models have been an effective tool to investigate viral pathogenesis and host immunity in humans. Here, we will review several commonly used murine models of WNV infection.

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Acknowledgements

This work was supported by NIH grants R01 AI072060 and R01 AI099123 (to T.W.).

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Authors and Affiliations

  1. Department of Microbiology & Immunology, University of Texas Medical Branch, Keiller 3.118B, Galveston, TX, 77555-0609, USA

    Brenna McGruder & Tian Wang

  2. Department of Immunology, National AIDS Research Institute, Pune, MH, 411026, India

    Vandana Saxena

  3. Department of Pathology, University of Texas Medical Branch, Galveston, TX, 77555, USA

    Tian Wang

  4. Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX, 77555, USA

    Tian Wang

Authors
  1. Brenna McGruder
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  2. Vandana Saxena
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  3. Tian Wang
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Corresponding author

Correspondence to Tian Wang .

Editor information

Editors and Affiliations

  1. Dept. of Path., MicroBio., and Immun., Univ. of South Carolina School of Med., Columbia, South Carolina, USA

    Tonya M. Colpitts

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McGruder, B., Saxena, V., Wang, T. (2016). Lessons from the Murine Models of West Nile Virus Infection. In: Colpitts, T. (eds) West Nile Virus. Methods in Molecular Biology, vol 1435. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3670-0_6

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  • DOI: https://doi.org/10.1007/978-1-4939-3670-0_6

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3668-7

  • Online ISBN: 978-1-4939-3670-0

  • eBook Packages: Springer Protocols

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