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Pediatric Cochlear Implantation pp 123–142Cite as

The Role of Electrophysiological Testing in Pediatric Cochlear Implantation

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Abstract

When cochlear implants (CIs) were first made available to children, clinicians often cautioned families and caregivers that the implant may or may not provide access to sound. This counseling was based upon uncertainty about each child’s potential to hear with the device. It often took several months of watching and waiting and adjustments to CI stimulation levels before a behavioral test confirmed sound detection. Today, a surgeon and implant team can leave the operating room knowing that the new CI functions and stimulates a response from the auditory nerve, as it is designed to do, by including an electrophysiological measure of auditory activity into the surgical procedure. Knowledge of stimulation levels obtained in the operating room may then be used at device activation to guide programming of stimulation levels needed to obtain a behavioral response.

Electrophysiological measures have provided an important addition to the battery of tests used to manage children with CIs. As will be discussed here, it is best to use these tests in a battery including behavioral measures in much the same way as similar electrophysiological measures are used with behavioral tests to diagnose and characterize hearing loss. The initial electrophysiological test of auditory activity evoked by the newly implanted device in the operating room provides answers to many urgent questions: (1) Does the implant work?; (2) does the auditory system respond to the electrical pulses?; and (3) what stimulation levels are required for hearing?. As the child uses his/her device over time, these questions may repeatedly arise. Additional questions may also emerge including: (1) Does the CI evoke unwanted effects such as nonauditory or other abnormal responses?; (2) is the auditory system developing as expected with the CI?; (3) are bilateral CIs providing accurate binaural cues? Electrophysiological measures can help answer these questions.

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References

  • Abbas PJ, Brown CJ, Shallop JK, Firszt JB, Hughes ML, Hong SH, et al. Summary of results using the nucleus CI24M implant to record the electrically evoked compound action potential. Ear Hear. 1999;20(1):45–59.

    Article  CAS  PubMed  Google Scholar 

  • Akhoun I, McKay CM, El-Deredy W. Electrically evoked compound action potential artifact rejection by independent component analysis: technique validation. Hear Res. 2013;302:60–73.

    Article  PubMed  PubMed Central  Google Scholar 

  • Arenberg Bierer J. Probing the electrode-neuron interface with focused cochlear implant stimulation. Trends Amplif. 2010;14(2):84–95.

    Google Scholar 

  • Bahmer A, Peter O, Baumann U. Recording and analysis of electrically evoked compound action potentials (ECAPs) with MED-EL cochlear implants and different artifact reduction strategies in Matlab. J Neurosci Methods. 2010;191(1):66–74.

    Article  PubMed  Google Scholar 

  • Brown CJ. Clinical uses of electrically evoked auditory nerve and brainstem responses. Curr Opin Otolaryngol Head Neck Surg. 2003;11(5):383–7.

    Article  PubMed  Google Scholar 

  • Brown CJ, Abbas PJ. Electrically evoked whole-nerve action potentials: parametric data from the cat. J Acoust Soc Am. 1990;88(5):2205–10.

    Article  CAS  PubMed  Google Scholar 

  • Brown CJ, Hughes ML, Luk B, Abbas PJ, Wolaver A, Gervais J. The relationship between EAP and EABR thresholds and levels used to program the nucleus 24 speech processor: data from adults. Ear Hear. 2000;21(2):151–63.

    Article  CAS  PubMed  Google Scholar 

  • Campbell JD, Cardon G, Sharma A. Clinical application of the P1 cortical auditory evoked potential biomarker in children with sensorineural hearing loss and auditory neuropathy spectrum disorder. Semin Hear. 2011;32(2):147–55.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cuda D, Murri A, Succo G. Focused tight dressing does not prevent cochlear implant magnet migration under 1.5 Tesla MRI. Acta Otorhinolaryngol Ital. 2013;33(2):133–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cushing SL, Papsin BC, Gordon KA. Incidence and characteristics of facial nerve stimulation in children with cochlear implants. Laryngoscope. 2006;116(10):1787–91.

    Article  PubMed  Google Scholar 

  • Cushing SL, Papsin BC, Strantzas S, Gordon KA. Facial nerve electromyography: a useful tool in detecting nonauditory side effects of cochlear implantation. J Otolaryngol Head Neck Surg. 2009;38(2):157–65.

    PubMed  Google Scholar 

  • Davids T, Valero J, Papsin BC, Harrison RV, Gordon KA. Effects of stimulus manipulation on electrophysiological responses in pediatric cochlear implant users. Part I: duration effects. Hear Res. 2008a;244(1–2):7–14.

    Article  PubMed  Google Scholar 

  • Davids T, Valero J, Papsin BC, Harrison RV, Gordon KA. Effects of stimulus manipulation on electrophysiological responses of pediatric cochlear implant users. Part II: rate effects. Hear Res. 2008b;244(1–2):15–24.

    Article  PubMed  Google Scholar 

  • Debener S, Hine J, Bleeck S, Eyles J. Source localization of auditory evoked potentials after cochlear implantation. Psychophysiology. 2008;45(1):20–4.

    PubMed  Google Scholar 

  • Dinces E, Chobot-Rhodd J, Sussman E. Behavioral and electrophysiological measures of auditory change detection in children following late cochlear implantation: a preliminary study. Int J Pediatr Otorhinolaryngol. 2009;73(6):843–51.

    Article  PubMed  PubMed Central  Google Scholar 

  • Finney EM, Fine I, Dobkins KR. Visual stimuli activate auditory cortex in the deaf. Nat Neurosci. 2001;4(12):1171–3.

    Article  CAS  PubMed  Google Scholar 

  • Friesen LM, Picton TW. A method for removing cochlear implant artifact. Hear Res. 2010;259(1–2):95–106.

    Article  PubMed  Google Scholar 

  • Gilley PM, Sharma A, Dorman M, Finley CC, Panch AS, Martin K. Minimization of cochlear implant stimulus artifact in cortical auditory evoked potentials. Clin Neurophysiol. 2006;117(8):1772–82.

    Article  PubMed  Google Scholar 

  • Gilley PM, Sharma A, Dorman MF. Cortical reorganization in children with cochlear implants. Brain Res. 2008;1239:56–65.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Goldwyn JH, Bierer SM, Bierer JA. Modeling the electrode-neuron interface of cochlear implants: effects of neural survival, electrode placement, and the partial tripolar configuration. Hear Res. 2010;268(1–2):93–104.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gordin A, Papsin B, Gordon K. Packing of the cochleostomy site affects auditory nerve response thresholds in precurved off-stylet cochlear implants. Otol Neurotol. 2010;31(2):204–9.

    Article  PubMed  Google Scholar 

  • Gordin A, Papsin B, James A, Gordon K. Evolution of cochlear implant arrays result in changes in behavioral and physiological responses in children. Otol Neurotol. 2009;30(7):908–15.

    Article  PubMed  Google Scholar 

  • Gordon KA, Chaikof MH, Salloum C, Goulding G, Papsin B. Toward a method for programming balanced bilateral cochlear implant stimulation levels in children. Cochlear Implants Int. 2012a;13(4):220–7.

    Article  PubMed  Google Scholar 

  • Gordon KA, Jiwani S, Papsin BC. Benefits and detriments of unilateral cochlear implant use on bilateral auditory development in children who are deaf. Front Psychol. 2013a;4:719.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gordon KA, Papsin BC. From nucleus 24 to 513: changing cochlear implant design affects auditory response thresholds. Otol Neurotol. 2013;34(3):436–42.

    Article  PubMed  Google Scholar 

  • Gordon KA, Papsin BC, Harrison RV. Activity-dependent developmental plasticity of the auditory brain stem in children who use cochlear implants. Ear Hear. 2003;24(6):485–500.

    Article  PubMed  Google Scholar 

  • Gordon KA, Papsin BC, Harrison RV. Toward a battery of behavioral and objective measures to achieve optimal cochlear implant stimulation levels in children. Ear Hear. 2004;25(5):447–63.

    Article  PubMed  Google Scholar 

  • Gordon KA, Papsin BC, Harrison RV. Effects of cochlear implant use on the electrically evoked middle latency response in children. Hear Res. 2005a;204(1–2):78–89.

    Article  PubMed  Google Scholar 

  • Gordon KA, Papsin BC, Harrison RV. An evoked potential study of the developmental time course of the auditory nerve and brainstem in children using cochlear implants. Audiol Neurootol. 2006;11(1):7–23.

    Article  PubMed  Google Scholar 

  • Gordon KA, Salloum C, Toor GS, van Hoesel R, Papsin BC. Binaural interactions develop in the auditory brainstem of children who are deaf: effects of place and level of bilateral electrical stimulation. J Neurosci. 2012b;32(12):4212–23.

    Article  CAS  PubMed  Google Scholar 

  • Gordon KA, Tanaka S, Papsin BC. Atypical cortical responses underlie poor speech perception in children using cochlear implants. Neuroreport. 2005b;16(18):2041–5.

    Article  PubMed  Google Scholar 

  • Gordon KA, Tanaka S, Wong DD, Papsin BC. Characterizing responses from auditory cortex in young people with several years of cochlear implant experience. Clin Neurophysiol. 2008;119(10):2347–62.

    Article  CAS  PubMed  Google Scholar 

  • Gordon KA, Tanaka S, Wong DD, Stockley T, Ramsden JD, Brown T, et al. Multiple effects of childhood deafness on cortical activity in children receiving bilateral cochlear implants simultaneously. Clin Neurophysiol. 2011a;122(4):823–33.

    Article  CAS  PubMed  Google Scholar 

  • Gordon KA, Valero J, Papsin BC. Auditory brainstem activity in children with 9–30 months of bilateral cochlear implant use. Hear Res. 2007;233(1–2):97–107.

    Article  CAS  PubMed  Google Scholar 

  • Gordon KA, Wong DD, Papsin BC. Cortical function in children receiving bilateral cochlear implants simultaneously or after a period of interimplant delay. Otol Neurotol. 2010;31(8):1293–9.

    Article  PubMed  Google Scholar 

  • Gordon KA, Wong DD, Papsin BC. Bilateral input protects the cortex from unilaterally-driven reorganization in children who are deaf. Brain. 2013b;136(Pt 5):1609–25.

    Article  PubMed  Google Scholar 

  • Gordon KA, Wong DD, Valero J, Jewell SF, Yoo P, Papsin BC. Use it or lose it? Lessons learned from the developing brains of children who are deaf and use cochlear implants to hear. Brain Topogr. 2011b;24(3–4):204–19.

    Article  CAS  PubMed  Google Scholar 

  • Gordon KA, Abbasalipour P, Papsin BC. Balancing current levels in children with bilateral cochlear implants using electrophysiological and behavioral measures, Hear Res. 2016;335:193–206.

    Article  PubMed  Google Scholar 

  • Goupell MJ, Stoelb C, Kan A, Litovsky RY. Effect of mismatched place-of-stimulation on the salience of binaural cues in conditions that simulate bilateral cochlear-implant listening. J Acoust Soc Am. 2013;133(4):2272–87.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gramfort A, Luessi M, Larson E, Engemann DA, Strohmeier D, Brodbeck C, et al. MEG and EEG data analysis with MNE-Python. Front Neurosci. 2013;7:267.

    Article  PubMed  PubMed Central  Google Scholar 

  • Gubbels SP, McMenomey SO. Safety study of the Cochlear Nucleus 24 device with internal magnet in the 1.5 Tesla magnetic resonance imaging scanner. Laryngoscope. 2006;116(6):865–71.

    Article  PubMed  Google Scholar 

  • Harrison RV. An animal model of auditory neuropathy. Ear Hear. 1998;19(5):355–61.

    Article  CAS  PubMed  Google Scholar 

  • Hassepass F, Stabenau V, Maier W, Arndt S, Laszig R, Beck R, et al. Revision surgery due to magnet dislocation in cochlear implant patients: an emerging complication. Otol Neurotol. 2014;35(1):29–34.

    Article  PubMed  Google Scholar 

  • Havenith S, Lammers MJ, Tange RA, Trabalzini F, della Volpe A, van der Heijden GJ, et al. Hearing preservation surgery: cochleostomy or round window approach? A systematic review. Otol Neurotol. 2013;34(4):667–74.

    Article  PubMed  Google Scholar 

  • He S, Grose JH, Teagle HF, Buchman CA. Objective measures of electrode discrimination with electrically evoked auditory change complex and speech-perception abilities in children with auditory neuropathy spectrum disorder. Ear Hear. 2014;35(3):e63–74.

    Article  PubMed  PubMed Central  Google Scholar 

  • He S, Grose JH, Teagle HF, Woodard J, Park LR, Hatch DR, et al. Gap detection measured with electrically evoked auditory event-related potentials and speech-perception abilities in children with auditory neuropathy spectrum disorder. Ear Hear. 2013;34(6):733–44.

    Article  PubMed  Google Scholar 

  • Henkin Y, Kileny PR, Hildesheimer M, Kishon-Rabin L. Phonetic processing in children with cochlear implants: an auditory event-related potentials study. Ear Hear. 2008;29(2):239–49.

    Article  PubMed  Google Scholar 

  • Henkin Y, Kishon-Rabin L, Tatin-Schneider S, Urbach D, Hildesheimer M, Kileny PR. Low-resolution electromagnetic tomography (LORETA) in children with cochlear implants: a preliminary report. Int J Audiol. 2004;43 Suppl 1:S48–51.

    PubMed  Google Scholar 

  • Hofmann M, Wouters J. Electrically evoked auditory steady state responses in cochlear implant users. J Assoc Res Otolaryngol. 2010;11(2):267–82.

    Article  PubMed  Google Scholar 

  • Holden LK, Finley CC, Firszt JB, Holden TA, Brenner C, Potts LG, et al. Factors affecting open-set word recognition in adults with cochlear implants. Ear Hear. 2013;34(3):342–60.

    Article  PubMed  PubMed Central  Google Scholar 

  • Hughes ML, Abbas PJ. Electrophysiologic channel interaction, electrode pitch ranking, and behavioral threshold in straight versus perimodiolar cochlear implant electrode arrays. J Acoust Soc Am. 2006;119(3):1538–47.

    Article  PubMed  Google Scholar 

  • Jeon EK, Brown CJ, Etler CP, O'Brien S, Chiou LK, Abbas PJ. Comparison of electrically evoked compound action potential thresholds and loudness estimates for the stimuli used to program the Advanced Bionics cochlear implant. J Am Acad Audiol. 2010;21(1):16–27.

    Article  PubMed  PubMed Central  Google Scholar 

  • Jeon JH, Bae MR, Song MH, Noh SH, Choi KH, Choi JY. Relationship between electrically evoked auditory brainstem response and auditory performance after cochlear implant in patients with auditory neuropathy spectrum disorder. Otol Neurotol. 2013;34(7):1261–6.

    Article  PubMed  Google Scholar 

  • Jiwani S, Papsin BC, Gordon KA. Central auditory development after long-term cochlear implant use. Clin Neurophysiol. 2013;124(9):1868–80.

    Article  PubMed  Google Scholar 

  • Jiwani S, Papsin BC, Gordon KA. Early unilateral cochlear implantation promotes mature cortical asymmetries in adolescents who are deaf.Hum Brain Mapp 2016:37(1):135–52.

    Google Scholar 

  • Kileny PR, Zwolan TA, Boerst A, Telian SA. Electrically evoked auditory potentials: current clinical applications in children with cochlear implants. Am J Otol. 1997;18(6 Suppl):S90–2.

    CAS  PubMed  Google Scholar 

  • Klop WM, Hartlooper A, Briare JJ, Frijns JH. A new method for dealing with the stimulus artefact in electrically evoked compound action potential measurements. Acta Otolaryngol. 2004;124(2):137–43.

    Article  PubMed  Google Scholar 

  • Kral A, Sharma A. Developmental neuroplasticity after cochlear implantation. Trends Neurosci. 2012;35(2):111–22.

    Article  CAS  PubMed  Google Scholar 

  • Kraus N, Micco AG, Koch DB, McGee T, Carrell T, Sharma A, et al. The mismatch negativity cortical evoked potential elicited by speech in cochlear-implant users. Hear Res. 1993;65(1–2):118–24.

    Article  CAS  PubMed  Google Scholar 

  • Kraus N, Skoe E, Parbery-Clark A, Ashley R. Experience-induced malleability in neural encoding of pitch, timbre, and timing. Ann N Y Acad Sci. 2009;1169:543–57.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lee DS, Lee JS, Oh SH, Kim S-K, Kim J-W, Chung J-K, et al. Deafness: cross-modal plasticity and cochlear implants. Nature. 2001;409(6817):149–50.

    Article  CAS  PubMed  Google Scholar 

  • Lee HJ, Giraud AL, Kang E, Oh SH, Kang H, Kim CS, et al. Cortical activity at rest predicts cochlear implantation outcome. Cereb Cortex. 2007;17(4):909–17.

    Article  PubMed  Google Scholar 

  • Lomber SG, Meredith MA, Kral A. Cross-modal plasticity in specific auditory cortices underlies visual compensations in the deaf. Nat Neurosci. 2010;13(11):1421–7.

    Article  CAS  PubMed  Google Scholar 

  • Long CJ, Holden TA, McClelland GH, Parkinson WS, Shelton C, Kelsall DC, et al. Examining the electro-neural interface of cochlear implant users using psychophysics, CT scans, and speech understanding. J Assoc Res Otolaryngol. 2014;15(2):293–304.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lopez-Valdes A, McLaughlin M, Viani L, Walshe P, Smith J, Zeng FG, et al. Auditory mismatch negativity in cochlear implant users: a window to spectral discrimination. Conf Proc IEEE Eng Med Biol Soc. 2013;2013:3555–8.

    PubMed  Google Scholar 

  • Majdani O, Leinung M, Rau T, Akbarian A, Zimmerling M, Lenarz M, et al. Demagnetization of cochlear implants and temperature changes in 3.0T MRI environment. Otolaryngol Head Neck Surg. 2008;139(6):833–9.

    Article  PubMed  Google Scholar 

  • Majdani O, Rau TS, Gotz F, Zimmerling M, Lenarz M, Lenarz T, et al. Artifacts caused by cochlear implants with non-removable magnets in 3T MRI: phantom and cadaveric studies. Eur Arch Otorhinolaryngol. 2009;266(12):1885–90.

    Article  PubMed  Google Scholar 

  • Mc Laughlin M, Lopez Valdes A, Reilly RB, Zeng FG. Cochlear implant artifact attenuation in late auditory evoked potentials: a single channel approach. Hear Res. 2013;302:84–95.

    Article  PubMed  Google Scholar 

  • McMahon CM, Patuzzi RB, Gibson WP, Sanli H. Frequency-specific electrocochleography indicates that presynaptic and postsynaptic mechanisms of auditory neuropathy exist. Ear Hear. 2008;29(3):314–25.

    Article  PubMed  Google Scholar 

  • Michalewski HJ, Starr A, Zeng FG, Dimitrijevic A. N100 cortical potentials accompanying disrupted auditory nerve activity in auditory neuropathy (AN): effects of signal intensity and continuous noise. Clin Neurophysiol. 2009;120(7):1352–63.

    Article  PubMed  PubMed Central  Google Scholar 

  • Migirov L, Wolf M. Magnet removal and reinsertion in a cochlear implant recipient undergoing brain MRI. ORL J Otorhinolaryngol Relat Spec. 2013;75(1):1–5.

    Article  PubMed  Google Scholar 

  • Miller CA, Abbas PJ, Brown CJ. An improved method of reducing stimulus artifact in the electrically evoked whole-nerve potential. Ear Hear. 2000;21(4):280–90.

    Article  CAS  PubMed  Google Scholar 

  • Moser T, Predoehl F, Starr A. Review of hair cell synapse defects in sensorineural hearing impairment. Otol Neurotol. 2013;34(6):995–1004.

    Article  PubMed  Google Scholar 

  • Mosher JC, Leahy RM, Lewis PS. EEG and MEG: forward solutions for inverse methods. IEEE Trans Biomed Eng. 1999;46(3):245–59.

    Article  CAS  PubMed  Google Scholar 

  • Nash-Kille A, Sharma A. Inter-trial coherence as a marker of cortical phase synchrony in children with sensorineural hearing loss and auditory neuropathy spectrum disorder fitted with hearing aids and cochlear implants. Clin Neurophysiol. 2014;125(7):1459–70.

    Article  PubMed  Google Scholar 

  • Pascual-Marqui RD, Michel CM, Lehmann D. Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. Int J Psychophysiol. 1994;18(1):49–65.

    Article  CAS  PubMed  Google Scholar 

  • Picton T. Human auditory evoked potentials. San Diego: Plural Publishing; 2010.

    Google Scholar 

  • Picton TW, John MS, Dimitrijevic A, Purcell D. Human auditory steady-state responses. Int J Audiol. 2003;42(4):177–219.

    Article  PubMed  Google Scholar 

  • Ponton CW. Critical periods for human cortical development: an ERP study in children with cochlear implant. In: Lomber SG, Eggermont JJ, editors. Reprogramming the cerebral cortex: plasticity following central and peripheral lesions. Oxford, Great Britian: Oxford University Press; 2006. p. 213–28.

    Chapter  Google Scholar 

  • Ponton CW, Don M. The mismatch negativity in cochlear implant users. Ear Hear. 1995;16(1):131–46.

    Article  CAS  PubMed  Google Scholar 

  • Ponton CW, Don M, Eggermont JJ, Waring MD, Masuda A. Maturation of human cortical auditory function: differences between normal-hearing children and children with cochlear implants. Ear Hear. 1996a;17(5):430–7.

    Article  CAS  PubMed  Google Scholar 

  • Ponton CW, Don M, Waring MD, Masuda A. Evoked responses to electric and acoustic stimulation of the human auditory system. In: Ogura C, Koga Y, Shimokochi M, editors. Recent advances in event-related brain potential research. Amsterdam: Elsevier Science B. V; 1996b. p. 490–5.

    Google Scholar 

  • Ponton CW, Eggermont JJ. Of kittens and kids: altered cortical maturation following profound deafness and cochlear implant use. Audiol Neurootol. 2001;6(6):363–80.

    Article  CAS  PubMed  Google Scholar 

  • Ponton CW, Eggermont JJ, Don M, Waring MD, Kwong B, Cunningham J, et al. Maturation of the mismatch negativity: effects of profound deafness and cochlear implant use. Audiol Neurootol. 2000;5(3–4):167–85.

    Article  CAS  PubMed  Google Scholar 

  • Propst EJ, Papsin BC, Stockley TL, Harrison RV, Gordon KA. Auditory responses in cochlear implant users with and without GJB2 deafness. Laryngoscope. 2006;116(2):317–27.

    Article  PubMed  Google Scholar 

  • Rance G, Barker EJ. Speech perception in children with auditory neuropathy/dyssynchrony managed with either hearing AIDS or cochlear implants. Otol Neurotol. 2008;29(2):179–82.

    Article  PubMed  Google Scholar 

  • Rance G, Cone-Wesson B, Wunderlich J, Dowell R. Speech perception and cortical event related potentials in children with auditory neuropathy. Ear Hear. 2002;23(3):239–53.

    Article  PubMed  Google Scholar 

  • Roth BJ, Balish M, Gorbach A, Sato S. How well does a three-sphere model predict positions of dipoles in a realistically shaped head? Electroencephalogr Clin Neurophysiol. 1993;87(4):175–84.

    Article  CAS  PubMed  Google Scholar 

  • Salloum CA, Valero J, Wong DD, Papsin BC, van Hoesel R, Gordon KA. Lateralization of interimplant timing and level differences in children who use bilateral cochlear implants. Ear Hear. 2010;31(4):441–56.

    Article  PubMed  Google Scholar 

  • Sandmann P, Kegel A, Eichele T, Dillier N, Lai W, Bendixen A, et al. Neurophysiological evidence of impaired musical sound perception in cochlear-implant users. Clin Neurophysiol. 2010;121(12):2070–82.

    Article  PubMed  Google Scholar 

  • Scherg M, Picton TW. Separation and identification of event-related potential components by brain electric source analysis. Electroencephalogr Clin Neurophysiol Suppl. 1991;42:24–37.

    CAS  PubMed  Google Scholar 

  • Shallop JK. Objective electrophysiological measures from cochlear implant patients. Ear Hear. 1993;14(1):58–63.

    Article  CAS  PubMed  Google Scholar 

  • Sharma A, Cardon G, Henion K, Roland P. Cortical maturation and behavioral outcomes in children with auditory neuropathy spectrum disorder. Int J Audiol. 2011;50(2):98–106.

    Article  PubMed  PubMed Central  Google Scholar 

  • Sharma A, Dorman M, Spahr AJ. A sensitive period for the development of the central auditory system in children with cochlear implants: implications for age of implantation. Ear Hear. 2002;23(6):532–9.

    Article  PubMed  Google Scholar 

  • Sharma A, Dorman MF, Kral A. The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants. Hear Res. 2005;203(1–2):134–43.

    Article  PubMed  Google Scholar 

  • Sparreboom M, Beynon AJ, Snik AF, Mylanus EA. Auditory cortical maturation in children with sequential bilateral cochlear implants. Otol Neurotol. 2014;35(1):35–42.

    Article  PubMed  Google Scholar 

  • Steel MM, Abbasalipour P, Salloum CA, Hasek D, Papsin BC, Gordon KA. Unilateral cochlear implant promotes normal-like loudness perception in adolescents with childhood deafness. Ear Hear. 2014;35(6):e291–301.

    Article  PubMed  Google Scholar 

  • Timm L, Vuust P, Brattico E, Agrawal D, Debener S, Buchner A, et al. Residual neural processing of musical sound features in adult cochlear implant users. Front Hum Neurosci. 2014;8:181.

    Article  PubMed  PubMed Central  Google Scholar 

  • Valero J, Blaser S, Papsin BC, James AL, Gordon KA. Electrophysiologic and behavioral outcomes of cochlear implantation in children with auditory nerve hypoplasia. Ear Hear. 2012;33(1):3–18.

    Article  PubMed  Google Scholar 

  • van den Honert C, Stypulkowski PH. Characterization of the electrically evoked auditory brainstem response (ABR) in cats and humans. Hear Res. 1986;21(2):109–26.

    Article  PubMed  Google Scholar 

  • Viola FC, De Vos M, Hine J, Sandmann P, Bleeck S, Eyles J, et al. Semi-automatic attenuation of cochlear implant artifacts for the evaluation of late auditory evoked potentials. Hear Res. 2012;284(1–2):6–15.

    Article  PubMed  Google Scholar 

  • Wable J, van den Abbeele T, Gallego S, Frachet B. Mismatch negativity: a tool for the assessment of stimuli discrimination in cochlear implant subjects. Clin Neurophysiol. 2000;111(4):743–51.

    Article  CAS  PubMed  Google Scholar 

  • Wong DD, Gordon KA. Beamformer suppression of cochlear implant artifacts in an electroencephalography dataset. IEEE Trans Biomed Eng. 2009;56(12):2851–7.

    Article  PubMed  Google Scholar 

  • Zeng FG, Kong YY, Michalewski HJ, Starr A. Perceptual consequences of disrupted auditory nerve activity. J Neurophysiol. 2005;93(6):3050–63.

    Article  PubMed  Google Scholar 

  • Zhu Z, Tang Q, Zeng FG, Guan T, Ye D. Cochlear-implant spatial selectivity with monopolar, bipolar and tripolar stimulation. Hear Res. 2012;283(1–2):45–58.

    Article  PubMed  Google Scholar 

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Acknowledgments

This chapter contains data collected in Archie’s Cochlear Implant Laboratory (www.sickkids.ca/Research/archies_cochlear_implant_lab) which is supported by our Cochlear Implant Team including the many children and families we follow in our program. A special thank you goes to Salima Jiwani, Melissa Polonenko, Vijayalakshmi Easwar, and Stephanie Jewell for their contributions to the figures and for reviewing the text and to Editors Drs. Young and Kirk for their helpful edits and suggestions.

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Authors and Affiliations

  1. Archie’s Cochlear Implant Laboratory, The Hospital for Sick Children, Room 6D08, 555 University Avenue, Toronto, ON, Canada, M5G 1X8

    Karen A. Gordon Ph.D., C.C.C.-A.

  2. Department of Otolaryngology—Head & Neck Surgery, University of Toronto, Toronto, ON, Canada

    Karen A. Gordon Ph.D., C.C.C.-A.

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  1. Karen A. Gordon Ph.D., C.C.C.-A.
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Correspondence to Karen A. Gordon Ph.D., C.C.C.-A. .

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Editors and Affiliations

  1. Section of Otology/Neurotology, Ann & Robert H Lurie Children’s Hospital Section of Otology/Neurotology, CHICAGO, Illinois, USA

    Nancy M Young

  2. Department of Speech and Hearing Science, Univ. of Illinois at Urbana-Champaign Department of Speech and Hearing Science, Champaign, Illinois, USA

    Karen Iler Kirk

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Gordon, K.A. (2016). The Role of Electrophysiological Testing in Pediatric Cochlear Implantation. In: Young, N., Iler Kirk, K. (eds) Pediatric Cochlear Implantation. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2788-3_8

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  • DOI: https://doi.org/10.1007/978-1-4939-2788-3_8

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4939-2787-6

  • Online ISBN: 978-1-4939-2788-3

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