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Primary Aldosteronism

Molecular Genetics, Endocrinology, and Translational Medicine

  • Book
  • © 2014

Overview

Editors:
  1. Per Hellman

    1. Department of Surgery, University Hospital, Uppsala, Sweden

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  • Presents Primary Aldosteronism (PA) from pathophysiology to quality of life aspects, covering genetics, diagnostics, different treatments in a truly translational manner

  • Discusses what is needed for the development of care of individuals with PA

  • Explores recent developments in understanding the genetics behind sporadic PA that may lead to novel methods to diagnose the disease in the future

  • Includes supplementary material: sn.pub/extras

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xi
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  2. Primary Aldosteronism: Molecular Mechanisms and Diagnosis

    • Gian Paolo Rossi, Livia Lenzini
    Pages 1-20

  3. Epidemiology and the Need for Screening

    • Richard Douglas Gordon
    Pages 21-38

  4. Low-Renin Hypertension

    • Per Hellman, Emil Hagström
    Pages 39-44

  5. Molecular Derangements in Sporadic Primary Aldosteronism

    • Per Hellman, Tobias Ã…kerström, Peyman Björklund
    Pages 45-52

  6. From Genetic Abnormalities to Pathophysiological Mechanisms

    • Maria-Christina Zennaro, Sheerazed Boulkroun
    Pages 53-74

  7. Familial Hyperaldosteronism Type I

    • Paolo Mulatero, Silvia Monticone, Franco Veglio, Tracy Ann Williams
    Pages 75-86

  8. Familial Hyperaldosteronism Type II

    • Michael Stowasser, Richard Douglas Gordon
    Pages 87-97

  9. Familial Hyperaldosteronism Type III

    • Tracy Ann Williams, Silvia Monticone, Franco Veglio, Paolo Mulatero
    Pages 99-108

  10. The Aldosterone–Renin Ratio: Role and Problems

    • Michael Stowasser, Richard Douglas Gordon
    Pages 109-126

  11. Confirmatory Testing for Primary Aldosteronism

    • Matthias Haase, Matthias Gruber, Xing Gao, Oliver Vonend, Holger S. Willenberg
    Pages 127-140

  12. Radiological and Radionuclide Imaging of Adrenocortical Tumours

    • Anders Sundin
    Pages 141-154

  13. Aldosterone and Cardiovascular Diseases

    • Andreas Tomasschitz, Stefan Pilz
    Pages 155-196

  14. Quality-of-Life Aspects of Primary Aldosteronism

    • Michael Stowasser, Ashraf H. Ahmed
    Pages 197-207

  15. Medical Treatment of Primary Aldosteronism

    • Yoshiyu Takeda, Masashi Demura, Takashi Yoneda
    Pages 209-214

  16. Surgical Treatment of Unilateral Excessive Aldosterone Production

    • Peter StÃ¥lberg, Per Hellman
    Pages 215-223

  17. Back Matter

    Pages 225-233
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Keywords

About this book

Primary Aldosteronism (PA) is a disease caused by the overproduction of aldosterone hormone from the adrenal glands. PA causes hypertension and the majority with this disease are undiagnosed for PA. There are new insights into this matter by using biochemistry as well as advanced radiology. In 2011, a breakthrough in the genetic derangements came, identifying a mutated potassium channel gene – KCNJ5 – in about 40% of PA with adenoma. Chapters in this book include a history of the disorder, epidemiology, genetics derangements, the KCNJ5 mutations and phenotype and more.

Editors and Affiliations

  • Department of Surgery, University Hospital, Uppsala, Sweden

    Per Hellman

Bibliographic Information

  • Book Title: Primary Aldosteronism

  • Book Subtitle: Molecular Genetics, Endocrinology, and Translational Medicine

  • Editors: Per Hellman

  • DOI: https://doi.org/10.1007/978-1-4939-0509-6

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2014

  • Hardcover ISBN: 978-1-4939-0508-9Published: 29 March 2014

  • Softcover ISBN: 978-1-4939-4622-8Published: 23 August 2016

  • eBook ISBN: 978-1-4939-0509-6Published: 28 March 2014

  • Edition Number: 1

  • Number of Pages: XI, 233

  • Number of Illustrations: 8 b/w illustrations, 17 illustrations in colour

  • Topics: Human Genetics, Endocrinology, Biomedicine general

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