Abstract
Legionellosis is an acute human infection commonly manifested as pneumonia and caused by any of several species of Legionella, including L. pneumophila, (11) L. bozemanii, (10) L. micdadei, (50) L. dumoffii, (10) L. gormanii, (69) L. longbeachae (65) and L. jordanis, (19) all of which are fastidious gram-negative bacilli. Occurring in clusters and sporadically, the long-incubation-period pneumonic form (Legionnaires’ disease) is frequently mistaken for“viral pneumonia,” which may be a serious error, because specific therapy may prevent death. Nonpneumonic, short-incubationperiod legionellosis (Pontiac fever) may also occur in clusters, but this syndrome appears to be selflimited.
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References
Anderson, R. D., Lauer, B. A., Fraser, D. W., Hayes, P. S., and Mcintosh, K., Infections with Legionella pneumophila in children, J. Infect. Dis. 143:386–390 (1981).
Baine, W. B., and Rasheed, J. K., Aromatic substrate specificity of browning by cultures of the Legionnaires’ disease bacterium, Ann. Intern. Med. 90:619–620 (1979).
Baine, W. B., Rasheed, J. K., Feeley, J. C., Gorman, G. W., and Casida, L. E., Jr., Effect of supplemental L-tyrosine on pigment production in cultures of Legionnaires’ disease bacterium, Curr. Microbiol. 1:93–94 (1978).
Band, J. B., Laventure, M., Davis, J. P., Mallison, G. F., Skaliy, P., Hayes, P. S., Schell, W. L., Weiss, I., Greenberg, D. J., and Fraser, D. W., Epidemic Legionnaires’ disease: Airborne transmission down a chimney, J. Am. med. Assoc. 245:2404–2407 (1981).
Beaty, H. N., Miller, A. A., Broome, C. V., Goings, S. A. J., and Phillips, C. A., Legionnaires’ disease in Vermont, May to October 1977, J. Am. Med. Assoc. 240:127–131 (1978).
Berdal, B. P., Farshy, C. E., and Feeley, J. C., Detection of Legionella pneumophila antigen in urine by enzyme-linked immunospecific assay, J. Clin. Microbiol. 9:575–578 (1979).
Blackmon, J. A., Hicklin, M. D., Chandler, R. W., and The Special Expert Pathology Panel, Legionnaires’ disease: Pathological and historical aspects of a“new” disease, Arch. Pathol. Lab. Med. 102:337–343 (1978).
Bock, B. V., Kirby, B. D., Edelstein, P. H., George, W. L., Snyder, K. M., Owens, M. L., Hatayama, C.M., Haley, C. E., Lewis, R. P., Meyer, R. D., and Finegold, S. M., Legionnaires’ disease in renal-transplant recipients, Lancet 1:410–413 (1978).
Bozeman, F. M., Humphries, J. W., and Campbell, J. M., A new group of rickettsia-like agents recovered from guinea pigs, Acta Virol. 12:87–93 (1968).
Brenner, D. J., Steigerwalt, A. G., Gorman, G. W., Weaver, R. E., Feeley, J. C., Cordes, L. G., Wilkinson, H. W., Patton, C., Thomason, B. M., and Sasseville, K. R. L.: Legionella bozemanii sp. nov. and Legionella dumoffii sp. nov.: Classification of two additional species of Legionella associated with human pneumonia, Curr. Microbiol. 4:111–116 (1980).
Brenner, D. J., Steigerwalt, A. G., and Mcdade, J. E., Classification of the Legionnaires’ disease bacterium: Legionella pneumophila, genus novum, species nova, of the family Legionellaceae, familia nova, Ann. Intern . Med. 90:656–658 (1979).
Broome, C. V., Cherry, W. B., Winn, W. C., Jr., and Macpherson, B. R., Rapid diagnosis of Legionnaires’ disease by direct immunofluorescent staining, Ann. Intern. Med. 90:1–4 (1979).
Broome, C. V., Goings, S. A. J., Thacker, S. B., Vogt, R. L., Beaty, H. N., Fraser, D. W., and Field Investigation Team, The Vermont epidemic of Legionnaires’ disease, Ann. Intern. Med. 90:573–577 (1979).
Centers for Disease Control, Legionnaires’ disease New York, Tennessee, Morbid. Mortal. Weekly Rep. 27:352–353 (1978).
Centers for Disease Control, Convention-associated Legionnaires’ disease, Morbid. Mortal. Weekly Rep. 27:387–388 (1978).
Centers for Disease Control, Preliminary studies on environmental decontamination of Legionella pneumophila, Morbid. Mortal. Weekly Rep. 28:286–287 (1979).
Chandler, F. W., Cole, R. M., Hicklin, M. D., Blackmon, J. A., and Callaway, C. S., Ultrastructure of the Legionnaires’ disease bacterium: A study using transmission electron microscopy, Ann. Intern. Med. 90:642–647 (1979).
Chandler, F. W., Hicklin, M. D., and Blackmon, J. A., Demonstration of the agent of Legionnaires’ disease in tissue, N. Engl. J. Med. 297:1218–1220 (1977).
Cherry, W. B., Gorman, G. W., Orrison, L. W., Moss, C. W., Steigerwalt, A. G., Wilkinson, H. W., Johnson, S. E., Mckinney, R. M., and Brenner, D. J., Legionella jordanis: A new species of Legionella isolated from water and sewage, J. Clin. Microbiol. 15:290–297 (1982).
Cherry, W. B., Pittman, B., Harris, P. P., Hebert, G. A., Thomason, B. M., Thacker, L., and Weaver, R. E., Detection of Legionnaires’ disease bacteria by direct immunofluorescent staining, J. Clin. Microbiol. 8:329–338 (1978).
Cohen, M. L., Unpublished data.
Cohen, M. L., Broome, C. V., Paris, A., Martin, W. T., and Allen, J. R., Fatal nosocomial Legionnaires’ disease: Clinical and epidemiologic characteristics, Ann. Intern. Med. 90:611–613 (1979).
Cordes, L. G., Fraser, D. W., Skaliy, P., Perlino, C. A., Elsea, W. R., and Mallison, G. F., Legionnaires’ disease outbreak at an Atlanta country club: Evidence for spread from an evaporative condenser, Am. J. Epidemiol. 111:425–431 (1980).
Cordes, L. G., Wiesenthal, A. M., Gorman, G. W., Phair, J. P., Sommers, H. M., Brown, A., Yu, V. L., Magnussen, M. H., Meyer, R. D., Wolf, J. S., Shands, K. N., and Fraser, D. W., Isolation of Legionella pneumophila from hospital shower heads, Ann. Intern. Med. 94:195–197 (1981).
Cordes, L. G., Wilkinson, H. W., Gorman, G. W., Fikes, B. J., and Fraser, D. W., Atypical Legionellalike organisms: Fastidious water-associated bacteria pathogenic for man, Lancet 2:927–930 (1979).
Deubner, D. C., and Gilliam, D. K., Fever of undetermined origin after cleaning of steam turbine condensers, Arch. Environ. Health 32:116–120 (1977).
Dondero, T. J., Jr., Clegg, H. W., II, Tsai, T. F., Weeks, R. M., Duncan, E., Strickler, J., Chapman, C., Mallison, G. F., Politi, B. D., Potter, M. E., and Schaffner, W., Legionnaires’ disease in Kingsport, Tennessee, Ann. Intern. Med. 90:569–573 (1979).
Dondero, T. J., Jr., Rendtorff, R. C., Mallison, G. F., Weeks, M., Levy, J., Wong, E. W., and Schaffner, W., Outbreak of Legionnaires’ disease associated with a contaminated air conditioning cooling tower, N. Engl. J. Med. 302:425–431 (1980).
Edelstein, P. H., Meyer, R. D., and Finegold, S. M., Isolation of Legionella pneumophila from blood, Lancet 1:750–751 (1979).
Edelstein, P. H., Meyer, R. D., and Finegold, S. M., Laboratory diagnosis of Legionnaires’ disease, Am. Rev. Respir. Dis. 121:317–327 (1980).
Edson, D. C., Stiefel, H. E., Wentworth, B. B., and Wilson, D. L., Prevalence of antibodies to Legionnaires’ disease: A seroepidemiologic survey of Michigan residents using the hemagglutination test, Ann. Intern. Med. 90:691–693 (1979).
England, A. C., III, Fraser, D. W., Plikaytis, B. D., Tsai, T. F., Storch, G., and Broome, C. V., Sporadic legionellosis in the United States: The first thousand cases, Ann. Intern. Med. 94:164–170 (1981).
Farshy, C. E., Klein, G. C., and Feeley, J. C., Detection of antibodies to Legionnaires disease organism by microagglutination and micro-enzyme-linked immunosorbent assay tests, J. Clin. Microbiol. 7:327–331 (1978).
Feeley, J. C., Gibson, R. J., Gorman, G. W., Langford, N. C., Rasheed, J. K., Mackel, D. C., and Baine, W. B., Charcoal yeast extract agar: A primary isolation medium for Legionella pneumophila, J. Clin. Microbiol. 10:437–441 (1979).
Feeley, J. C., Gorman, G. W., Weaver, R. E., Mackel, D. C., and Smith, H. W., Primary isolation media for the Legionnaires’ disease bacterium, J. Clin. Microbiol. 8:320–325 (1978).
Finland, M., “Legionnaires’ disease”: They came, saw, and conquered, Ann. Intern. Med. 90:710–713 (1979).
Fisher-Hoch, S. P., Bartlett, C. L. R., Tobin, J. O’H., Gillett, M. B., Nelson, A. M., Pritchard, J. E., Smith, M. G., Swann, R. A., Talbot, J. M., and Thomas, J. A., Investigation and control of an outbreak of Legionnaires’ disease in a district general hospital, Lancet 1:932–936 (1981).
Fliermans, C. B., Cherry, W. B., Orrison, L. H., and Thacker, L., Isolation of Legionella pneumophila from non epidemic-related aquatic habitat, Appl. Environ. Microbiol. 37:1239–1242 (1979).
Foy, H. M., Broome, C. V., Hayes, P. S., Allan, I., and Tobe, R., Legionnaires’ disease in a prepaid medical care group in Seattle 1963–1975, Lancet 1:767–770 (1979).
Fraser, D. W., Unpublished data.
Fraser, D. W., Legionnaires’ disease: 4 summers’ harvest, Am. J. Med. 68:1–2 (1980).
Fraser, D. W., Deubner, D. C., Hill, D. L., and Gilliam, D. K., Non-pneumonic, short-incubation-period legionellosis (Pontiac fever) in men who cleaned a steam turbine condenser, Science 205:690–691 (1979).
Fraser, D. W., Tsai, T. F., Orenstein, W., Parkin, W. E., Beecham, H. J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., Mcdade, J. E., Shepard, C. C., Brachman, P. S., and The Field Investigation Team, Legionnaires’ disease: Description of an epidemic of pneumonia, N. Engl. J. Med. 297:1189–1197 (1977).
Frenkel, J. K., Baker, L. H., Chonko, A. M., Autopsy diagnosis of Legionnaires disease in immunosuppressed patients: A paleodiagnosis using Giemsa stain (Wohlbach modification), Ann. Intern. Med. 90:559–562 (1979).
Glick, T. H., Gregg, M. B., Berman, B., Mallison, G. F., Rhodes, W. W., Jr., and Kassanoff, I., Pontiac fever: An epidemic of unknown etiology in a health department. I. Clinical and epidemiologic aspects, Am. J. Epidemiol. 107:149–160 (1978).
Grady, G. F., and Gilfillan, R. F., Relation of Mycoplasma pneumoniae seroreactivity, immunosuppression, and chronic disease to Legionnaires’ disease: A twelve-month prospective study of sporadic cases in Massachusetts, Ann. Intern. Med. 90:607–610 (1979).
Gump, D. W., Frank, R. O., Winn, W. C., Jr., Foster, R. S., Jr., Broome, C. V., and Cherry, W. B., Legionnaires’ disease in patients with associated serious disease, Ann. Intern. Med. 90:538–542 (1979).
Haley, C. E., Cohen, M. L., Halter, J., and Meyer, R. D., Nosocomial Legionnaires’ disease: A continuing common-source epidemic at Wadsworth Medical Center, Ann. Intern. Med. 90:583–586 (1979).
Hébert, G. A., Moss, C. W., Mcdougal, L. K., Bozeman, F. M., Mckinney, R. M., and Brenner, D. J., The rickettsia-like organisms Tatlock (1943) and Heba (1959): Bacteria phenotypically similar to but genetically distinct from Legionella pneumophila and the Wiga bacterium, Ann. Intern. Med. 92:45–52 (1980).
Hébert, G. A., Steigerwalt, A. G., and Brenner, D. J., Legionella micdadei species nova; Classification of a third species of Legionella associated with human pneumonia, Curr. Microbiol. 3:255–257 (1980).
Hébert, G. A., Thomason, B. M., Harris, P. P., Hicklin, M. D., and Mckinney, R. M.,“Pittsburgh pneumonia agent”: A bacterium phenotypically similar to Legionella pneumophila and identical to the Tatlock bacterium, Ann. Intern. Med. 92:53–54 (1980).
Hedlund, K. W., Mcgann, V. G., Copeland, D. S., Little, S. F., and Allen, R. G., Immunologic protection against the Legionnaires’ disease bacterium in the Akr/J mouse, Ann. Intern. Med. 90:676–679 (1979).
Helms, C. M., Viner, J. P., Sturm, R. H., Renner, E. D., and Johnson, W., Comparative features of pneumococcal, mycoplasmal, and Legionnaires’ disease pneumonias, Ann. Intern. Med. 90:543–547 (1979).
Horwitz, M. A., and Silverstein, S. C., Legionnaires’ disease bacterium (Legionella pneumophila) multiplies intracellularly in human monocytes, J. Clin. Invest. 66:441–450 (1980).
Kaufmann, A. F., Mcdade, J. E., Patton, C. M., Bennett, J. V., Skaliy, P., Feeley, J. C., anderson, D. C., Potter, M. E., Newhouse, V. F., Gregg, M. B., and Brachman, P. S., Pontiac Fever: Isolation of the etiologic agent (Legionella pneumophila) and demonstration of its mode of transmission, Am. J. Epidemiol. 114:337–347 (1981).
Kirby, B. D., Snyder, K. M., Meyer, R. D., and Finegold, S. M., Legionnaires’ disease: Clinical features of 24 cases, Ann. Intern. Med. 89:297–309 (1978).
Kohler, R. B., Zimmerman, S. E., Wilson, E., Allen, S. D., Edelstein, P. H., Wheat, L. J., and White, A., Rapid radioimmunoassay diagnosis of Legionnaires’ disease: Detection and partial characterization of urinary antigen, Ann. Intern. Med. 94:601–605 (1981).
Lattimer, G. L., Mccrone, C., and Galgon, J., Diagnosis of Legionnaires’ disease from transtracheal aspirate by direct fluorescent-antibody staining and isolation of the bacterium, N. Engl. J. Med. 299:1172–1173 (1978).
Lattimer, G. L., Rhodes, L. V., III, Salventi, J. S., Galgon, J. P., Stonebraker, V., Boley, S., and Haas, G., The Philadelphia epidemic of Legionnaires’ disease: Clinical, pulmonary, and serologic findings two years later, Ann. Intern. Med. 90:522–526 (1979).
Lewallen, K. R., Mckinney, R. M., Brenner, D. J., Moss, C. W., Dail, D. H., Thomason, B. M., and Bright, R. A., A newly identified bacterium phenotypically resembling, but genetically distinct from, Legionella pneumophila: An isolate in a case of pneumonia, Ann. Intern. Med. 91:831–834 (1979).
Marks, J. S., Tsai, T. F., Martone, W. J., Baron, R. C., Kennicott, J., Holtzhauer, F. J., Baird, I., Fay, D., Feeley, J. C., Mallison, G. F., Fraser, D. W., and Halpin, T. J., Nosocomial Legionnaires’ disease-Columbus, Ohio, Ann. Intern. Med. 90:565–569 (1979).
Mcdade, J. E., Brenner, D. J., and Bozeman, F. M., Legionnaires’ disease bacterium isolated in 1947, Ann. Intern. Med. 90:659–661 (1979).
Mcdade, J. E., and Shepard, C. C., Virulent to avirulent conversion of Legionnaires’ disease bacterium (Legionella pneumophila)-its effect on isolation techniques, J. Infect. Dis. 139:707–711 (1979).
Mcdade, J. E., Shepard, C. C., Fraser, D. W., Tsai, T. F., Redus, M. A., Dowdle, W. R., and The Laboratory Investigation Team, Legionnaires’ disease: Isolation of a bacterium and demonstration of its role in other respiratory disease, N. Engl. J. Med. 297:1197–1203 (1977) .
Mckinney, R. M., Porschen, R. K., Edelstein, P. H., Bissett, M. L., Harris, P. P., Bondell, S. P., Steigerwalt, A. G., Weaver, R. E., Ein, M. E., Lindquist, D. S., Kaps, R. S., and Brenner, D. J., Legionella longbeachae sp. nov., another etiologic agent of human pneumonia, Ann. Intern. Med. 94:739–743 (1981).
Miller, A. C., Early clinical differentiation between Legionnaires’ disease and other sporadic pneumonias, Ann. Intern. Med. 90:526–528 (1979).
Miller, R. P., Cooling towers and evaporative condensers, Ann. Intern. Med. 90:667–670 (1979).
Morris, G. K., Patton, C. M., Feeley, J. C., Johnson, S. E., Gorman, G. W., Martin, W. T., Skaliy, P., Mallison, G. F., Politi, B. D., and Mackel, D. C., Isolation of Legionnaires’ disease bacterium from environmental samples, Ann. Intern. Med. 90:664–666 (1979).
Morris, G. K., Steigerwalt, A., Feeley, J. C., Wong, E. S., Martin, W. T., Patton, C. M., and Breener, D. J., Legionella gormanii sp. nov., J. Clin. Microbiol. 12:718–721 (1980).
Moss, C. W., and Dees, S. B., Cellular fatty acid corn- position of Wiga, a rickettsia-like agent similar to Legionnaires’ disease bacterium, J. Clin. Microbiol. 10:390–391 (1979) .
Moss, C. W., Weaver, R. E., Dees, S. B., and Cherry, W. B., Cellular fatty acid composition of isolates from Legionnaires disease, J. Clin. Microbiol. 6:140–143 (1977).
Myerowitz, R. L., Pasculle, A. W., Dowling, J. W., Pazin, G. J., Puerzer, M., Gee, R. B., Rinaldo, C. R., and Hakala, T. R., Opportunistic lung infection due to“Pittsburgh pneumonia agent”, N. Engl. J. Med. 301:953–958 (1979).
Pasculle, A. W., Myerowitz, R. L., and Rinaldo, C. R., Jr., New bacterial agent of pneumonia isolated from renal-transplant recipients, Lancet 2:58–61 (1979).
Plouffe, J. F., and Baird, I. M., Lymphocyte transformation to Legionella pneumophila, J. Clin. Lab. Immun. 5:149–152, (1981).
Politi, B. D., Unpublished data.
Politi, B. D., Fraser, D. W., Mallison, G. F., Mohatt, J. V., Morris, G. K., Patton, C. M., Feeley, J. C., Telle, R. D., and Bennett, J. V., A major focus of Legionnaires’ disease in Bloomington, Indiana, Ann. Intern. Med. 90: 587–591 (1979).
Reid, D., Grist, N. R., and Najera, R., Illness associated with „package tours“: A combined Spanish-Scottish study, Bull. WHO 56:117–122 (1978).
Renner, E. D., Helms, C. M., Hierholzer, W. J., Jr., Hall, N., Wong, Y. W., Viner, J. P., Johnson, W., and Hausler, W. J., Jr., Legionnaires’ disease in pneumonia patients in Iowa: A retrospective seroepidemiologic study, 1972–1977, Ann. Intern. Med. 90:603–606 (1979).
Rogers, B. W., Donowitz, G. R., Walker, G. H., Harding, S. A., and Sande, M. A., Opportunistic pneumonia: A clinical study of five cases caused by an unidentified acid fast bacterium, N. Engl. J. Med. 301:959–961 (1979).
Ryan, M. E., Feldman, S., Pruitt, B., and Fraser, D. W., Legionnaires’ disease in a child with cancer, Pediatrics 64:951–953 (1979).
Sanford, J. P., Legionnaires’ disease: One person’s perspective, Ann. Intern. Med. 90:699–703 (1979).
Saravolatz, L. D., Arking, L., Wentworth, B., and Quinn, E., Prevalence of antibody to Legionnaires’ disease bacterium in hospital employees, Ann. Intern. Med. 90:601–603 (1979).
Saravolatz, L. D., Burch, K. H., Fisher, E., Madhavan, T., Kiani, D., Neblett, T., and Quinn, E. L., The compromised host and Legionnaires’ disease, Ann. Intern. Med. 90:533–537 (1979).
Shands, K. N., Ho, J. L., Gorman, G. W., Meyer, R. D., Edelstein, P. H., Finegold, S. M., and Fraser, D. W., Potable water as a source of Legionnaires’ disease, Clin. Res. 29:260A (1981).
Sharrar, R. G., Unpublished data.
Sharrar, R. G., Friedman, H. M., Miller, W. T., Yanak, M. J., and Abrutyn, E., Summertime pneumonias in Philadelphia in 1976: An epidemiologic study, Ann. Intern. Med. 90:577–580 (1979).
Skaliy, P., and Mceachern, H. V., Survival of the Legionnaires’ disease bacterium in water, Ann. Intern. Med. 90:662–663 (1979).
Storch, G., Baine, W. B., Fraser, D. W., Broome, C. V., Clegg, H. W., II, Cohen, M. L., Goings, S. A. J., Politi, B. D., Terranova, W. A., Tsai, T. F., Plikaytis, B. D., Shepard, C. C., and Bennett, J. V., Sporadic community-acquired Legionnaires’ disease in the United States: A case-control study, Ann. Intern . Med. 90:596–600 (1979).
Storch, G., Hayes, P. S., Hill, D. L., and Baine, W. B., Prevalence of antibody to Legionnaires’ disease bacterium in middle-aged and elderly Americans, J. Infect. Dis. 140:784–788 (1979).
Tatlock, H., A rickettsia-like organism recovered from guinea pigs, Proc. Soc. Exp. Biol. Med. 57:95–99 (1944).
Terranova, W., Cohen, M. L., and Fraser, D. W., 1974 outbreak of Legionnaires’ disease diagnosed in 1977: Clinical and epidemiological features, Lancet 2:122–124 (1978).
Thacker, S. B., Bennett, J. V., Tsai, T. F., Fraser, D. W., Mcdade, J. E., Shepard, C. C., Williams, K. H., Jr., Stuart, W. H., Dull, H. B., and Eickhoff, T. C., An outbreak in 1965 of severe respiratory illness caused by the Legionnaires’ disease bacterium, J. Infect. Dis. 138:512–519 (1978).
Thomason, B. M., Chandler, F. W., and Hollis, D. G., Flagella on Legionnaires’ disease bacteria: An interim report, Ann. Intern. Med. 91:224–226 (1979).
Thomason, B. M., Harris, P. P., Hicklin, M. D., Blackmon, J. A., Moss, C. W., and Matthews, F., A Legionella-like bacterium related to Wiga in a fatal case of pneumonia, Ann. Intern. Med. 91:673–676 (1979).
Tilton, R. C., Legionnaires’ disease antigen detected by enzyme-linked immunosorbent assay, Ann. Intern. Med. 90:697–698 (1979).
Tobin, J., and Mitchell, R. G., Legionnaires’ disease in a transplant unit, Communicable Dis. Rep. 79/43 (2 Nov. 1979).
Tsai, T. F., Finn, D. R., Plikaytis, B. D., Mccauley, W., Martin, S. M., and Fraser, D. W., Legionnaires’ disease: Clinical features of the epidemic in Philadelphia, Ann. Intern. Med. 90:509–517 (1979).
Tsai, T. F., and Fraser, D. W., The diagnosis of Legionnaires’ disease, Ann. Intern. Med. 89:413–414 (1978).
Wang, W. L. L., Blaser, M. J., Cravens, J., and Johnson, M. A., Growth, Survival and resistance of the Legionnaires’ disease bacterium, Ann. Intern. Med. 90:614–618 (1979).
Wilkinson, H. W., Cruce, D. D., and Broome, C. V., Validation of Legionella pneumophila indirect immunofluorescence assay with epidemic sera, J. Clin. Microbiol. 13:139–146 (1981).
Wilkinson, H. M., Fikes, B. J., and Cruce, D. D., Indirect immunofluorescence test for serodiagnosis of Legionnaires’ disease: Evidence for serogroup diversity of Legionnaires’ disease bacterial antigens and for miltiple specificity of human antibodies, J. Clin. Microbiol. 9:379–383 (1979).
Winn, W. C., Jr., Cherry, W. B., Frank, R. O., Casey, C. A., and Broome, C. V., Direct immunofluorescent detection of Legionella pneumophila in respiratory specimens, J. Clin. Microbiol. 11:59–64 (1980).
Winn, W. C., Jr., Glavin, F. L., Perl, D. P., and Craighead, J. E., Macroscopic pathology of the lung in Legionnaires’ disease, Ann. Intern. Med. 90:548–551 (1979).
Winn, W. C., Jr., and Myerowitz, R. L., The pathology of the Legionella pneumonias: A review of 74 cases and the literature, Human Pathol. 12:401–422 (1981).
Wong, E. S., Unpublished data.
Wong, K. H., Moss, C. W., Hochstein, D. H., Arko, R. J., and Schalla, W. O., “Endotoxicity” of the Legionnaires’ disease bacterium, Ann. Intern. Med. 90:624–627 (1979).
Wong, K. H., Mcmaster, R. B., Feeley, J. C., Arko, R. J., Schalla, W. O., and Chandler, F. W., Detection of hypersensitivity to Legionella pneumophila in guinea pigs by skin test, Curr. Microbiol. 4:105–116 (1980).
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Broome, C. V., and Fraser, D. W., Epidemiological aspects of legionellosis, Epidemiol. Rev. 1:1–16 (1979).
Edelstein, P. H., and Meyer, R. D., Laboratory diagnosis of Legionnaires’ disease, Amer. Rev. Respir. Dis. 121:317–327 (1980).
Fraser, D. W., Tsai, T. F., Orenstein, W., Parkin, W. E., Beecham, H. J., Sharrar, R. G., Harris, J., Mallison, G. F., Martin, S. M., Mcdade, J. E., Shepard, C. C., Brachman, P. S., and The Field Investigation Team, Legionnaires’ disease: Description of an epidemic of pneumonia, N. Engl. J. Med. 297:1189–1197 (1977).
Glick, T. H., Gregg, M. B., Berman, B., Mallison, G., Rhodes, W. W., Jr., and Kassanoff, I., Pontiac fever: An epidemic of unknown etiology in a health department. I. Clinical and epidemiologic aspects, Am. J. Epidemiol. 107:149–160 (1978).
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Fraser, D.W. (1982). Legionellosis. In: Evans, A.S., Feldman, H.A. (eds) Bacterial Infections of Humans. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-1140-0_15
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