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Biomembranes pp 167–233Cite as

Surface Alterations in Cells Infected by Avian Leukosis-Sarcoma Viruses

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Part of the book series: Biomembranes ((B,volume 8))

Abstract

The regulatory mechanisms involved in morphogenesis and in the subsequent maintenance of the differentiated state are poorly understood. However, it is clear that ontogenesis requires that cell proliferation and differentiation be strictly controlled to ensure appropriate development of the organism. If we accept hypothetically that it is primarily the spatial orientation of cells during ontogenesis that induces their respective differentiation (Crick, 1970; Wolpert, 1971), then the specific signals mediating spatial orientation must first be recognized by the receptors of the cell’s membrane in order to interpret and transfer the information to the nucleus for selective gene activation. This information mediating growth control and differentiation may consist, for example, of diffusible morphogenetic substances (Crick, 1970, 1971; Babloyantz and Hiernaux, 1974) or of phase transitions of at least two different signals (Goodwin and Cohen, 1969; Wolpert, 1969). In an already differentiated organ or lower organism, maintenance of differ-entiation and growth control may furthermore be mediated by specific surface receptors (surface recognition molecules, SRM)4 that distinguish between histologically identical and different cells (Moscona, 1961, 1973; Humphreys, 1963; De Long, 1970; Gierer et al., 1972; Kuhns et al., 1973).

Deutsche Forschungsgemeinschaft Scholar. Present address: Friedrich Miescher Laboratorium der Max Planck-Gesellschaft, 74 Tubingen, Spemannstr. 37.

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  1. Department of Tumour Virology, Imperial Cancer Research Fund Laboratories, Lincoln’s Inn Fields, London, England

    Reinhard Kurth

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  1. Reinhard Kurth
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  1. The Wistar Institute, Philadelphia, Pennsylvania, USA

    Lionel A. Manson

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Kurth, R. (1976). Surface Alterations in Cells Infected by Avian Leukosis-Sarcoma Viruses. In: Manson, L.A. (eds) Biomembranes. Biomembranes, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-9087-9_5

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  • DOI: https://doi.org/10.1007/978-1-4684-9087-9_5

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