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Mutagenic Effects of Oxidized Lipids

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Free Radicals, Lipoproteins, and Membrane Lipids

Part of the book series: NATO ASI Series ((NSSA,volume 189))

Abstract

Oxidized lipids are suspected as being mutagenic, the mutagenicity being associated in concept with carcinogenicity as well. However, although mutagenic responses for more highly oxidized lipid degradation products have been obtained in a variety of bioassays, convincing demonstration of mutagenicity of early formed products of lipid oxidation has not been readily achieved. In many of the studies conducted todate mutagenicity has been assessed using test strains of Salmonella typhimurium in the Ames test, the bioassay emphasized in the present report.

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Author information

Authors and Affiliations

  1. Department of Human Biological Chemistry and Genetics, University of Texas Medical Branch, Galveston, TX, 77550, USA

    Leland L. Smith & Sontin Mossanda Kensese

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  1. Leland L. Smith
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  2. Sontin Mossanda Kensese
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Editors and Affiliations

  1. INSERM Unit 58, Montpellier, France

    A. Crastes de Paulet

  2. INSERM Unit 101, Toulouse, France

    L. Douste-Blazy

  3. University of Milan, Milan, Italy

    R. Paoletti

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© 1990 Plenum Press, New York

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Smith, L.L., Kensese, S.M. (1990). Mutagenic Effects of Oxidized Lipids. In: de Paulet, A.C., Douste-Blazy, L., Paoletti, R. (eds) Free Radicals, Lipoproteins, and Membrane Lipids. NATO ASI Series, vol 189. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-7427-5_26

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  • DOI: https://doi.org/10.1007/978-1-4684-7427-5_26

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-7429-9

  • Online ISBN: 978-1-4684-7427-5

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