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Effects of Castration, Estrogen, and Androgen Administration

  • Chapter
Benign Prostatic Hypertrophy

Abstract

Although the etiology of benign prostatic hypertrophy (BPH) is poorly understood, it is known that aging and the presence of the testes are two requisites for it to occur. As the prostate is essentially an endocrine-responsive tissue, factors responsible for causing BPH as well as for its possible control or alleviation are thought by many investigators to be hormone-related. Accordingly, many studies have focused on the effect of the presence or absence of androgens, estrogens, and their metabolites in both normal and hyperplastic prostate. This chapter attempts to summarize the current status and to review highlights of the effects of castration and estrogen and androgen administration. We hope that by reviewing the results of prostatic responses to these manipulations, some possible mechanism of the hormonal etiology of BPH can be elucidated. The possible role of stromal-epithelial interaction in BPH is also discussed briefly.

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References

  1. Aragona C, Friesen HG: Specific prolactin binding sites in the prostate and testis of rats. Endocrinology 97: 677–684, 1975

    Article  PubMed  CAS  Google Scholar 

  2. Bard DR, Laznitzki I: The influence of oestradiol on the metabolism of androgens by human prostatic tissue. J Endocrinol 74: 1–9, 1977

    Article  PubMed  CAS  Google Scholar 

  3. Barkey RJ, Shani J, Smit T, Barzilai D: Specific binding of prolactin to seminal vesicle, prostate and testicular homogenates of immature, mature and aged rats. J Endocrinol 74: 163–173, 1977

    Article  PubMed  CAS  Google Scholar 

  4. Bartsch G, Oberholzer M, Rohr HP: The effect of antiestrogen, antiandrogen, and the prolactin inhibitor 2-bromo-alpha ergocriptine on the stromal tissue of human benign prostatic hyperplasia: correlation of stereological data and plasma hormones. Invest Urol 18: 308–312, 1981

    PubMed  CAS  Google Scholar 

  5. Bashirelahi N, Kneussl ES, Vassil TC, Young JD Jr, Sanefugi H, Trump B: Measurement and characterization of estrogen receptors in the human prostate. Prog Clin Biol Res 33: 65–84, 1979

    PubMed  CAS  Google Scholar 

  6. Bashirelahi N, O’Toole JH, Young JD: A specific 17 beta-estradiol receptor in human benign hypertrophic prostate. Biochem Med 15: 254–261, 1976

    Article  PubMed  CAS  Google Scholar 

  7. Berg OA: Effect of stilboesterol on the prostate gland in normal puppies and adult dogs. Acta Endocrinol (Copenh) 27: 155–169, 1958

    CAS  Google Scholar 

  8. Bockrath JM, Lee C, Grayhack JT: Incorporation and release of tritiated leucine in rat prostate during castration-induced involution. Invest Urol 19: 169–175, 1981

    PubMed  CAS  Google Scholar 

  9. Boesel RW, Shain SA: Aging in the AXC rat: androgen regulation of prostate prolactin receptors. J Androl 1: 269–276, 1980

    CAS  Google Scholar 

  10. Bolton NJ, Lahtonen P, Hammond GL, Vihko R: Distribution and concentrations of androgens in epithelial and stromal compartments of the human benign hypertrophic prostate. J Endocrinol 90: 125–131, 1981

    Article  PubMed  CAS  Google Scholar 

  11. Cabot AT: The question of castration for enlarged prostate. Ann Surg 24: 265–309, 1896

    Article  PubMed  CAS  Google Scholar 

  12. Cowan RA, Cook B, Cowan SK, Grant JK, Sirett DA, Wallace AM: Testosterone 5-alpha-reductase and the accumulation of dihydrotestosterone in benign prostatic hyperplasia. J Steroid Biochem 11: 609–613, 1979

    Article  PubMed  CAS  Google Scholar 

  13. Cunha GR, Chung LWK, Shannon JM, Reese BA: Stromal-epithelial interaction in sex differentiation. Biol Reprod 22: 19–42, 1980

    Article  PubMed  CAS  Google Scholar 

  14. De Klerk DP, Coffey DS, Ewing LL, McDermott IR, Reiner WG, Robinson CH, Scott WW, Strandberg JD, Talay P, Walsh PC, Wheaton ZG, Zirkin BR: Comparison of spontaneous and experimentally induced canine prostatic hyperplasia. J Clin Invest 64: 842–849, 1979

    Article  Google Scholar 

  15. Deming CL, Jenkins RH, Van Wagenen G: Some endocrinological relationships of prostatic hypertrophy: clinical and experimental studies; preliminary report. J Urol 33: 388–399, 1935

    Google Scholar 

  16. Ehrlichman RJ, Isaacs JT, Coffey DS: Differences in the effects of estradiol on dihydrotestosterone induced prostatic growth of the castrate dog and rat. Invest Urol 18: 466–470, 1981

    PubMed  Google Scholar 

  17. El Etreby MF, Friedreich E, Hasan SH, Mahrous AT, Schwarz K, Senge T, Tunn U, Neumann F: Role of the pituitary gland in experimental hormonal induction and prevention of benign prostatic hyperplasia in the dog. Cell Tissue Res 204: 367–378, 1979

    Article  PubMed  Google Scholar 

  18. Engel G, Lee C, Grayhack JT: Acid ribonuclease in rat prostate during castration-induced involution. Biol Reprod 22: 827–831, 1980

    Article  PubMed  CAS  Google Scholar 

  19. Geller J, Albert J, Lopez D, Geller S, Niwayama G: Comparison of androgen metabolites in benign prostatic hypertrophy (BPH) and normal prostate. J Clin Endocrinol Metab 43: 686–688, 1976

    Article  PubMed  CAS  Google Scholar 

  20. Grayhack JT: Effect of testosterone-estradiol administration on citric acid and fructose content of the rat prostate. Endocrinology 77: 1068–1074, 1965

    Article  PubMed  CAS  Google Scholar 

  21. Grayhack JT: Pituitary factors influencing growth of the prostate. Natl Cancer Inst Monogr 12: 189–199, 1963

    PubMed  CAS  Google Scholar 

  22. Grayhack JT: Reflections on the etiology of benign prostatic hypertrophy. In: Urological Research, Papers Presented in Honor of William Wallace Scott. Plenum Press, New York, 1972, pp 39–49

    Google Scholar 

  23. Grayhack JT, Bunce PL, Kearns JW, Scott WW: Influence of the pituitary on prostatic response to androgen in the rat. Bull Johns Hopkins Hosp 96: 154–163, 1955

    PubMed  CAS  Google Scholar 

  24. Grayhack JT, Lebowitz JM: Effect of prolactin on citric acid of lateral lobe of prostate of Sprague-Dawley rat. Invest Urol 5: 87–94, 1967

    CAS  Google Scholar 

  25. Griffiths J: An enlarged prostate gland eighteen days after bilateral or complete castration. Br Med J 1: 579–581, 1895

    Article  PubMed  CAS  Google Scholar 

  26. Hammond GL: Endogenous steroid levels in the human prostate from birth to old age: a comparison of normal and diseased tissue. J Endocrinol 78: 7–19, 1978

    Article  PubMed  CAS  Google Scholar 

  27. Holland JM, Lee C: Effects of pituitary grafts on testosterone stimulated growth of rat prostate. Biol Reprod 22: 351–355, 1980

    PubMed  CAS  Google Scholar 

  28. Huggins C, Clark PJ: Quantitative studies of prostatic secretion. II. The effect of castration and of estrogen injection on the normal and on the hyperplastic prostate glands of dogs. J Exp Med 72: 747–762, 1940

    Article  PubMed  CAS  Google Scholar 

  29. Huggins C, Russell PS: Quantitative effects of hypophysectomy on testis and prostate of dogs. Endocrinology 39: 1–7, 1946

    Article  PubMed  CAS  Google Scholar 

  30. Huggins C, Stevens RA: The effect of castration on benign hypertrophy of the prostate in man. J Urol 43: 705–714, 1940

    Google Scholar 

  31. Isaacs JT, Coffey DS: Changes in dihydrotestoster-one metabolism associated with the development of canine benign hyperplasia. Endocrinology 108: 445–453, 1981

    Article  PubMed  CAS  Google Scholar 

  32. Kolbusz WE, Lee C, Grayhack JT: Delay of castration-induced regression in rat prostate by pituitary homografts. J Urol 127: 581–584, 1982

    PubMed  CAS  Google Scholar 

  33. Krieg M, Bartsch W, Janssen W, Voigt KD: A comparative study of binding, metabolism and endogenous levels of androgens in normal, hyperplastic and carcinomatous human prostate. J Steroid Biochem 11: 615–624, 1979

    Article  PubMed  CAS  Google Scholar 

  34. Lee C: Physiology of castration-induced regression of the rat prostate. In Murphy G, Sandberg AA, Karrt JP (eds.): The Prostatic Cell: Structure and Function. Liss, New York, 1981, pp 145–159

    Google Scholar 

  35. Lee C, Prins GS, Henneberry MO, Grayhack JT: Effect of estradiol on the rat prostate in the presence and absence of testosterone and pituitary. J Androl 2: 293–299, 1981

    CAS  Google Scholar 

  36. Lesser B, Bruchovsky N: Effect of duration of period after castration on the response of the rat ventral prostate to androgen. Biochem J 149: 429–431, 1974

    Google Scholar 

  37. Lesser MA, Vose SN, Dixey GM: Effect of testosterone propionate on the prostate gland of patients over 45. J Urol 15: 297–300, 1955

    CAS  Google Scholar 

  38. Lostroh A J, Li CH: Stimulation of the sex accessories of hypophysectomized male rats by non-gonadotrophic hormones of the pituitary gland. Acta Endocrinol (Copenh) 25: 1–16, 1957

    CAS  Google Scholar 

  39. Mariotti A, Thornton M, Mawhinney M: Actions of androgen and estrogen on collagen levels in male accessory sex organs. Endocrinology 109: 837–843, 1981

    Article  PubMed  CAS  Google Scholar 

  40. McNeal JE: Origin and evolution of benign prostatic enlargement. Invest Urol 15: 340–345, 1978

    PubMed  CAS  Google Scholar 

  41. Meikle AW, Collier ES, Middleton RG, Fang SM: Supranormal nuclear content of 5-alpha dihydro-testosterone in benign hyperplastic prostate of humans. J Clin Endocrinol Metab 51: 945–947, 1980

    Article  PubMed  CAS  Google Scholar 

  42. Meikle AW, Collier ES, Stringham JD, Fang SM, Taylor GN: Elevated intranuclear dihydrotestos-terone in prostatic hyperplasia of aging dogs. J Steroid Biochem 14: 331–335, 1981

    Article  PubMed  CAS  Google Scholar 

  43. Meikle AW, Stringham JD, Olson DC: Subnormal tissue 3-alpha androstanediol and androsterone in prostatic hyperplasia. J Clin Endocrinol Metab 47: 909–913, 1978

    Article  PubMed  CAS  Google Scholar 

  44. Meites J, Lu KH, Wuttke W, Welsch CW, Nagasawa H, Quadri SK: Recent studies on functions and controls of prolactin secretion in rats. Recent Prog Horm Res 28: 471–526, 1972

    PubMed  CAS  Google Scholar 

  45. Moore RA, McLellan AM: A histological study of the effect of the sex hormones on the human prostate. J Urol 40: 641–657, 1938

    Google Scholar 

  46. Moore RJ, Gazak JM, Quebbeman JF, Wilson JD: Concentration of dihydrotestosterone and 3-alpha androstanediol in naturally occurring and androgen-induced prostatic hyperplasia in the dog. J Clin Invest 64: 1003–1010, 1979

    Article  PubMed  CAS  Google Scholar 

  47. Muellner SR, Hamilton JB: The effect of testosterone propionate on the tonus of the urinary bladder. J Urol 52: 139–148, 1944

    CAS  Google Scholar 

  48. Negro-Vilar A, Saad WA, McCann SM: Evidence for a role of prolactin in prostate and seminal vesicle growth in immature male rats. Endocrinology 100: 729–737, 1977

    Article  PubMed  CAS  Google Scholar 

  49. Paulson DF, Kane RD: Medrogestone: a prospective study in the pharmaceutical management of benign prostatic hyperplasia. J Urol 113: 811–815, 1975

    PubMed  CAS  Google Scholar 

  50. Prins GS, Lee C: Influence of prolactin-producing pituitary grafts on the in vivo uptake, distribution and disappearance of 3H-testosterone and 3H-dihy-drotestosterone by the rat prostate lobes. Endocrinology 110: 920–925, 1982

    Article  PubMed  CAS  Google Scholar 

  51. Rangno RE, McLeod PJ, Ruedy J, Ogilvie RI: Treatment of benign prostatic hypertrophy with medrogestone. Clin Pharmacol Ther 12: 658–665, 1971

    PubMed  CAS  Google Scholar 

  52. Saroff J, Kirdani RY, Chu TM, Wajsman Z, Murphy GP: Measurements of prolactin and androgens in patients with prostatic diseases. Oncology 37: 46–52, 1980

    Article  PubMed  CAS  Google Scholar 

  53. Scott WW: What makes the prostate grow? J Urol 70: 477–488, 1953

    PubMed  CAS  Google Scholar 

  54. Scott WW, De Klerk DP: Benign prostatic hyperplasia: current status of medical treatment. In Grayhack JT, Wilson JD, Scherbenske MJ (eds.): Benign Prostatic Hyperplasia. DHEW Publ. No. (NIH)76-1113, US Gov’t Printing Office, Washington, DC. 1976, pp 135–151

    Google Scholar 

  55. Scott WW, Wade JC: Medical treatment of benign nodular prostatic hyperplasia with cyproterone acetate. J Urol 101: 81–85, 1969

    PubMed  CAS  Google Scholar 

  56. Sharer WC, Lee C, Grayhack JT: Partial inhibition of castration-induced involution in rat prostate by chloroquine: a preliminary observation. Invest Urol 17: 135–137, 1979

    PubMed  CAS  Google Scholar 

  57. Siiteri PK, Wilson JD: Dihydrotestosterone in prostatic hypertrophy. I. The formation and content of dihydrotestosterone in the hypertrophic prostate of man. J Clin Invest 49: 1737–1745, 1970

    Article  PubMed  CAS  Google Scholar 

  58. Skoldefors H, Blomstedt B, Carlstrom K: Serum hormone levels in benign prostatic hyperplasia. Scand J Urol Nephrol 12: 111–114, 1978

    Article  PubMed  CAS  Google Scholar 

  59. Stanisic T, Sadlowski R, Lee C, Grayhack JT: Elevated rate of 3H-uridine incorporation in regressing rat ventral prostate. Invest Urol 16: 15–18, 1978

    PubMed  CAS  Google Scholar 

  60. Stanisic T, Sadlowski R, Lee C, Grayhack JT: Partial inhibition of castration-induced ventral prostate regression with actinomycin D and cycloheximide. Invest Urol 16: 19–22, 1978

    PubMed  CAS  Google Scholar 

  61. Tanabe ET, Lee C, Grayhack JT: Activities of cathepsin D in rat prostate during castration-induced involution. J Urol 127: 826–828, 1982

    PubMed  CAS  Google Scholar 

  62. Thomas JA, Manandhar M: Effects of prolactin and/or testosterone on nucleic acid levels in prostate glands of normal and castrated rats. J Endocrinol 65: 149–150, 1975

    Article  CAS  Google Scholar 

  63. Trachtenberg J, Hicks LL, Walsh PC: Androgenand estrogen-receptor content in spontaneous and experimentally induced canine prostatic hyperplasia. J Clin Invest 65: 1051–1059, 1980

    Article  PubMed  CAS  Google Scholar 

  64. Tunn U, Senge Th, Schenck B, Neumann F: Biochemical and histological studies on prostates in castrated dogs after treatment with androstanediol, oestradiol and cyproterone acetate. Acta Endocrinol (Copenh) 91: 373–384, 1979

    CAS  Google Scholar 

  65. Tunn U, Senge Th, Schenck B, Neumann F: Effects of cyproterone acetate on experimentally induced canine prostatic hyperplasia: a morphological and histological study. Urol Int 35: 125–140, 1980

    Article  PubMed  CAS  Google Scholar 

  66. Tveter KJ, Dahl E, Aakvaag A: Effect of antiandrogens on the prostate gland. In Spring-Mills E, Hafez ESE (eds.): Male Accessory Sex Glands. Elsevier/North-Holland, New York, 1980, pp 495–520

    Google Scholar 

  67. Uke E, Lee C, Grayhack JT: Effect of cis-4-hydroxyproline on prostatic regression in rats. J Urol, in press, 1982

    Google Scholar 

  68. VanderLaan WP: Observations on the hormonal control of the prostate gland. Lab Invest 9: 185–190, 1960

    PubMed  CAS  Google Scholar 

  69. Vermeulen A: Testicular hormonal secretion and aging in males. In Grayhack JT, Wilson JD, Scherbenske MJ (eds.): Benign Prostatic Hyperplasia. DHEW Publ. No. (NIH)76-1113, US Gov’t Printing Office, Washington, DC, 1976, pp 177–182

    Google Scholar 

  70. Vermeulen A, DeSy W: Androgens in patients with benign prostatic hyperplasia before and after prostatectomy. J Clin Endocrinol Metab 43: 1250–1254, 1976

    Article  PubMed  CAS  Google Scholar 

  71. Walsh PC, Wilson JD: The induction of prostatic hypertrophy in the dog with androstanediol. J Clin Invest 57: 1093–1097, 1976

    Article  PubMed  CAS  Google Scholar 

  72. Wendel EF, Brannen GE, Putong PB, Grayhack JT: The effect of orchiectomy and estrogens on benign prostatic hyperplasia. J Urol 108: 116–119, 1972

    PubMed  CAS  Google Scholar 

  73. White JW: The results of double castration in hypertrophy of the prostate. Ann Surg 22: 1–80, 1895

    Article  PubMed  CAS  Google Scholar 

  74. Wilkin RP, Bruchovsky N, Shnitka TK, Rennie PS, Comeau TL: Stromal 5-alpha-reductase activity is elevated in benign prostatic hyperplasia. Acta Endocrinol (Copenh) 94: 284–288, 1980

    CAS  Google Scholar 

  75. Wilson JD: The pathogenesis of benign prostatic hyperplasia. Am J Med 68: 745–756, 1980

    Article  PubMed  CAS  Google Scholar 

  76. Wilson JD, Walsh PC, Siiteri PK: Studies on the pathogenesis of benign prostatic hypertrophy in the dog. In Grayhack JT, Wilson JD, Scherbenske MJ (eds.): Benign Prostatic Hyperplasia. DHEW Publ. No. (NIH)76-1113, US Gov’t Printing Office, Washington, DC, 1976, pp 205–214

    Google Scholar 

  77. Witorsch RJ: Immunohistochemical studies of prolactin binding in sex accessory organs of the male rat. J Histochem Cytochem 26: 565–580, 1978

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Chung Lee
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  2. Charmayne Jesik
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Editors and Affiliations

  1. Department of Urology, University of California, San Francisco, San Francisco, California, 94143, USA

    Frank Hinman Jr. (Clinical Professor of Urology) (Clinical Professor of Urology)

  2. Department of Surgery, Division of Urology, Washington University School of Medicine, St. Louis, Missouri, 63110, USA

    Saul Boyarsky M.D., J.D., F.A.C.S. (Professor of Genitourinary Surgery and Biomedical Engineering) (Professor of Genitourinary Surgery and Biomedical Engineering)

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© 1983 Springer-Verlag New York Inc.

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Lee, C., Jesik, C. (1983). Effects of Castration, Estrogen, and Androgen Administration. In: Hinman, F., Boyarsky, S. (eds) Benign Prostatic Hypertrophy. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-5476-8_20

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  • DOI: https://doi.org/10.1007/978-1-4612-5476-8_20

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-5478-2

  • Online ISBN: 978-1-4612-5476-8

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