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Biopsy Interpretation—Electron Microscopy

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Abstract

The morphology of absorptive cells will be described in the greatest detail; the structural aspects ofthe other cells will be described only when they differ from those of the absorptive cell.

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References

  1. Dobbins WO III: Human intestinal epithelium as a biological membrane. In Trump F (Ed), Pathobiology of Cell Membranes. New York, Academic Press, 1975 pp 429–469.

    Google Scholar 

  2. Lorenzsonn V, Korsmo H, Olsen WA: Localization of sucrase-isomaltase in the rat enterocyte. Gastroenterology 92:98–105, 1987.

    PubMed  CAS  Google Scholar 

  3. Mooseker MS: Brush border motility: Microvillar contraction in triton-treated brush borders isolated from intestinal epithelium. J Cell Biol 71:417–433, 1976.

    Article  PubMed  CAS  Google Scholar 

  4. Tilney LG, Mooseker MS: Actin filament-membrane attachment: Are membrane particles involved? J Cell Biol 71:402–416, 1976.

    Article  PubMed  CAS  Google Scholar 

  5. Hirokawa N, Tilney LG, Fujiwara K, et al: Organization of actin, myosin, and intermediate filaments in the brush border of intestinal epithelial cells. J Cell Biol 94:425–443, 1982.

    Article  PubMed  CAS  Google Scholar 

  6. Burgess DR: Reactivation of intestinal epithelial cell brush border motility: ATP-dependent contraction via a terminal web contractile ring. J Cell Biol 95:853–863, 1982.

    Article  PubMed  CAS  Google Scholar 

  7. Howe CL, Mooseker MS: Characterization of the 110-kdalton actin-, calmodulin-, and membrane-binding protein from microvilli of intestinal epithelial cells. J Cell Biol 97:974–985, 1983.

    Article  PubMed  CAS  Google Scholar 

  8. Hull BE, Straehelin LA: The terminal web: A reevaluation of its structure and function. J Cell Biol 81:67–82, 1979.

    Article  PubMed  CAS  Google Scholar 

  9. Madara JL, Trier JS: Functional morphology of the mucosa of the small intestine. In LR Johnson (Ed.), Physiology of the Gastrointestinal Tract (2nd ed. New Y)rk, Raven Press, 1987, pp 4401–4441.

    Google Scholar 

  10. 9a. Weinstock M, Bonneville MA: Compartments rich in acidic carbohydrate protein complexes with electrolyte- and water-transporting cells. Lab Invest 24:355–367, 1971.

    PubMed  CAS  Google Scholar 

  11. McClugage SG, Low FN: Microdissection by ultrasonication: Porosity of the intestinal epithelial basal lamina. Am J Anat 171:207–216, 1984.

    Article  PubMed  CAS  Google Scholar 

  12. Hay E: Extracellular matrix. J Cell Biol 91:205s–223s, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Specian RD, Neutra MR: Cytoskeleton of intestinal goblet cells in rabbit and monkey. Gastroenterology 87:1313–1325, 1984.

    PubMed  CAS  Google Scholar 

  14. Cheng H, Leblond CP: Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian theory. Am J Anat 141:537–562, 1974.

    CAS  Google Scholar 

  15. Sandow MJ, Whitehead R: Progress report: The Paneth cell. Gut 20:420–431, 1979.

    Article  PubMed  CAS  Google Scholar 

  16. Bohane TD, Cutz E, Hamilton JR, et al: Acrodermatitis enteropathica, zinc, and the Paneth cell: A case report with family studies. Gastroentrology 73:587–592, 1977.

    CAS  Google Scholar 

  17. Lechago J: The endocrine cells of the digestive and respiratory systems and their pathology. In JMB Bloodworth (Ed), Endocrine Pathology. Baltimore, Williams & Wilkins, pp 513–555, 1982.

    Google Scholar 

  18. Facer P, Bishop AE, Lloyd RV, et al: Chromogranin: A newly recognized marker for endocrine cells of the human gastrointestinal tract. Gastroenterology 89:1366–1377, 1985.

    PubMed  CAS  Google Scholar 

  19. Larsson L-I, Goltermann N, de Magistris L, et al: Somatostatin cell processes as pathways for paracrine secretion. Science 205:1393–1394, 1979.

    Article  PubMed  CAS  Google Scholar 

  20. Christofides ND, Bryant MG, Ghatei MA, et al: Molecular forms of motilin in the mammalian and human gut and human plasma. Gastroenterology 80:292–300, 1981.

    PubMed  CAS  Google Scholar 

  21. Sjolund K, Sanden G, Hakanson R, et al: Endocrine cells in human intestine: An immunocytochemical study. Gastroenterology 85:1120–1130, 1983.

    PubMed  CAS  Google Scholar 

  22. Ferri G-L, Adrian TE, Ghatei MA, et al: Tissue localization and relative distribution of regulatory peptides in separated layers from the human bowel. Gastroenterology 84:777–786, 1983.

    PubMed  CAS  Google Scholar 

  23. Bloom SR, Polak JM: Regulatory peptides and hormone secreting tumours. In CC Booth, G Neale (Eds), Disorders of the Small Intestine. Boston, Blackwell Scientific Publishing, 1985, pp 376–397.

    Google Scholar 

  24. Owen RL: Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer’s patches in the normal unobstructed mouse intestine: An ultras-tructural study. Gastroenterology 72:440–451, 1977.

    PubMed  CAS  Google Scholar 

  25. Nabeyama A, Leblond CP: Caveolated cells characterized by deep surface invaginations and abundant filaments in mouse gastrointestinal epithelia. Am J Anat 140:147–166, 1974.

    Article  PubMed  CAS  Google Scholar 

  26. Blom H, Heiander HF: Quantitative ultrastructural studies on parietal cell regeneration in experimental ulcers in rat gastric mucosa. Gastroenterology 80:334–343,1981.

    PubMed  CAS  Google Scholar 

  27. Madara JL: Cup cells: Structure and distribution of a unique class of epithelial cells in guinea pig, rabbit, and monkey intestine. Gastroenterology 83:981–994, 1982.

    PubMed  CAS  Google Scholar 

  28. Madara JL, Carlson SL: Cup cells: Further structural characterization of the brush border and the suggestion that they may serve as an attachment site for an unidentified bacillus in guinea pig ileum. Gastroenterology 89:1374–1386, 1985.

    PubMed  CAS  Google Scholar 

  29. Bockman DE, Cooper MD: Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix, and Peyer’s patches: An electron microscopic study. Am J Anat 136:445–477, 1973.

    Article  Google Scholar 

  30. Owen RL, Jones AL: Epithelial cell specialization within human Peyer’s patches: An ultrastructural study of intestinal lymphoid follicles. Gastroenterology 66:189–203, 1974.

    PubMed  CAS  Google Scholar 

  31. Wolf JL, Bye WA: The membranous epithelial cell and the mucosal immune system. Ann Rev Med 35:95–112, 1984.

    Article  PubMed  CAS  Google Scholar 

  32. Wolf JL, Kauffman RS, Finberg R, et al: Determinants of reovirus interaction with the intestinal M cells and absorptive cells of murine intestine. Gastroenterology 85:291–300, 1983.

    PubMed  CAS  Google Scholar 

  33. Cornell R, Walker WA, Isselbacher KJ: Small intestinal absorption of horseradish peroxidase: A cytochemical study. Lab Invest 25:42–48, 1971.

    PubMed  CAS  Google Scholar 

  34. Hirata I, Austin LL, Blackwell WH, et al: Immunoelectron microscopie localization of HLA-DR antigen in control small intestine and colon and in inflammatory bowel disease. Dig Dis Sei 31:1317–1330, 1986.

    Article  CAS  Google Scholar 

  35. Keren DF, Hold PS, Collins HH, et al: The role of Peyers patches in the local immune response of rabbit ileum to live bacteria. J Immunol 120:1892–1896, 1978.

    PubMed  CAS  Google Scholar 

  36. Marsh MN: Studies of intestinal lymphoid tissue. I. Electron microscopic evidence of “blast transformation” in epithelial lymphocytes of mouse small intestinal mucosa. Gut 16:665–682, 1975.

    Article  PubMed  CAS  Google Scholar 

  37. Dobbins WO III: Progress report: Human intestinal intraepithelial lymphocytes. Gut 27:972–985, 1985.

    Article  Google Scholar 

  38. Austin LL, Dobbins WO III: Intraepithelial leucocytes of the intestinal mucosa in normal man and in Whipple’s disease: A light and electron microscopic study. Dig Dis Sei 27:311–320, 1982.

    Article  CAS  Google Scholar 

  39. Cerf-Bensussan N, Quaroni A, Kurnick JT, et al: Intraepithelial lymphocytes modulate la expression by intestinal epithelial cells. J Immunol 132:2244–2252, 1984.

    PubMed  CAS  Google Scholar 

  40. Galluci BB, Sale GE, McDonald GB, et al: The fine structure of human rectal epithelium in acute graft-versus-host disease. Am J Surg Pathol 6:293–305, 1982.

    Article  Google Scholar 

  41. Weber JR, Dobbins WO III: The intestinal and rectal epithelial lymphocyte in AIDS: An electron microscopic study. Am J Surg Pathol 10:627–239, 1986.

    Article  PubMed  Google Scholar 

  42. Parker FG, Barnes EN, Kaye GI: The pericryptal fibroblast sheath. IV. Replication, migration, and differentiation of the subepithelial fibroblasts of the crypt and villus of the rabbit jejunum. Gastroenterology 67:607–621, 1974.

    PubMed  CAS  Google Scholar 

  43. Joyce NC, Haire MF, Palade GE: Morphologic and biochemical evidence for a contractile cell network within the rat intestinal mucosa. Gastroenterology 92:68–81, 1987.

    PubMed  CAS  Google Scholar 

  44. Hirata I, Berrebi G, Austin LL, et al: Immunohistological characterization of intraepithelial and lamina propria lymphocytes in control ileum and colon and in inflammatory bowel disease. Dig Dis Sci 31:593–603, 1986.

    Article  CAS  Google Scholar 

  45. Clementi F, Palade GE: Intestinal capillaries: Permeability to peroxidase and ferritin. J Cell Biol 41:33–58, 1969.

    Article  PubMed  CAS  Google Scholar 

  46. Dobbins WO III, Rollins EL: Intestinal mucosal lymphatic permeability: An electron microscopic study of endothelial vesicles and cell junctions. J Ultrastruct Res 33:29–59, 1970.

    Article  PubMed  CAS  Google Scholar 

  47. Gabella G: Structure of muscles and nerves in the gastrointestinal tract. In LR Johnson (Ed), Physiology of the Gastrointestinal Tract (2nd ed). New York, Raven Press, 1987, pp 335–381.

    Google Scholar 

  48. Dahl JL, Bloom DD, Epstein ML, et al: Effect of chemical ablation of myenteric neurons on neurotransmitter levels in the rat jejunum. Gastroenterology 92:338–344, 1987.

    PubMed  CAS  Google Scholar 

  49. James AH: Gastric epithelium in the duodenum. Gut 5:258–294, 1964.

    Article  Google Scholar 

  50. Mansbach CM, Wilkins RM, Dobbins WO III, et al: Intestinal mucosal function and structure in the steatorrhea of Zollinger-Ellison syndrome. Arch Intern Med 121:487–494, 1968.

    Article  PubMed  Google Scholar 

  51. Florey HW, Jennings DA, O’Conner RC: The reactions of the intestine of the pig to gastric juice. J Pathol Bacteriol 49:105–123, 1939.

    Article  Google Scholar 

  52. Yokoyama I, Kozuka S, Ito K, et al: Gastric gland metaplasia in the small and large intestine. Gut 18:214–218, 1977.

    Article  PubMed  CAS  Google Scholar 

  53. Hoedemaeker PJ: Heterotopic gastric mucosa in the duodenum. Digestion 3:165–173, 1970.

    Article  PubMed  CAS  Google Scholar 

  54. Spiller RC, Shousha S, Barrison IG: Heterotopic gastric tissue in the duodenum: A report of eight cases. Dig Dis Sci 27:880–883, 1982.

    Article  CAS  Google Scholar 

  55. Shousha S, Barrison IG, El-Sayeed W, et al: A study of incidence and relationship of intestinal metaplasia of gastric antrum and gastric metaplasia of duodenum in patients with nonulcer dyspepsia. Dig Dis Sei 29:311–316, 1984.

    Article  CAS  Google Scholar 

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© 1990 Springer-Verlag New York, Inc.

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Dobbins, W.O. (1990). Biopsy Interpretation—Electron Microscopy. In: Diagnostic Pathology of the Intestinal Mucosa. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-3276-6_3

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  • DOI: https://doi.org/10.1007/978-1-4612-3276-6_3

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7946-4

  • Online ISBN: 978-1-4612-3276-6

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