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The Role of Laboratory Evaluation in the Management of Hospital-Based DM: “When Did HbA1C Become an Inpatient Test?”

  • Diabetes and Metabolic Disease (W. Ford, Section Editor)
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Abstract

Hyperglycemia in the hospital setting is deleterious to patient outcomes. Patients with and without diabetes mellitus (DM) may present with hyperglycemia when they are acutely ill. The poor outcomes associated with hyperglycemia are potentially preventable with improved protocols to screen, diagnose, and treat DM in perioperative, critically ill, and non-critically ill patients. The role of lab tests, specifically the utility of hemoglobin A1C (HbA1c), in these scenarios is not well described. HbA1c is a rapid, cost-effective test that does not require a fasting blood sample. It can be used to screen, diagnose, and monitor glycemic control in patients with pre-diabetes or DM. Newer studies also support its use as a bundled measure in hospital quality improvement initiatives. Judicious use of HbA1c in the hospital can lead to improvement in quality of diabetes care and patient outcomes.

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References

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  1. Umpierrez GE, Kitabchi AE. ICU care for patients with diabetes. Curr Opin Endocrinol. 2004;11:75–81.

    Article  Google Scholar 

  2. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med. 2001;345(19):1359–67.

    Article  PubMed  Google Scholar 

  3. van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICU. N Engl J Med. 2006;354(5):449–61.

    Article  PubMed  Google Scholar 

  4. Deedwania P, Kosiborod M, Barrett E, et al. Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on nutrition, physical activity, and metabolism. Circulation. 2008;117(12):1610–9.

    Article  PubMed  Google Scholar 

  5. Kitabchi AE, Freire AX, Umpierrez GE. Evidence for strict inpatient blood glucose control: time to revise glycemic goals in hospitalized patients. Metabolism. 2008;57(1):116–20.

    Article  CAS  PubMed  Google Scholar 

  6. Brunkhorst FM, Engel C, Bloos F, et al. Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125–39.

    Article  CAS  PubMed  Google Scholar 

  7. Preiser JC, Brunkhorst F. Tight glucose control and hypoglycemia. Crit Care Med. 2008; 36(4):1391; 1391–2.

  8. Garber AJ, Moghissi ES, Bransome ED Jr, et al. American College of Endocrinology position statement on inpatient diabetes and metabolic control. Endocr Pract. 2004;10(Suppl 2):4–9.

    PubMed  Google Scholar 

  9. Stranders I, Diamant M, van Gelder RE, et al. Admission blood glucose level as risk indicator of death after myocardial infarction in patients with and without diabetes mellitus. Arch Intern Med. 2004;164(9):982–8.

    Article  PubMed  Google Scholar 

  10. McAlister FA, Majumdar SR, Blitz S, et al. The relation between hyperglycemia and outcomes in 2,471 patients admitted to the hospital with community-acquired pneumonia. Diabetes Care. 2005;28(4):810–5.

    Article  PubMed  Google Scholar 

  11. Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax. 2006;61(4):284–9.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  12. Noordzij PG, Boersma E, Schreiner F, et al. Increased preoperative glucose levels are associated with perioperative mortality in patients undergoing noncardiac, nonvascular surgery. Eur J Endocrinol. 2007;156(1):137–42.

    Article  CAS  PubMed  Google Scholar 

  13. Umpierrez GE, Isaacs SD, Bazargan N, et al. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87(3):978–82.

    Article  CAS  PubMed  Google Scholar 

  14. Gough S, Manley S, Stratton I. HbA1C in diabetes: case studies using IFCC units. West Sussex: Wiley; 2010. p. 16.

    Book  Google Scholar 

  15. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent DM. N Engl J Med. 1993;329(14):977–86.

    Article  Google Scholar 

  16. Ferri FF. Ferri’s clinical advisor 2015: 5 books in 1. Philadelphia: Mosby, Elsevier Inc; 2014. p. 368. e2–74.

    Google Scholar 

  17. •• Standards of Medical Care in Diabetes 2014. American Diabetes Association. Diabetes Care. 2014;37 Suppl 1: S14–80. This article makes evidence based recommendations on strategies to improve diabetes process of care. It summarizes the established roles of HbA1C in the management of diabetes.

  18. Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321(7258):405–12.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  19. Nathan DM, Kuenen J, Borg R, et al. Translating the A1C assay into estimated average glucose values. Diabetes Care. 2008;31(8):1473–8.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Ekoe JM, Punthakee Z, Ransom T, et al. Screening for Type 1 and Type 2 Diabetes. Clinical practice guidelines. Canadian Diabetes Association Clinical Practice Guidelines Expert Committee. Can J Diabetes. 2013;37(Suppl 1):S12–5.

    Article  PubMed  Google Scholar 

  21. Centers for Disease Control and Prevention. National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States, 2011. Atlanta: Department of Health and Human Services, Centers for Disease Control and Prevention; 2011.

  22. Finfer S, Chittock DR, Su SY, et al. Intensive versus conventional glucose control in critically ill patients. N Engl J Med. 2009;360(13):1283–97.

    Article  PubMed  Google Scholar 

  23. American Association of Clinical Endocrinologists and American Diabetes. Association consensus statement on inpatient glycemic control. Diabetes Care. 2009;32(6):1119–31.

    Article  Google Scholar 

  24. Golightly LK, Jones MA, Hamamura DH, et al. Management of diabetes mellitus in hospitalized patients: efficiency and effectiveness of sliding-scale insulin therapy. Pharmacotherapy. 2006;26(10):1421–32.

    Article  CAS  PubMed  Google Scholar 

  25. Lansang MC, Umpierrez GE. Management of inpatient hyperglycemia in noncritically Ill patients. Diabetes Spectr. 2008;21(4):248–55.

    Article  Google Scholar 

  26. Sacks DB, Arnold M, Bakris GL, et al. Guidelines and recommendations for laboratory analysis in the diagnosis and management of diabetes mellitus. Diabetes Care. 2011;34(6):e61–99.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  27. Howanitz PJ, Cembrowski GS, Steindel SJ, et al. Physician goals and laboratory test turnaround times. A College of American Pathologists Q-Probes study of 2763 clinicians and 722 institutions. Arch Pathol Lab Med. 1993;117(1):22–8.

    CAS  PubMed  Google Scholar 

  28. Weir CJ, Murray GD, Dyker AG, et al. Is hyperglycemia an independent predictor of poor outcome after acute stroke? Results from a long term follow up study. Br Med J. 1997;314(7090):1303–6.

    Article  CAS  Google Scholar 

  29. Giakoumidakis K, Eltheni R, Patelarou E, et al. Effects of intensive glycemic control on outcomes of cardiac surgery. Heart Lung. 2013;42(2):146–51.

    Article  PubMed  Google Scholar 

  30. Sathya B, Davis B, Taveira T, et al. Intensity of peri-operative glycemic control and postoperative outcomes in patients with diabetes: a meta-analysis. Diabetes Res Clin Pract. 2013;102(1):8–15.

    Article  CAS  PubMed  Google Scholar 

  31. Scott RD. The Direct Medical Costs of Healthcare-Associated Infections in U.S. Hospitals and the benefits of prevention. Atlanta: Centers for Disease Control and Prevention, 2009. http://www.cdc.gov/hai/pdfs/hai/scott_costpaper.pdf. Accessed 22 Nov 2014.

  32. Mraovic B, Suh D, Jacovides C, et al. Perioperative hyperglycemia and postoperative infection after lower limb arthroplasty. J Diabetes Sci Technol. 2011;5(2):412–8.

    Article  PubMed Central  PubMed  Google Scholar 

  33. Ata A, Lee J, Bestle SL, et al. Postoperative Hyperglycemia and Surgical Site Infection in General Surgery Patients. Arch Surg. 2010;145(9):858–64.

    Article  PubMed  Google Scholar 

  34. Friedman D, Sexton DJ, Connelly SM, et al. Risk factors for surgical site infection complicating laminectomy. Infect Control Hosp Epidemiol. 2007;28(9):1060–5.

    Article  PubMed  Google Scholar 

  35. • Aspey HA, Coan, KE, Castro JC, et al. Overcoming clinical inertia in the management of postoperative patients with diabetes. Endocr Prac. 2014:20(4):320–8. This article highlights the importance of process improvement in diabetic care in the postoperative patient. The higher rate of surgical site infection and associated morbidity in patients with poor glucose control is an area where improvement in management practices can significantly benefit patients.

  36. Tonks KT, Jones GR, McGeechan K, et al. Hyperglycemia in hospital inpatients: still a sticky situation. Intern Med J. 2010;40(7):521–6.

    Article  CAS  PubMed  Google Scholar 

  37. Schnipper JL, Barsky EE, Shaykevich S, et al. Inpatient management of diabetes and hyperglycemia among general medicine patients at a Large Teaching Hospital. J Hosp Med. 2006;1(3):145–50.

    Article  PubMed  Google Scholar 

  38. National Hospital Discharge Survey: 2010 table, Average length of stay and days of care—number and rate of discharges by first-listed diagnostic categories. Centers for Disease Control and Prevention. http://www.cdc.gov/nchs/data/nhsr/nhsr029.pdf. Accessed 22 Nov 2014.

  39. Valentine NA, Alhawassi TM, Roberts GW, et al. Detecting undiagnosed diabetes using glycated haemoglobin: an automated screening test in hospitalized patients. Med J Aust. 2011;194(4):160–4.

    PubMed  Google Scholar 

  40. Mazurek JA, Hailpern SM, Goring T, et al. Prevalence of hemoglobin A1c greater than 6.5 % and 7.0 % among hospitalized patients without known diagnosis of diabetes at an Urban Inner City Hospital. J Clin Endocrinol Metab. 2010;95(3):1344–8.

    Article  CAS  PubMed  Google Scholar 

  41. Wexler DJ, Nathan DM, Grant RW, et al. Prevalence of elevated hemoglobin A1c among patients admitted to the hospital without a diagnosis of diabetes. J Clin Endocrinol Metab. 2008;93(11):4238–44.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  42. •• Juarez DT, Demaris KM, Goo R, et al. Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience. Diabetes Metab Syndr Obes. 2014:7:487–94. This article summarizes recent evidence on the effectiveness of using HbA1C as a screening and diagnostic tool for diabetes. It also examines the limitation of using this test for diagnosis of diabetes.

  43. • Malcolm JC, Kocourek J, Keely E, et al. Implementation of a screening program to detect previously undiagnosed dysglycemia in hospitalized patients. Can J Diabetes. 2014;38(2):79–84. This article examines HbA1C as a screening test in hospitalized patients to detect dysglycemia and attending physicians responsiveness to initiation of recommended treatment when dysglycemia was present. It highlights the role of HbA1C as a screening tool in the hospital and the need for change in provider actions to improve diabetes care in the hospital.

  44. • Horwitz DA, Schwartz ES, Scott MG, et al. Emergency department patients with diabetes have better glycemic control when they have identifiable primary care providers. Acad Emerg Med. 2012;19(6):650–5. This article outlines the use of HbA1C in the hospital to assess long-term control of diabetes in patients with and without a PCP.

  45. •• Umpierrez GE, Reyes D, Smiley D, et al. Hospital discharge algorithm based on admission HbA1c for the management of patients with type 2 diabetes. Diabetes Care. 2014;37(11):2934–9. This article gives an excellent example of an innovative method by which HbA1C can be used in the hospital to improve diabetes care in the hospital as well as design a structured discharge algorithm for patients with diabetes.

  46. • Siddique H, Alam MM, Safi AW, et al. In-patient diabetes care: the impact of diabetes outreach team on long-term glycaemic control. Int J Clin Pract. 2014;68(11):1333–7. This article outlines an effective way to utilize HbA1C in the hospital in conjunction with a designated diabetes outreach team to provide comprehensive care, structured patient education and appropriate intervention.

  47. •• Strack B, DeShazo JP, Gennings C, et al. Impact of HbA1c measurement on hospital readmission rates: analysis of 70,000 clinical database patient records. BioMed Res Int. 2014;2014:781670. This article demonstrates the usefulness of HbA1c measurement as an indicator to predict readmission rates and develop strategies to lower costs of inpatient care.

  48. Dungan K, Lyons S, Manu K, et al. An individualized inpatient diabetes education and hospital transition program for poorly controlled hospitalized patients with diabetes. Endocr Pract. 2014:1–24. (Epub ahead of print).

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Correspondence to Sowmya Kanikkannan.

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This article is part of the Topical Collection on Diabetes and Metabolic Disease.

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Kanikkannan, S., Sukul, V. The Role of Laboratory Evaluation in the Management of Hospital-Based DM: “When Did HbA1C Become an Inpatient Test?”. Curr Emerg Hosp Med Rep 3, 43–49 (2015). https://doi.org/10.1007/s40138-015-0066-x

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