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Anti-nociceptive, CNS, antibacterial and antifungal activities of methanol seed extracts of Nephelium lappaceum L

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Abstract

Methanol seed (raw, boiled and roasted) extracts of Nephelium lappaceum L (N. lappaceum) were investigated for anti-nociceptive, CNS, antibacterial and antifungal activities. Antinociceptive activity was evaluated by Eddy’s hot plate method. CNS activity was evaluated by rota rod and actophotometer. The antibacterial and antifungal activity was evaluated by cup plate method and by minimum inhibitory concentration (MIC) method. In acute toxicity, all three extracts was found to be safe up to 2,500 mg/kg dose. The anti-nociceptive activity exhibited by raw methanol seed extract was found to be superior than boiled methanol seed extracts. Roasted methanol seed extracts did not show any activity. In rota rod test, methanol extract of raw and boiled seed extracts were significantly (P < 0.05) affected the motor coordination in mice. But, methanol extracts of roasted seed did not affect motor coordination in mice. The locomotor activity was significantly (P < 0.05) reduced in mice treated with raw and boiled methanol seed extracts. No significant reduction in locomotor activity was observed in mice treated with roasted methanol seed extract. Dose dependent response of raw and boiled methanol seed extracts was noticed in rota rod test and locomotor activity assessment. The antibacterial activity of methanol seed extracts (raw, boiled and roasted) of N. lappaceum L was tested against two strains of gram positive and two strains of gram negative pathogenic bacteria. The raw and boiled methanol seed extracts of N. lappaceum was most sensitive (MIC 40 g/mL) to Staphylococcus epidermidis. All three methanol extracts of seeds did not show antifungal activity.

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Authors and Affiliations

  1. KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore, 641048, Tamilnadu, India

    Aiyalu Rajasekaran

  2. School of Pharmacy, AIMST University, Bedong, Malaysia

    Shunmugam Ganesan, Nadarajah Kamini, Chandramohan Lavanya, Liew Lee Yoon & Hui Shian Oh

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  1. Aiyalu Rajasekaran
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  2. Shunmugam Ganesan
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  3. Nadarajah Kamini
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  4. Chandramohan Lavanya
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  5. Liew Lee Yoon
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  6. Hui Shian Oh
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Correspondence to Aiyalu Rajasekaran.

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Rajasekaran, A., Ganesan, S., Kamini, N. et al. Anti-nociceptive, CNS, antibacterial and antifungal activities of methanol seed extracts of Nephelium lappaceum L . Orient Pharm Exp Med 13, 149–157 (2013). https://doi.org/10.1007/s13596-012-0095-x

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  • DOI: https://doi.org/10.1007/s13596-012-0095-x

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