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Circulating retinol-binding protein 4 concentrations in patients with coronary artery disease and patients with type 2 diabetes mellitus

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Abstract

Circulating Retinol-Binding Protein 4 (RBP4) has recently been identified as a marker of insulin resistance. We tested this hypothesis in patients with coronary artery disease (CAD), patients with type 2 diabetes mellitus (T2DM), and in non-diabetic control subjects. We studied plasma RBP4 levels and RBP4-to-transthyrethin (TTR) ratio, estimating the excess circulating RBP4 in proportion to TTR, in 45 individuals divided into three groups (15 CAD, 15 T2DM, and 15 controls). Plasma RBP4 levels were significantly lower in patients with T2DM than in non-diabetic control subjects (P = 0.05). The RBP4/TTR ratio was not statistically different between the groups. There was no difference in plasma RBP4 levels and RBP4/TTR ratio between non-diabetic CAD patients and control subjects or those with and without metabolic syndrome. No significant associations were found between RBP4 and RBP4/TTR ratio, as dependent parameters, with markers of the metabolic syndrome and lipid metabolism. RBP4 does not seem to be a valuable marker for identification of the metabolic syndrome or insulin resistance in patients with T2DM or CAD.

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Authors and Affiliations

  1. Division of Cardiology, Department of Internal Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Jafar Mahmoudi & Mona Hedayat

  2. Department of Nutrition and Biochemistry, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Maryam Mahmoudi, Fereydoon Siassi, Maryam Chamari & Ali-Akbar Saboor-Yaraghi

  3. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Mona Hedayat, Hassan Abolhassani & Nima Rezaei

  4. Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Parvin Pasalar

  5. Department of Biochemistry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Parvin Pasalar

  6. Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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  1. Mohammad Jafar Mahmoudi
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  2. Maryam Mahmoudi
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  3. Fereydoon Siassi
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  4. Mona Hedayat
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  5. Parvin Pasalar
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  6. Maryam Chamari
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  7. Hassan Abolhassani
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  8. Nima Rezaei
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  9. Ali-Akbar Saboor-Yaraghi
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Correspondence to Ali-Akbar Saboor-Yaraghi.

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Mahmoudi, M.J., Mahmoudi, M., Siassi, F. et al. Circulating retinol-binding protein 4 concentrations in patients with coronary artery disease and patients with type 2 diabetes mellitus. Int J Diabetes Dev Ctries 32, 105–110 (2012). https://doi.org/10.1007/s13410-012-0077-z

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  • DOI: https://doi.org/10.1007/s13410-012-0077-z

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