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The prediction of survival of patients with gastric cancer with PD-L1 expression using contrast-enhanced ultrasonography

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Tumor Biology

Abstract

Gastric cancer is the one of the most common cancers around the world. The prognosis of gastric cancer remains poor, due to the biological characteristics of the primary tumor as well as the recurrence after treatment. Accumulating evidence suggests the implication of programmed death ligand-1 (PD-L1) in the pathogenesis and prognosis of cancer. This study aimed to explore the CEUS as a valuable tool to improve the assessment of the therapeutic effect of the PD-L1 blocker in the treatment of gastric cancer. A total number of 105 patients with gastric cancer were enrolled in this study from June 2008 to December 2011 in our hospital. The association of PD-L1 expression level (105 cases) and CEUS parameters (100 cases) with the prognosis of gastric cancer was examined. The results showed that PD-L1-positive staining was associated with the depth of invasion, differentiation, and poor prognosis of patients with gastric cancer. The CEUS intensity (positive) exhibited poor prognosis compared to the negative counterpart. Moreover, PD-L1 and CEUS co-positivity was significantly related to a poor prognosis. The characteristic of ultrasonography images correlated with the expression of PD-L1 (r = 0.46, P = 0.0003). Collectively, the mean intensity of contrast-enhanced ultrasonography is a useful predictor in the PD-L1 expression in gastric cancer. The ultrasonography and CEUS parameter could be considered as the predictor of response to PD-L1 blocker treatment in the clinical practice.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundations of China (No. 81171904 and 81401412). We thank all the people and patients who participated in this study.

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    Authors and Affiliations

    1. Department of Rehabilitation Medicine, Center of Bone Metabolism and Repair, State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042, China

      Lin-Ang Wang & Lin Chen

    2. Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, 400042, China

      Qing Li

    3. Department of Diagnostic and Therapeutic Ultrasonography, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China

      Xi Wei

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    1. Lin-Ang Wang
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    2. Xi Wei
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    3. Qing Li
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    4. Lin Chen
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    Correspondence to Lin-Ang Wang.

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    Lin-Ang Wang and Xi Wei contributed equally to this work.

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    Wang, LA., Wei, X., Li, Q. et al. The prediction of survival of patients with gastric cancer with PD-L1 expression using contrast-enhanced ultrasonography. Tumor Biol. 37, 7327–7332 (2016). https://doi.org/10.1007/s13277-015-4600-y

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    • DOI: https://doi.org/10.1007/s13277-015-4600-y

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