Skip to main content

Advertisement

Log in

Surgical Decision Making in the Management of Well-Differentiated Thyroid Cancer

  • Review Article
  • Published:
Indian Journal of Surgical Oncology Aims and scope Submit manuscript

Abstract

The incidence of thyroid cancer in the United States has been increasing. The biologic behavior of well-differentiated thyroid cancer (WDTC) can vary from indolent tumor to an aggressive disease with invasion of critical structures and/or widespread distant metastasis. Therefore, the risk stratification is crucial in understanding the biology of thyroid cancer, its prognosis and appropriate therapeutic interventions. In fact, understanding the nuances of biological behavior of thyroid carcinomas lays the foundation for the idea of selective surgical management of this disease.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Hundahl SA, Cady B, Cunningham MP et al (2000) Initial results from a prospective cohort study of 5583 cases of thyroid carcinoma treated in the United States during 1996. U.S. and German Thyroid Cancer Study Group. An American College of Surgeons Commission on Cancer Patient Care Evaluation study. Cancer 89:202–217

    Article  PubMed  CAS  Google Scholar 

  2. Tuttle RM, Leboeuf R, Martorella AJ (2007) Papillary thyroid cancer: monitoring and therapy. Endocrinol Metab Clin North Am 36:753–778, vii

    Article  PubMed  CAS  Google Scholar 

  3. Davies L, Welch HG (2006) Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 295:2164–2167

    Article  PubMed  CAS  Google Scholar 

  4. Shaha AR (2004) Implications of prognostic factors and risk groups in the management of differentiated thyroid cancer. Laryngoscope 114(3):393–402

    Article  PubMed  Google Scholar 

  5. Shaha A, Loree TR, Shah JP (1994) Intermediate-risk group for differentiated carcinoma of the thyroid. Surgery 116:1036–1041

    PubMed  CAS  Google Scholar 

  6. Shah JP, Loree TR, Dharker D, et al. Lobectomy vs. total thyroidectomy for differentiated carcinoma of the thyroid: a matched pair analysis. Am J Surg 166(4): 331–335

  7. Shaha AR, Shah JP, Loree TR (1997) Low-risk differentiated thyroid cancer: the need for selective treatment. Ann Surg Oncol 4:328–333

    Article  PubMed  CAS  Google Scholar 

  8. Shaha AR, Shah JP, Loree TR (1996) Patterns of nodal metastasis based on histologic varieties in differentiated carcinoma of the thyroid. Am J Surg 172:692–694

    Article  PubMed  CAS  Google Scholar 

  9. Nikiforov YE, Nikiforova MN (2011) Molecular genetics and diagnosis of thyroid cancer. Nat Rev Endocrinol 7:569–580

    Article  PubMed  CAS  Google Scholar 

  10. Neimeier LA, Akatsu HK, Song C, et al. (2011) A combined molecular-pathologic score improves risk stratification of thyroid papillary microcarcinoma. Cancer

  11. Shah JP (2008) Exploring biology in selecting treatment for differentiated cancer of the thyroid gland. Eur Arch Otorhinolaryngol 265:1155–1160

    Article  PubMed  Google Scholar 

  12. Noguchi M et al (1993) Multivariate study of prognostic factors of differentiated thyroid carcinoma: the significance of histologic subtype. Int Surg 78:10–15

    PubMed  CAS  Google Scholar 

  13. Sugitani I, Kasai N, Fujimoto Y et al (2004) A novel classification system for patients with PTC: addition of the new variables of large (3 cm or greater) nodal metastases and reclassification during the follow-up period. Surgery 135:139–148

    Article  PubMed  Google Scholar 

  14. Sherman SI, Brierley JD, Sperling M et al (1998) Prospective multicenter study of thyroid carcinoma treatment: initial analysis of staging and outcome. National Thyroid Cancer Treatment Cooperative Study Registry Group. Cancer 83(5):1012–1021

    Article  PubMed  CAS  Google Scholar 

  15. Shah JP, Loree TR, Dharker D et al (1995) Prognostic factors in differentiated carcinoma of the thyroid gland. Am J Surg 170(5):467–470

    Article  PubMed  Google Scholar 

  16. Hay ID, McConahey WM, Goellner JR (2002) Managing patients with papillary thyroid carcinoma: insights gained from Mayo Clinic’s experience of treating 2,512 consecutive patients during 1940 through 2000. Trans Am Clin Climatol Assoc 113:241–260

    PubMed  Google Scholar 

  17. Anderson PE, Kinsella J, Loree TR et al (1995) Differentiated carcinoma of the thyroid with extrathyroidal extension. Am J Surg 170(5):467–470

    Article  Google Scholar 

  18. Tsumori T, Nakao K, Miyata M et al (1985) Clinicopathologic study of thyroid carcinoma infiltrating the trachea. Cancer 56:2843–2848

    Article  PubMed  CAS  Google Scholar 

  19. Shin DH, Mark EJ, Suen HC et al (1993) Pathologic staging of papillary carcinoma of the thyroid with airway invasion based on the anatomic manner of extension to the trachea: a clinicopathologic study based on 22 patients who underwent thyroidectomy and airway resection. Hum Pathol 24(8):700–866

    Article  Google Scholar 

  20. McCaffey TV, Bergstralh EJ, Hay ID (1994) Locally invasive papillary thyroid carcinoma:1940–1990. Head Neck 16:165–172

    Article  Google Scholar 

  21. Friedman M, Danielzadeh JA, Caldarelli DD (1994) Treatment of patients with carcinoma invading the airway. Arch Otolaryngol Head Neck Surg 120:1377–1381

    Article  PubMed  CAS  Google Scholar 

  22. Price DL, Shah JP (2009) Surgery for locally extensive carcinomas of the thyroid gland. Oper Tech Otolaryngol 20:7–17

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ashok R. Shaha.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chernichenko, N., Shaha, A.R. Surgical Decision Making in the Management of Well-Differentiated Thyroid Cancer. Indian J Surg Oncol 3, 161–165 (2012). https://doi.org/10.1007/s13193-012-0148-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13193-012-0148-0

Keywords

Navigation