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Expanding Access to Naloxone in the United States

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References

  1. Warner M, Hui L, Makuc DL, Anderson RN et al (2011) Drug poisoning deaths in the United States, 1980–2008. NCHS data brief no 81. National Center for Health Statistics, Hyattsville

    Google Scholar 

  2. Wheeler E, Davidson PJ, Jones S et al (2012) Community-based opioid overdose prevention programs providing naloxone-United States, 2010. MMWR 61(06):101–5

    Google Scholar 

  3. Jones CM, Mack KA, Paulozzi LJ (2013) Pharmaceutical overdose deaths, United Sates 2010. JAMA 309:657–9

    Article  CAS  PubMed  Google Scholar 

  4. Heroin-related deaths in the US. Blog for the National Center for Health Statistics http://nchstats.com/2014/02/05/heroin-related-deaths-in-the-us/. Accessed April 11 2014.

  5. Maryland Department of Health and Mental Hygiene http://dhmh.maryland.gov/newsroom1/Pages/DHMH-Warns-of-Potent-and-Deadly-Drug-Combination.aspx Accessed April 2014.

  6. Ogilvie L, Stanley C, Lewis L et al (2013) Notes from the field: acetyl fentanyl overdose fatalities-Rhode Island March–May 2013. MMWR 62(34):703–4

    Google Scholar 

  7. Philadelphia Department of Public Health. Overdoses from tainted opioids recommendations for management. Health Advisory 2014; https://hip.phila.gov/xv/Portals/0/HIP/Health_Alerts/2014/PDPH-HAN_Advisory_2_TaintedOpioidOverdoses_012814.pdf Accessed April 2014.

  8. Centers for Disease Control and Prevention (2012) CDC Grand Rounds: prescription drug overdoses—a U.S. epidemic. MMWR 61(01):10–3

    Google Scholar 

  9. Pattinson KT (2008) Opioids and the control of respiration. Br J Anaesth 100(6):747–58

    Article  CAS  PubMed  Google Scholar 

  10. Lalley PM (2008) Opioidergic and dopaminergic modulation of respiration. Respir Physiol Neurobiol 164:160–7

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Lalley PM (2003) Mu-opioid receptor agonist effects on medullary respiratory neurons in the cat: evidence for involvement in certain types of ventilatory disturbances. Am J Physiol Regul Integr Comp Physiol 285:R1287–304

    CAS  PubMed  Google Scholar 

  12. Wermeling DP (2013) A response to the opioid overdose epidemic: naloxone nasal spray. Drug Deliv and Transl Res 3:63–74

    Article  CAS  Google Scholar 

  13. Wolfe TR, Braude DA (2010) Intranasal medication delivery for children: a brief review and update. Pediatrics 126:532–7

    Article  PubMed  Google Scholar 

  14. Sporer KA, Kral AH (2007) Prescription naloxone: a novel approach to heroin overdose prevention. Ann Emerg Med 49(2):172–7

    Article  PubMed  Google Scholar 

  15. Piper TM, Stancliff S, Rudenstine S et al (2008) Evaluation of a naloxone distribution administration program in New York City. Subs Abuse Misuse 43:858–70

    Article  Google Scholar 

  16. Enteen L, Bauer J, McLean R et al (2010) Overdose prevention and naloxone prescription for opioid users in San Francisco. J Urban Health 87(6):931–41

    Article  PubMed Central  PubMed  Google Scholar 

  17. Dietze P, Cantwell K, Burgess S (2002) Bystander resuscitation attempts at heroin overdose: does it improve outcomes? Drug Alcohol Depend 67:213–8

    Article  PubMed  Google Scholar 

  18. Doe-Simkins M, Quinn E, Xuan Z et al (2014) Overdose rescues by trained and untrained participants and change in opioid use among substance-using participants in overdose education and naloxone distribution programs: a retrospective study. BMC Public Health 14(297):1–11

    Google Scholar 

  19. Loimer N, Hofmann P, Choudhry HR (1992) Nasal administration of naloxone for detection of opiate dependence. J Psychiatr Res 26(1):39–43

    Article  CAS  PubMed  Google Scholar 

  20. Loimer N, Hofmann P, Choudhry HR (1994) Nasal administration of naloxone is as effective as the intravenous route in opiate addicts. Int J Addict 29(6):819–27

    CAS  PubMed  Google Scholar 

  21. Kelly AM, Koutsogiannis Z (2002) Intranasal naloxone for life-threatening opioid overdose. Emerg Med J 19(4):375

    Article  PubMed Central  PubMed  Google Scholar 

  22. Seal KH, Thawley R, Gee L et al (2005) Naloxone distribution and cardiopulmonary resuscitation training for injection drug users to prevent heroin overdose death: a pilot intervention study. J Urban Health 82:303–11

    Article  PubMed Central  PubMed  Google Scholar 

  23. Maxwell S, Bigg D, Stanczykiewicz K et al (2006) Prescribing naloxone to actively injecting heroin users: a program to reduce heroin overdose deaths. J Addict Dis 25(3):89–96

    Article  PubMed  Google Scholar 

  24. Tobin KA, Sherman SG, Beilenson P et al (2009) Evaluation of the Staying Alive programme: training injection drug users to properly administer naloxone and save lives. Int J Drug Policy 20:131–6

    Article  PubMed  Google Scholar 

  25. Doe-Simkins M, Walley AY, Epstein A et al (2009) Saved by the nose: bystander-administered intranasal naloxone hydrochloride for opioid overdose. Am J Public Health 99(5):788–90

    Article  PubMed Central  PubMed  Google Scholar 

  26. Benett AS, Bell A, Tomedi L et al (2011) Characteristics of an overdose prevention response, and naloxone distribution program in Pittsburgh and Allegheny County, Pennsylvania. J Urban Health 88(6):1020–30

    Article  Google Scholar 

  27. Walley A, Xuan Z, Hackman HH et al (2013) Opioid overdose rates and implementation of overdose education and nasal naloxone distribution in Massachusetts: interrupted time series analysis. BMJ 346:f174, 1:12

    Article  PubMed  Google Scholar 

  28. Walley AY, Doe-Simkins M, Quinn E et al (2013) Opioid overdose prevention with intranasal naloxone among people who take methadone. J Subst Abuse Treat 44:241–7

    Article  PubMed  Google Scholar 

  29. Wagner KD, Valente TW, Casanova M et al (2010) Evaluation of an overdose prevention and response training programme for injection drug users in the Skid Row area of Los Angeles, CA. Int J Drug Policy 21(3):186–93

    Article  PubMed  Google Scholar 

  30. Su A, Brason FW, Sanford C et al (2011) Project Lazarus: community-based overdose prevention in rural North Carolina. Pain Med 12:S77–85

    Article  Google Scholar 

  31. Buajordet I, Naess AC, Jacobsen D et al (2004) Adverse events after naloxone treatment of episodes of suspected acute opioid overdose. Euro J Emerg Med 11:19–23

    Article  Google Scholar 

  32. Sporer KA (1999) Acute heroin overdose. Ann Intern Med 130(7):584–90

    Article  CAS  PubMed  Google Scholar 

  33. Merigian KS (1993) Cocaine-induced ventricular arrhythmias and rapid atrial fibrillation temporarily related to naloxone administration. Am J Emerg Med 11:96–7

    Article  CAS  PubMed  Google Scholar 

  34. Osterwalder JJ (1996) Naloxone—for intoxications with intravenous heroin and heroin mixtures—harmless or hazardous? A prospective clinical study. J Toxicol Clin Toxicol 34(4):409–16

    Article  CAS  PubMed  Google Scholar 

  35. Kim D, Irwin KS, Koshnood K (2009) Expanded access to naloxone: options for critical response to the epidemic of opioid overdose mortality. Am J Public Health 99(3):402–7

    Article  PubMed Central  PubMed  Google Scholar 

  36. Wampler DA, Molina K, McManus J, Laws P, Manifold A (2011) No deaths associated with patient refusal of transport after naloxone-reversed opioid overdose. Prehosp Emerg Care 15:320–4

    Article  PubMed  Google Scholar 

  37. Vilke GM, Sloane C, Smith AM et al (2003) Assessment for deaths in out-of-hospital heroin overdoses patients treated with naloxone who refuse transport. Acad Emerg Med 10(8):893–6

    Article  PubMed  Google Scholar 

  38. Leece P, Orkin A (2013) Opioid overdose fatality prevention (letter). JAMA 309(9):873–4

    Article  CAS  PubMed  Google Scholar 

  39. Morris J (2000) Defining the precautionary principle. In: rethinking risk and the precautionary principle. New York: Butterworth-Heinemann, 1–21.

  40. Goklany IM (2002) From precautionary principle to risk-risk analysis. Nat Biotechnol 20:1075

    Article  CAS  PubMed  Google Scholar 

  41. Belestky L, Rich JD, Walley AY (2013) Opioid overdose fatality prevention (reply to letter). JAMA 309(9):874

    Article  Google Scholar 

  42. Strang J, Powis B, Best D et al (1999) Preventing opiate overdose fatalities with take-home naloxone: pre-launch study of possible impact and acceptability. Addiction 94:199–204

    Article  CAS  PubMed  Google Scholar 

  43. Dettmer K, Saunders B, Strang J (2001) Take home naloxone and the prevention of deaths from opiate overdose: two pilot schemes. BMJ 322(7291):895–6

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  44. Tracy M, Piper TM, Ompad D et al (2005) Circumstances of witnessed drug overdose in New York City: implications for intervention. Drug Alcohol Depend 79:181–90

    Article  PubMed  Google Scholar 

  45. Lagu T, Anderson BJ, Stein M (2006) Overdoses among friends: drug users-are willing to administer naloxone to others. J Subst Abuse Treat 30:129–33

    Article  PubMed  Google Scholar 

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Disclaimer

While individual practitioners may differ, these are the positions of the ACMT, AACT, and AAPCC at the time written, after review of the issue and pertinent literature.

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Authors and Affiliations

  1. American Academy of Clinical Toxicology, McLean, VA, USA

    Suzanne Doyon

  2. American College of Medical Toxicology, Phoenix, AZ, USA

    Steven E. Aks

  3. American Association of Poison Control Centers, Alexandria, VA, USA

    Scott Schaeffer

Authors
  1. Suzanne Doyon
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  2. Steven E. Aks
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  3. Scott Schaeffer
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Corresponding author

Correspondence to Steven E. Aks.

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Doyon, S., Aks, S.E. & Schaeffer, S. Expanding Access to Naloxone in the United States. J. Med. Toxicol. 10, 431–434 (2014). https://doi.org/10.1007/s13181-014-0432-1

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  • DOI: https://doi.org/10.1007/s13181-014-0432-1

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