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Gait variability at fast-pace walking speed: A biomarker of mild cognitive impairment?

  • Published:
The journal of nutrition, health & aging

Abstract

Background

The interpretation of the increase in stride-to-stride variability of stride time (STV) regarding the evolution of cognitive deficits across the dementia spectrum is matter of debate.

Objective

The aim of this study was to compare STV at usual and fast-pace walking speeds of MCI patients with that of cognitively healthy individuals (CHI) and Alzheimer’s disease (AD) patients with mild dementia, while considering the effects of potential confounders.

Methods

STV while walking at usual and fast-pace walking speeds was recorded with the GAITRite® system from 116 older adults (mean age 75.6±6.5 years; 55.2% female) divided into 3 groups according to their cognitive status (44 CHI, 39 MCI patients and 33 AD patients with mild dementia).

Results

The full adjusted multiple linear regression models showed that high STV was associated with slow gait speed at usual-pace walking speed (P=0.002) and with the MCI status at fast-pace walking speed (P=0.015).

Conclusions

High STV at fast-pace walking speed was a specific gait disturbance of MCI patients in the sample of studied participants, and thus could be used in the future as a specific biomarker of MCI patients.

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References

  1. Beauchet O, Allali G, Berrut G, Hommet C, Dubost V, Assal F. Gait analysis in demented participants: Interests and perspectives. Neuropsychiatr Dis Treat. 2008;4:155–160.

    Article  PubMed  Google Scholar 

  2. Verghese J, Wang C, Lipton RB, Holtzer R, Xue X. Quantitative gait dysfunction and risk of cognitive decline and dementia. J Neurol Neurosurg Psychiatry 2007;78:929–935.

    Article  PubMed  Google Scholar 

  3. Verghese J, Robbins M, Holtzer R, Zimmerman M, Wang C, Xue X. Gait dysfunction in mild cognitive impairment syndromes. J Am Geriatr Soc. 2008;56:1244–1251.

    Article  PubMed  Google Scholar 

  4. Goldman WP, Baty JD, Buckles VD, Sahrmann S, Morris JC. Motor dysfunction in mildly demented AD individuals without extrapyramidal signs. Neurology 1999;53:956–962.

    Article  PubMed  CAS  Google Scholar 

  5. Kluger A, Gianutsos JG, Golomb J, Ferris SH, George AE, Franssen E. Patterns of motor impairement in normal aging, mild cognitive decline, and early Alzheimer’s disease. J Gerontol B Psychol Sci Soc Sci. 1997;52:P28–39.

    Article  PubMed  CAS  Google Scholar 

  6. Allali G, Assal F, Kressig RW, Dubost V, Herrmann FR, Beauchet O. Impact of impaired executive function on gait stability. Dement Geriatr Cogn Disord. 2008;26:364–369.

    Article  PubMed  Google Scholar 

  7. Beauchet O, Allali G, Annweiler C, Bridenbaugh S, Assal F, Kressig RW. Gait variability among healthy adults: low and high stride-to-stride variability are both a reflection of gait stability. Gerontology 2009; 55: 702–706.

    Article  PubMed  Google Scholar 

  8. Beauchet O, Annweiler C, Lecordroch Y, Allali G, Dubost V, Herrmann FR. Walking speed-related changes in stride time variability: effects of decreased speed. J Neuroeng Rehabil. 2009;6:32.

    Article  PubMed  Google Scholar 

  9. Poujol L, Annweiler C, Allali G, Fantino B, Beauchet O. Effect of psychoactive medication on gait variability in community-dwelling older adults: a cross-sectional study. J Am Geriatr Soc. 2010;58:1207–1208.

    Article  PubMed  Google Scholar 

  10. Beauchet O, Annweiler C, Lecordroch Y, Allali G, Dubost V, Herrmann FR, Kressig RW. Walking speed-related changes in stride time variability: effects of decreased speed. J Neuroeng Rehabil. 2009;6:32.

    Article  PubMed  Google Scholar 

  11. Dubost V, Annweiler C, Aminian K, Najafi B, Herrmann FR, Beauchet O. Stride-tostride variability while enumerating animal names among healthy young adults: result of stride velocity or effect of attention-demanding task? Gait Posture. 2008;27:138–143

    Article  PubMed  Google Scholar 

  12. Kressig RW, Beauchet O. Guidelines for clinical applications of spatio-temporal gait analysis in older adults. Aging Clin Exp Res. 2006;18:174–176

    PubMed  Google Scholar 

  13. Annweiler C, Schott AM, Montero-Odasso M, Berrut G, Fantino B, Herrmann FR, Beauchet O. Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: the EPIDOS study. J Bone Miner Res. 2010;25:1858–1866.

    Article  PubMed  CAS  Google Scholar 

  14. Annweiler C, Fantino B, Schott AM, Krolak-Salmon P, Allali G, Beauchet O. Vitamin D insufficiency and mild cognitive impairment: cross-sectional association. Eur J Neurol. 2012;19:1023–1029.

    Article  PubMed  CAS  Google Scholar 

  15. Folstein MF, Folstein SE, McHugh PR. “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–198.

    Article  PubMed  CAS  Google Scholar 

  16. Shah A, Herbert R, Lewis S, Mahendran R, Platt J, Bhattacharyya B. Screening for depression among acutely ill geriatric inpatients with a short Geriatric Depression Scale. Age Ageing 1997;26:217–221.

    Article  PubMed  CAS  Google Scholar 

  17. Dubois B, Slachevsky A, Litvan I, Pillon B. The FAB: a Frontal Assessment Battery at bedside. Neurology, 2000; 55:1621–1626.

    Article  PubMed  CAS  Google Scholar 

  18. Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer’s disease. Am J Psychiatry 1984; 141:1356–1364.

    PubMed  CAS  Google Scholar 

  19. Brown EC, Casey A, Fisch RI, Neuringer C. Trail making test as a screening device for the detection of brain damage. J Consult Psychol. 1958;22:469–474.

    Article  PubMed  CAS  Google Scholar 

  20. Grober E, Buschke H, Crystal H, Bang S, Dresner R. Screening for dementia by memory testing. Neurology. 1988;38:900–903.

    Article  PubMed  CAS  Google Scholar 

  21. Van der Linden M, Coyette F, Poitrenaud F, Kalafat M, Calicis F, Adam, F. L’épreuve de rappel libre/rappel indicé à 16 items (RL/RI-16). In L’évaluation des troubles de la mémoire, (ed. Solal ), 2004, Marseille.

  22. Pérès K, Chrysostome V, Fabrigoule C, Orgogozo JM, Dartigues JF, Barberger-Gateau P. Restriction in complex activities of daily living in MCI: impact on outcome. Neurology 2006;67:461–466.

    Article  PubMed  Google Scholar 

  23. Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund LO. Mild cognitive impairment—beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J Intern Med. 2004;256:240–246.

    Article  PubMed  CAS  Google Scholar 

  24. McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944.

    Article  PubMed  CAS  Google Scholar 

  25. Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, Kuiper M, Steinling M, Wolters EC, Valk J. Atrophy of medial temporal lobes on MRI in “probable” Alzheimer’s disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992;55:967–972.

    Article  PubMed  CAS  Google Scholar 

  26. Rosano C, Brach J, Studenski S, Longstreth WT, Jr., Newman AB. Gait variability is associated with subclinical brain vascular abnormalities in high-functioning older adults. Neuroepidemiology 2007;29:193–200.

    Article  PubMed  Google Scholar 

  27. Zimmerman ME, Lipton RB, Pan JW, Hetherington HP, Verghese J. MRI- and MRS-derived hippocampal correlates of quantitative locomotor function in older adults. Brain Res. 2009;1291:73–81.

    Article  PubMed  CAS  Google Scholar 

  28. Scherder E, Eggermont L, Swaab D, van Heuvelen M, Kamsma Y, de Greef M. Gait in ageing and associated dementias; its relationship with cognition. Neurosci Biobehav Rev 2007;31:485–497.

    Article  PubMed  Google Scholar 

  29. Dickerson BC, Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer’s disease: insights from functional MRI studies. Neuropsychologia 2008;46:1624–1635.

    Article  PubMed  Google Scholar 

  30. Dubois B, Feldman HH, Jacova C, Cummings JL, Dekosky ST, Barberger-Gateau P. Revising the definition of Alzheimer’s disease: a new lexicon. Lancet Neurol. 2011;9:1118–1127.

    Article  Google Scholar 

  31. Dubois B, Feldman HH, Jacova C, Dekosky ST, Barberger-Gateau P, Cummings J. Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDSADRDA criteria. Lancet Neurol. 2007;6:734–746.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers, France

    Olivier Beauchet, C. Launay & C. Annweiler

  2. UPRES EA 2646, University of Angers, UNAM, Angers, France

    Olivier Beauchet

  3. Department of Neurology, Geneva University Hospital and University of Geneva, Geneva, Switzerland

    G. Allali

  4. Department of Rehabilitation and Geriatrics, Geneva University Hospitals and University of Geneva, Geneva, Switzerland

    F. R. Herrmann

  5. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, 49933, Angers Cedex 9, France

    Olivier Beauchet

Authors
  1. Olivier Beauchet
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  2. G. Allali
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  3. C. Launay
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  4. F. R. Herrmann
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  5. C. Annweiler
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Corresponding author

Correspondence to Olivier Beauchet.

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Beauchet, O., Allali, G., Launay, C. et al. Gait variability at fast-pace walking speed: A biomarker of mild cognitive impairment?. J Nutr Health Aging 17, 235–239 (2013). https://doi.org/10.1007/s12603-012-0394-4

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  • DOI: https://doi.org/10.1007/s12603-012-0394-4

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