Skip to main content
SpringerLink
Log in

Comparison of the prognostic value of myocardial perfusion imaging using a CZT-SPECT camera with a conventional anger camera

  • Original Article
  • Published:
Journal of Nuclear Cardiology Aims and scope

Abstract

Background

Recent studies have shown that myocardial perfusion imaging (MPI) in cadmium-zinc-telluride (CZT) cameras allow faster exams with less radiation dose but there are little data comparing its prognosis information with that of dedicated cardiac Na-I SPECT cameras

Objective

The objective of this study is to compare the prognostic value of MPI using an ultrafast protocol with low radiation dose in a CZT-SPECT and a traditional one.

Methods

Group 1 was submitted to a two-day MIBI protocol in a conventional camera, and group 2 was submitted to a 1-day MIBI protocol in CZT camera. MPI were classified as normal or abnormal, and perfusion scores were calculated. Propensity score matching methods were performed

Results

3554 patients were followed during 33±8 months. Groups 1 and 2 had similar distribution of age, gender, body mass index, risk factors, previous revascularization, and use of pharmacological stress. Group 1 had more abnormal scans, higher scores than group 2. Annualized hard events rate was higher in group 1 with normal scans but frequency of revascularization was similar to normal group 2. Patients with abnormal scans had similar event rates in both groups

Conclusion

New protocol of MPI in CZT-SPECT showed similar prognostic results to those obtained in dedicated cardiac Na-I SPECT camera, with lower prevalence of hard events in patients with normal scan.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3

Similar content being viewed by others

Abbreviations

MPI:

Myocardial perfusion imaging

CAD:

Coronary artery disease

SPECT:

Single-photon emission computed tomography

CZT:

Cadmium-zinc-telluride

BMI:

Body mass index

PCI:

Percutaneous coronary intervention

CABG:

Coronary artery bypass surgery

References

  1. Gimelli A, Rossi G, Landi P, Marzullo P, Iervasi G, L’abbate A, et al. Stress/rest myocardial perfusion abnormalities by gated SPECT: Still the best predictor of cardiac events in stable ischemic heart disease. J Nucl Med. 2009;50(4):546–53.

    Article  PubMed  Google Scholar 

  2. Underwood SR, Godman B, Salyani S, Ogle JR, Ell PJ. Economics of myocardial perfusion imaging in Europe—the EMPIRE Study. Eur Heart J. 1999;20(2):157–66.

    Article  CAS  PubMed  Google Scholar 

  3. De Puey EG. Advances in SPECT camera software and hardware: Currently available and new on the horizon. J Nucl Cardiol. 2012;19(3):551–81.

    Article  Google Scholar 

  4. Duvall WL, Croft LB, Ginsberg ES, Einstein AJ, Guma KA, George T, et al. Reduced isotope dose and imaging time with a high-efficiency CZT SPECT camera. J Nucl Cardiol. 2011;18(5):847–57.

    Article  PubMed  Google Scholar 

  5. Herzog BA, Buechel RR, Katz R, Brueckner M, Husmann L, Burger IA, et al. Nuclear myocardial perfusion imaging with a cadmium-zinc-telluride detector technique: optimized protocol for scan time reduction. J Nucl Med. 2010;51(1):46–51.

    Article  PubMed  Google Scholar 

  6. Slomka PJ, Patton JA, Berman DS, Germano G. Advances in technical aspects of myocardial perfusion SPECT imaging. J Nucl Cardiol. 2009;16(2):255–76.

    Article  PubMed  Google Scholar 

  7. De Lorenzo A, Peclat T, Amaral AC, Lima RSL. Prognostic evaluation in obese patients using a dedicated multipinhole cadmium-zinc telluride SPECT camera. Int J Cardiovasc Imaging. 2015;2015:1–7.

    Google Scholar 

  8. Diamond GA, Forrester JS, Hirsch M, Staniloff HM, Vas R, Berman DS, et al. Application of conditional probability analysis to the clinical diagnosis of coronary artery disease. J Clin Investig. 1980;65(5):1210–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Lima R, De Lorenzo A, Camargo G, Oliveira G, Reis T, Peclat T, et al. Prognostic value of myocardium perfusion imaging with a new reconstruction algorithm. J Nucl Cardiol. 2014;21(1):149–57.

    Article  PubMed  Google Scholar 

  10. Henzlova MJ, Cerqueira MD, Hansen CL, Taillefer R, Yao S-S. ASNC imaging guidelines for nuclear cardiology procedures: stress protocols and tracers. J Nucl Cardiol. 2009. doi:10.1007/s12350-009-9062-4.

    Google Scholar 

  11. Lima R, Peclat T, Amaral AC, Nakamoto A, Lavagnoli D, De Lorenzo A. Preliminary data on the prognostic value of a new protocol of ultra-fast myocardial scintigraphy with less radiation in CZT gamma camera. Arq Bras Cardiol: Im Cardiov. 2016;29(1):11–6.

    Google Scholar 

  12. Thygesen K, Alpert JS, White HD. Universal definitions of myocardial infarction. J Am Coll Cardiol. 2007;50:2173–95.

    Article  PubMed  Google Scholar 

  13. Douglas PS, Hendel RC, Cummings JE, Dent JM, Hodgson JM, Hoffmann U, et al. ACCF/ACR/AHA/ASE/ASNC/HRS/NASCI/RSNA/SAIP/SCAI/SCCT/SCMR 2008 Health Policy Statement on Structured Reporting in Cardiovascular Imaging. J Am Coll Cardiol. 2009;53:76–90.

    Article  PubMed  Google Scholar 

  14. Sharir T, Pinskiy M, Pardes A, Rochman A, Prokhorov V, Kovalski G, et al. Comparison of the diagnostic accuracies of very low stress-dose with standard-dose myocardial perfusion imaging: Automated quantification of one-day, stress-first SPECT using a CZT camera. J Nucl Card. 2016;23(1):11–20.

    Article  Google Scholar 

  15. Gimelli A, Bottai M, Giorgetti A, Genovesi D, Kusch A, Ripoli A, et al. Comparison between ultrafast and standard single-photon emission CT in patients with coronary artery disease: a pilot study. Circ Cardiovasc Imaging. 2011;4(1):51–8.

    Article  PubMed  Google Scholar 

  16. Oldan JD, Shaw LK, Hofmann P, Phelan M, Nelson J, Pagnanelli R, et al. Prognostic value of the cadmium-zinc-telluride camera: A comparison with a conventional (Anger) camera. J Nucl Cardiol. 2015. doi:10.1007/s12350-015-0224-2.

    PubMed Central  Google Scholar 

  17. Yokota S, Mouden M, Ottervanger JP, Engbers E, Knollema S, Timmer JR, et al. Prognostic value of normal stress-only myocardial perfusion imaging: a comparison between conventional and CZT-based SPECT. Eur J Nucl Med Mol Imaging. 2016;43(2):296–301.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors had no financial support for this research. The authors would like to thanks Dr. Ilan Gottlieb for his review and valuable suggestions.

Author information

Authors and Affiliations

  1. Department of Cardiology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Ronaldo Lima MD, PhD & Gabriel Camargo MD

  2. Nuclear Medicine, Clínica de Diagnóstico por Imagem, Rio de Janeiro, Brazil

    Ronaldo Lima MD, PhD

  3. Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    Thais Peclat MD, Thalita Soares BMBS, Caio Ferreira BMBS & Ana Carolina Souza BMBS

Authors
  1. Ronaldo Lima MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Thais Peclat MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Thalita Soares BMBS
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Caio Ferreira BMBS
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ana Carolina Souza BMBS
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Gabriel Camargo MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ronaldo Lima MD, PhD.

Ethics declarations

Disclosure

The authors declare that they have no conflict of interest.

Ethical standards

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments of comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

See related editorial, doi:10.1007/s12350-016-0640-y.

The authors of this article have provided a PowerPoint file, available for download at SpringerLink, which summarises the contents of the paper and is free for re-use at meetings and presentations. Search for the article DOI on http://SpringerLink.com

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PPTX 610 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lima, R., Peclat, T., Soares, T. et al. Comparison of the prognostic value of myocardial perfusion imaging using a CZT-SPECT camera with a conventional anger camera. J. Nucl. Cardiol. 24, 245–251 (2017). https://doi.org/10.1007/s12350-016-0618-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12350-016-0618-9

Keywords

Search

Navigation