Abstract
Introduction
Gastric metastases from renal cell carcinoma (RCC) are rare with few cases described in the literature.
Case report
We report the history of a 77-year-old male patient who underwent a right radical nephrectomy because of RCC. Two years after the diagnosis, he presented with abdominal pain and evidence of upper gastrointestinal bleeding. Esophagogastroduodenoscopy revealed a 3 cm, ulcerated, pedunculated polypoid mass in the stomach that was removed with a diathermic snare. Histology with immunohistochemistry confirmed the diagnosis of metastatic RCC. Three months of follow-up revealed no further episode of rebleeding.
Discussion
We identified (using the PubMed database) 44 cases of gastric metastasis of RCC in the literature; the majority were male patients, with mean age at presentation of 67.2 years and average time from nephrectomy to presentation of gastric metastases of 6.9 years. Our results suggest that endoscopy may have an important role in the treatment of these patients for controlling the complications and/or improving mean survival time.
Conclusion
Gastric metastases of RCC are rare but should be considered even many years after diagnosis and treatment of RCC, particularly in patients with gastrointestinal symptoms.
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References
Campbell SC, Andrew CN. Renal tumours. In: Wein AJ, Kavoussi LR, Novick AC, et al., editors. Campbell-Walsh urology. 9th ed. Saunders Elsevier Pub; 2007. p. 1582–605.
Maldazys JD, DeKernion JB. Prognostic factors in metastatic renal cell carcinoma. J Urol. 1986;136:376–9.
De Palma GD, Masone S, Rega M, et al. Metastatic tumors of the stomach. Clinical and endoscopic features. World J Gastroenterol. 2006;12:7326–8.
Sullivan WG, Cabot EB, Donohue RE. Metastatic renal cell carcinoma to stomach. Urology. 1980;15(4):375–8.
Nakamura R, Shimada A, Hara Y, et al. One case of intussusception due to intestinal metastasis of renal carcinoma. Jpn J Clin Surg. 1984;43:1637–40.
Cosme A, Orive V, Alzate LF, Torrado J, et al. Metástasis gástrica de un hipernefroma. Gastroenterol Hepatol. 1984;7:400–1.
Bisesti V, Parrella E, Cataldi C, et al. Ser di un raro caso di metastasi gastrica di adenocarcinoma renale. Osp Ital Pediatr. 1984;19:609–20.
Ibáñez Olcoz J, Jiménez López CE, Oteo Revuelta JA, et al. Gastric metastasis of renal adenocarcinoma. Presentation of a case and review of the literature. Rev Esp Enferm Apar Dig. 1989;76:259–61.
Márquez JL, Herrera JM, Herrera J, et al. Gastric metastasis of renal cell adenocarcinoma. Rev Esp Enferm Dig. 1992;81:129–30.
Durous E, Isaac S, Dubreuil C, et al. Late gastric metastasis of cancer of the kidney. Presse Med. 1992;21:996.
Otawa T, Muto I. A case of synchronous gastric metastasis from renal cell carcinoma with the chief complaint of hematemesis. Jpn J Clin Surg. 1992;53:1219–22.
Herrera Puerto J, Caballero Gómez M, Márquez Galán JL, et al. Metastatic hypernephroma of the stomach. Arch Esp Urol. 1993;46:729–31.
Boruchowicz A, Desreumaux P, Maunoury V, et al. Dysphagia revealing esophageal and gastric metastases of renal carcinoma. Am J Gastroenterol. 1995;90:2263–4.
Blake MA, Owens A, O’Donoghue DP, et al. Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: report of three cases. Gut. 1995;37:835–7.
Odori T, Tsuboi Y, Katoh K, et al. A solitary hematogenous metastasis to the gastric wall from renal cell carcinoma four years after radical nephrectomy. J Clin Gastroenterol. 1998;26:153–4.
Picchio M, Paioletti A, Santini E, Iacoponi S, Cordahi M. Gastric metastasis from renal cell carcinoma fourteen years after radical nephrectomy. Acta Chir Belg. 2000;100:228–30.
Mascarenhas B, Konety B, Rubin JT. Recurrent metastatic renal cell carcinoma presenting as a bleeding gastric ulcer after a complete response to high-dose interleukin-2 treatment. Urology. 2001;57:168.
Kobayashi O, Murakami H, Yoshida T, et al. Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World J Surg. 2004;28:548–51.
Kok Wee L, Shyu RY, Sheu LF, Hsieh TY, Yan JC, Chen PJ. Metastatic renal cell cancer. Gastrointest Endosc. 2004;60:265.
Suárez Fonseca C, Carballido Rodríguez J, González Lama Y, et al. Gastric metastasis from renal cell carcinoma. Pathogenical hypothesis and literature revision. Actas Urol Esp. 2004;28(6):472–6.
Lamb GW, Moss J, Edwards R, Aitchison M. Case report: octreotide as an adjunct to embolisation in the management of recurrent bleeding upper gastrointestinal metastases from primary renal cell cancer. Int Urol Nephrol. 2005;37:691–3.
Riviello C, Tanini I, Cipriani G, et al. Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: a case report and a review of literature. World J Gastroenterol. 2006;12:5234–6.
Portanova M, Yabar A, Lombardi E, et al. Concomitant gastric and pancreatic metastases from renal cell carcinoma: case study. Rev Gastroenterol Peru. 2006;26:84–8.
Pezzoli A, Matarese V, Boccia S, Simone L, et al. Gastrointestinal bleeding from gastric metastasis of renal cell carcinoma, treated by endoscopic polypectomy. Endoscopy. 2007;39(Suppl 1):E52.
Saidi RF, Remine SG. Isolated gastric metastasis from renal cell carcinoma 10 years after radical nephrectomy. J Gastroenterol Hepatol. 2007;22:143–4.
Pollheimer MJ, Hinterleitner TA, Pollheimer VS, et al. Renal cell carcinoma metastatic to the stomach: single centre experience and literature review. BJU Int. 2008;102:315–9.
Ko WO, Yang US, Kim NS, et al. A case of a gastric metastasis of a renal cell carcinoma. Korean J Gastrointest Endosc. 2008;36:288–91.
Kibria R, Sharma K, Ali SA, Rao P. Upper gastrointestinal bleeding revealing the stomach metastases of renal cell carcinoma. J Gastrointest Cancer. 2009;40:51–4.
Yamamoto D, Hamada Y, Okazaki S, et al. Metastatic gastric tumor from renal cell carcinoma. Gastric Cancer. 2009;12:170–3.
Maeda T, Kozakai N, Nishiyama T, Ishii T, Sugiura H, Nakamura K. Gastric metastasis from renal cell carcinoma 20 months after radical nephrectomy: a case report. Hinyokika Kiyo. 2009;55:137–40.
Tiwari P, Tiwari A, Vijay M, et al. Upper gastro-intestinal bleeding—rare presentation of renal cell carcinoma. Urol Ann. 2010;2(3):127–9.
García-Campelo R, Quindós M, Vázquez DD, et al. Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma. Anticancer Drugs. 2010;21(Suppl 1):S13–5.
Sugasawa H, Ichikura T, Ono S, et al. Isolated gastric metastasis from renal cell carcinoma 19 years after radical nephrectomy. Int J Clin Oncol. 2010;15:196–200.
Eslick GD, Kalantar JS. Gastric metastasis in renal cell carcinoma: a case report and systematic review. J Gastrointest Cancer. 2011;42:296–301.
Cruz A, Ramírez LM, Sánchez E, et al. Gastric metastasis from renal cancer six years after nephrectomy. Rev Esp Enferm Dig. 2011;103(12):660–1.
Kim MY, Jung HY, Choi KD, et al. Solitary synchronous metastatic gastric cancer arising from t1b renal cell carcinoma: a case report and systematic review. Gut Liver. 2012;6(3):388–9436.
Xu J, Latif S, Wei S. Metastatic renal cell carcinoma presenting as gastric polyps: a case report and review of the literature. Int J Surg Case Rep. 2012;3(12):601–4.
Gómez-de-la-Cuesta S, Fernández-Salazar L, Velayos-Jiménez B, et al. Gastric metastasis from renal cell carcinoma. Rev Esp Enferm Dig. 2012;104(6):334–5.
Siriwardana HP, Harvey MH, Kadirkamanathan SS, et al. Endoscopic mucosal resection of a solitary metastatic tumor in the stomach: a case report. Surg Laparosc Endosc Percutan Tech. 2012;22(3):e132–4.
Namikawa T, Iwabu J, Kitagawa H, et al. Solitary gastric metastasis from a renal cell carcinoma, presenting 23 years after radical nephrectomy. Endoscopy. 2012;44(Suppl 2 UCTN):E177–8.
Rodrigues S, Bastos P, Macedo G. A rare cause of hematemesis: gastric metastases from renal cell carcinoma. Gastrointest Endosc. 2012;75(4):894.
Thyavihally YB, Mahantshetty U, Chamarajanagar RS, et al. Management of renal cell carcinoma with solitary metastasis. World J Surg Oncol. 2005;3:48.
Namikawa T, Munekage M, Kitagawa H, et al. Metastatic gastric tumors arising from renal cell carcinoma: clinical characteristics and outcomes of this uncommon disease. Oncol Lett. 2012;4(4):631–63.
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Conflict of Interest: The authors have nothing to declare.
Human/Animal Rights: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).
Informed Consent: Informed consent was obtained from the patient to be included in the study.
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Rita, H., Isabel, A., Iolanda, C. et al. Treatment of gastric metastases from renal cell carcinoma with endoscopic therapy. Clin J Gastroenterol 7, 148–154 (2014). https://doi.org/10.1007/s12328-014-0470-x
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DOI: https://doi.org/10.1007/s12328-014-0470-x