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Determination of the survival rate in patients with congestive heart failure stratified by 123I-MIBG imaging: a meta-analysis from the studies performed in Japan

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Abstract

Background

The goals of this meta-analysis were to determine survival rates in patients with heart failure (HF) assessed by 123I-MIBG imaging results using recently published studies and to determine the prognostic value of 123I-MIBG imaging.

Methods

We reviewed published cohort studies carried out in Japan that compared the prognosis of patients with their 123I-MIBG activity quantified as late heart-to-mediastinum ratio (H/M) or washout rate by performing a PubMed search for articles in English up to December 2006. Studies were selected if they analyzed a clearly defined lethal outcome (cardiovascular death) using life tables to estimate the odds ratio at 24 months after enrollment.

Results

Of 158 articles related to cardiac 123I-MIBG, seven referred to studies that met the inclusion criteria: 5 evaluated H/M via 123I-MIBG in a total of 866 patients and 4 calculated washout rate in a total of 491 patients. A low H/M indicated a high risk of cardiac death: pooled odds ratio, 5.2; 95% confidence interval (CI) of 3.1–5.7. A high washout was also associated with lethal events with a pooled odds ratio of 2.8 (CI: 1.6–5.0). The association between washout and cardiac death was heterogeneous (Chi-square = 11.0, P < 0.02), whereas that between late H/M and fatal events was homogeneous (Chi-square = 2.3, P = no significance).

Conclusion

This meta-analysis of published studies of 123I-MIBG studies conducted in Japan indicated that both a decreased cardiac 123I-MIBG activity (H/M) and an increased washout rate are indicative of a poor prognosis in patients with chronic heart failure.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8677, Japan

    Yoichi Kuwabara

  2. Department of Nuclear Medicine, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, 060-8638, Japan

    Nagara Tamaki

  3. Department of Cardiology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo, 060-8543, Japan

    Tomoaki Nakata

  4. Department of Cardiovascular Medicine, Toho University Omori Medical Center, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 143-8541, Japan

    Shohei Yamashina & Junichi Yamazaki

Authors
  1. Yoichi Kuwabara
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  2. Nagara Tamaki
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  3. Tomoaki Nakata
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  4. Shohei Yamashina
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  5. Junichi Yamazaki
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Correspondence to Junichi Yamazaki.

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Kuwabara, Y., Tamaki, N., Nakata, T. et al. Determination of the survival rate in patients with congestive heart failure stratified by 123I-MIBG imaging: a meta-analysis from the studies performed in Japan. Ann Nucl Med 25, 101–107 (2011). https://doi.org/10.1007/s12149-010-0452-0

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  • DOI: https://doi.org/10.1007/s12149-010-0452-0

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