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P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation

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Abstract

Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors. Activation of these receptors regulates a wide range of physiological and pathological processes. In this review, we present an overview of the current literature regarding P2X and P2Y receptors in the CNS with a focus on the contribution of P2X7 and P2Y2 receptor-mediated responses to neuroinflammatory and neuroprotective mechanisms.

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Authors and Affiliations

  1. Department of Biochemistry, University of Missouri, 540E Life Sciences Center, 1201 Rollins Road, Columbia, MO, 65211-7310, USA

    Gary A. Weisman, Jean M. Camden, Deepa Ajit, Lucas T. Woods & Laurie Erb

  2. Interdisciplinary Neuroscience Program, University of Missouri, Columbia, MO, USA

    Gary A. Weisman & Troy S. Peterson

  3. Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO, USA

    Gary A. Weisman, Jean M. Camden, Troy S. Peterson, Deepa Ajit, Lucas T. Woods & Laurie Erb

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  1. Gary A. Weisman
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  2. Jean M. Camden
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  3. Troy S. Peterson
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  4. Deepa Ajit
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  5. Lucas T. Woods
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  6. Laurie Erb
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Correspondence to Gary A. Weisman.

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Weisman, G.A., Camden, J.M., Peterson, T.S. et al. P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation. Mol Neurobiol 46, 96–113 (2012). https://doi.org/10.1007/s12035-012-8263-z

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  • DOI: https://doi.org/10.1007/s12035-012-8263-z

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