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Adjunct Management of Male Hypogonadism

  • Male Sexual Dysfunction and Disorders (AW Pastuszak and TS Köhler, Section Editors)
  • Published:
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Abstract

While testosterone replacement therapy (TRT) has been the main strategy in the management of male hypogonadism, the significant risks associated with TRT have driven the search for alternative strategies to treat hypogonadism. With the high preponderance of secondary and mixed-dysfunction hypogonadism, medications such as clomiphene citrate, aromatase inhibitors, and human chorionic gonadotropin (HCG), which target the hypothalamus/pituitary portions of the hypothalamus-pituitary-gonadal axis, have increasingly been studied despite not being FDA-approved for treatment of male hypogonadism. While these agents have demonstrated some promise in managing male hypogonadism, the current evidence behind their use remains weak and there is a need for well-designed, prospective trials that can further elucidate the roles for these agents in the management of male hypogonadism.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Authors and Affiliations

  1. Department of Urology, Weill Cornell Medicine, 525 East 68th Street, Starr 900, New York, NY, 10065, USA

    Phil Vu Bach, Bobby B. Najari & James A. Kashanian

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  1. Phil Vu Bach
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  2. Bobby B. Najari
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Correspondence to James A. Kashanian.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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PVB and BBN were supported by The Frederick J. and Theresa Dow Wallace Fund of the New York Community Trust.

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This article is part of the Topical Collection on Male Sexual Dysfunction and Disorders

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Bach, P.V., Najari, B.B. & Kashanian, J.A. Adjunct Management of Male Hypogonadism. Curr Sex Health Rep 8, 231–239 (2016). https://doi.org/10.1007/s11930-016-0089-7

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