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Ten Developments in the Use of Biologicals for Systemic Lupus Erythematosus

  • SYSTEMIC LUPUS ERYTHEMATOSUS (M PETRI, SECTION EDITOR)
  • Published:
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Abstract

Belimumab has recently been approved, and several other types of biological therapy with different mechanisms of action are currently in phase II and III studies. This review puts these approaches in context, emphasizing mechanistic categories and clinical trial designs. Most of the promising approaches involve B cell depletion or modulation. Post-approval experience with belimumab is critically reviewed.

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Conflict of interest

Dr Wallace consults for UCB, Pfizer, Amgen, and Lilly and consults and is on the speaker's bureau for Glaxo Smith Kline.

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  1. Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA

    Daniel J. Wallace

  2. 8737 Beverly Blvd, Suite 302, West Hollywood, CA, 90048, USA

    Daniel J. Wallace

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Correspondence to Daniel J. Wallace.

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This article is part of the Topical Collection on Systemic Lupus Erythematosus

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Wallace, D.J. Ten Developments in the Use of Biologicals for Systemic Lupus Erythematosus. Curr Rheumatol Rep 15, 337 (2013). https://doi.org/10.1007/s11926-013-0337-z

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