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Gold nanoparticles: sonocatalytic synthesis using ethanolic extract of Andrographis paniculata and functionalization with polycaprolactone-gelatin composites

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Abstract

Gold nanoparticles (AuNPs) were synthesized by sonication using ethanolic leaf extract of Andrographis paniculata. We investigated the optimum parameters for AuNP synthesis and functionalization with polycaprolactone-gelatin (PCL-GL) composites. The AuNPs were characterized with various biophysical techniques such as TEM, XRD, FT-IR and EDX spectroscopy. TEM images showed that nanoparticles were spherical in shape with a size range from 5 to 75 nm. EDX analysis revealed the presence of molecular oxygen and carbon on the surface of AuNPs. The synthesized AuNPs were tested for their effect on HeLa (human cervical cancer) and MCF-7 (human breast cancer) cell lines and found to be nontoxic and biocompatible, which are potential carriers for hydrophobic drugs.

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Authors and Affiliations

  1. Biomaterials and Tissue Engineering Laboratory, Department of Biotechnology, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India

    Punuri Jayasekhar Babu & Utpal Bora

  2. Biotech Hub, Centre for the Environment, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India

    Punuri Jayasekhar Babu, Sibyala Saranya, Pragya Sharma, Ranjan Tamuli & Utpal Bora

  3. Department of Biotechnology, D.R.W. College, Gudur, SPS Nellore, Andhra, Pradesh, 524101, India

    Sibyala Saranya

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  1. Punuri Jayasekhar Babu
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  2. Sibyala Saranya
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  4. Ranjan Tamuli
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Correspondence to Utpal Bora.

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Babu, P.J., Saranya, S., Sharma, P. et al. Gold nanoparticles: sonocatalytic synthesis using ethanolic extract of Andrographis paniculata and functionalization with polycaprolactone-gelatin composites. Front. Mater. Sci. 6, 236–249 (2012). https://doi.org/10.1007/s11706-012-0175-3

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  • DOI: https://doi.org/10.1007/s11706-012-0175-3

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