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Metabolic Effects of Bariatric Surgery in Insulin-Sensitive Morbidly Obese Subjects

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Abstract

Background

The effects of bariatric surgery (BS) in metabolically healthy morbidly obese (MO) subjects are not well established. Against this background, we characterized the metabolic and inflammatory profiles of MO subjects with insulin sensitivity (IS) in the normal range, and evaluated the changes on these parameters following BS in this population.

Methods

We conducted a retrospective analysis of prospectively collected data in MO women undergoing BS between 2006 and 2010. Anthropometric, metabolic comorbidities, and inflammatory markers were compared at baseline and 12 months after BS, between 52 women (10.4 %) presenting with a HOMA-IR <2.94 (80th percentile reference population) (IS-MO group) and an age- and BMI-matched group of women (n = 52) with HOMA-IR >2.94.

Results

The IS-MO women presented a more favorable metabolic and inflammatory profile as compared to the IR-MO group. However, an enlarged waist circumference (WC), a high-sensitivity C-reactive protein (hs-CRP) >3 mg/dL, and metabolic syndrome (MS) were present in 100 %, 90 %, and 51.9 % of the IS-MO group at baseline. At 12 months after surgery, all the MS components and hs-CRP improved in IS-MO subjects (p < 0.01). The prevalence of the MS in the IS-MO group significantly decreased (11 %, p < 0.05) despite WC and hs-CRP being abnormal respectively in 53.3 % and 20.0 % of women in this group.

Conclusions

In MO women, an IS in the normal range is associated with a limited protection from metabolic co-morbidities. Nonetheless, BS results in the amelioration of the altered metabolic and inflammatory profiles also in this group of subjects.

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Conflict of Interest

As authors of this manuscript, Amanda Jiménez, Verónica Perea, Ricard Corcelles, Violeta Moizé, Antonio Lacy, and Josep Vidal declare that they do not have competing financial interests to disclose in relation to the work described herein.

Disclosure Statement

The authors have no conflicts of interest to disclose.

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Authors and Affiliations

  1. Obesity Unit, Hospital Clinic Universitari, Barcelona, Spain

    Amanda Jiménez, Verónica Perea, Ricard Corcelles, Violeta Moizé, Antonio Lacy & Josep Vidal

  2. Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    Josep Vidal

  3. Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain

    Antonio Lacy & Josep Vidal

  4. Obesity Unit, Endocrinology and Diabetes Department, Hospital Clínic Universitari, Villarroel 170, 08036, Barcelona, Spain

    Josep Vidal

Authors
  1. Amanda Jiménez
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  2. Verónica Perea
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  3. Ricard Corcelles
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  4. Violeta Moizé
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  5. Antonio Lacy
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  6. Josep Vidal
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Correspondence to Josep Vidal.

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Jiménez, A., Perea, V., Corcelles, R. et al. Metabolic Effects of Bariatric Surgery in Insulin-Sensitive Morbidly Obese Subjects. OBES SURG 23, 494–500 (2013). https://doi.org/10.1007/s11695-012-0817-7

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  • DOI: https://doi.org/10.1007/s11695-012-0817-7

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