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Nasopharyngeal carcinoma: correlation of apparent diffusion coefficient value with prognostic parameters

Carcinoma nasofaringeo: correlazione tra il valore del coefficiente apparente di diffusione e i parametri prognostici

  • Head and Neck Radiology / Radiologia del Capo e del Collo
  • Published:
La radiologia medica Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to correlate the apparent diffusion coefficient (ADC) value with the prognostic parameters of nasopharyngeal carcinoma (NPC).

Materials and methods

This was a prospective study conducted on 30 consecutive patients (19 men, 11 women; mean age 61 years) with NPC. Patients underwent diffusion-weighted magnetic resonance (DW-MR) singleshot echoplanar imaging at 1.5 Tesla. NPC ADC value was correlated with pathological tumour type, pathological tumour grade, tumour volume and nodal status.

Results

Mean NPC ADC value was 0.99±0.11×10−3mm2/s. ADC values of well-differentiated and moderately differentiated tumours differed significantly (p=0.005) from those of poorly differentiated and undifferentiated NPC. There was also a significant difference in ADC value among small, medium and large tumour volume (p=0.03). ADC value was also significantly lower (p=0.003) when metastatic cervical lymph nodes were present. ADC value correlated inversely with tumour volume (r=−0.799, p=0.03).

Conclusions

ADC value can be considered a noninvasive prognostic parameter that correlates well with prognostic parameters of NPC.

Riassunto

Obiettivo

Lo scopo di questo studio è stato quello di correlare il valore del coefficiente apparente di diffusione (ADC) con i parametri prognostici del carcinoma nasofaringeo (NPC).

Materiali e metodi

Questo è stato uno studio prospettico su 30 pazienti consecutivi (19 uomini e 11 donne, con un’età media di 61 anni) con NPC. I pazienti sono stati sottoposti a Risonanza Magnetica a 1,5 Tesla con studio di diffusione usando sequenze ecoplanari single-shot. Il valore di ADC del NPC è stato correlato con il tipo di tumore, il grado, il volume tumorale e lo stato linfonodale.

Risultati

Il valore medio dell’ADC dei NPC è stato 0,99±0,11x10−3mm2/s. I valori di ADC dei tumori ben differenziati e moderatamente differenziati sono stati significativamente diversi (p=0,005) rispetto ai valori degli NPC scarsamente differenziati o indifferenziati. C’è stata anche una differenza significativa nei valori di ADC tra tumori di piccole, medie o grandi dimensioni (p=0,03). I valori di ADC sono inoltre stati significativamente inferiori (p=0,003) in caso di presenza di metastasi linfonodali cervicali. Il valore di ADC dei carcinomi nasofaringei è risultato essere inversamente proporzionale al volume tumorale (r=-0,799, p=0,03).

Conclusioni

Il valore di ADC può essere considerato un parametro prognostico non invasivo che correla con i parametri prognostici per l’NPC.

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Authors and Affiliations

  1. Department of Radiology, Mansoura Faculty of Medicine, Mansoura, 13351, Egypt

    Ahmed Abdel Khalek Abdel Razek

  2. Department of ENT and Head and Neck Surgery, Mansoura Faculty of Medicine, Mansoura, Egypt

    Elsharawey Kamal

Authors
  1. Ahmed Abdel Khalek Abdel Razek
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  2. Elsharawey Kamal
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Correspondence to Ahmed Abdel Khalek Abdel Razek.

Additional information

Presented as oral presentation at the Assembly and annual meeting of Radiological Society of North America (RSNA).

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Abdel Razek, A.A.K., Kamal, E. Nasopharyngeal carcinoma: correlation of apparent diffusion coefficient value with prognostic parameters. Radiol med 118, 534–539 (2013). https://doi.org/10.1007/s11547-012-0890-x

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  • DOI: https://doi.org/10.1007/s11547-012-0890-x

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