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Interplay Between Wnt/β-Catenin Signaling and HIV: Virologic and Biologic Consequences in the CNS

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Abstract

Considerable studies have evaluated the interaction between Wnt/β-catenin signaling and numerous cellular processes. Emerging findings now demonstrate that Wnt/β-catenin signaling interacts with the life cycle of the Human Immunodeficiency Virus type 1 (HIV-1). Wnt/β-catenin is a restrictive pathway to HIV replication in multiple target cells including peripheral blood mononuclear cells and astrocytes. The molecular interaction between Wnt/β-catenin signaling and HIV has been evaluated in astrocytes because they express robust level of this pathway. The cross talk that occurs between these two components has significant biologic consequences to HIV-mediated neuropathogenesis. This perspective highlights current knowledge regarding the interaction between Wnt/β-catenin signaling and HIV, the interplay between these two pathways as it impacts key features of NeuroAIDS, and provides an assessment of knowledge gaps in the field that could propel our understanding of this interaction to inform novel strategies to exploit Wnt signaling for therapeutic intervention in HIV/NeuroAIDS.

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Acknowledgment

I thank colleagues in the Wnt signaling field that have paved the way and discovered key tools to benefit the greater Wnt field community. I also thank present and past members of the Al-Harthi lab who propelled these studies forward (Lisa J. Henderson, Srinivasa Narasipura, Maureen Richards, Deborah Carrol-Anzinger; Anvita Kumar, and Wei Li). This work was supported by the following grants from the National Institutes of Health: R01 NS060632, R03 DA 026723, R01 DA 033966, and PO1A1082971.

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  1. Department of Immunology and Microbiology, Rush University Medical Center, 1735 W. Harrison Street, 614 Cohn, Chicago, IL, 60612, USA

    Lena Al-Harthi

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  1. Lena Al-Harthi
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Correspondence to Lena Al-Harthi.

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Al-Harthi, L. Interplay Between Wnt/β-Catenin Signaling and HIV: Virologic and Biologic Consequences in the CNS. J Neuroimmune Pharmacol 7, 731–739 (2012). https://doi.org/10.1007/s11481-012-9411-y

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